Vault-13

89BIO INC ETNB

COM · Common Stock · CUSIP 282559103

189 institutional holders +31 vs Q4 2024
154,462,666154.5m shares reported held*
$1.1bnreported value*
52 new 90 added 32 reduced 22 sold out net bought ≈ $237.4m (+32.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($39.2k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $7.38. Options: 9 managers hold calls ($3.1m notional), 11 hold puts ($7.7m).

Trends to Q1 2025

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 86Q4 22: 106Q1 23: 149Q2 23: 159Q3 23: 162Q4 23: 155Q1 24: 152Q2 24: 147Q3 24: 146Q4 24: 158Q1 25: 189189Q3 22Q1 23Q3 23Q1 24Q3 24Q1 25
Numbers
QuarterHolders
Q3 202286
Q4 2022106
Q1 2023149
Q2 2023159
Q3 2023162
Q4 2023155
Q1 2024152
Q2 2024147
Q3 2024146
Q4 2024158
Q1 2025189

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q2 23: 103 bought or addedQ2 23: 72 cut or sold outQ3 23: 89 bought or addedQ3 23: 77 cut or sold outQ3 23Q4 23: 93 bought or addedQ4 23: 80 cut or sold outQ1 24: 91 bought or addedQ1 24: 77 cut or sold outQ1 24Q2 24: 84 bought or addedQ2 24: 65 cut or sold outQ3 24: 80 bought or addedQ3 24: 55 cut or sold outQ3 24Q4 24: 97 bought or addedQ4 24: 54 cut or sold outQ1 25: 142 bought or addedQ1 25: 54 cut or sold outQ1 25
Numbers
QuarterBought or addedCut or sold out
Q2 202310372
Q3 20238977
Q4 20239380
Q1 20249177
Q2 20248465
Q3 20248055
Q4 20249754
Q1 202514254

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5m$10m$15mQ2 24 calls: $1.2mQ2 24 puts: $10.8mQ2 24P/C 8.72Q3 24 calls: $1.2mQ3 24 puts: $9.2mQ3 24P/C 7.39Q4 24 calls: $1.4mQ4 24 puts: $8.9mQ4 24P/C 6.44Q1 25 calls: $3.1mQ1 25 puts: $7.7mQ1 25P/C 2.47
Numbers
QuarterCallsPutsP/C
Q2 2024$1.2m$10.8m8.72
Q3 2024$1.2m$9.2m7.39
Q4 2024$1.4m$8.9m6.44
Q1 2025$3.1m$7.7m2.47

Biggest buyers

RA CAPITAL MANAGEMENT, L.P. Added +5,714,285+5.7m
MONTANOVA CAPITAL, LLC Added +4,132,548+4.1m
JANUS HENDERSON GROUP PLC Added +3,948,849+3.9m
Deep Track Capital, LP Added +2,838,084+2.8m
Logos Global Management LP New +2,500,000+2.5m
Polar Capital Holdings Plc New +2,500,000+2.5m
Avoro Capital Advisors LLC Added +2,250,000+2.2m
BlackRock, Inc. Added +2,185,245+2.2m
Beck Bode, LLC New +1,815,524+1.8m
EMERALD ADVISERS, LLC New +1,550,671+1.6m

Biggest sellers

RTW INVESTMENTS, LP Reduced -5,510,534-5.5m
BVF INC/IL Sold out -4,333,885-4.3m
Frazier Life Sciences Management, L.P. Sold out -1,000,000-1.0m
ALLIANCEBERNSTEIN L.P. Reduced -888,310-888.3k
Balyasny Asset Management L.P. Reduced -682,800-682.8k
STEMPOINT CAPITAL LP Sold out -545,800-545.8k
Laurion Capital Management LP Reduced -487,806-487.8k
Walleye Capital LLC Reduced -388,254-388.3k
ADAGE CAPITAL PARTNERS GP, L.L.C. Sold out -350,000-350.0k
Aberdeen Group plc Sold out -329,338-329.3k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $772.8k106.3k shares
Caption Management, LLC New $545.2k75.0k shares
Shay Capital LLC New $472.6k65.0k shares
SIMPLEX TRADING, LLC Reduced $356.0k49.1k shares
CITADEL ADVISORS LLC Added $316.2k43.5k shares
CITIGROUP INC New $290.8k40.0k shares
JANE STREET GROUP, LLC New $264.6k36.4k shares
GROUP ONE TRADING LLC Reduced $96.7k13.3k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

