Vault-13

89BIO INC ETNB

COM · Common Stock · CUSIP 282559103

162 institutional holders +3 vs Q2 2023
72,408,71472.4m shares reported held*
$1.1bnreported value*
27 new 62 added 55 reduced 22 sold out net sold ≈ $87.7m (-5.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $15.44. Options: 22 managers hold calls ($40.3m notional), 13 hold puts ($13.8m).

Trends to Q3 2023

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 86Q4 22: 106Q1 23: 149Q2 23: 159Q3 23: 162162Q3 22Q4 22Q1 23Q2 23Q3 23
Numbers
QuarterHolders
Q3 202286
Q4 2022106
Q1 2023149
Q2 2023159
Q3 2023162

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 70 bought or addedQ4 22: 38 cut or sold outQ4 22Q1 23: 112 bought or addedQ1 23: 47 cut or sold outQ1 23Q2 23: 103 bought or addedQ2 23: 72 cut or sold outQ2 23Q3 23: 89 bought or addedQ3 23: 77 cut or sold outQ3 23
Numbers
QuarterBought or addedCut or sold out
Q4 20227038
Q1 202311247
Q2 202310372
Q3 20238977

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ4 22 calls: $5.8mQ4 22 puts: $852.4kQ4 22P/C 0.15Q1 23 calls: $55.5mQ1 23 puts: $25.0mQ1 23P/C 0.45Q2 23 calls: $6.7mQ2 23 puts: $19.0mQ2 23P/C 2.83Q3 23 calls: $40.3mQ3 23 puts: $13.8mQ3 23P/C 0.34
Numbers
QuarterCallsPutsP/C
Q4 2022$5.8m$852.4k0.15
Q1 2023$55.5m$25.0m0.45
Q2 2023$6.7m$19.0m2.83
Q3 2023$40.3m$13.8m0.34

Biggest buyers

BRAIDWELL LP New +1,590,387+1.6m
Laurion Capital Management LP Added +478,632+478.6k
WESTFIELD CAPITAL MANAGEMENT CO LP Added +476,655+476.7k
BARCLAYS PLC Added +428,297+428.3k
CITADEL ADVISORS LLC Added +419,653+419.7k
PRICE T ROWE ASSOCIATES INC /MD/ Added +361,027+361.0k
CHARLES SCHWAB INVESTMENT MANAGEMENT INC Added +322,339+322.3k
Assenagon Asset Management S.A. New +317,751+317.8k
BlackRock Inc. Added +316,057+316.1k
Logos Global Management LP New +310,000+310.0k

Biggest sellers

Boxer Capital, LLC Sold out -2,100,000-2.1m
Cormorant Asset Management, LP Sold out -1,350,000-1.4m
MORGAN STANLEY Reduced -1,047,262-1.0m
MARSHALL WACE, LLP Reduced -915,286-915.3k
LORD, ABBETT & CO. LLC Reduced -798,752-798.8k
DEUTSCHE BANK AG\ Reduced -771,532-771.5k
Invesco Ltd. Reduced -654,653-654.7k
EVENTIDE ASSET MANAGEMENT, LLC Sold out -642,073-642.1k
Avidity Partners Management LP Sold out -526,376-526.4k
JANE STREET GROUP, LLC Reduced -424,187-424.2k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $5.8m377.4k shares
Ikarian Capital, LLC New $5.4m3.5k shares
Paradigm Biocapital Advisors LP New $5.1m329.1k shares
Holocene Advisors, LP New $4.6m300.0k shares
Integral Health Asset Management, LLC New $3.1m200.0k shares
Alyeska Investment Group, L.P. Unchanged $2.3m150.0k shares
Caption Management, LLC New $1.9m120.0k shares
PERCEPTIVE ADVISORS LLC New $1.6m400.0k shares
ACUTA CAPITAL PARTNERS, LLC New $1.5m1.0k shares
LMR Partners LLP New $1.5m95.5k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $7.0m450.4k shares
Hudson Bay Capital Management LP New $2.0m131.0k shares
GROUP ONE TRADING LLC Reduced $1.4m89.3k shares
CITADEL ADVISORS LLC Reduced $982.0k63.6k shares
SIMPLEX TRADING, LLC Reduced $795.0k51.5k shares
J. Goldman & Co LP New $640.8k41.5k shares
LMR Partners LLP New $508.0k32.9k shares
JANE STREET GROUP, LLC Reduced $284.1k18.4k shares
WOLVERINE TRADING, LLC New $163.7k10.6k shares
Belvedere Trading LLC New $71.0k4.6k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
VANGUARD GROUP INC 13G · institution new · filed 2025-07-29 5.6% new 8.2m 2025-07-29
SUVRETTA CAPITAL MANAGEMENT, LLC 13G · institution -4.3 pts · filed 2025-11-13 5.6% -4.3 pts 8.3m 2025-11-13

