Vault-13

89BIO INC ETNB

COM · Common Stock · CUSIP 282559103

149 institutional holders +43 vs Q4 2022
71,888,67271.9m shares reported held*
$1.1bnreported value*
63 new 49 added 28 reduced 19 sold out net bought ≈ $391.1m (+25.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($277.8k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $15.23. Options: 24 managers hold calls ($55.5m notional), 18 hold puts ($25.0m).

Trends to Q1 2023

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 86Q4 22: 106Q1 23: 149149Q3 22Q4 22Q1 23
Numbers
QuarterHolders
Q3 202286
Q4 2022106
Q1 2023149

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 70 bought or addedQ4 22: 38 cut or sold outQ4 22Q1 23: 112 bought or addedQ1 23: 47 cut or sold outQ1 23
Numbers
QuarterBought or addedCut or sold out
Q4 20227038
Q1 202311247

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ3 22 calls: $2.5mQ3 22 puts: $476.0kQ3 22P/C 0.19Q4 22 calls: $5.8mQ4 22 puts: $852.4kQ4 22P/C 0.15Q1 23 calls: $55.5mQ1 23 puts: $25.0mQ1 23P/C 0.45
Numbers
QuarterCallsPutsP/C
Q3 2022$2.5m$476.0k0.19
Q4 2022$5.8m$852.4k0.15
Q1 2023$55.5m$25.0m0.45

Biggest buyers

STATE STREET CORP Added +2,965,364+3.0m
JANUS HENDERSON GROUP PLC Added +2,726,659+2.7m
RA CAPITAL MANAGEMENT, L.P. Added +2,461,538+2.5m
FEDERATED HERMES, INC. New +2,353,115+2.4m
MONTANOVA CAPITAL, LLC New +2,210,536+2.2m
BVF INC/IL New +1,846,154+1.8m
Avidity Partners Management LP New +1,842,976+1.8m
MORGAN STANLEY Added +1,507,728+1.5m
LORD, ABBETT & CO. LLC New +1,501,224+1.5m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +1,187,408+1.2m

Biggest sellers

ORBIMED ADVISORS LLC Sold out -3,658,869-3.7m
Deep Track Capital, LP Reduced -2,050,000-2.0m
Commodore Capital LP Sold out -758,244-758.2k
Walleye Capital LLC Sold out -479,756-479.8k
Ikarian Capital, LLC Sold out -454,000-454.0k
MARSHALL WACE, LLP Reduced -357,840-357.8k
DAFNA Capital Management LLC Sold out -324,173-324.2k
Cubist Systematic Strategies, LLC Reduced -287,010-287.0k
BARCLAYS PLC Reduced -256,269-256.3k
RENAISSANCE TECHNOLOGIES LLC Reduced -201,267-201.3k

Biggest calls

Caption Management, LLC New $25.9m1.7m shares
Holocene Advisors, LP New $8.5m560.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $4.7m310.5k shares
SILVERARC CAPITAL MANAGEMENT, LLC New $3.0m200.0k shares
Rock Springs Capital Management LP New $2.5m164.5k shares
JANE STREET GROUP, LLC New $2.4m155.6k shares
Alyeska Investment Group, L.P. New $2.3m150.0k shares
Ghost Tree Capital, LLC New $1.5m100.0k shares
CITADEL ADVISORS LLC Added $1.2m81.6k shares
MILLENNIUM MANAGEMENT LLC New $848.0k55.7k shares

Biggest puts

Caption Management, LLC New $5.4m353.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $5.2m340.2k shares
JANE STREET GROUP, LLC New $3.5m232.6k shares
CITADEL ADVISORS LLC Added $2.9m193.2k shares
SIMPLEX TRADING, LLC Added $2.4m157.3k shares
North Fourth Asset Management, LP New $1.5m100.0k shares
MILLENNIUM MANAGEMENT LLC New $1.4m90.0k shares
GROUP ONE TRADING LLC New $577.2k37.9k shares
Pentwater Capital Management LP New $533.0k35.0k shares
Belvedere Trading LLC Added $440.1k28.9k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
VANGUARD GROUP INC 13G · institution new · filed 2025-07-29 5.6% new 8.2m 2025-07-29
SUVRETTA CAPITAL MANAGEMENT, LLC 13G · institution -4.3 pts · filed 2025-11-13 5.6% -4.3 pts 8.3m 2025-11-13

