FATE THERAPEUTICS INC FATE
COM · Common Stock · CUSIP 31189P102 · ISIN US31189P1021
A clinical-stage biopharmaceutical company in San Diego, United States
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Diego, CA
- Websitefatetherapeutics.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 115.4m as of 2025-11-06, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $0.98. Options: 3 managers hold calls ($70.5k notional), 4 hold puts ($121.6k).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 240 |
| Q4 2022 | 229 |
| Q1 2023 | 184 |
| Q2 2023 | 190 |
| Q3 2023 | 172 |
| Q4 2023 | 160 |
| Q1 2024 | 168 |
| Q2 2024 | 184 |
| Q3 2024 | 165 |
| Q4 2024 | 160 |
| Q1 2025 | 133 |
| Q2 2025 | 140 |
| Q3 2025 | 143 |
| Q4 2025 | 146 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 87 | 82 |
| Q2 2024 | 91 | 72 |
| Q3 2024 | 58 | 96 |
| Q4 2024 | 73 | 87 |
| Q1 2025 | 56 | 81 |
| Q2 2025 | 69 | 62 |
| Q3 2025 | 65 | 55 |
| Q4 2025 | 51 | 70 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $63.7k | $6.2k | 0.10 |
| Q2 2025 | $263.7k | $40.4k | 0.15 |
| Q3 2025 | $112.1k | $48.5k | 0.43 |
| Q4 2025 | $70.5k | $121.6k | 1.73 |
Biggest buyers
| Point72 Asset Management, L.P. | New | +1.5m |
| RENAISSANCE TECHNOLOGIES LLC | Added | +1.1m |
| TWO SIGMA INVESTMENTS, LP | Added | +833.3k |
| TWO SIGMA ADVISERS, LP | Added | +644.3k |
| DAFNA Capital Management LLC | New | +550.0k |
| JANE STREET GROUP, LLC | Added | +239.0k |
| ACADIAN ASSET MANAGEMENT LLC | Added | +221.7k |
| VANGUARD GROUP INC | Added | +172.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +131.3k |
| LPL Financial LLC | Added | +120.9k |
Biggest sellers
| Wilshire Advisors LLC | Sold out | -8.5m |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Sold out | -814.6k |
| Vestal Point Capital, LP | Reduced | -790.0k |
| TANG CAPITAL MANAGEMENT LLC | Reduced | -700.0k |
| DIMENSIONAL FUND ADVISORS LP | Reduced | -517.5k |
| BlackRock, Inc. | Reduced | -504.2k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -441.3k |
| Woodline Partners LP | Reduced | -356.0k |
| Schonfeld Strategic Advisors LLC | Reduced | -351.9k |
| Graham Capital Management, L.P. | Reduced | -273.5k |
Biggest calls
| GROUP ONE TRADING LLC | Added | $42.1k42.8k shares |
| LPL Financial LLC | New | $24.6k25.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $3.8k3.9k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $74.4k75.9k shares |
| CITADEL ADVISORS LLC | Added | $32.6k33.2k shares |
| GROUP ONE TRADING LLC | Reduced | $8.8k9.0k shares |
| SIMPLEX TRADING, LLC | Added | $5.8k5.9k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Redmile Group, LLC 13D · may seek influence no change · filed 2026-04-22 | 14.9% |
Fell to 5% or below in the last year: BlackRock, Inc. (1.9%, 2026-07-08), VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 4 | $237.7k | $47.2k |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 1 | $2.7k | $2.7k |
| Q4 2024 | 1 | $668.6k | 1 | $573.9k | — |
| Q1 2025 | 0 | — | 3 | $31.4k | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 2 | $24.9k | — |
| Q4 2025 | 0 | — | 0 | — | — |
None reported in Q4 2025.
