ETON PHARMACEUTICALS INC ETON
COM · Common Stock · CUSIP 29772L108
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersDeer Park, IL
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($87.5k this quarter). Holder counts are more reliable. Shares outstanding: 26.8m as of 2025-08-05, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $14.25. Options: 5 managers hold calls ($4.5m notional), 3 hold puts ($169.6k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 33 |
| Q4 2022 | 32 |
| Q1 2023 | 36 |
| Q2 2023 | 34 |
| Q3 2023 | 51 |
| Q4 2023 | 57 |
| Q1 2024 | 45 |
| Q2 2024 | 46 |
| Q3 2024 | 49 |
| Q4 2024 | 72 |
| Q1 2025 | 87 |
| Q2 2025 | 88 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 31 | 10 |
| Q4 2023 | 32 | 17 |
| Q1 2024 | 15 | 26 |
| Q2 2024 | 13 | 22 |
| Q3 2024 | 22 | 18 |
| Q4 2024 | 51 | 14 |
| Q1 2025 | 54 | 33 |
| Q2 2025 | 61 | 44 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $1.6m | $9.0k | 0.01 |
| Q4 2024 | $3.9m | $69.3k | 0.02 |
| Q1 2025 | $891.4k | $475.6k | 0.53 |
| Q2 2025 | $4.5m | $169.6k | 0.04 |
Biggest buyers
| BlackRock, Inc. | Added | +1.2m |
| Divisadero Street Capital Management, LP | New | +497.7k |
| MORGAN STANLEY | Added | +362.2k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +294.6k |
| Soleus Capital Management, L.P. | New | +285.0k |
| VANGUARD GROUP INC | Added | +211.2k |
| STATE STREET CORP | Added | +209.0k |
| THOMPSON SIEGEL & WALMSLEY LLC | Added | +191.4k |
| NORTHERN TRUST CORP | Added | +177.8k |
| TWO SIGMA INVESTMENTS, LP | Added | +132.2k |
Biggest sellers
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -418.2k |
| MILLENNIUM MANAGEMENT LLC | Sold out | -355.9k |
| CANNELL CAPITAL LLC | Reduced | -303.2k |
| STIFEL FINANCIAL CORP | Reduced | -211.8k |
| Mink Brook Asset Management LLC | Reduced | -126.3k |
| PRELUDE CAPITAL MANAGEMENT, LLC | Reduced | -125.8k |
| Cubist Systematic Strategies, LLC | Sold out | -103.2k |
| JANE STREET GROUP, LLC | Sold out | -95.9k |
| Informed Momentum Co LLC | Sold out | -77.8k |
| Aristides Capital LLC | Reduced | -74.0k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $2.8m198.5k shares |
| CITADEL ADVISORS LLC | Added | $615.6k43.2k shares |
| SIMPLEX TRADING, LLC | Added | $558.0k39.2k shares |
| GROUP ONE TRADING LLC | Added | $542.9k38.1k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $168.2k11.8k shares |
| GROUP ONE TRADING LLC | New | $1.4k100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| EcoR1 Capital, LLC 13G · institution filed 2025-02-14 | 7.7% |
| BlackRock, Inc. 13G · institution +1.2 pts · filed 2026-07-28 | 6.9% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 2 | $4.1m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-16 | Krempa David Chief Business Officer | Sold | $150.6k10.2k shares |
| 2025-06-13 | Krempa David Chief Business Officer | Sold | $100.4k6.8k shares |
| 2025-06-12 | Krempa David Chief Business Officer | Sold | $253.3k17.0k shares |
| 2025-06-10 | Opaleye Management Inc. 10% owner · By Opaleye, L.P. | Bought | $79.1k5.0k shares |
| 2025-06-10 | Opaleye Management Inc. 10% owner · Managed Account | Bought | $46.4k2.9k shares |
| 2025-06-05 | BRYNJELSEN SEAN President & CEO, director | Sold | $1.2m70.0k shares |
| 2025-06-04 | BRYNJELSEN SEAN President & CEO, director | Sold | $1.2m70.0k shares |
| 2025-06-03 | BRYNJELSEN SEAN President & CEO, director | Sold | $1.2m70.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| Opaleye Management Inc. 8.25% of their portfolio | 2.9m $40.8m | Added +7.9k |
| EcoR1 Capital, LLC 1.71% of their portfolio | 2.0m $28.9m | Added +91.3k |
| BlackRock, Inc. 0.00% of their portfolio | 1.5m $21.8m | Added +1.2m |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.3m $18.7m | Added +211.2k |
| Nantahala Capital Management, LLC 1.19% of their portfolio | 1.2m $16.8m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 592.9k $8.5m | Added +294.6k |
| MORGAN STANLEY 0.00% of their portfolio | 509.6k $7.3m | Added +362.2k |
| Divisadero Street Capital Management, LP 0.47% of their portfolio | 497.7k $7.1m | New |
| National Philanthropic Trust 0.09% of their portfolio | 492.1k $7.0m | Unchanged |
| Westside Investment Management, Inc. 1.25% of their portfolio | 472.8k $6.7m | Reduced -20.9k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 405.9k $5.8m | Added +131.9k |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 392.7k $5.6m | Reduced -9.7k |
| CANNELL CAPITAL LLC 1.73% of their portfolio | 388.2k $5.5m | Reduced -303.2k |
| THOMPSON SIEGEL & WALMSLEY LLC 0.09% of their portfolio | 381.3k $5.4m | Added +191.4k |
| STATE STREET CORP 0.00% of their portfolio | 323.2k $4.6m | Added +209.0k |
| Soleus Capital Management, L.P. 0.28% of their portfolio | 285.0k $4.1m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 262.2k $3.7m | Added +177.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 242.6k $3.5m | Added +129.5k |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 222.1k $3.2m | Reduced -10.4k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 214.6k $3.1m | Added +132.2k |
| UBS Group AG 0.00% of their portfolio | 212.5k $3.0m | Added +116.7k |
