Vault-13

89BIO INC ETNB

COM · Common Stock · CUSIP 282559103

187 institutional holders -2 vs Q1 2025
161,383,892161.4m shares reported held*
$1.6bnreported value*
30 new 79 added 57 reduced 33 sold out net bought ≈ $65.4m (+7.0m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($712.6k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $9.82. Options: 12 managers hold calls ($3.7m notional), 14 hold puts ($17.4m).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 86Q4 22: 106Q1 23: 149Q2 23: 159Q3 23: 162Q4 23: 155Q1 24: 152Q2 24: 147Q3 24: 146Q4 24: 158Q1 25: 189Q2 25: 187187Q3 22Q2 23Q1 24Q4 24Q2 25
Numbers
QuarterHolders
Q3 202286
Q4 2022106
Q1 2023149
Q2 2023159
Q3 2023162
Q4 2023155
Q1 2024152
Q2 2024147
Q3 2024146
Q4 2024158
Q1 2025189
Q2 2025187

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q3 23: 89 bought or addedQ3 23: 77 cut or sold outQ4 23: 93 bought or addedQ4 23: 80 cut or sold outQ4 23Q1 24: 91 bought or addedQ1 24: 77 cut or sold outQ2 24: 84 bought or addedQ2 24: 65 cut or sold outQ2 24Q3 24: 80 bought or addedQ3 24: 55 cut or sold outQ4 24: 97 bought or addedQ4 24: 54 cut or sold outQ4 24Q1 25: 142 bought or addedQ1 25: 54 cut or sold outQ2 25: 109 bought or addedQ2 25: 90 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q3 20238977
Q4 20239380
Q1 20249177
Q2 20248465
Q3 20248055
Q4 20249754
Q1 202514254
Q2 202510990

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5m$10m$15m$20mQ3 24 calls: $1.2mQ3 24 puts: $9.2mQ3 24P/C 7.39Q4 24 calls: $1.4mQ4 24 puts: $8.9mQ4 24P/C 6.44Q1 25 calls: $3.1mQ1 25 puts: $7.7mQ1 25P/C 2.47Q2 25 calls: $3.7mQ2 25 puts: $17.4mQ2 25P/C 4.74
Numbers
QuarterCallsPutsP/C
Q3 2024$1.2m$9.2m7.39
Q4 2024$1.4m$8.9m6.44
Q1 2025$3.1m$7.7m2.47
Q2 2025$3.7m$17.4m4.74

Biggest buyers

Holocene Advisors, LP New +3,065,387+3.1m
Point72 Asset Management, L.P. New +2,274,151+2.3m
ADAGE CAPITAL PARTNERS GP, L.L.C. New +1,969,000+2.0m
Assenagon Asset Management S.A. Added +1,742,299+1.7m
MORGAN STANLEY Added +1,555,776+1.6m
VANGUARD GROUP INC Added +1,078,545+1.1m
DIMENSIONAL FUND ADVISORS LP Added +595,237+595.2k
SILVERARC CAPITAL MANAGEMENT, LLC Added +526,589+526.6k
Woodline Partners LP Added +521,907+521.9k
MILLENNIUM MANAGEMENT LLC Added +510,020+510.0k

Biggest sellers

Logos Global Management LP Sold out -2,500,000-2.5m
Beck Bode, LLC Sold out -1,815,524-1.8m
CITADEL ADVISORS LLC Reduced -1,249,944-1.2m
Rock Springs Capital Management LP Reduced -804,441-804.4k
LORD, ABBETT & CO. LLC Sold out -733,404-733.4k
WESTFIELD CAPITAL MANAGEMENT CO LP Reduced -523,924-523.9k
Sio Capital Management, LLC Sold out -500,000-500.0k
SPHERA FUNDS MANAGEMENT LTD. Reduced -412,668-412.7k
Nuveen, LLC Reduced -397,130-397.1k
Redmile Group, LLC Reduced -341,236-341.2k