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| Redmile Group, LLC 0.93% of their portfolio | 12.9m $12.6m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 10.2m $10.0m | Reduced -504.2k |
| VANGUARD GROUP INC 0.00% of their portfolio | 9.0m $8.8m | Added +172.9k |
| JOHNSON & JOHNSON 0.60% of their portfolio | 3.4m $3.3m | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 2.9m $2.9m | Added +221.7k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.5m $2.4m | Reduced -61.9k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 2.4m $2.3m | Added +1.1m |
| STATE STREET CORP 0.00% of their portfolio | 2.3m $2.2m | Reduced -151.9k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 1.7m $1.7m | Added +833.3k |
| Vestal Point Capital, LP 0.06% of their portfolio | 1.7m $1.7m | Reduced -790.0k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 1.7m $1.6m | Added +644.3k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 1.6m $1.6m | Reduced -517.5k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 1.5m $1.5m | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.4m $1.4m | Reduced -51.4k |
| TANG CAPITAL MANAGEMENT LLC 0.06% of their portfolio | 1.2m $1.1m | Reduced -700.0k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.2m $1.1m | Added +30.6k |
| MORGAN STANLEY 0.00% of their portfolio | 916.9k $901.0k | Reduced -13.0k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 842.8k $828.1k | Added +239.0k |
| Monaco Asset Management SAM 0.24% of their portfolio | 830.0k $815.6k | Added +60.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 784.6k $771.0k | Reduced -1.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 749.3k $736.3k | Reduced -75.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 732.7k $719.9k | Reduced -81.8k |
| Bruce & Co., Inc. 0.22% of their portfolio | 729.2k $716.5k | Unchanged |
| DAFNA Capital Management LLC 0.13% of their portfolio | 550.0k $540.4k | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 522.6k $513.5k | Reduced -441.3k |
| UBS Group AG 0.00% of their portfolio | 403.5k $396.7k | Added +88.8k |
| Invesco Ltd. 0.00% of their portfolio | 379.0k $372.4k | Added +64.2k |
| Privium Fund Management B.V. 0.07% of their portfolio | 369.1k $362.7k | Added +35.9k |
| Knott David M Jr 0.17% of their portfolio | 365.0k $358.6k | Unchanged |
| XTX Topco Ltd 0.01% of their portfolio | 364.7k $358.4k | Reduced -73.2k |
| Woodline Partners LP 0.00% of their portfolio | 356.6k $350.4k | Reduced -356.0k |
| Nuveen, LLC 0.00% of their portfolio | 336.9k $331.0k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 310.2k $304.8k | Added +131.3k |
| BARCLAYS PLC 0.00% of their portfolio | 308.5k $303.2k | Added +98.1k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 307.6k $302.2k | Reduced -8.7k |
| Quadrature Capital Ltd 0.00% of their portfolio | 298.1k $292.9k | Reduced -79.3k |
| Man Group plc 0.00% of their portfolio | 261.2k $256.6k | Added +41.5k |
| GSA CAPITAL PARTNERS LLP 0.02% of their portfolio | 213.6k $210.0k | Reduced -97.2k |
| Graham Capital Management, L.P. 0.01% of their portfolio | 195.6k $192.2k | Reduced -273.5k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 195.4k $192.5k | Added +97.6k |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 192.7k $189.3k | Reduced -351.9k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 187.7k $184.4k | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 172.3k $169.3k | Added +38.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 151.1k $148.4k | Added +4.6k |
| Assenagon Asset Management S.A. 0.00% of their portfolio | 148.7k $146.1k | Added +2.8k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 146.8k $144.3k | Reduced -7.3k |
| LPL Financial LLC 0.00% of their portfolio | 144.8k $142.3k | Added +120.9k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 135.0k $132.7k | Added +35.0k |
