Vault-13

89BIO INC ETNB

COM · Common Stock · CUSIP 282559103

159 institutional holders +10 vs Q1 2023
78,076,33678.1m shares reported held*
$1.5bnreported value*
44 new 59 added 36 reduced 36 sold out net bought ≈ $113.0m (+6.0m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($196.0k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $18.95. Options: 9 managers hold calls ($6.7m notional), 10 hold puts ($19.0m).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 86Q4 22: 106Q1 23: 149Q2 23: 159159Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 202286
Q4 2022106
Q1 2023149
Q2 2023159

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 70 bought or addedQ4 22: 38 cut or sold outQ4 22Q1 23: 112 bought or addedQ1 23: 47 cut or sold outQ1 23Q2 23: 103 bought or addedQ2 23: 72 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20227038
Q1 202311247
Q2 202310372

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ3 22 calls: $2.5mQ3 22 puts: $476.0kQ3 22P/C 0.19Q4 22 calls: $5.8mQ4 22 puts: $852.4kQ4 22P/C 0.15Q1 23 calls: $55.5mQ1 23 puts: $25.0mQ1 23P/C 0.45Q2 23 calls: $6.7mQ2 23 puts: $19.0mQ2 23P/C 2.83
Numbers
QuarterCallsPutsP/C
Q3 2022$2.5m$476.0k0.19
Q4 2022$5.8m$852.4k0.15
Q1 2023$55.5m$25.0m0.45
Q2 2023$6.7m$19.0m2.83

Biggest buyers

BlackRock Inc. Added +3,400,611+3.4m
PICTET ASSET MANAGEMENT SA Added +2,598,575+2.6m
STATE STREET CORP Added +1,572,817+1.6m
MARSHALL WACE, LLP Added +956,571+956.6k
DEUTSCHE BANK AG\ Added +795,659+795.7k
VANGUARD GROUP INC Added +763,656+763.7k
Invesco Ltd. Added +699,301+699.3k
VICTORY CAPITAL MANAGEMENT INC Added +689,061+689.1k
GEODE CAPITAL MANAGEMENT, LLC Added +673,044+673.0k
Octagon Capital Advisors LP Added +666,784+666.8k

Biggest sellers

ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -1,748,838-1.7m
Cormorant Asset Management, LP Reduced -1,450,000-1.4m
Avidity Partners Management LP Reduced -1,316,600-1.3m
Deep Track Capital, LP Reduced -1,296,900-1.3m
MILLENNIUM MANAGEMENT LLC Reduced -1,223,497-1.2m
Point72 Asset Management, L.P. Sold out -1,021,647-1.0m
CITADEL ADVISORS LLC Reduced -819,999-820.0k
Artal Group S.A. Sold out -500,000-500.0k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced -396,305-396.3k
Hudson Bay Capital Management LP Sold out -343,670-343.7k

Biggest calls

Alyeska Investment Group, L.P. Unchanged $2.8m150.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $1.2m63.0k shares
GROUP ONE TRADING LLC Added $805.4k42.5k shares
JANE STREET GROUP, LLC Reduced $765.6k40.4k shares
SIMPLEX TRADING, LLC Added $505.0k26.7k shares
CITADEL ADVISORS LLC Reduced $354.4k18.7k shares
D. E. Shaw & Co., Inc. New $199.0k10.5k shares
Walleye Trading LLC New $56.9k3.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $9.4m498.4k shares
GROUP ONE TRADING LLC Added $2.3m123.0k shares
JANE STREET GROUP, LLC Reduced $2.3m119.4k shares
SIMPLEX TRADING, LLC Reduced $2.1m109.7k shares
JPMORGAN CHASE & CO Added $1.3m69.1k shares
CITADEL ADVISORS LLC Reduced $1.3m66.2k shares
D. E. Shaw & Co., Inc. New $233.1k12.3k shares
Walleye Capital LLC New $55.0k2.9k shares
Walleye Trading LLC New $37.9k2.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
VANGUARD GROUP INC 13G · institution new · filed 2025-07-29 5.6% new 8.2m 2025-07-29
SUVRETTA CAPITAL MANAGEMENT, LLC 13G · institution -4.3 pts · filed 2025-11-13 5.6% -4.3 pts 8.3m 2025-11-13

Fell to 5% or below in the last year: Deep Track Capital, LP (0.0%, 2026-02-13), Pentwater Capital Management LP (0.0%, 2025-11-14)