Biggest calls

MILLENNIUM MANAGEMENT LLC New $687.4k70.0k shares
GROUP ONE TRADING LLC Added $424.2k43.2k shares
CITIGROUP INC Unchanged $392.8k40.0k shares
Caption Management, LLC Reduced $392.8k40.0k shares
Walleye Capital LLC New $372.2k37.9k shares
NOMURA HOLDINGS INC New $353.5k36.0k shares
SIMPLEX TRADING, LLC Reduced $299.0k30.5k shares
CITADEL ADVISORS LLC Reduced $288.7k29.4k shares
JANE STREET GROUP, LLC Reduced $244.5k24.9k shares
WOLVERINE TRADING, LLC New $106.5k10.8k shares

Biggest puts

Caption Management, LLC Added $6.5m665.6k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $6.1m619.6k shares
GROUP ONE TRADING LLC Added $1.3m129.8k shares
MILLENNIUM MANAGEMENT LLC New $982.0k100.0k shares
CITADEL ADVISORS LLC Added $743.4k75.7k shares
CITIGROUP INC Unchanged $392.8k40.0k shares
NOMURA HOLDINGS INC New $353.5k36.0k shares
Crawford Fund Management, LLC Reduced $324.1k33.0k shares
SIMPLEX TRADING, LLC Added $253.0k25.8k shares
JANE STREET GROUP, LLC Reduced $203.3k20.7k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
VANGUARD GROUP INC 13G · institution new · filed 2025-07-29 5.6% new 8.2m 2025-07-29
SUVRETTA CAPITAL MANAGEMENT, LLC 13G · institution -4.3 pts · filed 2025-11-13 5.6% -4.3 pts 8.3m 2025-11-13

Fell to 5% or below in the last year: Deep Track Capital, LP (0.0%, 2026-02-13), Pentwater Capital Management LP (0.0%, 2025-11-14)

