FULCRUM THERAPEUTICS INC FULC
COM · Common Stock · CUSIP 359616109
Company in Cambridge, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, MA
- Founded2016
- Websitefulcrumtx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 52.1m as of 2022-11-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $7.28. Options: 5 managers hold calls ($4.2m notional), 5 hold puts ($379.7k).
Trends to Q4 2022
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 106 |
| Q4 2022 | 111 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $5.2m | $312.0k | 0.06 |
| Q4 2022 | $4.2m | $379.7k | 0.09 |
Biggest buyers
| RA CAPITAL MANAGEMENT, L.P. | Added | +2.5m |
| RTW INVESTMENTS, LP | Added | +1.0m |
| MONTANOVA CAPITAL, LLC | Added | +746.8k |
| Nantahala Capital Management, LLC | New | +500.0k |
| BlackRock Inc. | Added | +496.6k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +230.8k |
| CITADEL ADVISORS LLC | Added | +174.1k |
| VANGUARD GROUP INC | Added | +164.5k |
| DIMENSIONAL FUND ADVISORS LP | Added | +152.8k |
| TWO SIGMA INVESTMENTS, LP | New | +133.0k |
Biggest sellers
| FMR LLC | Reduced | -2.6m |
| TRV GP III, LLC | Reduced | -2.0m |
| Point72 Asset Management, L.P. | Sold out | -1.5m |
| COWEN AND COMPANY, LLC | Reduced | -986.8k |
| Venrock Adviser, LLC | Reduced | -752.7k |
| PERCEPTIVE ADVISORS LLC | Sold out | -294.1k |
| Monashee Investment Management LLC | Sold out | -200.0k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -200.0k |
| Sofinnova Investments, Inc. | Reduced | -165.9k |
| Deep Track Capital, LP | Reduced | -132.1k |
Biggest calls
| CITADEL ADVISORS LLC | Reduced | $2.3m322.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.8m243.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $85.0k11.7k shares |
| GROUP ONE TRADING LLC | Reduced | $8.0k1.1k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $167.4k23.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $139.0k19.1k shares |
| SIMPLEX TRADING, LLC | Added | $55.0k7.6k shares |
| GROUP ONE TRADING LLC | Added | $18.2k2.5k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| TANG CAPITAL MANAGEMENT LLC 13G · passive investor +2.2 pts · filed 2026-07-15 | 10.4% |
| EcoR1 Capital, LLC 13G · institution no change · filed 2026-06-25 | 9.0% |
| Nantahala Capital Management, LLC 13G · institution +3.6 pts · filed 2026-08-14 | 8.2% |
| BlackRock Portfolio Management LLC 13G · institution +2.1 pts · filed 2026-10-27 | 8.1% |
| BlackRock, Inc. 13G · institution +1.2 pts · filed 2026-07-28 | 7.2% |
| MONTANOVA CAPITAL, LLC 13G · institution -3.9 pts · filed 2026-08-14 | 5.5% |
Fell to 5% or below in the last year: BANK OF AMERICA CORP /DE/ (1.5%, 2026-10-28), RA CAPITAL MANAGEMENT, L.P. (0.0%, 2026-08-14), TCG Crossover GP II, LLC (0.0%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q4 2022
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2021 | 0 | — | 0 | — | — |
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 1 | $3.5m | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2022-12-27 | RA Capital Healthcare Fund LP +3 10% owner · See Footnotes | Bought | $24.5k4.1k shares |
| 2022-12-19 | RA Capital Healthcare Fund LP +3 10% owner · See Footnotes | Bought | $582.8k98.8k shares |
| 2022-12-16 | RA Capital Healthcare Fund LP +3 10% owner · See Footnotes | Bought | $7.3m1.3m shares |
| 2022-12-15 | RA Capital Healthcare Fund LP +3 10% owner · See Footnotes | Bought | $1.3m237.0k shares |
| 2022-12-14 | RA Capital Healthcare Fund LP +3 10% owner · See Footnotes | Bought | $4.5m824.6k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2022
| Manager | Shares | Change |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. 1.40% of their portfolio | 9.5m $69.2m | Added +2.5m |
| FMR LLC 0.00% of their portfolio | 5.2m $38.1m | Reduced -2.6m |
| RTW INVESTMENTS, LP 0.74% of their portfolio | 5.0m $36.4m | Added +1.0m |
