ENGENE THERAPEUTICS INC ENGN
COM · Common Stock · CUSIP 29286X101
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 67.0m as of 2026-06-09, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.73. Options: 5 managers hold calls ($246.2k notional), 4 hold puts ($769.7k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2026 | 2 |
| Q2 2026 | 56 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $0 | $0 | — |
| Q4 2025 | $0 | $0 | — |
| Q1 2026 | $0 | $0 | — |
| Q2 2026 | $246.2k | $769.7k | 3.13 |
Biggest buyers
| BML Capital Management, LLC | New | +6.7m |
| Siren, L.L.C. | New | +6.3m |
| PERCEPTIVE ADVISORS LLC | New | +4.8m |
| AMERIPRISE FINANCIAL INC | New | +2.7m |
| Nextech Invest Ltd. | New | +2.3m |
| ADAR1 Capital Management, LLC | New | +2.1m |
| Vestal Point Capital, LP | New | +1.7m |
| ACORN CAPITAL ADVISORS, LLC | New | +1.3m |
| Peapod Lane Capital LLC | New | +1.1m |
| Balyasny Asset Management L.P. | New | +1.0m |
Biggest sellers
| MARSHALL WACE, LLP | Sold out | -343.9k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $107.1k61.9k shares |
| CITADEL ADVISORS LLC | New | $53.3k30.8k shares |
| JANE STREET GROUP, LLC | New | $32.9k19.0k shares |
| GROUP ONE TRADING LLC | New | $28.5k16.5k shares |
| SIMPLEX TRADING, LLC | New | $24.4k14.1k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $541.7k313.1k shares |
| JANE STREET GROUP, LLC | New | $94.8k54.8k shares |
| SIMPLEX TRADING, LLC | New | $76.5k44.2k shares |
| CITADEL ADVISORS LLC | New | $56.7k32.8k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Invus Global Management, LLC 13G · passive investor +1.5 pts · filed 2026-08-13 | 9.3% |
Fell to 5% or below in the last year: Deep Track Capital, LP (0.0%, 2026-08-14), Blue Owl Capital Holdings LP (0.8%, 2026-08-12)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 1 | $10.1k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-22 | Grossman William Interim Chief Medical Officer, director | Bought | $10.1k5.1k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BML Capital Management, LLC 6.59% of their portfolio | 6.7m $11.5m | New |
| Siren, L.L.C. 0.22% of their portfolio | 6.3m $10.8m | New |
| PERCEPTIVE ADVISORS LLC 0.13% of their portfolio | 4.8m $8.3m | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 2.7m $4.6m | New |
| Nextech Invest Ltd. 0.19% of their portfolio | 2.3m $4.0m | New |
| ADAR1 Capital Management, LLC 0.17% of their portfolio | 2.1m $3.6m | New |
| Vestal Point Capital, LP 0.07% of their portfolio | 1.7m $2.9m | New |
| ACORN CAPITAL ADVISORS, LLC 0.60% of their portfolio | 1.3m $2.2m | New |
| Peapod Lane Capital LLC 1.29% of their portfolio | 1.1m $1.9m | New |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 1.0m $1.7m | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 966.6k $1.7m | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 829.7k $1.4m | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 717.7k $1.2m | New |
| Affinity Asset Advisors, LLC 0.05% of their portfolio | 600.0k $1.0m | New |
| UBS Group AG 0.00% of their portfolio | 509.1k $880.7k | New |
| Eversept Partners, LP 0.04% of their portfolio | 469.6k $812.4k | New |
| Kynam Capital Management, LP 0.04% of their portfolio | 457.9k $792.1k | New |
| Seven Fleet Capital Management LP 0.12% of their portfolio | 411.1k $711.1k | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 382.5k $661.7k | New |
| Rangeley Capital, LLC 0.49% of their portfolio | 305.1k $527.8k | New |
| BARCLAYS PLC 0.00% of their portfolio | 282.5k $488.8k | New |
| KENNEDY CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 268.7k $464.9k | New |
| Woodline Partners LP 0.00% of their portfolio | 250.0k $432.5k | New |
| Quadrature Capital Ltd 0.00% of their portfolio | 239.0k $413.5k | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 215.4k $372.6k | New |
| Elmind Capital, LP 0.09% of their portfolio | 210.0k $363.3k | New |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 200.2k $346.3k | New |
| Privium Fund Management B.V. 0.05% of their portfolio | 170.0k $294.1k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 164.6k $284.7k | New |
| XTX Topco Ltd 0.00% of their portfolio | 151.4k $262.0k | New |
| Marquette Asset Management, LLC 0.03% of their portfolio | 150.5k $260.4k | New |
| Persistent Asset Partners Ltd 0.06% of their portfolio | 114.5k $198.1k | New |
| DAFNA Capital Management LLC 0.02% of their portfolio | 74.7k $129.1k | New |
| Jain Global LLC 0.00% of their portfolio | 43.2k $74.8k | New |
| Scientech Research LLC 0.06% of their portfolio | 40.7k $70.4k | New |
| Verdad Advisers, LP 0.07% of their portfolio | 39.3k $68.0k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 38.3k $66.2k | New |
| GSA CAPITAL PARTNERS LLP 0.00% of their portfolio | 37.3k $65.0k | New |
| MORGAN STANLEY 0.00% of their portfolio | 33.1k $57.2k | New |
| Engineers Gate Manager LP 0.00% of their portfolio | 27.3k $47.2k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 25.4k $44.0k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 24.5k $42.3k | New |
| SECTORAL ASSET MANAGEMENT INC 0.03% of their portfolio | 21.7k $37.5k | New |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 21.4k $36.9k | New |
| SEI INVESTMENTS CO 0.00% of their portfolio | 18.5k $32.0k | New |
| HRT FINANCIAL LP 0.00% of their portfolio | 16.8k $29.0k | New |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 14.0k $24.2k | New |
| Virtu Financial LLC 0.00% of their portfolio | 14.0k $24.0k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 11.3k $20.0k | New |
| PFS Partners, LLC 0.01% of their portfolio | 11.0k $19.0k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 6.8k $11.8k | New |
| WOLVERINE ASSET MANAGEMENT LLC 0.00% of their portfolio | 3.0k $5.1k | New |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 399 $690 | New |
| Farther Finance Advisors, LLC 0.00% of their portfolio | 100 $173 | New |
| Aquatic Capital Management LLC 0.00% of their portfolio | 29 $50 | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 28 $48 | Unchanged |