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 4.08% of their portfolio BOSTON, MA 11,416,94811.4m $216.4m $216.4m 4.08% Unchanged
2 BlackRock Inc. 0.00% of their portfolio New York, NY 4,650,1834.7m $88.1m $88.1m 0.00% Added +3.4m +3,400,611
3 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 4,643,1914.6m $88.0m $88.0m 0.00% Added +1.6m +1,572,817
4 JANUS HENDERSON GROUP PLC 0.05% of their portfolio LONDON, X0 4,119,9184.1m $78.0m $78.0m 0.05% Added +373.9k +373,880
5 PICTET ASSET MANAGEMENT SA 0.08% of their portfolio GENEVA 73, V8 3,575,1263.6m $67.7m $67.7m 0.08% Added +2.6m +2,598,575
6 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 3,369,9413.4m $63.9m $63.9m 0.00% Added +763.7k +763,656
7 Holocene Advisors, LP 0.22% of their portfolio New York, NY 2,638,4992.6m $50.0m $50.0m 0.22% Added +543.5k +543,456
8 MONTANOVA CAPITAL, LLC 2.42% of their portfolio New York, NY 2,393,2362.4m $45.4m $45.4m 2.42% Added +182.7k +182,700
9 FEDERATED HERMES, INC. 0.10% of their portfolio PITTSBURGH, PA 2,133,9052.1m $40.4m $40.4m 0.10% Reduced -219.2k -219,210
10 Boxer Capital, LLC 1.85% of their portfolio San Diego, CA 2,100,0002.1m $39.8m $39.8m 1.85% Unchanged
11 MARSHALL WACE, LLP 0.09% of their portfolio LONDON, X0 2,086,0422.1m $39.5m $39.5m 0.09% Added +956.6k +956,571
12 BVF INC/IL 0.98% of their portfolio San Francisco, CA 1,846,1541.8m $35.0m $35.0m 0.98% Unchanged
13 LORD, ABBETT & CO. LLC 0.05% of their portfolio JERSEY CITY, NJ 1,675,2841.7m $31.7m $31.7m 0.05% Added +174.1k +174,060
14 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,647,0161.6m $31.2m $31.2m 0.00% Added +34.2k +34,177
15 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.06% of their portfolio Boston, MA 1,426,1621.4m $27.0m $27.0m 0.06% Reduced -1.7m -1,748,838
16 Cormorant Asset Management, LP 1.46% of their portfolio BOSTON, MA 1,350,0001.4m $25.6m $25.6m 1.46% Reduced -1.4m -1,450,000
17 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,176,9891.2m $22.3m $22.3m 0.00% Added +673.0k +673,044
18 CITADEL ADVISORS LLC 0.02% of their portfolio MIAMI, FL 1,084,3561.1m $20.5m $20.5m 0.02% Reduced -820.0k -819,999
19 Octagon Capital Advisors LP 2.82% of their portfolio NEW YORK, NY 1,066,7841.1m $20.2m $20.2m 2.82% Added +666.8k +666,784
20 WESTFIELD CAPITAL MANAGEMENT CO LP 0.10% of their portfolio BOSTON, MA 835,231835.2k $15.8m $15.8m 0.10% Added +80.0k +80,021
21 DEUTSCHE BANK AG\ 0.01% of their portfolio FRANKFURT AM MAIN, 2M 804,096804.1k $15.2m $15.2m 0.01% Added +795.7k +795,659
22 TWO SIGMA ADVISERS, LP 0.04% of their portfolio NEW YORK, NY 802,400802.4k $15.2m $15.2m 0.04% Reduced -98.7k -98,700
23 Redmile Group, LLC 0.55% of their portfolio LARKSPUR, CA 761,955762.0k $14.4m $14.4m 0.55% Reduced -138.0k -138,045
24 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 749,217749.2k $14.2m $14.2m 0.00% Added +699.3k +699,301
25 VICTORY CAPITAL MANAGEMENT INC 0.02% of their portfolio San Antonio, TX 746,021746.0k $14.1m $14.1m 0.02% Added +689.1k +689,061
26 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 742,432742.4k $14.1m $14.1m 0.01% Added +31.6k +31,600
27 Laurion Capital Management LP 0.59% of their portfolio NEW YORK, NY 727,006727.0k $13.8m $13.8m 0.59% Added +290.1k +290,121
28 ALKEON CAPITAL MANAGEMENT LLC 0.08% of their portfolio New York, NY 700,000700.0k $13.3m $13.3m 0.08% Added +200.0k +200,000
29 EAGLE ASSET MANAGEMENT INC 0.07% of their portfolio ST PETERSBURG, FL 655,806655.8k $12.4m $12.4m 0.07% New
30 EVENTIDE ASSET MANAGEMENT, LLC 0.21% of their portfolio Boston, MA 642,073642.1k $12.2m $12.2m 0.21% Unchanged
31 TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio NEW YORK, NY 632,685632.7k $12.0m $12.0m 0.03% Reduced -235.3k -235,276
32 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 615,167615.2k $11.7m $11.7m 0.00% Added +147.0k +146,976