Caption Management, LLC Reduced $2.6m356.8k shares
Jefferies Financial Group Inc. Reduced $1.9m268.2k shares
GROUP ONE TRADING LLC Reduced $735.7k101.2k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $579.4k79.7k shares
JANE STREET GROUP, LLC Added $463.1k63.7k shares
CITADEL ADVISORS LLC Reduced $366.4k50.4k shares
LMR Partners LLP New $363.5k50.0k shares
CITIGROUP INC New $290.8k40.0k shares
Crawford Fund Management, LLC Reduced $258.1k35.5k shares
SIMPLEX TRADING, LLC Added $102.0k14.1k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
VANGUARD GROUP INC 13G · institution new · filed 2025-07-29 5.6% new 8.2m 2025-07-29
SUVRETTA CAPITAL MANAGEMENT, LLC 13G · institution -4.3 pts · filed 2025-11-13 5.6% -4.3 pts 8.3m 2025-11-13

Fell to 5% or below in the last year: Deep Track Capital, LP (0.0%, 2026-02-13), Pentwater Capital Management LP (0.0%, 2025-11-14)

Holders, Q1 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 JANUS HENDERSON GROUP PLC 0.09% of their portfolio LONDON, X0 20,462,90520.5m $165.3m $165.3m 0.09% Added +3.9m +3,948,849
2 RA CAPITAL MANAGEMENT, L.P. 2.41% of their portfolio BOSTON, MA 19,889,68319.9m $144.6m $144.6m 2.41% Added +5.7m +5,714,285
3 MONTANOVA CAPITAL, LLC 4.22% of their portfolio New York, NY 14,335,24414.3m $104.2m $104.2m 4.22% Added +4.1m +4,132,548
4 BlackRock, Inc. 0.00% of their portfolio New York, NY 10,075,34410.1m $73.2m $73.2m 0.00% Added +2.2m +2,185,245
5 Deep Track Capital, LP 2.19% of their portfolio GREENWICH, CT 9,316,3339.3m $67.7m $67.7m 2.19% Added +2.8m +2,838,084
6 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 7,163,6097.2m $52.1m $52.1m 0.00% Added +1.5m +1,471,278
7 Avoro Capital Advisors LLC 0.72% of their portfolio NEW YORK, NY 6,350,0006.3m $46.2m $46.2m 0.72% Added +2.2m +2,250,000
8 CITADEL ADVISORS LLC 0.04% of their portfolio MIAMI, FL 5,086,8365.1m $37.0m $37.0m 0.04% Added +357.0k +356,984
9 Pictet Asset Management Holding SA 0.03% of their portfolio CAROUGE, V8 4,204,8874.2m $30.6m $30.6m 0.03% Added +1.2m +1,197,853
10 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 4,030,3074.0m $29.3m $29.3m 0.00% Added +1.1m +1,085,075
11 WESTFIELD CAPITAL MANAGEMENT CO LP 0.14% of their portfolio BOSTON, MA 3,894,7413.9m $28.3m $28.3m 0.14% Added +7.9k +7,947
12 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 2,897,9742.9m $21.1m $21.1m 0.00% Added +690.4k +690,366
13 Logos Global Management LP 3.23% of their portfolio San Francisco, CA 2,500,0002.5m $18.2m $18.2m 3.23% New
14 Polar Capital Holdings Plc 0.11% of their portfolio London, X0 2,500,0002.5m $18.2m $18.2m 0.11% New
15 RTW INVESTMENTS, LP 0.22% of their portfolio NEW YORK, NY 1,967,5272.0m $14.3m $14.3m 0.22% Reduced -5.5m -5,510,534
16 Redmile Group, LLC 1.30% of their portfolio LARKSPUR, CA 1,886,4441.9m $13.7m $13.7m 1.30% Reduced -280.7k -280,732
17 Beck Bode, LLC 2.46% of their portfolio DEDHAM, MA 1,815,5241.8m $13.2m $13.2m 2.46% New
18 EMERALD ADVISERS, LLC 0.51% of their portfolio LEOLA, PA 1,550,6711.6m $11.3m $11.3m 0.51% New