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 JANUS HENDERSON GROUP PLC 0.10% of their portfolio LONDON, X0 20,788,36320.8m $204.2m $204.2m 0.10% Added +325.5k +325,458
2 RA CAPITAL MANAGEMENT, L.P. 3.29% of their portfolio BOSTON, MA 19,889,68319.9m $195.3m $195.3m 3.29% Unchanged
3 MONTANOVA CAPITAL, LLC 5.26% of their portfolio New York, NY 14,210,00014.2m $139.5m $139.5m 5.26% Reduced -125.2k -125,244
4 BlackRock, Inc. 0.00% of their portfolio New York, NY 10,569,42410.6m $103.8m $103.8m 0.00% Added +494.1k +494,080
5 Deep Track Capital, LP 3.00% of their portfolio GREENWICH, CT 9,500,0009.5m $93.3m $93.3m 3.00% Added +183.7k +183,667
6 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 8,242,1548.2m $80.9m $80.9m 0.00% Added +1.1m +1,078,545
7 Avoro Capital Advisors LLC 1.16% of their portfolio NEW YORK, NY 6,750,0006.8m $66.3m $66.3m 1.16% Added +400.0k +400,000
8 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 4,249,9574.2m $41.7m $41.7m 0.00% Added +219.7k +219,650
9 Pictet Asset Management Holding SA 0.04% of their portfolio CAROUGE, V8 4,035,3904.0m $39.6m $39.6m 0.04% Reduced -169.5k -169,497
10 CITADEL ADVISORS LLC 0.03% of their portfolio MIAMI, FL 3,836,8923.8m $37.7m $37.7m 0.03% Reduced -1.2m -1,249,944
11 WESTFIELD CAPITAL MANAGEMENT CO LP 0.14% of their portfolio BOSTON, MA 3,370,8173.4m $33.1m $33.1m 0.14% Reduced -523.9k -523,924
12 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 3,111,2993.1m $30.6m $30.6m 0.00% Added +213.3k +213,325
13 Holocene Advisors, LP 0.07% of their portfolio New York, NY 3,065,3873.1m $30.1m $30.1m 0.07% New
14 Polar Capital Holdings Plc 0.13% of their portfolio London, X0 2,475,0002.5m $24.3m $24.3m 0.13% Reduced -25.0k -25,000
15 Point72 Asset Management, L.P. 0.05% of their portfolio STAMFORD, CT 2,274,1512.3m $22.3m $22.3m 0.05% New
16 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 2,185,0052.2m $21.5m $21.5m 0.00% Added +1.6m +1,555,776
17 Assenagon Asset Management S.A. 0.03% of their portfolio SENNINGERBERG, N4 2,171,1942.2m $21.3m $21.3m 0.03% Added +1.7m +1,742,299
18 SILVERARC CAPITAL MANAGEMENT, LLC 4.09% of their portfolio BOSTON, MA 2,037,0872.0m $20.0m $20.0m 4.09% Added +526.6k +526,589
19 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio Boston, MA 1,969,0002.0m $19.3m $19.3m 0.03% New
20 RTW INVESTMENTS, LP 0.28% of their portfolio NEW YORK, NY 1,967,5272.0m $19.3m $19.3m 0.28% Unchanged
21 EMERALD ADVISERS, LLC 0.66% of their portfolio LEOLA, PA 1,844,3701.8m $18.1m $18.1m 0.66% Added +293.7k +293,699
22 Redmile Group, LLC 1.61% of their portfolio LARKSPUR, CA 1,545,2081.5m $15.2m $15.2m 1.61% Reduced -341.2k -341,236
23 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 1,253,0851.3m $12.3m $12.3m 0.00% Added +257.6k +257,636
24 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 1,249,9541.2m $12.3m $12.3m 0.00% Added +468.0k +468,002
25 Woodline Partners LP 0.06% of their portfolio San Francisco, CA 1,222,6611.2m $12.0m $12.0m 0.06% Added +521.9k +521,907
26 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 1,183,2231.2m $11.6m $11.6m 0.00% Added +595.2k +595,237
27 University of Wisconsin Foundation 12.67% of their portfolio MADISON, WI 1,153,3571.2m $11.3m $11.3m 12.67% Unchanged
28 EMERALD MUTUAL FUND ADVISERS TRUST 0.69% of their portfolio LEOLA, PA 1,145,8131.1m $11.3m $11.3m 0.69% Added +62.8k +62,840
29 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 1,132,4371.1m $11.1m $11.1m 0.00% Added +47.0k +46,973
30 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 1,063,9721.1m $10.4m $10.4m 0.00% Added +78.2k +78,201
31 Integral Health Asset Management, LLC 0.96% of their portfolio New York, NY 1,050,0001.1m $10.3m $10.3m 0.96% Unchanged
32 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 962,474962.5k $9.5m $9.5m 0.01% Added +510.0k +510,020
33 READYSTATE ASSET MANAGEMENT LP 0.37% of their portfolio CHICAGO, IL 902,076902.1k $8.9m $8.9m 0.37% Added +216.9k +216,907
