ENTRADA THERAPEUTICS INC TRDA
COM · Common Stock · CUSIP 29384C108
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoston, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($42.6k this quarter). Holder counts are more reliable. Shares outstanding: 38.2m as of 2025-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $5.92. Options: 3 managers hold calls ($10.2m notional), 1 hold puts ($81.2k).
Trends to Q3 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 33 |
| Q4 2022 | 48 |
| Q1 2023 | 54 |
| Q2 2023 | 57 |
| Q3 2023 | 56 |
| Q4 2023 | 63 |
| Q1 2024 | 78 |
| Q2 2024 | 85 |
| Q3 2024 | 98 |
| Q4 2024 | 103 |
| Q1 2025 | 111 |
| Q2 2025 | 108 |
| Q3 2025 | 116 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2023 | 31 | 16 |
| Q1 2024 | 37 | 26 |
| Q2 2024 | 58 | 20 |
| Q3 2024 | 61 | 27 |
| Q4 2024 | 59 | 38 |
| Q1 2025 | 44 | 54 |
| Q2 2025 | 65 | 49 |
| Q3 2025 | 75 | 44 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2024 | $30.8m | $102.9k | 0.00 |
| Q1 2025 | $15.9m | $20.8k | 0.00 |
| Q2 2025 | $11.8m | $0 | 0.00 |
| Q3 2025 | $10.2m | $81.2k | 0.01 |
Biggest buyers
| MILLENNIUM MANAGEMENT LLC | Added | +666.3k |
| ACADIAN ASSET MANAGEMENT LLC | Added | +252.1k |
| JPMORGAN CHASE & CO | Added | +251.7k |
| CITADEL ADVISORS LLC | Added | +235.4k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +214.8k |
| JANE STREET GROUP, LLC | Added | +196.4k |
| MORGAN STANLEY | Added | +183.7k |
| Qube Research & Technologies Ltd | Added | +154.1k |
| BNP PARIBAS FINANCIAL MARKETS | Added | +145.2k |
| GOLDMAN SACHS GROUP INC | Added | +138.2k |
Biggest sellers
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -2.2m |
| JANUS HENDERSON GROUP PLC | Sold out | -1.5m |
| FMR LLC | Reduced | -464.2k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -106.3k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | Sold out | -102.0k |
| FEDERATED HERMES, INC. | Reduced | -94.7k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | Sold out | -87.4k |
| FIRST TRUST ADVISORS LP | Sold out | -75.1k |
| 5AM Venture Management, LLC | Reduced | -52.0k |
| NORTHERN TRUST CORP | Reduced | -46.7k |
Biggest calls
| Merck & Co., Inc. | Unchanged | $10.1m1.7m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $79.5k13.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $32.0k5.6k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $81.2k14.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| 5AM Ventures V, L.P. 13D · may seek influence filed 2025-11-18 | 10.8% |
| MPM BioVentures 2014, L.P. 13D · may seek influence filed 2026-09-10 | 9.9% |
| ROCHE FINANCE LTD 13G · exempt (held before listing) filed 2025-02-14 | 6.9% |
| BlackRock, Inc. 13G · institution new · filed 2025-02-04 | 5.3% |
Fell to 5% or below in the last year: TCG Crossover GP I, LLC (2.7%, 2026-08-14), PRICE T ROWE ASSOCIATES INC /MD/ (0.9%, 2025-11-14)
Insider purchases and sales in Q3 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2023 | 0 | — | 2 | $241.0k | $241.0k |
| Q1 2024 | 1 | $178.7k | 3 | $103.8k | $103.8k |
| Q2 2024 | 1 | $830.3k | 2 | $349.0k | $349.0k |
| Q3 2024 | 0 | — | 4 | $668.4k | $668.4k |
| Q4 2024 | 0 | — | 2 | $1.0m | $1.0m |
| Q1 2025 | 0 | — | 1 | $19.0k | $19.0k |
| Q2 2025 | 0 | — | 1 | $688.5k | — |
| Q3 2025 | 0 | — | 1 | $380.5k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-07-09 | ROCKLAGE SCOTT M +5 10% owner | Sold | $150.5k20.1k shares |
| 2025-07-09 | PARMAR KUSH Director · By 5AM Ventures V, L.P. | Sold | $150.5k20.1k shares |
| 2025-07-09 | ROCKLAGE SCOTT M +5 10% owner · By 5AM Opportunities I, L.P. | Sold | $52.0k6.9k shares |
| 2025-07-09 | PARMAR KUSH Director · By 5AM Opportunities I, L.P. | Sold | $52.0k6.9k shares |
| 2025-07-01 | PARMAR KUSH Director · By 5AM Ventures V, L.P. | Sold | $132.3k18.6k shares |
| 2025-07-01 | ROCKLAGE SCOTT M +5 10% owner | Sold | $132.3k18.6k shares |
| 2025-07-01 | PARMAR KUSH Director · By 5AM Opportunities I, L.P. | Sold | $45.7k6.4k shares |