33 JANE STREET GROUP, LLC 0.02% of their portfolio NEW YORK, NY 598,137598.1k $11.3m $11.3m 0.02% Added +379.8k +379,761
34 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 559,632559.6k $10.6m $10.6m 0.00% Added +458.0k +458,040
35 Orchard Capital Management, LLC 3.46% of their portfolio CHICAGO, IL 542,879542.9k $10.3m $10.3m 3.46% Reduced -9.0k -9,000
36 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 532,774532.8k $10.1m $10.1m 0.00% Reduced -11.8k -11,755
37 Avidity Partners Management LP 0.35% of their portfolio DALLAS, TX 526,376526.4k $10.0m $10.0m 0.35% Reduced -1.3m -1,316,600
38 Deep Track Capital, LP 0.45% of their portfolio GREENWICH, CT 503,100503.1k $9.5m $9.5m 0.45% Reduced -1.3m -1,296,900
39 Artia Global Partners LP 3.04% of their portfolio MIAMI, FL 465,465465.5k $8.8m $8.8m 3.04% New
40 Driehaus Capital Management LLC 0.10% of their portfolio Chicago, IL 433,111433.1k $8.2m $8.2m 0.10% Added +131.5k +131,530
41 D. E. Shaw & Co., Inc. 0.01% of their portfolio New York, NY 409,246409.2k $7.8m $7.8m 0.01% Added +252.7k +252,743
42 Rafferty Asset Management, LLC 0.04% of their portfolio New York, NY 401,851401.9k $7.6m $7.6m 0.04% Added +82.4k +82,353
43 SILVERARC CAPITAL MANAGEMENT, LLC 2.54% of their portfolio BOSTON, MA 396,497396.5k $7.5m $7.5m 2.54% Reduced -41.7k -41,718
44 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 383,091383.1k $7.3m $7.3m 0.00% Added +131.1k +131,107
45 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 376,007376.0k $7.1m $7.1m 0.00% New
46 Parkman Healthcare Partners LLC 1.15% of their portfolio STAMFORD, CT 348,875348.9k $6.6m $6.6m 1.15% Added +101.9k +101,919
47 Alyeska Investment Group, L.P. 0.05% of their portfolio CHICAGO, IL 334,887334.9k $6.3m $6.3m 0.05% Added +1.4k +1,402
48 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 320,150320.1k $6.1m $6.1m 0.01% Reduced -1.2m -1,223,497
49 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio JUPITER, FL 303,688303.7k $5.8m $5.8m 0.03% Reduced -271.1k -271,092
50 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 247,796247.8k $4.7m $4.7m 0.01% Reduced -396.3k -396,305
51 Schonfeld Strategic Advisors LLC 0.04% of their portfolio NEW YORK, NY 235,604235.6k $4.5m $4.5m 0.04% Reduced -117.6k -117,642
52 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 228,019228.0k $4.3m $4.3m 0.00% Added +182.7k +182,742
53 Soleus Capital Management, L.P. 0.48% of their portfolio GREENWICH, CT 226,500226.5k $4.3m $4.3m 0.48% Reduced -267.5k -267,500
54 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 220,719220.7k $4.2m $4.2m 0.00% New
55 Candriam S.C.A. 0.03% of their portfolio STRASSEN, N4 220,000220.0k $4.2m $4.2m 0.03% Added +60.0k +60,000
56 Informed Momentum Co LLC 0.76% of their portfolio SOLANA BEACH, CA 216,438216.4k $4.1m $4.1m 0.76% Reduced -70.0k -69,982
57 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 215,254215.3k $4.1m $4.1m 0.00% Reduced -318.9k -318,851
58 Connor, Clark & Lunn Investment Management Ltd. 0.02% of their portfolio VANCOUVER, A1 212,058212.1k $4.0m $4.0m 0.02% Added +122.7k +122,719
59 NORGES BANK 0.00% of their portfolio OSLO, Q8 202,500202.5k $3.8m $3.8m 0.00% Not comparable
60 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 202,158202.2k $3.8m $3.8m 0.00% Added +2.3k +2,322
61 Newtyn Management, LLC 0.90% of their portfolio NEW YORK, NY 200,000200.0k $3.8m $3.8m 0.90% Unchanged
62 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 196,068196.1k $3.7m $3.7m 0.00% Added +43.2k +43,192
63 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 166,665166.7k $3.2m $3.2m 0.00% Added +145.6k +145,639
64 PICTON MAHONEY ASSET MANAGEMENT 0.15% of their portfolio Toronto, A6 166,296166.3k $3.2m $3.2m 0.15% Reduced -31.1k -31,145
65 Tri Locum Partners LP 1.17% of their portfolio NEW YORK, NY 165,897165.9k $3.1m $3.1m 1.17% Added +8.7k +8,672
