CLIMB BIO INC CLYM
COM · Common Stock · CUSIP 28658R106
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWellesley Hills, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 68.2m as of 2025-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $5.04.
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 23 |
| Q4 2022 | 21 |
| Q1 2023 | 20 |
| Q2 2023 | 23 |
| Q3 2023 | 24 |
| Q4 2023 | 24 |
| Q1 2024 | 22 |
| Q2 2024 | 48 |
| Q3 2024 | 72 |
| Q4 2024 | 81 |
| Q1 2025 | 77 |
| Q2 2025 | 70 |
| Q3 2025 | 68 |
| Q4 2025 | 65 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 8 | 7 |
| Q2 2024 | 40 | 9 |
| Q3 2024 | 57 | 14 |
| Q4 2024 | 46 | 30 |
| Q1 2025 | 33 | 35 |
| Q2 2025 | 38 | 48 |
| Q3 2025 | 24 | 47 |
| Q4 2025 | 35 | 39 |
Biggest buyers
| MPM BIOIMPACT LLC | New | +2.7m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +1.4m |
| ADAR1 Capital Management, LLC | Added | +1.3m |
| GREAT POINT PARTNERS LLC | New | +979.5k |
| Point72 Asset Management, L.P. | New | +716.7k |
| Driehaus Capital Management LLC | New | +600.9k |
| SPHERA FUNDS MANAGEMENT LTD. | Added | +497.4k |
| TWO SIGMA INVESTMENTS, LP | Added | +454.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +302.9k |
| CITADEL ADVISORS LLC | New | +239.0k |
Biggest sellers
| RA CAPITAL MANAGEMENT, L.P. | Reduced | -20.1m |
| TANG CAPITAL MANAGEMENT LLC | Sold out | -1.0m |
| CANTOR FITZGERALD, L. P. | Sold out | -547.2k |
| Deep Track Capital, LP | Sold out | -509.8k |
| Alyeska Investment Group, L.P. | Sold out | -485.4k |
| BlackRock, Inc. | Reduced | -346.2k |
| UBS Group AG | Reduced | -334.1k |
| CITIGROUP INC | Reduced | -319.2k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -216.5k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -175.4k |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
RA CAPITAL MANAGEMENT, L.P.
13D · may seek influence
no change · filed 2026-07-07
Stated purposeItem 4 of the Statement is hereby amended and supplemented as follows: On June 29, 2026 Dr. Breanna Celebi (O'Reilly), an Analyst of RA Capital, was appointed to the Board of Directors of the Issuer as the designee of RA Capital, replacing Dr. Andrew Levin, who resigned from the Board of Directors effective June 29, 2026. Full filing |
33.0% |
| FMR LLC 13G · institution new · filed 2026-07-08 | 11.9% |
| Pontifax Management 4 G.P. (2015) Ltd. 13G · passive investor new · filed 2025-09-18 | 7.7% |
| Flynn James E 13G · passive investor new · filed 2026-10-28 | 5.2% |
| BlackRock, Inc. 13G · institution new · filed 2026-10-27 | 5.0% |
Fell to 5% or below in the last year: MPM BioImpact LLC (0.0%, 2026-08-14)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 1 | $50.0m | 1 | $9.0k | — |
| Q3 2024 | 0 | — | 2 | $3.5m | $9.7k |
| Q4 2024 | 0 | — | 1 | $2.5k | $2.5k |
| Q1 2025 | 0 | — | 1 | $1.6k | $1.6k |
| Q2 2025 | 0 | — | 2 | $26.7k | $26.7k |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 1 | $754.7k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-12 | RA Capital Healthcare Fund LP +6 Director · See footnotes | Bought | $290.2k101.5k shares |
| 2025-12-11 | RA Capital Healthcare Fund LP +6 Director · See footnotes | Bought | $464.6k213.1k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. 0.80% of their portfolio | 11.3m $77.7m | Reduced -20.1m |
| MPM BIOIMPACT LLC 1.22% of their portfolio | 2.7m $10.7m | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 1.9m $7.7m | Added +1.4m |
| ADAR1 Capital Management, LLC 0.43% of their portfolio | 1.4m $5.7m | Added +1.3m |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.3m $5.4m | Added +24.7k |
| Affinity Asset Advisors, LLC 0.37% of their portfolio | 1.3m $5.2m | Unchanged |
| Kynam Capital Management, LP 0.27% of their portfolio | 1.0m $4.1m | Unchanged |
| GREAT POINT PARTNERS LLC 1.27% of their portfolio | 979.5k $3.9m | New |
| SPHERA FUNDS MANAGEMENT LTD. 0.78% of their portfolio | 932.2k $3.7m | Added +497.4k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 716.7k $2.9m | New |
| Driehaus Capital Management LLC 0.02% of their portfolio | 600.9k $2.4m | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 566.7k $2.3m | Added +454.0k |