Fell to 5% or below in the last year: Deep Track Capital, LP (0.0%, 2026-02-13), Pentwater Capital Management LP (0.0%, 2025-11-14)

Holders, Q3 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 3.47% of their portfolio BOSTON, MA 11,416,94811.4m $176.3m $176.3m 3.47% Unchanged
2 BlackRock Inc. 0.00% of their portfolio New York, NY 4,966,2405.0m $76.7m $76.7m 0.00% Added +316.1k +316,057
3 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 4,306,6404.3m $66.5m $66.5m 0.00% Reduced -336.6k -336,551
4 JANUS HENDERSON GROUP PLC 0.04% of their portfolio LONDON, X0 4,029,2034.0m $62.2m $62.2m 0.04% Reduced -90.7k -90,715
5 Pictet Asset Management Holding SA 0.07% of their portfolio CAROUGE, V8 3,887,9543.9m $60.0m $60.0m 0.07% First filing
6 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 3,525,7823.5m $54.4m $54.4m 0.00% Added +155.8k +155,841
7 MONTANOVA CAPITAL, LLC 2.25% of their portfolio New York, NY 2,694,4042.7m $41.6m $41.6m 2.25% Added +301.2k +301,168
8 Holocene Advisors, LP 0.15% of their portfolio New York, NY 2,235,8052.2m $34.5m $34.5m 0.15% Reduced -402.7k -402,694
9 FEDERATED HERMES, INC. 0.09% of their portfolio PITTSBURGH, PA 2,129,6012.1m $32.9m $32.9m 0.09% Reduced -4.3k -4,304
10 BVF INC/IL 0.77% of their portfolio San Francisco, CA 1,846,1541.8m $28.5m $28.5m 0.77% Unchanged
11 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.06% of their portfolio Boston, MA 1,698,4171.7m $26.2m $26.2m 0.06% Added +272.3k +272,255
12 BRAIDWELL LP 0.78% of their portfolio STAMFORD, CT 1,590,3871.6m $24.6m $24.6m 0.78% New
13 CITADEL ADVISORS LLC 0.03% of their portfolio MIAMI, FL 1,504,0091.5m $23.2m $23.2m 0.03% Added +419.7k +419,653
14 WESTFIELD CAPITAL MANAGEMENT CO LP 0.14% of their portfolio BOSTON, MA 1,311,8861.3m $20.3m $20.3m 0.14% Added +476.7k +476,655
15 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,293,9881.3m $20.0m $20.0m 0.00% Added +117.0k +116,999
16 Octagon Capital Advisors LP 3.31% of their portfolio NEW YORK, NY 1,219,1571.2m $18.8m $18.8m 3.31% Added +152.4k +152,373
17 Laurion Capital Management LP 0.49% of their portfolio NEW YORK, NY 1,205,6381.2m $18.6m $18.6m 0.49% Added +478.6k +478,632
18 MARSHALL WACE, LLP 0.04% of their portfolio LONDON, X0 1,170,7561.2m $18.1m $18.1m 0.04% Reduced -915.3k -915,286
19 LORD, ABBETT & CO. LLC 0.03% of their portfolio JERSEY CITY, NJ 876,532876.5k $13.5m $13.5m 0.03% Reduced -798.8k -798,752
20 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 827,383827.4k $12.8m $12.8m 0.01% Added +85.0k +84,951
21 Redmile Group, LLC 0.56% of their portfolio LARKSPUR, CA 761,955762.0k $11.8m $11.8m 0.56% Unchanged
22 EAGLE ASSET MANAGEMENT INC 0.07% of their portfolio ST PETERSBURG, FL 712,898712.9k $11.0m $11.0m 0.07% Added +57.1k +57,092
23 ALKEON CAPITAL MANAGEMENT LLC 0.07% of their portfolio New York, NY 700,000700.0k $10.8m $10.8m 0.07% Unchanged
24 BARCLAYS PLC 0.01% of their portfolio LONDON, X0 624,365624.4k $9.6m $9.6m 0.01% Added +428.3k +428,297