19 SILVERARC CAPITAL MANAGEMENT, LLC 2.29% of their portfolio BOSTON, MA 1,510,4981.5m $11.0m $11.0m 2.29% Added +1.4m +1,413,987
20 University of Wisconsin Foundation 7.12% of their portfolio MADISON, WI 1,153,3571.2m $8.4m $8.4m 7.12% Added +236.0k +236,000
21 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 1,085,4641.1m $7.9m $7.9m 0.00% Added +230.7k +230,677
22 EMERALD MUTUAL FUND ADVISERS TRUST 0.56% of their portfolio LEOLA, PA 1,082,9731.1m $7.9m $7.9m 0.56% New
23 Integral Health Asset Management, LLC 0.85% of their portfolio New York, NY 1,050,0001.1m $7.6m $7.6m 0.85% Added +50.0k +50,000
24 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 1,035,9571.0m $7.5m $7.5m 0.00% First filing
25 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 995,449995.4k $7.2m $7.2m 0.00% Added +188.4k +188,367
26 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 985,771985.8k $7.2m $7.2m 0.00% Added +174.9k +174,945
27 Erste Asset Management GmbH 0.08% of their portfolio VIENNA, C4 883,000883.0k $6.5m $6.5m 0.08% Added +120.0k +120,000
28 Alyeska Investment Group, L.P. 0.02% of their portfolio CHICAGO, IL 852,227852.2k $6.2m $6.2m 0.02% Reduced -73.2k -73,170
29 Rock Springs Capital Management LP 0.35% of their portfolio Baltimore, MD 844,441844.4k $6.1m $6.1m 0.35% Added +291.7k +291,700
30 Candriam S.C.A. 0.04% of their portfolio STRASSEN, N4 831,823831.8k $6.0m $6.0m 0.04% Reduced -223.8k -223,838
31 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 826,860826.9k $6.0m $6.0m 0.00% Added +186.9k +186,886
32 ADAR1 Capital Management, LLC 1.12% of their portfolio AUSTIN, TX 804,220804.2k $5.8m $5.8m 1.12% Added +289.1k +289,082
33 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 781,952782.0k $5.7m $5.7m 0.00% Added +423.4k +423,378
34 LORD, ABBETT & CO. LLC 0.02% of their portfolio JERSEY CITY, NJ 733,404733.4k $5.3m $5.3m 0.02% New
35 Woodline Partners LP 0.03% of their portfolio San Francisco, CA 700,754700.8k $5.1m $5.1m 0.03% Added +305.9k +305,928
36 FMR LLC 0.00% of their portfolio BOSTON, MA 690,012690.0k $5.0m $5.0m 0.00% Added +597.8k +597,845
37 READYSTATE ASSET MANAGEMENT LP 0.25% of their portfolio CHICAGO, IL 685,169685.2k $5.0m $5.0m 0.25% New
38 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 629,229629.2k $4.6m $4.6m 0.00% Added +287.3k +287,278
39 SPHERA FUNDS MANAGEMENT LTD. 1.11% of their portfolio TEL AVIV, L3 618,343618.3k $4.5m $4.5m 1.11% Added +61.8k +61,811
40 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 587,986588.0k $4.3m $4.3m 0.00% Added +245.8k +245,757
41 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 504,300504.3k $3.7m $3.7m 0.01% Added +206.6k +206,600
42 Sio Capital Management, LLC 1.10% of their portfolio NEW YORK, NY 500,000500.0k $3.6m $3.6m 1.10% New
43 INFINITUM ASSET MANAGEMENT, LLC 1.16% of their portfolio FORT LAUDERDALE, FL 500,000500.0k $3.6m $3.6m 1.16% New
44 Orchard Capital Management, LLC 2.31% of their portfolio CHICAGO, IL 464,358464.4k $3.4m $3.4m 2.31% Added +421.7k +421,733
45 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 452,454452.5k $3.3m $3.3m 0.00% Reduced -255.7k -255,742