| Peapod Lane Capital LLC 1.93% of their portfolio | 566.0k $2.3m | Added +4.1k |
| NAN FUNG TRINITY (HK) LTD 0.15% of their portfolio | 463.7k $1.9m | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 445.3k $1.8m | Added +302.9k |
| KOTLER KEVIN 1.18% of their portfolio | 400.0k $1.6m | First filing |
| BlackRock, Inc. 0.00% of their portfolio | 389.3k $1.6m | Reduced -346.2k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 320.6k $1.3m | Reduced -216.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 310.8k $1.2m | Reduced -965 |
| MARSHALL WACE, LLP 0.00% of their portfolio | 304.0k $1.2m | Added +74.1k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 296.3k $1.2m | Reduced -175.4k |
| TD Asset Management Inc 0.00% of their portfolio | 246.2k $984.8k | Added +156.8k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 239.0k $956.2k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 224.9k $899.5k | Added +151.2k |
| 683 Capital Management, LLC 0.07% of their portfolio | 201.7k $806.6k | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 187.4k $749.6k | Added +107.7k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 159.3k $637.2k | Added +50.0k |
| MORGAN STANLEY 0.00% of their portfolio | 148.5k $594.2k | Added +62.2k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 140.6k $566.6k | Added +101.7k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 139.5k $558.1k | New |
| STATE STREET CORP 0.00% of their portfolio | 128.9k $515.6k | Added +25.8k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 124.7k $498.8k | Added +43.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 124.7k $498.7k | Reduced -753 |
| ArchPoint Investors 0.12% of their portfolio | 121.4k $485.6k | New |
| Squadron Capital Management LLC 0.18% of their portfolio | 100.0k $400.0k | First filing |
| OMERS ADMINISTRATION Corp 0.00% of their portfolio | 85.5k $341.9k | New |
| Seven Fleet Capital Management LP 0.21% of their portfolio | 76.4k $305.6k | First filing |
| UBS Group AG 0.00% of their portfolio | 71.3k $285.3k | Reduced -334.1k |
| LPL Financial LLC 0.00% of their portfolio | 62.0k $248.0k | Added +1.0k |
| BARCLAYS PLC 0.00% of their portfolio | 61.9k $247.4k | Added +37.1k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 49.5k $198.4k | Added +37.5k |
| Hudson Bay Capital Management LP 0.00% of their portfolio | 48.7k $194.9k | New |
| XTX Topco Ltd 0.00% of their portfolio | 34.9k $139.4k | Added +5.7k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 34.6k $138.4k | Reduced -2.0k |
| CITIZENS FINANCIAL GROUP INC/RI 0.00% of their portfolio | 28.2k $112.7k | Reduced -17.8k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 19.9k $79.7k | Reduced -20.8k |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 14.2k $56.9k | New |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 11.1k $44.5k | Reduced -3.4k |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 11.0k $44.0k | New |
| Chicago Partners Investment Group LLC 0.00% of their portfolio | 11.0k $55.0k | Added +630 |
| Virtu Financial LLC 0.00% of their portfolio | 10.7k $43.0k | New |
| Scientech Research LLC 0.03% of their portfolio | 10.4k $41.7k | New |
| CITIGROUP INC 0.00% of their portfolio | 10.3k $41.3k | Reduced -319.2k |
| Persistent Asset Partners Ltd 0.02% of their portfolio | 9.2k $36.9k | Reduced -19.0k |
| FMR LLC 0.00% of their portfolio | 6.3k $25.4k | Reduced -793 |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 5.1k $20.3k | Reduced -690 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 3.4k $13.4k | Reduced -9.9k |
| HARBOUR INVESTMENTS, INC. 0.00% of their portfolio | 2.0k $8.0k | Unchanged |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 600 $2.4k | Reduced -22.0k |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 573 $2.3k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 513 $2.1k | Reduced -1.3k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 408 $1.0k | Reduced -283 |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 46 $184 | Reduced -44.0k |
| CWM, LLC 0.00% of their portfolio | 29 $0 | Reduced -78 |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 1 $4 | Unchanged |