25 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 599,754599.8k $9.3m $9.3m 0.00% Reduced -1.0m -1,047,262
26 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 580,662580.7k $9.0m $9.0m 0.00% Added +21.0k +21,030
27 VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio San Antonio, TX 555,773555.8k $8.6m $8.6m 0.01% Reduced -190.2k -190,248
28 Orchard Capital Management, LLC 3.10% of their portfolio CHICAGO, IL 542,879542.9k $8.4m $8.4m 3.10% Unchanged
29 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 518,674518.7k $8.0m $8.0m 0.00% Reduced -96.5k -96,493
30 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 489,004489.0k $7.6m $7.6m 0.00% Added +322.3k +322,339
31 Artia Global Partners LP 2.99% of their portfolio MIAMI, FL 465,465465.5k $7.2m $7.2m 2.99% Unchanged
32 Alyeska Investment Group, L.P. 0.05% of their portfolio CHICAGO, IL 459,887459.9k $7.1m $7.1m 0.05% Added +125.0k +125,000
33 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 435,401435.4k $6.7m $6.7m 0.00% Reduced -97.4k -97,373
34 Driehaus Capital Management LLC 0.09% of their portfolio Chicago, IL 432,174432.2k $6.7m $6.7m 0.09% Reduced -937 -937
35 TWO SIGMA ADVISERS, LP 0.02% of their portfolio NEW YORK, NY 412,700412.7k $6.4m $6.4m 0.02% Reduced -389.7k -389,700
36 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 397,802397.8k $6.1m $6.1m 0.00% Added +21.8k +21,795
37 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 382,245382.2k $5.9m $5.9m 0.00% Added +361.0k +361,027
38 Rafferty Asset Management, LLC 0.03% of their portfolio New York, NY 381,945381.9k $5.9m $5.9m 0.03% Reduced -19.9k -19,906
39 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 381,067381.1k $5.9m $5.9m 0.01% Added +133.3k +133,271
40 Parkman Healthcare Partners LLC 1.03% of their portfolio STAMFORD, CT 363,553363.6k $5.6m $5.6m 1.03% Added +14.7k +14,678
41 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 346,946346.9k $5.4m $5.4m 0.00% Reduced -36.1k -36,145
42 Soleus Capital Management, L.P. 0.54% of their portfolio GREENWICH, CT 346,033346.0k $5.3m $5.3m 0.54% Added +119.5k +119,533
43 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 343,674343.7k $5.3m $5.3m 0.00% Added +123.0k +122,955
44 SPHERA FUNDS MANAGEMENT LTD. 1.18% of their portfolio TEL AVIV, L3 319,301319.3k $4.9m $4.9m 1.18% Added +184.3k +184,301
45 Assenagon Asset Management S.A. 0.02% of their portfolio SENNINGERBERG, N4 317,751317.8k $4.9m $4.9m 0.02% New
46 Logos Global Management LP 0.68% of their portfolio San Francisco, CA 310,000310.0k $4.8m $4.8m 0.68% New
47 Schonfeld Strategic Advisors LLC 0.04% of their portfolio NEW YORK, NY 277,562277.6k $4.3m $4.3m 0.04% Added +42.0k +41,958
48 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 251,305251.3k $3.9m $3.9m 0.00% Added +36.1k +36,051
49 Tri Locum Partners LP 1.24% of their portfolio NEW YORK, NY 249,571249.6k $3.9m $3.9m 1.24% Added +83.7k +83,674