46 PANAGORA ASSET MANAGEMENT INC 0.02% of their portfolio BOSTON, MA 429,392429.4k $3.1m $3.1m 0.02% Added +314.0k +314,000
47 Assenagon Asset Management S.A. 0.01% of their portfolio SENNINGERBERG, N4 428,895428.9k $3.1m $3.1m 0.01% Added +186.3k +186,293
48 RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio ST. PETERSBURG, FL 382,291382.3k $2.8m $2.8m 0.00% Added +4.9k +4,921
49 Vivo Capital, LLC 0.36% of their portfolio Palo Alto, CA 376,804376.8k $2.7m $2.7m 0.36% New
50 Exome Asset Management LLC 2.30% of their portfolio NEW YORK, NY 353,882353.9k $2.6m $2.6m 2.30% Added +128.6k +128,559
51 Balyasny Asset Management L.P. 0.01% of their portfolio Chicago, IL 336,649336.6k $2.4m $2.4m 0.01% Reduced -682.8k -682,800
52 Apis Capital Advisors, LLC 1.11% of their portfolio New York, NY 315,000315.0k $2.3m $2.3m 1.11% New
53 HARBOR CAPITAL ADVISORS, INC. 0.10% of their portfolio CHICAGO, IL 314,772314.8k $2.3m $2.3m 0.10% Added +62.9k +62,874
54 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 309,916309.9k $2.3m $2.3m 0.00% Added +61.8k +61,760
55 Eversept Partners, LP 0.25% of their portfolio NEW YORK, NY 303,731303.7k $2.2m $2.2m 0.25% New
56 Laurion Capital Management LP 0.16% of their portfolio NEW YORK, NY 292,467292.5k $2.1m $2.1m 0.16% Reduced -487.8k -487,806
57 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 268,798268.8k $2.0m $2.0m 0.00% Added +90.1k +90,107
58 SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.03% of their portfolio BALA CYNWYD, PA 266,466266.5k $1.9m $1.9m 0.03% Added +205.5k +205,474
59 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 265,582265.6k $1.9m $1.9m 0.00% Added +239.9k +239,942
60 COMERICA BANK 0.01% of their portfolio DALLAS, TX 258,123258.1k $1.9m $1.9m 0.01% Added +1.5k +1,540
61 Hudson Bay Capital Management LP 0.01% of their portfolio STAMFORD, CT 250,200250.2k $1.8m $1.8m 0.01% New
62 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 250,193250.2k $1.8m $1.8m 0.00% Reduced -84.6k -84,612
63 DIADEMA PARTNERS LP 1.34% of their portfolio MORRISTOWN, NJ 231,436231.4k $1.7m $1.7m 1.34% New
64 ROYCE & ASSOCIATES LP 0.02% of their portfolio New York, NY 226,050226.1k $1.6m $1.6m 0.02% New
65 F/m Investments LLC 0.06% of their portfolio WASHINGTON, DC 214,837214.8k $1.6m $1.6m 0.06% New
66 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 207,130207.1k $1.5m $1.5m 0.00% Added +94.8k +94,789
67 Swiss National Bank 0.00% of their portfolio ZURICH, V8 205,500205.5k $1.5m $1.5m 0.00% Added +43.9k +43,900
68 UBS Group AG 0.00% of their portfolio ZURICH, V8 203,207203.2k $1.5m $1.5m 0.00% Added +90.0k +90,022
69 Newtyn Management, LLC 0.23% of their portfolio NEW YORK, NY 200,000200.0k $1.5m $1.5m 0.23% Reduced -40.0k -40,000
70 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 188,449188.4k $1.4m $1.4m 0.00% Reduced -49.1k -49,072
71 ALGERT GLOBAL LLC 0.03% of their portfolio SAN FRANCISCO, CA 186,991187.0k $1.4m $1.4m 0.03% Added +1.6k +1,584
72 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 185,295185.3k $1.3m $1.3m 0.00% Added +71.7k +71,726