| 2025-07-01 | ROCKLAGE SCOTT M +5 10% owner · By 5AM Opportunities I, L.P. | Sold | $45.7k6.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q3 2025
| Manager | Shares | Change |
|---|---|---|
| BAKER BROS. ADVISORS LP 0.20% of their portfolio | 4.9m $28.2m | Unchanged |
| MPM ASSET MANAGEMENT LLC 57.09% of their portfolio | 4.4m $25.4m | Unchanged |
| 5AM Venture Management, LLC 9.04% of their portfolio | 4.3m $24.7m | Reduced -52.0k |
| BlackRock, Inc. 0.00% of their portfolio | 2.0m $11.9m | Added +21.9k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.6m $9.3m | Reduced -635 |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 954.4k $5.5m | Reduced -106.3k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 836.6k $4.9m | Added +666.3k |
| StepStone Group LP 2.08% of their portfolio | 761.3k $4.4m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 645.1k $3.7m | Added +13.6k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 594.3k $3.4m | Added +214.8k |
| TCG Crossover Management, LLC 0.17% of their portfolio | 585.0k $3.4m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 498.6k $2.9m | Added +2.8k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 394.3k $2.3m | Reduced -29.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 360.5k $2.1m | Reduced -2.2m |
| MORGAN STANLEY 0.00% of their portfolio | 346.8k $2.0m | Added +183.7k |
| ROYCE & ASSOCIATES LP 0.02% of their portfolio | 345.5k $2.0m | Added +122.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 335.7k $1.9m | Added +235.4k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 315.8k $1.8m | Added +95.1k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 297.9k $1.7m | Added +252.1k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 287.9k $1.7m | Added +154.1k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 267.8k $1.6m | Added +251.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 253.6k $1.5m | Reduced -46.7k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 247.5k $1.4m | Added +196.4k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 222.3k $1.3m | Added +138.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 185.3k $1.1m | Reduced -18.4k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 148.2k $859.6k | Added +145.2k |
| ALGERT GLOBAL LLC 0.01% of their portfolio | 129.8k $752.9k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 126.4k $733.4k | Added +90.0k |
| Trexquant Investment LP 0.01% of their portfolio | 122.9k $712.6k | Added +112.3k |
| Cubist Systematic Strategies, LLC 0.01% of their portfolio | 122.7k $711.5k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 105.8k $613.7k | Added +7.8k |
| MOORE CAPITAL MANAGEMENT, LP 0.01% of their portfolio | 105.0k $609.0k | Unchanged |
| Walleye Capital LLC 0.00% of their portfolio | 96.7k $560.8k | Added +79.3k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 93.2k $540.5k | New |
| XTX Topco Ltd 0.03% of their portfolio | 93.1k $539.9k | New |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 75.4k $437.3k | Added +300 |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 71.5k $415.0k | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 69.9k $405.6k | Added +25.0k |
| CANTOR FITZGERALD, L. P. 0.08% of their portfolio | 67.3k $3.9m | New |
| BARCLAYS PLC 0.00% of their portfolio | 60.6k $351.7k | Added +2.5k |
| Quantinno Capital Management LP 0.00% of their portfolio | 58.2k $337.7k | Added +39.6k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 56.9k $330.2k | Added +1.1k |
| Nuveen, LLC 0.00% of their portfolio | 56.4k $327.2k | Unchanged |
| GSA CAPITAL PARTNERS LLP 0.03% of their portfolio | 56.0k $325.0k | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 52.1k $302.1k | Added +7.4k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 51.5k $298.7k | New |
| Nan Fung Group Holdings Ltd 0.48% of their portfolio | 49.1k $284.7k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 42.1k $245.0k | Added +3.5k |