50 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 225,499225.5k $3.5m $3.5m 0.00% Added +23.3k +23,341
51 Candriam S.C.A. 0.02% of their portfolio STRASSEN, N4 220,000220.0k $3.4m $3.4m 0.02% Unchanged
52 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 217,905217.9k $3.4m $3.4m 0.00% Reduced -10.1k -10,114
53 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 211,777211.8k $3.3m $3.3m 0.01% Reduced -420.9k -420,908
54 Newtyn Management, LLC 0.76% of their portfolio NEW YORK, NY 200,500200.5k $3.1m $3.1m 0.76% Added +500 +500
55 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio JUPITER, FL 175,624175.6k $2.7m $2.7m 0.01% Reduced -128.1k -128,064
56 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 173,950173.9k $2.7m $2.7m 0.00% Reduced -424.2k -424,187
57 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 161,856161.9k $2.5m $2.5m 0.00% Added +27.3k +27,294
58 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 161,171161.2k $2.5m $2.5m 0.00% Added +6.6k +6,617
59 PICTON MAHONEY ASSET MANAGEMENT 0.10% of their portfolio Toronto, A6 144,882144.9k $2.2m $2.2m 0.10% Reduced -21.4k -21,414
60 TWINBEECH CAPITAL LP 0.04% of their portfolio PURCHASE, NY 136,116136.1k $2.1m $2.1m 0.04% New
61 Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio ST. PETERSBURG, FL 132,105132.1k $2.0m $2.0m 0.00% Reduced -23.4k -23,423
62 University of Wisconsin Foundation 2.24% of their portfolio MADISON, WI 126,516126.5k $2.0m $2.0m 2.24% New
63 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 125,972126.0k $1.9m $1.9m 0.01% Reduced -4.8k -4,808
64 Caption Management, LLC 0.23% of their portfolio OKLAHOMA CITY, OK 116,000116.0k $1.8m $1.8m 0.23% New
65 Swiss National Bank 0.00% of their portfolio ZURICH, V8 112,100112.1k $1.7m $1.7m 0.00% Added +1.1k +1,100
66 Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio VANCOUVER, A1 108,441108.4k $1.7m $1.7m 0.01% Reduced -103.6k -103,617
67 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 105,853105.9k $1.6m $1.6m 0.00% Reduced -214.3k -214,297
68 RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio ST PETERSBURG, FL 102,988103.0k $1.6m $1.6m 0.00% Added +3.5k +3,464
69 SIMPLEX TRADING, LLC 0.06% of their portfolio CHICAGO, IL 102,675102.7k $1.6m $1.6m 0.06% Added +68.8k +68,817
70 UBS Group AG 0.00% of their portfolio ZURICH, V8 100,982101.0k $1.6m $1.6m 0.00% Reduced -22.8k -22,836
71 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.03% of their portfolio CHICAGO, IL 98,83898.8k $1.5m $1.5m 0.03% Added +15.0k +15,000
72 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 94,56494.6k $1.5m $1.5m 0.00% Reduced -654.7k -654,653
73 Deep Track Capital, LP 0.05% of their portfolio GREENWICH, CT 91,07891.1k $1.4m $1.4m 0.05% Reduced -412.0k -412,022
74 GROUP ONE TRADING LLC 0.05% of their portfolio CHICAGO, IL 88,04588.0k $1.4m $1.4m 0.05% Added +79.2k +79,185