66 Raymond James Financial Services Advisors, Inc. 0.01% of their portfolio ST. PETERSBURG, FL 155,528155.5k $2.9m $2.9m 0.01% Added +46.6k +46,562
67 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 154,554154.6k $2.9m $2.9m 0.00% Added +101.1k +101,130
68 ALGERT GLOBAL LLC 0.13% of their portfolio SAN FRANCISCO, CA 151,829151.8k $2.9m $2.9m 0.13% Added +114.9k +114,864
69 BANK OF MONTREAL /CAN/ 0.00% of their portfolio TORONTO, A6 149,701149.7k $3.0m $3.0m 0.00% New
70 SPHERA FUNDS MANAGEMENT LTD. 0.55% of their portfolio TEL AVIV, L3 135,000135.0k $2.6m $2.6m 0.55% New
71 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 134,562134.6k $2.5m $2.5m 0.00% Reduced -249.0k -249,026
72 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 130,780130.8k $2.5m $2.5m 0.01% Added +51.3k +51,332
73 UBS Group AG 0.00% of their portfolio ZURICH, V8 123,818123.8k $2.3m $2.3m 0.00% Reduced -17.3k -17,306
74 Swiss National Bank 0.00% of their portfolio ZURICH, V8 111,000111.0k $2.1m $2.1m 0.00% New
75 Tekla Capital Management LLC 0.08% of their portfolio Boston, MA 105,898105.9k $2.0m $2.0m 0.08% Unchanged
76 RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio ST PETERSBURG, FL 99,52499.5k $1.9m $1.9m 0.00% Added +29.4k +29,421
77 Velan Capital Investment Management LP 1.69% of their portfolio ALPHARETTA, GA 95,00095.0k $1.8m $1.8m 1.69% Reduced -3.5k -3,500
78 Weiss Multi-Strategy Advisers LLC 0.04% of their portfolio NEW YORK, NY 94,69994.7k $1.8m $1.8m 0.04% Added +80.0k +79,957
79 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 89,53489.5k $1.7m $1.7m 0.00% Unchanged
80 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.03% of their portfolio CHICAGO, IL 83,83883.8k $1.6m $1.6m 0.03% Added +27.9k +27,899
81 GILDER GAGNON HOWE & CO LLC 0.02% of their portfolio New York, NY 80,96381.0k $1.5m $1.5m 0.02% Added +5.0k +4,960
82 1492 Capital Management LLC 0.87% of their portfolio MILWAUKEE, WI 78,40478.4k $1.5m $1.5m 0.87% Reduced -36 -36
83 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 78,21678.2k $1.5m $1.5m 0.00% New
84 PROFUND ADVISORS LLC 0.07% of their portfolio BETHESDA, MD 72,57372.6k $1.4m $1.4m 0.07% Added +14.5k +14,497
85 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 71,75471.8k $1.4m $1.4m 0.01% Added +3.2k +3,223
86 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 69,01869.0k $1.3m $1.3m 0.00% New
87 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 65,44665.4k $1.2m $1.2m 0.00% New
88 Bellevue Group AG 0.02% of their portfolio ZURICH, V8 65,20065.2k $1.2m $1.2m 0.02% Reduced -1.8k -1,800
89 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 53,56253.6k $1.0m $1.0m 0.01% Added +20.2k +20,250
90 Legal & General Group Plc 0.00% of their portfolio London, X0 51,10151.1k $968.4k $968.4k 0.00% New
91 Walleye Capital LLC 0.02% of their portfolio NEW YORK, NY 49,88349.9k $945.3k $945.3k 0.02% New
92 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 43,69943.7k $811.2k $811.2k 0.00% Added +30.3k +30,348
93 HighVista Strategies LLC 0.38% of their portfolio BOSTON, MA 43,63943.6k $827.0k $827.0k 0.38% New
94 Pekin Hardy Strauss, Inc. 0.11% of their portfolio CHICAGO, IL 36,08536.1k $683.8k $683.8k 0.11% Reduced -150.6k -150,559
95 SIMPLEX TRADING, LLC 0.03% of their portfolio CHICAGO, IL 33,85833.9k $641.0k $641.0k 0.03% Reduced -123.8k -123,842
96 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 32,61932.6k $618.1k $618.1k 0.00% New
97 Graham Capital Management, L.P. 0.02% of their portfolio ROWAYTON, CT 30,02430.0k $569.0k $569.0k 0.02% New
98 BOURGEON CAPITAL MANAGEMENT LLC 0.13% of their portfolio Darien, CT 30,00030.0k $568.5k $568.5k 0.13% Added +11.7k +11,650
99 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 29,75429.8k $563.8k $563.8k 0.00% New
100 Endurant Capital Management LP 0.72% of their portfolio San Mateo, CA 29,28229.3k $554.9k $554.9k 0.72% Added +9.7k +9,697