Vault-13

89BIO INC ETNB

COM · Common Stock · CUSIP 282559103

152 institutional holders -3 vs Q4 2023
100,063,755100.1m shares reported held*
$1.2bnreported value*
22 new 69 added 52 reduced 25 sold out net bought ≈ $49.0m (+4.2m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $11.63. Options: 9 managers hold calls ($9.1m notional), 9 hold puts ($15.3m).

Trends to Q1 2024

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 86Q4 22: 106Q1 23: 149Q2 23: 159Q3 23: 162Q4 23: 155Q1 24: 152152Q3 22Q1 23Q3 23Q1 24
Numbers
QuarterHolders
Q3 202286
Q4 2022106
Q1 2023149
Q2 2023159
Q3 2023162
Q4 2023155
Q1 2024152

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 70 bought or addedQ4 22: 38 cut or sold outQ4 22Q1 23: 112 bought or addedQ1 23: 47 cut or sold outQ1 23Q2 23: 103 bought or addedQ2 23: 72 cut or sold outQ2 23Q3 23: 89 bought or addedQ3 23: 77 cut or sold outQ3 23Q4 23: 93 bought or addedQ4 23: 80 cut or sold outQ4 23Q1 24: 91 bought or addedQ1 24: 77 cut or sold outQ1 24
Numbers
QuarterBought or addedCut or sold out
Q4 20227038
Q1 202311247
Q2 202310372
Q3 20238977
Q4 20239380
Q1 20249177

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ2 23 calls: $6.7mQ2 23 puts: $19.0mQ2 23P/C 2.83Q3 23 calls: $40.3mQ3 23 puts: $13.8mQ3 23P/C 0.34Q4 23 calls: $8.3mQ4 23 puts: $16.2mQ4 23P/C 1.95Q1 24 calls: $9.1mQ1 24 puts: $15.3mQ1 24P/C 1.69
Numbers
QuarterCallsPutsP/C
Q2 2023$6.7m$19.0m2.83
Q3 2023$40.3m$13.8m0.34
Q4 2023$8.3m$16.2m1.95
Q1 2024$9.1m$15.3m1.69

Biggest buyers

JANUS HENDERSON GROUP PLC Added +3,688,241+3.7m
RTW INVESTMENTS, LP Added +1,799,617+1.8m
MONTANOVA CAPITAL, LLC Added +1,409,570+1.4m
RA CAPITAL MANAGEMENT, L.P. Added +1,350,000+1.4m
BlackRock Inc. Added +1,183,788+1.2m
MPM BIOIMPACT LLC New +967,742+967.7k
MILLENNIUM MANAGEMENT LLC Added +528,312+528.3k
VANGUARD GROUP INC Added +415,386+415.4k
WESTFIELD CAPITAL MANAGEMENT CO LP Added +402,999+403.0k
University of Wisconsin Foundation Added +371,621+371.6k

Biggest sellers

ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -2,675,000-2.7m
FEDERATED HERMES, INC. Sold out -1,962,566-2.0m
Frazier Life Sciences Management, L.P. Reduced -1,000,000-1.0m
Pictet Asset Management Holding SA Reduced -847,489-847.5k
CITADEL ADVISORS LLC Reduced -608,797-608.8k
MARSHALL WACE, LLP Sold out -554,337-554.3k
MORGAN STANLEY Reduced -540,654-540.7k
STEMPOINT CAPITAL LP Sold out -408,257-408.3k
Qube Research & Technologies Ltd Reduced -386,224-386.2k
DEUTSCHE BANK AG\ Reduced -330,443-330.4k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $2.0m171.1k shares
Alyeska Investment Group, L.P. Unchanged $1.7m150.0k shares
SIMPLEX TRADING, LLC Added $1.2m99.3k shares
GROUP ONE TRADING LLC Reduced $1.1m96.5k shares
CITADEL ADVISORS LLC Reduced $1.0m87.4k shares
Caption Management, LLC New $1.0m86.0k shares
CITIGROUP INC New $814.8k70.0k shares
WOLVERINE TRADING, LLC New $230.5k19.8k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

Caption Management, LLC Unchanged $5.5m474.9k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $5.2m446.5k shares
Jefferies Financial Group Inc. Added $1.9m163.9k shares
GROUP ONE TRADING LLC Reduced $1.1m95.0k shares
CITADEL ADVISORS LLC Added $720.5k61.9k shares
SIMPLEX TRADING, LLC Reduced $538.0k46.3k shares
PEAK6 Investments LLC New $174.6k15.0k shares
Crawford Fund Management, LLC New $128.0k11.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
VANGUARD GROUP INC 13G · institution new · filed 2025-07-29 5.6% new 8.2m 2025-07-29
SUVRETTA CAPITAL MANAGEMENT, LLC 13G · institution -4.3 pts · filed 2025-11-13 5.6% -4.3 pts 8.3m 2025-11-13

