Vault-13

89BIO INC ETNB

COM · Common Stock · CUSIP 282559103

155 institutional holders -7 vs Q3 2023
95,848,96595.8m shares reported held*
$1.1bnreported value*
22 new 71 added 40 reduced 40 sold out net bought ≈ $244.9m (+21.9m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $11.17. Options: 9 managers hold calls ($8.3m notional), 9 hold puts ($16.2m).

Trends to Q4 2023

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 86Q4 22: 106Q1 23: 149Q2 23: 159Q3 23: 162Q4 23: 155155Q3 22Q4 22Q1 23Q2 23Q3 23Q4 23
Numbers
QuarterHolders
Q3 202286
Q4 2022106
Q1 2023149
Q2 2023159
Q3 2023162
Q4 2023155

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 70 bought or addedQ4 22: 38 cut or sold outQ4 22Q1 23: 112 bought or addedQ1 23: 47 cut or sold outQ1 23Q2 23: 103 bought or addedQ2 23: 72 cut or sold outQ2 23Q3 23: 89 bought or addedQ3 23: 77 cut or sold outQ3 23Q4 23: 93 bought or addedQ4 23: 80 cut or sold outQ4 23
Numbers
QuarterBought or addedCut or sold out
Q4 20227038
Q1 202311247
Q2 202310372
Q3 20238977
Q4 20239380

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ1 23 calls: $55.5mQ1 23 puts: $25.0mQ1 23P/C 0.45Q2 23 calls: $6.7mQ2 23 puts: $19.0mQ2 23P/C 2.83Q3 23 calls: $40.3mQ3 23 puts: $13.8mQ3 23P/C 0.34Q4 23 calls: $8.3mQ4 23 puts: $16.2mQ4 23P/C 1.95
Numbers
QuarterCallsPutsP/C
Q1 2023$55.5m$25.0m0.45
Q2 2023$6.7m$19.0m2.83
Q3 2023$40.3m$13.8m0.34
Q4 2023$8.3m$16.2m1.95

Biggest buyers

RTW INVESTMENTS, LP New +5,578,931+5.6m
JANUS HENDERSON GROUP PLC Added +4,885,938+4.9m
MORGAN STANLEY Added +2,378,766+2.4m
BVF INC/IL Added +2,201,200+2.2m
MONTANOVA CAPITAL, LLC Added +2,194,030+2.2m
Frazier Life Sciences Management, L.P. New +2,000,000+2.0m
Laurion Capital Management LP Added +1,498,564+1.5m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +1,426,583+1.4m
Holocene Advisors, LP Added +1,254,823+1.3m
Redmile Group, LLC Added +1,207,447+1.2m

Biggest sellers

BRAIDWELL LP Sold out -1,590,387-1.6m
Octagon Capital Advisors LP Sold out -1,219,157-1.2m
LORD, ABBETT & CO. LLC Sold out -876,532-876.5k
ALKEON CAPITAL MANAGEMENT LLC Sold out -700,000-700.0k
MARSHALL WACE, LLP Reduced -616,419-616.4k
VICTORY CAPITAL MANAGEMENT INC Sold out -555,773-555.8k
Artia Global Partners LP Sold out -465,465-465.5k
Driehaus Capital Management LLC Sold out -432,174-432.2k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -358,024-358.0k
AMERIPRISE FINANCIAL INC Sold out -346,946-346.9k

Biggest calls

Alyeska Investment Group, L.P. Unchanged $1.7m150.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $1.5m130.1k shares
GROUP ONE TRADING LLC Added $1.4m123.2k shares
CITADEL ADVISORS LLC Added $1.2m105.2k shares
SIMPLEX TRADING, LLC Added $1.1m94.1k shares
JANE STREET GROUP, LLC Added $761.8k68.2k shares
Walleye Trading LLC Reduced $584.2k52.3k shares
GTS SECURITIES LLC New $207.8k18.6k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

Caption Management, LLC New $5.3m474.9k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $5.3m474.6k shares
Jefferies Financial Group Inc. New $1.8m162.4k shares
GROUP ONE TRADING LLC Added $1.3m117.4k shares
SIMPLEX TRADING, LLC Added $1.1m101.7k shares
CITADEL ADVISORS LLC Reduced $655.7k58.7k shares
JANE STREET GROUP, LLC Added $654.6k58.6k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares
FNY Investment Advisers, LLC New $020 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
VANGUARD GROUP INC 13G · institution new · filed 2025-07-29 5.6% new 8.2m 2025-07-29
SUVRETTA CAPITAL MANAGEMENT, LLC 13G · institution -4.3 pts · filed 2025-11-13 5.6% -4.3 pts 8.3m 2025-11-13