| Aristides Capital LLC 0.76% of their portfolio | 167.6k $2.4m | Reduced -74.0k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.05% of their portfolio | 135.3k $1.9m | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 127.3k $1.8m | Added +53.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 109.4k $1.6m | Reduced -65.8k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 108.2k $1.5m | Reduced -211.8k |
| Apis Capital Advisors, LLC 0.54% of their portfolio | 106.0k $1.5m | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 100.9k $1.4m | Added +47.8k |
| Squarepoint Ops LLC 0.00% of their portfolio | 93.8k $1.3m | Added +29.0k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 90.4k $1.3m | Added +12.2k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 87.7k $1.2m | Added +48.4k |
| ANCHOR CAPITAL ADVISORS LLC 0.04% of their portfolio | 87.7k $1.2m | Added +27.5k |
| Diametric Capital, LP 0.65% of their portfolio | 84.9k $1.2m | Added +65.3k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 77.8k $1.1m | Added +64.6k |
| Nuveen, LLC 0.00% of their portfolio | 58.9k $839.6k | New |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 54.3k $773.4k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 45.8k $652.5k | Added +1.1k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.06% of their portfolio | 43.6k $621.3k | Reduced -125.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 36.9k $526.1k | Added +24.5k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 36.6k $521.5k | New |
| Aquatic Capital Management LLC 0.01% of their portfolio | 35.9k $510.9k | New |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 34.6k $492.4k | Reduced -52.3k |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 32.4k $461.7k | Reduced -2.5k |
| BRC Group Holdings, Inc. 0.52% of their portfolio | 31.5k $448.9k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 30.6k $436.0k | Reduced -418.2k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 29.2k $416.3k | Added +3.9k |
| Quantbot Technologies LP 0.01% of their portfolio | 25.2k $359.6k | Added +17.4k |
| Man Group plc 0.00% of their portfolio | 23.8k $338.5k | Added +1.4k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 23.1k $328.5k | Added +5.7k |
| ESSEX INVESTMENT MANAGEMENT CO LLC 0.05% of their portfolio | 20.2k $287.6k | Reduced -237 |
| Hillsdale Investment Management Inc. 0.01% of their portfolio | 18.9k $269.4k | Reduced -80 |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 18.1k $258.1k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 17.4k $247.9k | New |
| CHICAGO TRUST Co NA 0.03% of their portfolio | 16.7k $238.0k | Unchanged |
| MetLife Investment Management, LLC 0.00% of their portfolio | 15.5k $221.4k | New |
| Mink Brook Asset Management LLC 0.19% of their portfolio | 15.1k $215.7k | Reduced -126.3k |
| PDT Partners, LLC 0.01% of their portfolio | 14.9k $212.2k | Reduced -10.9k |
| Steward Partners Investment Advisory, LLC 0.00% of their portfolio | 14.1k $200.4k | Added +6.6k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 14.0k $200.0k | New |
| Engineers Gate Manager LP 0.00% of their portfolio | 13.9k $197.9k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 13.8k $195.9k | Added +13.0k |
| Magnetar Financial LLC 0.00% of their portfolio | 13.7k $195.7k | New |
| Invesco Ltd. 0.00% of their portfolio | 13.5k $192.1k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 12.8k $183.0k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 12.1k $172.0k | New |
| State of Tennessee, Department of Treasury 0.00% of their portfolio | 12.0k $171.0k | Reduced -1.9k |
| State of Wyoming 0.02% of their portfolio | 11.5k $163.9k | Reduced -14.9k |
| Quantum Private Wealth, LLC 0.05% of their portfolio | 11.5k $163.9k | Unchanged |
| Y-Intercept (Hong Kong) Ltd 0.00% of their portfolio | 11.0k $156.6k | Reduced -2.4k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 10.1k $144.0k | Added +8.5k |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 10.0k $142.5k | New |
| CITIGROUP INC 0.00% of their portfolio | 9.1k $129.7k | Added +9.1k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 8.1k $115.4k | New |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 6.1k $87.5k | New |
| AlphaQuest LLC 0.01% of their portfolio | 5.9k $84.8k | Added +1.8k |
| Legal & General Group Plc 0.00% of their portfolio | 2.9k $40.6k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 2.6k $37.3k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 2.6k $36.5k | Reduced -413 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 1.6k $22.8k | New |
| Truvestments Capital LLC 0.00% of their portfolio | 1.2k $16.9k | Unchanged |
| AMALGAMATED BANK 0.00% of their portfolio | 876 $12.0k | New |
| FMR LLC 0.00% of their portfolio | 455 $6.5k | Added +445 |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 433 $6.2k | Added +356 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 200 $2.9k | New |
| Vermillion & White Wealth Management Group, LLC 0.00% of their portfolio | 150 $2.1k | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 102 $1.5k | Added +2 |
| Sterling Capital Management LLC 0.00% of their portfolio | 62 $884 | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio | 0 $0 | Unchanged |