75 Walleye Capital LLC 0.02% of their portfolio NEW YORK, NY 85,24985.2k $1.3m $1.3m 0.02% Added +35.4k +35,366
76 Endurant Capital Management LP 1.14% of their portfolio San Mateo, CA 82,15382.2k $1.3m $1.3m 1.14% Added +52.9k +52,871
77 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 81,47381.5k $1.3m $1.3m 0.00% Added +3.3k +3,257
78 GILDER GAGNON HOWE & CO LLC 0.02% of their portfolio New York, NY 81,20781.2k $1.3m $1.3m 0.02% Added +244 +244
79 1492 Capital Management LLC 0.78% of their portfolio MILWAUKEE, WI 78,40478.4k $1.2m $1.2m 0.78% Unchanged
80 Weiss Multi-Strategy Advisers LLC 0.02% of their portfolio NEW YORK, NY 66,33166.3k $1.0m $1.0m 0.02% Reduced -28.4k -28,368
81 PROFUND ADVISORS LLC 0.05% of their portfolio BETHESDA, MD 64,02564.0k $988.5k $988.5k 0.05% Reduced -8.5k -8,548
82 SILVERARC CAPITAL MANAGEMENT, LLC 0.35% of their portfolio BOSTON, MA 60,24760.2k $930.2k $930.2k 0.35% Reduced -336.2k -336,250
83 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 58,77958.8k $907.5k $907.5k 0.00% Reduced -6.7k -6,667
84 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 55,67155.7k $859.6k $859.6k 0.01% Added +2.1k +2,109
85 BOURGEON CAPITAL MANAGEMENT LLC 0.20% of their portfolio Darien, CT 55,50055.5k $856.9k $856.9k 0.20% Added +25.5k +25,500
86 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 55,48855.5k $856.7k $856.7k 0.00% Reduced -34.0k -34,046
87 Erste Asset Management GmbH 0.01% of their portfolio VIENNA, C4 53,00053.0k $818.3k $818.3k 0.01% New
88 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 52,68952.7k $813.5k $813.5k 0.00% New
89 Skandinaviska Enskilda Banken AB (publ) 0.01% of their portfolio STOCKHOLM, V7 51,40051.4k $794.0k $794.0k 0.01% Added +24.8k +24,800
90 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 50,92150.9k $786.2k $786.2k 0.00% Added +27.2k +27,166
91 Legal & General Group Plc 0.00% of their portfolio London, X0 50,62650.6k $781.7k $781.7k 0.00% Reduced -475 -475
92 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 49,96150.0k $771.4k $771.4k 0.00% Reduced -19.1k -19,057
93 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 49,60049.6k $765.8k $765.8k 0.00% New
94 ALGERT GLOBAL LLC 0.03% of their portfolio SAN FRANCISCO, CA 46,82446.8k $723.0k $723.0k 0.03% Reduced -105.0k -105,005
95 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 42,36642.4k $654.1k $654.1k 0.00% Reduced -1.3k -1,333
96 DARK FOREST CAPITAL MANAGEMENT LP 0.05% of their portfolio NEW YORK, NY 39,47139.5k $609.4k $609.4k 0.05% New
97 Bellevue Group AG 0.01% of their portfolio ZURICH, V8 39,20039.2k $605.2k $605.2k 0.01% Reduced -26.0k -26,000
98 Jefferies Financial Group Inc. 0.01% of their portfolio NEW YORK, NY 38,05038.0k $587.5k $587.5k 0.01% New
99 HighVista Strategies LLC 0.24% of their portfolio BOSTON, MA 33,79233.8k $521.7k $521.7k 0.24% Reduced -9.8k -9,847
100 ACUTA CAPITAL PARTNERS, LLC 0.37% of their portfolio REDWOOD CITY, CA 32,80032.8k $506.4k $506.4k 0.37% New