| MONTANOVA CAPITAL, LLC 1.31% of their portfolio | 4.3m $31.1m | Added +746.8k |
| BlackRock Inc. 0.00% of their portfolio | 3.3m $23.8m | Added +496.6k |
| TRV GP IV, LLC 7.25% of their portfolio | 2.3m $17.1m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.1m $15.4m | Added +164.5k |
| Logos Global Management LP 1.71% of their portfolio | 2.0m $14.6m | Added +50.0k |
| TRV GP III, LLC 11.20% of their portfolio | 2.0m $14.3m | Reduced -2.0m |
| COWEN AND COMPANY, LLC 1.05% of their portfolio | 1.4m $9.9m | Reduced -986.8k |
| MORGAN STANLEY 0.00% of their portfolio | 1.2m $8.5m | Reduced -26.7k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio | 1.1m $8.2m | Reduced -200.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 855.8k $6.2m | Added +230.8k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 816.2k $5.9m | Added +174.1k |
| STATE STREET CORP 0.00% of their portfolio | 780.4k $5.7m | Added +54.9k |
| Deep Track Capital, LP 0.24% of their portfolio | 768.6k $5.6m | Reduced -132.1k |
| Sofinnova Investments, Inc. 0.28% of their portfolio | 631.4k $4.6m | Reduced -165.9k |
| Nantahala Capital Management, LLC 0.33% of their portfolio | 500.0k $3.6m | New |
| Venrock Adviser, LLC 0.55% of their portfolio | 447.3k $3.3m | Reduced -752.7k |
| HARVARD MANAGEMENT CO INC 0.37% of their portfolio | 410.7k $3.0m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 390.5k $2.8m | Added +79.2k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 386.8k $2.8m | Added +152.8k |
| Rock Springs Capital Management LP 0.07% of their portfolio | 384.6k $2.8m | Unchanged |
| NORGES BANK 0.00% of their portfolio | 356.6k $2.6m | Not comparable |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 315.4k $2.3m | Reduced -29.3k |
| BESSEMER GROUP INC 0.01% of their portfolio | 287.0k $2.1m | Added +1.3k |
| Alphabet Inc. 0.11% of their portfolio | 255.5k $1.9m | Unchanged |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 253.7k $1.8m | Added +95.5k |
| Parkman Healthcare Partners LLC 0.40% of their portfolio | 206.9k $1.5m | Reduced -28.5k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 197.9k $1.4m | Added +65.4k |
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC 0.44% of their portfolio | 193.7k $1.4m | Unchanged |
| ACUTA CAPITAL PARTNERS, LLC 0.83% of their portfolio | 185.0k $1.3m | Reduced -35.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 184.7k $1.3m | Reduced -11.3k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 176.1k $1.3m | Added +93.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 150.5k $1.1m | Added +105.9k |
| Fiduciary Trust Co 0.02% of their portfolio | 136.6k $994.1k | Added +4.1k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 133.0k $968.4k | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 125.9k $916.8k | Added +62.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 114.9k $836.4k | Added +22.1k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 106.6k $776.0k | Added +40.0k |
| Man Group plc 0.00% of their portfolio | 96.2k $700.0k | Added +10.4k |
| Swiss National Bank 0.00% of their portfolio | 89.6k $652.3k | Unchanged |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.01% of their portfolio | 84.6k $615.6k | Added +26.8k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 64.0k $465.9k | Added +13.7k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 59.7k $435.0k | Added +9.0k |
| J. Goldman & Co LP 0.03% of their portfolio | 59.1k $430.2k | Reduced -89.4k |
| Tekla Capital Management LLC 0.02% of their portfolio | 58.5k $426.1k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 57.6k $419.6k | Added +27.8k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 50.3k $366.4k | Added +4.3k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 43.8k $319.0k | Added +21.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 42.8k $311.6k | Added +5.2k |