Fell to 5% or below in the last year: Deep Track Capital, LP (0.0%, 2026-02-13), Pentwater Capital Management LP (0.0%, 2025-11-14)

Holders, Q1 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 1.89% of their portfolio BOSTON, MA 12,766,94812.8m $148.6m $148.6m 1.89% Added +1.4m +1,350,000
2 JANUS HENDERSON GROUP PLC 0.08% of their portfolio LONDON, X0 12,603,38212.6m $146.6m $146.6m 0.08% Added +3.7m +3,688,241
3 RTW INVESTMENTS, LP 1.27% of their portfolio NEW YORK, NY 7,378,5487.4m $85.9m $85.9m 1.27% Added +1.8m +1,799,617
4 BlackRock Inc. 0.00% of their portfolio New York, NY 6,637,9846.6m $77.3m $77.3m 0.00% Added +1.2m +1,183,788
5 MONTANOVA CAPITAL, LLC 3.09% of their portfolio New York, NY 6,298,0046.3m $73.3m $73.3m 3.09% Added +1.4m +1,409,570
6 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 5,543,5885.5m $64.5m $64.5m 0.00% Added +144.2k +144,230
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 4,722,9714.7m $55.0m $55.0m 0.00% Added +415.4k +415,386
8 BVF INC/IL 1.30% of their portfolio San Francisco, CA 4,047,3544.0m $47.1m $47.1m 1.30% Unchanged
9 Pictet Asset Management Holding SA 0.05% of their portfolio CAROUGE, V8 3,710,1913.7m $43.2m $43.2m 0.05% Reduced -847.5k -847,489
10 Holocene Advisors, LP 0.15% of their portfolio New York, NY 3,450,6893.5m $40.2m $40.2m 0.15% Reduced -39.9k -39,939
11 Laurion Capital Management LP 0.87% of their portfolio NEW YORK, NY 2,699,4702.7m $31.4m $31.4m 0.87% Reduced -4.7k -4,732
12 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 2,437,8662.4m $28.4m $28.4m 0.00% Reduced -540.7k -540,654
13 Redmile Group, LLC 0.97% of their portfolio LARKSPUR, CA 2,264,5662.3m $26.4m $26.4m 0.97% Added +295.2k +295,164
14 WESTFIELD CAPITAL MANAGEMENT CO LP 0.13% of their portfolio BOSTON, MA 2,164,1472.2m $25.2m $25.2m 0.13% Added +403.0k +402,999
15 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,740,8671.7m $20.3m $20.3m 0.00% Added +363.2k +363,157
16 CITADEL ADVISORS LLC 0.02% of their portfolio MIAMI, FL 1,569,5421.6m $18.3m $18.3m 0.02% Reduced -608.8k -608,797
17 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 1,087,1971.1m $12.7m $12.7m 0.01% Added +528.3k +528,312
18 Frazier Life Sciences Management, L.P. 0.49% of their portfolio PALO ALTO, CA 1,000,0001.0m $11.6m $11.6m 0.49% Reduced -1.0m -1,000,000
19 MPM BIOIMPACT LLC 1.82% of their portfolio BOSTON, MA 967,742967.7k $11.3m $11.3m 1.82% New
20 SUPERSTRING CAPITAL MANAGEMENT LP 7.24% of their portfolio NEW YORK, NY 941,287941.3k $11.0m $11.0m 7.24% Reduced -80.2k -80,190
21 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 827,657827.7k $9.6m $9.6m 0.00% Reduced -46 -46
22 Orchard Capital Management, LLC 2.56% of their portfolio CHICAGO, IL 749,350749.4k $8.7m $8.7m 2.56% Added +10.1k +10,142
23 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 744,948744.9k $8.7m $8.7m 0.00% Added +113.8k +113,836
24 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 714,531714.5k $8.3m $8.3m 0.00% Added +96.5k +96,530
25 EAGLE ASSET MANAGEMENT INC 0.04% of their portfolio ST PETERSBURG, FL 679,767679.8k $7.3m $7.3m 0.04% Reduced -22.3k -22,328
26 Erste Asset Management GmbH 0.11% of their portfolio VIENNA, C4 673,000673.0k $7.8m $7.8m 0.11% Added +170.0k +170,000
27 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 629,233629.2k $7.3m $7.3m 0.00% Added +129.9k +129,880
28 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 550,594550.6k $6.4m $6.4m 0.00% Added +308.2k +308,205
29 SPHERA FUNDS MANAGEMENT LTD. 0.97% of their portfolio TEL AVIV, L3 515,882515.9k $6.0m $6.0m 0.97% Added +107.2k +107,208
30 University of Wisconsin Foundation 6.54% of their portfolio MADISON, WI 498,137498.1k $5.8m $5.8m 6.54% Added +371.6k +371,621
31 Aberdeen Group plc 0.01% of their portfolio EDINBURGH, X0 470,387470.4k $5.5m $5.5m 0.01% Added +256.2k +256,195
32 Rafferty Asset Management, LLC 0.02% of their portfolio New York, NY 461,952462.0k $5.4m $5.4m 0.02% Added +8.3k +8,278
