GAIN THERAPEUTICS INC GANX
COM · Common Stock · CUSIP 36269B105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBethesda, MD
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 43.6m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.01. Options: 4 managers hold calls ($245.8k notional), 1 hold puts ($72.5k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 24 |
| Q4 2022 | 22 |
| Q1 2023 | 23 |
| Q2 2023 | 25 |
| Q3 2023 | 25 |
| Q4 2023 | 25 |
| Q1 2024 | 27 |
| Q2 2024 | 29 |
| Q3 2024 | 20 |
| Q4 2024 | 26 |
| Q1 2025 | 34 |
| Q2 2025 | 36 |
| Q3 2025 | 38 |
| Q4 2025 | 48 |
| Q1 2026 | 42 |
| Q2 2026 | 50 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 7 | 15 |
| Q4 2024 | 18 | 6 |
| Q1 2025 | 21 | 4 |
| Q2 2025 | 17 | 9 |
| Q3 2025 | 23 | 9 |
| Q4 2025 | 35 | 13 |
| Q1 2026 | 16 | 25 |
| Q2 2026 | 27 | 13 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $168.8k | $0 | 0.00 |
| Q4 2025 | $375.5k | $145.9k | 0.39 |
| Q1 2026 | $502.1k | $99.7k | 0.20 |
| Q2 2026 | $245.8k | $72.5k | 0.29 |
Biggest buyers
| Cambridge Investment Research Advisors, Inc. | Added | +568.6k |
| GSA CAPITAL PARTNERS LLP | Added | +319.7k |
| MARSHALL WACE, LLP | Added | +153.8k |
| Squarepoint Ops LLC | New | +136.4k |
| CITADEL ADVISORS LLC | Added | +129.6k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +80.4k |
| Stratos Wealth Partners, LTD. | Added | +68.4k |
| XTX Topco Ltd | New | +55.3k |
| BlackRock, Inc. | Added | +49.9k |
| COMMONWEALTH EQUITY SERVICES, LLC | Added | +28.8k |
Biggest sellers
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -353.1k |
| JANE STREET GROUP, LLC | Reduced | -161.3k |
| Potomac Capital Management, Inc. | Reduced | -62.2k |
| Schonfeld Strategic Advisors LLC | Sold out | -24.5k |
| JONES FINANCIAL COMPANIES LLLP | Reduced | -23.0k |
| NORTHERN TRUST CORP | Reduced | -17.0k |
| MORGAN STANLEY | Reduced | -13.7k |
| SIMPLEX TRADING, LLC | Sold out | -13.4k |
| Kestra Advisory Services, LLC | Sold out | -12.0k |
| UBS Group AG | Reduced | -5.5k |
Biggest calls
| JANE STREET GROUP, LLC | Added | $84.4k41.6k shares |
| CITADEL ADVISORS LLC | Added | $82.6k40.7k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $58.7k28.9k shares |
| SIMPLEX TRADING, LLC | Added | $20.1k9.9k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $72.5k35.7k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| MARSHALL WACE, LLP 0.00% of their portfolio | 1.9m $3.9m | Added +153.8k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 1.1m $2.3m | Added +568.6k |
| Potomac Capital Management, Inc. 1.41% of their portfolio | 946.4k $1.9m | Reduced -62.2k |
| GSA CAPITAL PARTNERS LLP 0.08% of their portfolio | 632.1k $1.3m | Added +319.7k |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 608.6k $1.1m | Reduced -23.0k |
| DME Capital Management, LP 0.03% of their portfolio | 566.1k $1.1m | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 480.3k $974.9k | Added +80.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 453.5k $921.4k | Added +6.2k |
| BlackRock, Inc. 0.00% of their portfolio | 275.0k $558.2k | Added +49.9k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 231.5k $470.0k | Added +1.6k |
| UBS Group AG 0.00% of their portfolio | 215.0k $436.5k | Reduced -5.5k |
| Stratos Wealth Partners, LTD. 0.00% of their portfolio | 200.0k $406.0k | Added +68.4k |
| Cresset Asset Management, LLC 0.00% of their portfolio | 160.0k $324.8k | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 157.5k $319.8k | Unchanged |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 154.5k $313.7k | Added +129.6k |
| Squarepoint Ops LLC 0.00% of their portfolio | 136.4k $276.8k | New |
| MORGAN STANLEY 0.00% of their portfolio | 126.0k $255.7k | Reduced -13.7k |
| LPL Financial LLC 0.00% of their portfolio | 117.3k $238.0k | Added +13.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 97.0k $196.9k | Reduced -17.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 78.2k $158.8k | Reduced -353.1k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 58.5k $118.7k | Added +28.8k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 55.6k $112.9k | Reduced -161.3k |
| XTX Topco Ltd 0.00% of their portfolio | 55.3k $112.2k | New |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 35.8k $72.7k | Unchanged |
| BENEDICT FINANCIAL ADVISORS INC 0.01% of their portfolio | 35.0k $71.0k | Added +19.5k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 30.0k $60.9k | Unchanged |
| Apollon Wealth Management, LLC 0.00% of their portfolio | 26.5k $53.8k | Unchanged |
| Virtu Financial LLC 0.00% of their portfolio | 21.0k $43.0k | Added +10.3k |
| Oliver Luxxe Assets LLC 0.01% of their portfolio | 20.2k $41.1k | Unchanged |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 18.4k $37.3k | Unchanged |
| HighTower Advisors, LLC 0.00% of their portfolio | 17.2k $34.9k | New |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 17.1k $30.7k | Added +1.5k |
| Wealthspire Advisors, LLC 0.00% of their portfolio | 16.9k $34.3k | Unchanged |
| Sandhill Capital Partners LLC 0.00% of their portfolio | 15.4k $31.3k | Unchanged |
| Millington Financial Advisors, LLC 0.01% of their portfolio | 15.0k $25.6k | Unchanged |
| HB Wealth Management, LLC 0.00% of their portfolio | 12.8k $25.9k | New |
| TWO SIGMA SECURITIES, LLC 0.00% of their portfolio | 12.7k $25.9k | New |
| HARBOUR INVESTMENTS, INC. 0.00% of their portfolio | 10.7k $21.8k | New |
| NewEdge Advisors, LLC 0.00% of their portfolio | 10.6k $21.5k | Unchanged |
| MERCER GLOBAL ADVISORS INC /ADV 0.00% of their portfolio | 10.0k $20.3k | New |
| Sanctuary Advisors, LLC 0.00% of their portfolio | 10.0k $20.3k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 9.4k $19.1k | Reduced -1.6k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 8.3k $16.9k | Added +2.8k |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 3.8k $7.7k | Reduced -2.6k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 2.0k $4.1k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.7k $3.4k | Unchanged |
| Arax Advisory Partners 0.00% of their portfolio | 1.7k $3.5k | New |
| BARCLAYS PLC 0.00% of their portfolio | 1.4k $2.7k | New |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 165 $335 | New |
| Larson Financial Group LLC 0.00% of their portfolio | 10 $20 | Unchanged |