73 Jefferies Financial Group Inc. 0.02% of their portfolio NEW YORK, NY 181,000181.0k $1.3m $1.3m 0.02% Added +31.6k +31,604
74 Caption Management, LLC 0.06% of their portfolio OKLAHOMA CITY, OK 180,600180.6k $1.3m $1.3m 0.06% Reduced -85.8k -85,762
75 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 176,834176.8k $1.3m $1.3m 0.00% New
76 Affinity Asset Advisors, LLC 0.20% of their portfolio NEW YORK, NY 175,000175.0k $1.3m $1.3m 0.20% New
77 Ghisallo Capital Management LLC 0.11% of their portfolio BOSTON, MA 175,000175.0k $1.3m $1.3m 0.11% New
78 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 168,110168.1k $1.2m $1.2m 0.00% Added +103.9k +103,931
79 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 153,826153.8k $1.1m $1.1m 0.00% Reduced -888.3k -888,310
80 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 152,138152.1k $1.1m $1.1m 0.00% Added +22.2k +22,158
81 J. Goldman & Co LP 0.04% of their portfolio NEW YORK, NY 142,565142.6k $1.0m $1.0m 0.04% New
82 Hennion & Walsh Asset Management, Inc. 0.05% of their portfolio Parsippany, NJ 140,306140.3k $1.0m $1.0m 0.05% Added +45.8k +45,812
83 Rafferty Asset Management, LLC 0.00% of their portfolio New York, NY 137,247137.2k $997.8k $997.8k 0.00% Added +48.5k +48,502
84 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 118,705118.7k $863.0k $863.0k 0.00% Reduced -44.5k -44,468
85 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 115,751115.8k $841.5k $841.5k 0.00% Added +79.5k +79,515
86 SUPERSTRING CAPITAL MANAGEMENT LP 0.95% of their portfolio NEW YORK, NY 109,156109.2k $793.6k $793.6k 0.95% Reduced -23.8k -23,826
87 Legal & General Group Plc 0.00% of their portfolio London, X0 106,725106.7k $775.5k $775.5k 0.00% Added +30.8k +30,837
88 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 103,977104.0k $755.9k $755.9k 0.00% Added +27.1k +27,056
89 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 101,666101.7k $739.1k $739.1k 0.00% Added +23.6k +23,607
90 Ikarian Capital, LLC 0.24% of their portfolio DALLAS, TX 100,000100.0k $727.0k $727.0k 0.24% New
91 Trexquant Investment LP 0.01% of their portfolio STAMFORD, CT 99,18399.2k $721.1k $721.1k 0.01% New
92 JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio FLORHAM PARK, NJ 98,84898.8k $718.6k $718.6k 0.00% New
93 PRELUDE CAPITAL MANAGEMENT, LLC 0.07% of their portfolio NEW YORK, NY 98,08798.1k $713.1k $713.1k 0.07% Added +29.1k +29,086
94 B Group, Inc. 0.60% of their portfolio DALLAS, TX 95,62395.6k $695.2k $695.2k 0.60% New
95 Atom Investors LP 0.08% of their portfolio AUSTIN, TX 93,16793.2k $677.3k $677.3k 0.08% New
96 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 90,00090.0k $1.0m $1.0m 0.00% Unchanged
97 Jain Global LLC 0.01% of their portfolio NEW YORK, NY 88,48288.5k $643.3k $643.3k 0.01% New
98 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 80,19980.2k $583.0k $583.0k 0.00% New
99 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 75,09675.1k $545.9k $545.9k 0.00% Reduced -233.4k -233,363
100 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 74,56774.6k $542.1k $542.1k 0.00% Added +24.2k +24,229