Fell to 5% or below in the last year: Deep Track Capital, LP (0.0%, 2026-02-13), Pentwater Capital Management LP (0.0%, 2025-11-14)

Holders, Q4 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 1.99% of their portfolio BOSTON, MA 11,416,94811.4m $127.5m $127.5m 1.99% Unchanged
2 JANUS HENDERSON GROUP PLC 0.06% of their portfolio LONDON, X0 8,915,1418.9m $99.6m $99.6m 0.06% Added +4.9m +4,885,938
3 RTW INVESTMENTS, LP 0.97% of their portfolio NEW YORK, NY 5,578,9315.6m $62.3m $62.3m 0.97% New
4 BlackRock Inc. 0.00% of their portfolio New York, NY 5,454,1965.5m $60.9m $60.9m 0.00% Added +488.0k +487,956
5 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 5,399,3585.4m $60.3m $60.3m 0.00% Added +1.1m +1,092,718
6 MONTANOVA CAPITAL, LLC 2.50% of their portfolio New York, NY 4,888,4344.9m $54.6m $54.6m 2.50% Added +2.2m +2,194,030
7 Pictet Asset Management Holding SA 0.06% of their portfolio CAROUGE, V8 4,557,6804.6m $50.9m $50.9m 0.06% Added +669.7k +669,726
8 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 4,307,5854.3m $48.1m $48.1m 0.00% Added +781.8k +781,803
9 BVF INC/IL 1.13% of their portfolio San Francisco, CA 4,047,3544.0m $45.2m $45.2m 1.13% Added +2.2m +2,201,200
10 Holocene Advisors, LP 0.15% of their portfolio New York, NY 3,490,6283.5m $39.0m $39.0m 0.15% Added +1.3m +1,254,823
11 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.07% of their portfolio Boston, MA 3,125,0003.1m $34.9m $34.9m 0.07% Added +1.4m +1,426,583
12 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 2,978,5203.0m $33.3m $33.3m 0.00% Added +2.4m +2,378,766
13 Laurion Capital Management LP 1.08% of their portfolio NEW YORK, NY 2,704,2022.7m $30.2m $30.2m 1.08% Added +1.5m +1,498,564
14 CITADEL ADVISORS LLC 0.02% of their portfolio MIAMI, FL 2,178,3392.2m $24.3m $24.3m 0.02% Added +674.3k +674,330
15 Frazier Life Sciences Management, L.P. 1.19% of their portfolio PALO ALTO, CA 2,000,0002.0m $22.3m $22.3m 1.19% New
16 Redmile Group, LLC 0.79% of their portfolio LARKSPUR, CA 1,969,4022.0m $22.0m $22.0m 0.79% Added +1.2m +1,207,447
17 FEDERATED HERMES, INC. 0.05% of their portfolio PITTSBURGH, PA 1,962,5662.0m $21.9m $21.9m 0.05% Reduced -167.0k -167,035
18 WESTFIELD CAPITAL MANAGEMENT CO LP 0.11% of their portfolio BOSTON, MA 1,761,1481.8m $19.7m $19.7m 0.11% Added +449.3k +449,262
19 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,377,7101.4m $15.4m $15.4m 0.00% Added +83.7k +83,722
20 SUPERSTRING CAPITAL MANAGEMENT LP 8.14% of their portfolio NEW YORK, NY 1,021,4771.0m $11.4m $11.4m 8.14% First filing
21 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 827,703827.7k $9.2m $9.2m 0.00% Added +320 +320
22 Orchard Capital Management, LLC 2.59% of their portfolio CHICAGO, IL 739,208739.2k $8.3m $8.3m 2.59% Added +196.3k +196,329
23 EAGLE ASSET MANAGEMENT INC 0.04% of their portfolio ST PETERSBURG, FL 702,095702.1k $7.8m $7.8m 0.04% Reduced -10.8k -10,803
24 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 631,112631.1k $7.0m $7.0m 0.00% Added +112.4k +112,438
25 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 618,001618.0k $6.9m $6.9m 0.00% Added +37.3k +37,339
26 Alyeska Investment Group, L.P. 0.04% of their portfolio CHICAGO, IL 583,187583.2k $6.5m $6.5m 0.04% Added +123.3k +123,300
27 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 558,885558.9k $6.2m $6.2m 0.01% Added +453.0k +453,032
28 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 554,337554.3k $6.2m $6.2m 0.01% Reduced -616.4k -616,419
29 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 543,552543.6k $6.1m $6.1m 0.00% Reduced -80.8k -80,813
30 Erste Asset Management GmbH 0.08% of their portfolio VIENNA, C4 503,000503.0k $5.6m $5.6m 0.08% Added +450.0k +450,000
31 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 499,353499.4k $5.6m $5.6m 0.00% Added +10.3k +10,349