34 Erste Asset Management GmbH 0.07% of their portfolio VIENNA, C4 883,000883.0k $8.7m $8.7m 0.07% Unchanged
35 ADAR1 Capital Management, LLC 1.40% of their portfolio AUSTIN, TX 875,983876.0k $8.6m $8.6m 1.40% Added +71.8k +71,763
36 Candriam S.C.A. 0.04% of their portfolio STRASSEN, N4 766,211766.2k $7.5m $7.5m 0.04% Reduced -65.6k -65,612
37 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 638,827638.8k $6.3m $6.3m 0.00% Reduced -397.1k -397,130
38 Alyeska Investment Group, L.P. 0.02% of their portfolio CHICAGO, IL 576,973577.0k $5.7m $5.7m 0.02% Reduced -275.3k -275,254
39 RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio ST. PETERSBURG, FL 571,602571.6k $5.6m $5.6m 0.00% Added +189.3k +189,311
40 FMR LLC 0.00% of their portfolio BOSTON, MA 569,005569.0k $5.6m $5.6m 0.00% Reduced -121.0k -121,007
41 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 521,282521.3k $5.1m $5.1m 0.00% Added +454.6k +454,594
42 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 513,400513.4k $5.0m $5.0m 0.01% Added +9.1k +9,100
43 INFINITUM ASSET MANAGEMENT, LLC 1.09% of their portfolio FORT LAUDERDALE, FL 500,000500.0k $4.9m $4.9m 1.09% Unchanged
44 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 488,711488.7k $4.8m $4.8m 0.00% Reduced -338.1k -338,149
45 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 391,410391.4k $3.8m $3.8m 0.00% Added +122.6k +122,612
46 Schonfeld Strategic Advisors LLC 0.03% of their portfolio NEW YORK, NY 383,188383.2k $3.8m $3.8m 0.03% New
47 Vivo Capital, LLC 0.38% of their portfolio Palo Alto, CA 376,804376.8k $3.7m $3.7m 0.38% Unchanged
48 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 367,267367.3k $3.6m $3.6m 0.00% Added +117.1k +117,074
49 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 349,572349.6k $3.4m $3.4m 0.00% Added +39.7k +39,656
50 UBS Group AG 0.00% of their portfolio ZURICH, V8 349,445349.4k $3.4m $3.4m 0.00% Added +146.2k +146,238
51 PANAGORA ASSET MANAGEMENT INC 0.01% of their portfolio BOSTON, MA 329,881329.9k $3.2m $3.2m 0.01% Reduced -99.5k -99,511
52 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 329,861329.9k $3.2m $3.2m 0.00% Added +161.8k +161,751
53 Apis Capital Advisors, LLC 1.12% of their portfolio New York, NY 322,000322.0k $3.2m $3.2m 1.12% Added +7.0k +7,000
54 Trexquant Investment LP 0.03% of their portfolio STAMFORD, CT 281,027281.0k $2.8m $2.8m 0.03% Added +181.8k +181,844
55 DARK FOREST CAPITAL MANAGEMENT LP 0.11% of their portfolio NEW YORK, NY 266,395266.4k $2.6m $2.6m 0.11% Added +206.0k +205,974
56 SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.07% of their portfolio BALA CYNWYD, PA 255,796255.8k $2.5m $2.5m 0.07% Reduced -10.7k -10,670
57 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 254,256254.3k $2.5m $2.5m 0.00% Reduced -11.3k -11,326
58 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 254,109254.1k $2.5m $2.5m 0.00% Added +65.7k +65,660
59 Eversept Partners, LP 0.23% of their portfolio NEW YORK, NY 235,990236.0k $2.3m $2.3m 0.23% Reduced -67.7k -67,741
60 JENNISON ASSOCIATES LLC 0.00% of their portfolio NEW YORK, NY 234,190234.2k $2.3m $2.3m 0.00% New
61 Exome Asset Management LLC 1.95% of their portfolio NEW YORK, NY 233,426233.4k $2.3m $2.3m 1.95% Reduced -120.5k -120,456
62 ROYCE & ASSOCIATES LP 0.02% of their portfolio New York, NY 226,058226.1k $2.2m $2.2m 0.02% Added +8 +8
63 Hudson Bay Capital Management LP 0.01% of their portfolio STAMFORD, CT 225,700225.7k $2.2m $2.2m 0.01% Reduced -24.5k -24,500
64 HARBOR CAPITAL ADVISORS, INC. 0.09% of their portfolio CHICAGO, IL 217,752217.8k $2.1m $2.1m 0.09% Reduced -97.0k -97,020
65 F/m Investments LLC 0.08% of their portfolio WASHINGTON, DC 217,742217.7k $2.1m $2.1m 0.08% Added +2.9k +2,905
66 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 216,325216.3k $2.1m $2.1m 0.00% Added +9.2k +9,195