33 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.01% of their portfolio Boston, MA 450,000450.0k $5.2m $5.2m 0.01% Reduced -2.7m -2,675,000
34 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 418,259418.3k $4.9m $4.9m 0.01% Added +203.7k +203,657
35 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 408,639408.6k $4.8m $4.8m 0.00% Added +136.7k +136,740
36 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 354,088354.1k $4.1m $4.1m 0.00% Reduced -189.5k -189,464
37 UBS Group AG 0.00% of their portfolio ZURICH, V8 320,732320.7k $3.7m $3.7m 0.00% Added +36.2k +36,235
38 Candriam S.C.A. 0.02% of their portfolio STRASSEN, N4 310,000310.0k $3.6m $3.6m 0.02% Added +30.0k +30,000
39 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 307,924307.9k $3.6m $3.6m 0.00% Added +68.9k +68,897
40 Alyeska Investment Group, L.P. 0.02% of their portfolio CHICAGO, IL 300,000300.0k $3.5m $3.5m 0.02% Reduced -283.2k -283,187
41 Integral Health Asset Management, LLC 0.34% of their portfolio New York, NY 300,000300.0k $3.5m $3.5m 0.34% New
42 Newtyn Management, LLC 0.58% of their portfolio NEW YORK, NY 250,000250.0k $2.9m $2.9m 0.58% Reduced -22.5k -22,500
43 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 248,746248.7k $2.9m $2.9m 0.00% Added +26.3k +26,326
44 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 246,100246.1k $2.9m $2.9m 0.01% Added +117.3k +117,342
45 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 231,007231.0k $2.7m $2.7m 0.00% Reduced -68.0k -67,982
46 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 179,962180.0k $2.1m $2.1m 0.00% Added +13.8k +13,752
47 Parkman Healthcare Partners LLC 0.26% of their portfolio STAMFORD, CT 179,899179.9k $2.1m $2.1m 0.26% Reduced -39.5k -39,549
48 COMERICA BANK 0.01% of their portfolio DALLAS, TX 171,000171.0k $2.0m $2.0m 0.01% Added +15.1k +15,070
49 Swiss National Bank 0.00% of their portfolio ZURICH, V8 147,200147.2k $1.7m $1.7m 0.00% Added +4.4k +4,400
50 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 143,500143.5k $1.7m $1.7m 0.00% Reduced -23.8k -23,800
51 Caption Management, LLC 0.18% of their portfolio OKLAHOMA CITY, OK 140,984141.0k $1.6m $1.6m 0.18% Reduced -119.0k -119,016
52 RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio ST PETERSBURG, FL 135,273135.3k $1.6m $1.6m 0.00% Added +26.9k +26,870
53 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 134,054134.1k $1.6m $1.6m 0.01% Added +56.3k +56,296
54 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 130,996131.0k $1.5m $1.5m 0.00% Reduced -117.9k -117,935
55 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 121,626121.6k $1.4m $1.4m 0.00% Reduced -276.2k -276,238
56 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 118,755118.8k $1.4m $1.4m 0.00% Reduced -3.1k -3,108
57 Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio ST. PETERSBURG, FL 117,305117.3k $1.4m $1.4m 0.00% Added +13.0k +13,019
58 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 115,422115.4k $1.3m $1.3m 0.00% Added +26.1k +26,125
59 CAPSTONE INVESTMENT ADVISORS, LLC 0.02% of their portfolio NEW YORK, NY 103,767103.8k $1.2m $1.2m 0.02% New
60 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 101,610101.6k $1.2m $1.2m 0.00% Added +17.5k +17,521
61 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 101,514101.5k $1.2m $1.2m 0.00% Added +15.7k +15,659
62 NATIXIS 0.01% of their portfolio PARIS, I0 99,00099.0k $1.2m $1.2m 0.01% New
63 SILVERARC CAPITAL MANAGEMENT, LLC 0.30% of their portfolio BOSTON, MA 92,29892.3k $1.1m $1.1m 0.30% Reduced -66.4k -66,421
64 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 90,00090.0k $1.0m $1.0m 0.00% Unchanged
65 Jefferies Financial Group Inc. 0.02% of their portfolio NEW YORK, NY 79,90179.9k $930.0k $930.0k 0.02% Added +15.8k +15,785
66 1492 Capital Management LLC 0.51% of their portfolio MILWAUKEE, WI 79,16879.2k $921.5k $921.5k 0.51% Reduced -50 -50