| National Philanthropic Trust 0.00% of their portfolio | 125.0k $122.8k | Unchanged |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 121.5k $119.4k | Reduced -16.1k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 111.2k $109.3k | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 95.2k $122.8k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 91.7k $89.8k | Reduced -65.5k |
| State of Tennessee, Department of Treasury 0.00% of their portfolio | 90.0k $107.1k | New |
| Leo Wealth, LLC 0.01% of their portfolio | 70.4k $69.2k | Unchanged |
| Shay Capital LLC 0.01% of their portfolio | 70.0k $68.8k | New |
| Virtu Financial LLC 0.00% of their portfolio | 68.9k $68.0k | New |
| SEI INVESTMENTS CO 0.00% of their portfolio | 67.6k $66.5k | Reduced -78 |
| Corient Private Wealth LP 0.00% of their portfolio | 59.7k $58.6k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 54.5k $54.0k | Unchanged |
| Cerity Partners LLC 0.00% of their portfolio | 52.5k $51.6k | Added +1.7k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 52.4k $51.5k | Added +1.7k |
| CWM, LLC 0.00% of their portfolio | 51.8k $51.0k | Reduced -14.3k |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 51.7k $50.8k | Reduced -4.7k |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 50.9k $50.1k | Reduced -13.3k |
| HRT FINANCIAL LP 0.00% of their portfolio | 48.5k $47.0k | Reduced -12.3k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 43.4k $42.7k | Reduced -57.4k |
| SG Americas Securities, LLC 0.00% of their portfolio | 38.9k $38.0k | Added +24.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 35.7k $35.0k | New |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 34.9k $35.3k | Reduced -3.8k |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 34.1k $34.0k | Unchanged |
| HighTower Advisors, LLC 0.00% of their portfolio | 32.2k $31.7k | Reduced -5.0k |
| Focus Partners Wealth 0.00% of their portfolio | 32.0k $31.4k | Added +19.8k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 29.3k $28.8k | Added +1.9k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 28.0k $27.5k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 27.5k $27.0k | Added +16.9k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 26.5k $26.1k | New |
| FPC INVESTMENT ADVISORY, INC. 0.01% of their portfolio | 26.5k $26.0k | Unchanged |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 25.5k $25.1k | Added +6.0k |
| CANADA LIFE ASSURANCE Co 0.00% of their portfolio | 24.4k $24.0k | Reduced -5.3k |
| Creative Planning 0.00% of their portfolio | 23.9k $23.5k | Reduced -2.4k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 23.2k $22.8k | Reduced -20.0k |
| Bronte Capital Management Pty Ltd. 0.00% of their portfolio | 22.9k $22.5k | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 22.5k $22.1k | Unchanged |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 20.8k $20.4k | Unchanged |
| Quinn Opportunity Partners LLC 0.00% of their portfolio | 20.0k $19.7k | Unchanged |
| ProShare Advisors LLC 0.00% of their portfolio | 19.9k $19.5k | Reduced -2.8k |
| NINE MASTS CAPITAL Ltd 0.00% of their portfolio | 19.4k $19.1k | New |
| Parametrica Management Ltd 0.03% of their portfolio | 18.5k $18.2k | Unchanged |
| TIAA TRUST, NATIONAL ASSOCIATION 0.00% of their portfolio | 17.6k $17.3k | Unchanged |
| Sagewood Asset Management LP 0.01% of their portfolio | 15.0k $14.7k | First filing |
| Mariner, LLC 0.00% of their portfolio | 14.9k $14.6k | Reduced -8.0k |
| Pallas Capital Advisors LLC 0.00% of their portfolio | 14.7k $14.4k | Reduced -2.1k |
| Parcion Private Wealth LLC 0.00% of their portfolio | 14.1k $13.8k | Reduced -412 |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 13.9k $13.7k | New |
| MERCER GLOBAL ADVISORS INC /ADV 0.00% of their portfolio | 13.9k $13.7k | Reduced -2.5k |
| FMR LLC 0.00% of their portfolio | 12.8k $12.5k | Added +2.3k |
| Narwhal Capital Management 0.00% of their portfolio | 12.7k $12.5k | Unchanged |
| AlphaCore Capital LLC 0.00% of their portfolio | 12.7k $12.5k | New |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 12.6k $12.4k | Added +28 |