67 SUPERSTRING CAPITAL MANAGEMENT LP 2.60% of their portfolio NEW YORK, NY 212,377212.4k $2.1m $2.1m 2.60% Added +103.2k +103,221
68 Hennion & Walsh Asset Management, Inc. 0.08% of their portfolio Parsippany, NJ 211,955212.0k $2.1m $2.1m 0.08% Added +71.6k +71,649
69 Atom Investors LP 0.18% of their portfolio AUSTIN, TX 205,947205.9k $2.0m $2.0m 0.18% Added +112.8k +112,780
70 SPHERA FUNDS MANAGEMENT LTD. 0.53% of their portfolio TEL AVIV, L3 205,675205.7k $2.0m $2.0m 0.53% Reduced -412.7k -412,668
71 Newtyn Management, LLC 0.30% of their portfolio NEW YORK, NY 200,000200.0k $2.0m $2.0m 0.30% Unchanged
72 Orchard Capital Management, LLC 2.15% of their portfolio CHICAGO, IL 198,119198.1k $1.9m $1.9m 2.15% Reduced -266.2k -266,239
73 Swiss National Bank 0.00% of their portfolio ZURICH, V8 195,200195.2k $1.9m $1.9m 0.00% Reduced -10.3k -10,300
74 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 193,818193.8k $1.9m $1.9m 0.00% Added +41.7k +41,680
75 COMERICA BANK 0.01% of their portfolio DALLAS, TX 188,003188.0k $1.8m $1.8m 0.01% Reduced -70.1k -70,120
76 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 151,696151.7k $1.5m $1.5m 0.00% Added +35.9k +35,945
77 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 149,018149.0k $1.5m $1.5m 0.00% Reduced -36.3k -36,277
78 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 148,001148.0k $1.5m $1.5m 0.00% Added +29.3k +29,296
79 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 138,410138.4k $1.4m $1.4m 0.00% New
80 Susquehanna Portfolio Strategies, LLC 0.03% of their portfolio Bala Cynwyd, PA 126,508126.5k $1.2m $1.2m 0.03% Added +102.4k +102,408
81 Rafferty Asset Management, LLC 0.00% of their portfolio New York, NY 122,353122.4k $1.2m $1.2m 0.00% Reduced -14.9k -14,894
82 ALGERT GLOBAL LLC 0.03% of their portfolio SAN FRANCISCO, CA 121,981122.0k $1.2m $1.2m 0.03% Reduced -65.0k -65,010
83 Verition Fund Management LLC 0.01% of their portfolio GREENWICH, CT 121,162121.2k $1.2m $1.2m 0.01% New
84 Caption Management, LLC 0.10% of their portfolio OKLAHOMA CITY, OK 114,401114.4k $1.1m $1.1m 0.10% Reduced -66.2k -66,199
85 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 112,430112.4k $1.1m $1.1m 0.00% Reduced -41.4k -41,396
86 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 105,654105.7k $1.0m $1.0m 0.00% Added +1.7k +1,677
87 Legal & General Group Plc 0.00% of their portfolio London, X0 105,171105.2k $1.0m $1.0m 0.00% Reduced -1.6k -1,554
88 DIADEMA PARTNERS LP 0.60% of their portfolio MORRISTOWN, NJ 98,38298.4k $966.1k $966.1k 0.60% Reduced -133.1k -133,054
89 J. Goldman & Co LP 0.03% of their portfolio NEW YORK, NY 96,33996.3k $946.0k $946.0k 0.03% Reduced -46.2k -46,226
90 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 90,00090.0k $1.1m $1.1m 0.00% Unchanged
91 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 86,58986.6k $850.3k $850.3k 0.00% Reduced -15.1k -15,077
92 TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio STAMFORD, CT 84,20884.2k $826.9k $826.9k 0.01% Added +14.5k +14,488
93 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 80,02980.0k $786.0k $786.0k 0.00% Added +17.7k +17,726
94 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 79,57379.6k $781.4k $781.4k 0.00% Added +4.5k +4,477
95 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 79,53279.5k $781.0k $781.0k 0.00% Reduced -667 -667
96 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 75,37275.4k $740.2k $740.2k 0.00% Added +805 +805
97 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 74,66174.7k $733.2k $733.2k 0.00% Added +8.6k +8,626
98 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 74,37174.4k $730.6k $730.6k 0.00% Added +1.5k +1,515
99 PRELUDE CAPITAL MANAGEMENT, LLC 0.07% of their portfolio NEW YORK, NY 70,38770.4k $691.2k $691.2k 0.07% Reduced -27.7k -27,700
100 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 67,54767.5k $663.3k $663.3k 0.00% Added +12.1k +12,137