| PDT Partners, LLC 0.05% of their portfolio | 41.4k $301.4k | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 40.0k $291.2k | Reduced -35.0k |
| ALPS ADVISORS INC 0.00% of their portfolio | 35.4k $257.4k | New |
| CORNERCAP INVESTMENT COUNSEL INC 0.04% of their portfolio | 34.9k $254.0k | New |
| XTX Topco Ltd 0.05% of their portfolio | 34.9k $253.9k | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 34.9k $253.9k | Added +8.0k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 34.3k $249.7k | Added +1.7k |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 30.7k $223.5k | Reduced -5.8k |
| COUNTRY TRUST BANK 0.01% of their portfolio | 30.2k $219.8k | Unchanged |
| BRANDYWINE MANAGERS, LLC 0.66% of their portfolio | 26.1k $190.2k | Unchanged |
| OCCUDO QUANTITATIVE STRATEGIES LP 0.02% of their portfolio | 26.0k $189.3k | Reduced -6.6k |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 23.2k $169.2k | Reduced -5.8k |
| SVB FINANCIAL GROUP 0.06% of their portfolio | 22.4k $22.4k | First filing |
| Graham Capital Management, L.P. 0.01% of their portfolio | 21.4k $155.4k | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 21.0k $153.0k | Added +330 |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 20.6k $150.0k | Added +4.4k |
| Blackstone Inc. 0.00% of their portfolio | 19.2k $139.9k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 18.9k $137.5k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 18.8k $136.6k | Reduced -5.0k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 18.7k $135.9k | Added +4 |
| Old Well Partners, LLC 0.11% of their portfolio | 17.3k $125.9k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 17.0k $123.9k | Added +2.0k |
| Alpine Global Management, LLC 0.04% of their portfolio | 16.1k $117.0k | New |
| SG Americas Securities, LLC 0.00% of their portfolio | 16.0k $117.0k | Added +4.2k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 15.5k $113.0k | Reduced -4.6k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 14.8k $107.7k | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 13.9k $101.4k | Added +1.1k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 13.6k $98.8k | Added +18 |
| Invesco Ltd. 0.00% of their portfolio | 13.0k $94.5k | Added +1.7k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 12.8k $93.3k | New |
| BARCLAYS PLC 0.00% of their portfolio | 11.7k $85.1k | First filing |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 11.7k $85.1k | New |
| Corton Capital Inc. 0.07% of their portfolio | 11.6k $84.2k | New |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 0.01% of their portfolio | 11.1k $80.9k | New |
| ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio | 10.7k $78.0k | Added +428 |
| Delphia (USA) Inc. 0.09% of their portfolio | 10.6k $77.3k | New |
| Bank Julius Baer & Co. Ltd, Zurich 0.00% of their portfolio | 8.5k $62.0k | Added +134 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 7.7k $56.0k | Added +7.2k |
| AMALGAMATED BANK 0.00% of their portfolio | 5.7k $42.0k | Added +1.7k |
| UBS Group AG 0.00% of their portfolio | 3.8k $27.6k | New |
| PrairieView Partners, LLC 0.00% of their portfolio | 3.6k $26.0k | Unchanged |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 3.3k $42.2k | Added +1.3k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 3.2k $23.3k | Reduced -2.4k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 2.7k $19.3k | Unchanged |
| Metropolitan Life Insurance Co/NY 0.00% of their portfolio | 2.1k $15.1k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.8k $13.0k | Reduced -289 |
| CITIGROUP INC 0.00% of their portfolio | 1.8k $12.8k | Reduced -167 |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 1.7k $12.0k | Added +509 |
| SOA Wealth Advisors, LLC. 0.00% of their portfolio | 800 $5.8k | New |