32 Rafferty Asset Management, LLC 0.02% of their portfolio New York, NY 453,674453.7k $5.1m $5.1m 0.02% Added +71.7k +71,729
33 SPHERA FUNDS MANAGEMENT LTD. 0.85% of their portfolio TEL AVIV, L3 408,674408.7k $4.6m $4.6m 0.85% Added +89.4k +89,373
34 STEMPOINT CAPITAL LP 1.31% of their portfolio NEW YORK, NY 408,257408.3k $4.6m $4.6m 1.31% First filing
35 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 403,324403.3k $4.5m $4.5m 0.01% New
36 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 397,864397.9k $4.4m $4.4m 0.00% Added +146.6k +146,559
37 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 378,840378.8k $4.2m $4.2m 0.00% Added +346.3k +346,276
38 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 298,989299.0k $3.3m $3.3m 0.00% Reduced -44.7k -44,685
39 UBS Group AG 0.00% of their portfolio ZURICH, V8 284,497284.5k $3.2m $3.2m 0.00% Added +183.5k +183,515
40 Candriam S.C.A. 0.02% of their portfolio STRASSEN, N4 280,000280.0k $3.1m $3.1m 0.02% Added +60.0k +60,000
41 Newtyn Management, LLC 0.60% of their portfolio NEW YORK, NY 272,500272.5k $3.0m $3.0m 0.60% Added +72.0k +72,000
42 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 271,899271.9k $3.0m $3.0m 0.00% Reduced -163.5k -163,502
43 Caption Management, LLC 0.32% of their portfolio OKLAHOMA CITY, OK 260,000260.0k $2.9m $2.9m 0.32% Added +144.0k +144,000
44 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 248,931248.9k $2.8m $2.8m 0.00% Added +23.4k +23,432
45 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 242,389242.4k $2.7m $2.7m 0.00% Reduced -155.4k -155,413
46 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 239,027239.0k $2.7m $2.7m 0.00% New
47 Weiss Multi-Strategy Advisers LLC 0.07% of their portfolio NEW YORK, NY 230,000230.0k $2.6m $2.6m 0.07% Added +163.7k +163,669
48 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 222,420222.4k $2.5m $2.5m 0.00% Added +4.5k +4,515
49 Parkman Healthcare Partners LLC 0.35% of their portfolio STAMFORD, CT 219,448219.4k $2.5m $2.5m 0.35% Reduced -144.1k -144,105
50 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 214,602214.6k $2.4m $2.4m 0.00% Added +52.7k +52,746
51 Aberdeen Group plc 0.01% of their portfolio EDINBURGH, X0 214,192214.2k $2.4m $2.4m 0.01% New
52 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 167,300167.3k $1.9m $1.9m 0.00% Reduced -245.4k -245,400
53 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 166,210166.2k $1.9m $1.9m 0.00% Reduced -214.9k -214,857
54 SILVERARC CAPITAL MANAGEMENT, LLC 0.55% of their portfolio BOSTON, MA 158,719158.7k $1.8m $1.8m 0.55% Added +98.5k +98,472
55 COMERICA BANK 0.01% of their portfolio DALLAS, TX 155,930155.9k $1.7m $1.7m 0.01% Added +155.9k +155,854
56 Swiss National Bank 0.00% of their portfolio ZURICH, V8 142,800142.8k $1.6m $1.6m 0.00% Added +30.7k +30,700
57 Monashee Investment Management LLC 0.28% of their portfolio Boston, MA 140,000140.0k $1.6m $1.6m 0.28% New
58 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 128,758128.8k $1.4m $1.4m 0.00% Reduced -83.0k -83,019
59 University of Wisconsin Foundation 2.35% of their portfolio MADISON, WI 126,516126.5k $1.4m $1.4m 2.35% Unchanged
60 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 121,863121.9k $1.4m $1.4m 0.00% Reduced -4.1k -4,109
61 RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio ST PETERSBURG, FL 108,403108.4k $1.2m $1.2m 0.00% Added +5.4k +5,415
62 Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio ST. PETERSBURG, FL 104,286104.3k $1.2m $1.2m 0.00% Reduced -27.8k -27,819
63 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 101,218101.2k $1.1m $1.1m 0.00% Added +6.7k +6,654
64 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 90,00090.0k $1.0m $1.0m 0.00% Added +70.0k +70,000
65 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 89,29789.3k $997.4k $997.4k 0.00% Reduced -84.7k -84,653
66 TWINBEECH CAPITAL LP 0.02% of their portfolio PURCHASE, NY 86,68986.7k $968.3k $968.3k 0.02% Reduced -49.4k -49,427