67 Legal & General Group Plc 0.00% of their portfolio London, X0 76,47276.5k $890.1k $890.1k 0.00% Added +2.9k +2,903
68 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 75,00275.0k $873.0k $873.0k 0.00% Reduced -147 -147
69 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 72,70072.7k $846.2k $846.2k 0.00% Added +13.6k +13,600
70 PROFUND ADVISORS LLC 0.03% of their portfolio BETHESDA, MD 71,74071.7k $835.1k $835.1k 0.03% Reduced -1.4k -1,401
71 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 65,94765.9k $767.6k $767.6k 0.01% Added +13.5k +13,491
72 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 60,10360.1k $699.6k $699.6k 0.00% Added +3.3k +3,268
73 NOMURA HOLDINGS INC 0.01% of their portfolio TOKYO, M0 58,96359.0k $686.3k $686.3k 0.01% Reduced -23.0k -23,037
74 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 55,49355.5k $645.9k $645.9k 0.00% Added +41.5k +41,536
75 Trexquant Investment LP 0.01% of their portfolio STAMFORD, CT 54,27054.3k $631.7k $631.7k 0.01% New
76 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 48,39748.4k $563.3k $563.3k 0.00% Reduced -330.4k -330,443
77 TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio STAMFORD, CT 47,63047.6k $554.4k $554.4k 0.01% New
78 Jump Financial, LLC 0.01% of their portfolio Chicago, IL 46,30346.3k $539.0k $539.0k 0.01% New
79 Pennant Investors, LP 0.14% of their portfolio Summit, NJ 44,50044.5k $518.0k $518.0k 0.14% Unchanged
80 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 40,59740.6k $472.5k $472.5k 0.00% Added +8.0k +7,978
81 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 38,96839.0k $453.6k $453.6k 0.00% Added +7.1k +7,140
82 Steward Partners Investment Advisory, LLC 0.00% of their portfolio STAMFORD, CT 36,11036.1k $420.3k $420.3k 0.00% New
83 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.01% of their portfolio CHICAGO, IL 35,96236.0k $418.6k $418.6k 0.01% Reduced -43.1k -43,113
84 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 34,90234.9k $406.3k $406.3k 0.00% Reduced -66.3k -66,316
85 BOURGEON CAPITAL MANAGEMENT LLC 0.08% of their portfolio Darien, CT 33,65033.6k $391.7k $391.7k 0.08% Reduced -1.6k -1,650
86 Gilliland Jeter Wealth Management LLC 0.13% of their portfolio LITTLE ROCK, AR 32,92632.9k $383.3k $383.3k 0.13% Added +13.9k +13,926
87 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 31,22131.2k $364.0k $364.0k 0.00% Added +7.0k +7,000
88 Corton Capital Inc. 0.13% of their portfolio Carrying Place, A6 29,45229.5k $342.8k $342.8k 0.13% Reduced -6.0k -6,027
89 SHERBROOKE PARK ADVISERS LLC 0.07% of their portfolio WHITE PLAINS, NY 29,00229.0k $337.6k $337.6k 0.07% New
90 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 28,97629.0k $337.3k $337.3k 0.00% Added +2.9k +2,935
91 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 27,79827.8k $323.6k $323.6k 0.00% Reduced -5.6k -5,593
92 Entropy Technologies, LP 0.03% of their portfolio NEW YORK, NY 27,15427.2k $316.1k $316.1k 0.03% Reduced -6.4k -6,353
93 Parkwood LLC 0.03% of their portfolio CLEVELAND, OH 26,70126.7k $311.0k $311.0k 0.03% Reduced -17.5k -17,505
94 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 25,32225.3k $294.7k $294.7k 0.00% New
95 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 24,87424.9k $289.5k $289.5k 0.00% Reduced -469 -469
96 HARBOR CAPITAL ADVISORS, INC. 0.04% of their portfolio CHICAGO, IL 24,25724.3k $282.0k $282.0k 0.04% Added +19.5k +19,498
97 ALGERT GLOBAL LLC 0.01% of their portfolio SAN FRANCISCO, CA 23,38423.4k $272.2k $272.2k 0.01% Reduced -23.4k -23,440
98 E Fund Management Co., Ltd. 0.02% of their portfolio GUANGZHOU, F4 21,83021.8k $254.1k $254.1k 0.02% Reduced -2.5k -2,533
99 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 20,73720.7k $241.4k $241.4k 0.00% Added +5.3k +5,319
100 ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio PHOENIX, AZ 20,49220.5k $238.5k $238.5k 0.00% Added +235 +235