| GREAT LAKES ADVISORS, LLC 0.00% of their portfolio | 41.0k $238.0k | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 40.0k $232.0k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 39.4k $228.7k | Added +333 |
| Corton Capital Inc. 0.55% of their portfolio | 38.8k $225.3k | Added +10.1k |
| TD Asset Management Inc 0.00% of their portfolio | 37.8k $219.2k | Reduced -10.0k |
| MARTINGALE ASSET MANAGEMENT L P 0.01% of their portfolio | 37.1k $214.9k | Reduced -2.4k |
| FMR LLC 0.00% of their portfolio | 31.9k $185.3k | Reduced -464.2k |
| Atom Investors LP 0.01% of their portfolio | 30.8k $178.7k | New |
| OCCUDO QUANTITATIVE STRATEGIES LP 0.02% of their portfolio | 29.5k $171.0k | Added +19.3k |
| OXFORD ASSET MANAGEMENT LLP 0.06% of their portfolio | 29.2k $169.1k | New |
| Invesco Ltd. 0.00% of their portfolio | 29.1k $168.6k | Added +6.7k |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio | 28.2k $163.6k | Added +13.2k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 25.8k $149.4k | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 24.3k $141.1k | Added +1.6k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 21.6k $125.4k | Added +3.5k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 21.0k $121.8k | Added +5.5k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 20.6k $117.2k | New |
| UBS Group AG 0.00% of their portfolio | 18.9k $109.7k | Reduced -5.8k |
| SHERBROOKE PARK ADVISERS LLC 0.05% of their portfolio | 18.6k $107.7k | New |
| Quadrature Capital Ltd 0.00% of their portfolio | 17.9k $103.4k | New |
| Allspring Global Investments Holdings, LLC 0.00% of their portfolio | 15.9k $92.4k | Reduced -157 |
| Virtus Investment Advisers, LLC 0.02% of their portfolio | 14.5k $84.1k | Added +2.5k |
| NewEdge Advisors, LLC 0.00% of their portfolio | 14.2k $82.2k | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 14.0k $81.1k | Reduced -21.6k |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 13.8k $80.3k | Reduced -3.9k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 13.1k $76.0k | Reduced -2.3k |
| Jain Global LLC 0.00% of their portfolio | 12.0k $69.3k | New |
| Inscription Capital, LLC 0.01% of their portfolio | 11.8k $68.6k | New |
| AXQ CAPITAL, LP 0.03% of their portfolio | 11.6k $67.1k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 11.5k $66.7k | Reduced -25.3k |
| IHT Wealth Management, LLC 0.00% of their portfolio | 11.1k $64.4k | Added +400 |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 9.5k $54.9k | Added +4.5k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 8.9k $51.5k | Unchanged |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 8.8k $51.1k | Added +3.7k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 7.4k $42.7k | Added +3.5k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 7.2k $41.5k | Reduced -9.2k |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 6.7k $38.7k | Reduced -956 |
| AlphaQuest LLC 0.00% of their portfolio | 6.5k $37.6k | Reduced -33.1k |
| Versant Capital Management, Inc 0.00% of their portfolio | 4.0k $23.3k | Added +2.6k |
| STRS OHIO 0.00% of their portfolio | 3.8k $22.0k | Reduced -41.2k |
| Legal & General Group Plc 0.00% of their portfolio | 2.6k $14.8k | Unchanged |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 2.4k $14.0k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 2.0k $11.9k | Reduced -11.4k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 2.0k $11.7k | Reduced -94.7k |
| Sterling Capital Management LLC 0.00% of their portfolio | 1.9k $11.3k | Added +1.2k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 1.8k $10.4k | Added +1 |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 1.5k $8.5k | Added +5 |
| Point72 (DIFC) Ltd 0.00% of their portfolio | 1.4k $7.9k | New |
| Arax Advisory Partners 0.00% of their portfolio | 1.3k $7.4k | Added +814 |
| CWM, LLC 0.00% of their portfolio | 1.2k $7.0k | Added +816 |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 1.2k $6.7k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 852 $5.0k | Unchanged |