67 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 85,85585.9k $959.0k $959.0k 0.00% Reduced -75.3k -75,316
68 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 84,08984.1k $939.3k $939.3k 0.00% Added +2.6k +2,616
69 NOMURA HOLDINGS INC 0.01% of their portfolio TOKYO, M0 82,00082.0k $915.9k $915.9k 0.01% New
70 1492 Capital Management LLC 0.50% of their portfolio MILWAUKEE, WI 79,21879.2k $884.9k $884.9k 0.50% Added +814 +814
71 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.03% of their portfolio CHICAGO, IL 79,07579.1k $883.3k $883.3k 0.03% Reduced -19.8k -19,763
72 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 77,75877.8k $868.6k $868.6k 0.01% Reduced -199.8k -199,804
73 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 75,14975.1k $839.4k $839.4k 0.00% Added +16.4k +16,370
74 Legal & General Group Plc 0.00% of their portfolio London, X0 73,56973.6k $821.8k $821.8k 0.00% Added +22.9k +22,943
75 PROFUND ADVISORS LLC 0.04% of their portfolio BETHESDA, MD 73,14173.1k $817.0k $817.0k 0.04% Added +9.1k +9,116
76 HRT FINANCIAL LP 0.01% of their portfolio NEW YORK, NY 65,19265.2k $728.0k $728.0k 0.01% New
77 Jefferies Financial Group Inc. 0.01% of their portfolio NEW YORK, NY 64,11664.1k $716.2k $716.2k 0.01% Added +26.1k +26,066
78 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 59,10059.1k $660.1k $660.1k 0.00% Added +6.4k +6,411
79 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 56,83556.8k $634.8k $634.8k 0.00% Added +6.9k +6,874
80 ALPS ADVISORS INC 0.00% of their portfolio Denver, CO 52,45652.5k $585.9k $585.9k 0.00% Reduced -3.2k -3,215
81 ALGERT GLOBAL LLC 0.02% of their portfolio SAN FRANCISCO, CA 46,82446.8k $523.0k $523.0k 0.02% Unchanged
82 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 45,64445.6k $509.8k $509.8k 0.00% Added +3.3k +3,278
83 Pennant Investors, LP 0.15% of their portfolio Summit, NJ 44,50044.5k $497.1k $497.1k 0.15% New
84 Parkwood LLC 0.08% of their portfolio CLEVELAND, OH 44,20644.2k $494.0k $494.0k 0.08% Added +16.3k +16,341
85 Skandinaviska Enskilda Banken AB (publ) 0.00% of their portfolio STOCKHOLM, V7 39,40039.4k $440.1k $440.1k 0.00% Reduced -12.0k -12,000
86 Dynamic Technology Lab Private Ltd 0.05% of their portfolio SINGAPORE, U0 38,54538.5k $431.0k $431.0k 0.05% Added +19.7k +19,730
87 Corton Capital Inc. 0.13% of their portfolio Carrying Place, A6 35,47935.5k $396.3k $396.3k 0.13% New
88 BOURGEON CAPITAL MANAGEMENT LLC 0.09% of their portfolio Darien, CT 35,30035.3k $394.3k $394.3k 0.09% Reduced -20.2k -20,200
89 ExodusPoint Capital Management, LP 0.00% of their portfolio NEW YORK, NY 35,21835.2k $393.0k $393.0k 0.00% New
90 Entropy Technologies, LP 0.07% of their portfolio NEW YORK, NY 33,50733.5k $374.3k $374.3k 0.07% First filing
91 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 33,39133.4k $373.0k $373.0k 0.00% Reduced -17.5k -17,530
92 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 32,61932.6k $364.4k $364.4k 0.00% Unchanged
93 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 31,82831.8k $355.5k $355.5k 0.00% Added +978 +978
94 Walleye Capital LLC 0.00% of their portfolio NEW YORK, NY 30,19330.2k $337.3k $337.3k 0.00% Reduced -55.1k -55,056
95 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 28,89628.9k $322.8k $322.8k 0.00% New
96 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 28,31928.3k $316.0k $316.0k 0.00% New
97 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 26,04126.0k $290.9k $290.9k 0.00% Added +1.2k +1,190
98 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 25,34325.3k $283.1k $283.1k 0.00% Added +478 +478
99 E Fund Management Co., Ltd. 0.02% of their portfolio GUANGZHOU, F4 24,36324.4k $272.1k $272.1k 0.02% Added +4.7k +4,742
100 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 24,22124.2k $271.0k $271.0k 0.00% Reduced -358.0k -358,024