Fell to 5% or below in the last year: Deep Track Capital, LP (0.0%, 2026-02-13)

Holders, Q1 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 3.94% of their portfolio BOSTON, MA 11,416,94811.4m $173.9m $173.9m 3.94% Added +2.5m +2,461,538
2 JANUS HENDERSON GROUP PLC 0.04% of their portfolio LONDON, X0 3,746,0383.7m $57.1m $57.1m 0.04% Added +2.7m +2,726,659
3 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.11% of their portfolio Boston, MA 3,175,0003.2m $48.4m $48.4m 0.11% Added +1.2m +1,187,408
4 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 3,070,3743.1m $46.8m $46.8m 0.00% Added +3.0m +2,965,364
5 Cormorant Asset Management, LP 2.81% of their portfolio BOSTON, MA 2,800,0002.8m $42.6m $42.6m 2.81% Added +250.0k +250,000
6 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,606,2852.6m $39.7m $39.7m 0.00% Added +1.0m +1,027,990
7 FEDERATED HERMES, INC. 0.09% of their portfolio PITTSBURGH, PA 2,353,1152.4m $35.8m $35.8m 0.09% New
8 MONTANOVA CAPITAL, LLC 1.62% of their portfolio New York, NY 2,210,5362.2m $33.7m $33.7m 1.62% New
9 Boxer Capital, LLC 1.57% of their portfolio San Diego, CA 2,100,0002.1m $32.0m $32.0m 1.57% Added +700.0k +700,000
10 Holocene Advisors, LP 0.16% of their portfolio New York, NY 2,095,0432.1m $31.9m $31.9m 0.16% Added +194.5k +194,511
11 CITADEL ADVISORS LLC 0.03% of their portfolio MIAMI, FL 1,904,3551.9m $29.0m $29.0m 0.03% Added +954.0k +954,043
12 BVF INC/IL 1.03% of their portfolio San Francisco, CA 1,846,1541.8m $28.1m $28.1m 1.03% New
13 Avidity Partners Management LP 0.93% of their portfolio DALLAS, TX 1,842,9761.8m $28.1m $28.1m 0.93% New
14 Deep Track Capital, LP 1.17% of their portfolio GREENWICH, CT 1,800,0001.8m $27.4m $27.4m 1.17% Reduced -2.0m -2,050,000
15 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,612,8391.6m $24.6m $24.6m 0.00% Added +1.5m +1,507,728
16 MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio NEW YORK, NY 1,543,6471.5m $23.5m $23.5m 0.03% Reduced -12.6k -12,586
17 LORD, ABBETT & CO. LLC 0.04% of their portfolio JERSEY CITY, NJ 1,501,2241.5m $22.9m $22.9m 0.04% New
18 BlackRock Inc. 0.00% of their portfolio New York, NY 1,249,5721.2m $19.0m $19.0m 0.00% Added +180.0k +179,991
19 MARSHALL WACE, LLP 0.04% of their portfolio LONDON, X0 1,129,4711.1m $17.2m $17.2m 0.04% Reduced -357.8k -357,840
20 Point72 Asset Management, L.P. 0.06% of their portfolio STAMFORD, CT 1,021,6471.0m $15.6m $15.6m 0.06% Reduced -3.0k -2,967
21 PICTET ASSET MANAGEMENT SA 0.02% of their portfolio GENEVA 73, V8 976,551976.6k $14.9m $14.9m 0.02% New
22 TWO SIGMA ADVISERS, LP 0.04% of their portfolio NEW YORK, NY 901,100901.1k $13.7m $13.7m 0.04% Added +81.7k +81,700
23 Redmile Group, LLC 0.59% of their portfolio LARKSPUR, CA 900,000900.0k $13.7m $13.7m 0.59% New
24 TWO SIGMA INVESTMENTS, LP 0.04% of their portfolio NEW YORK, NY 867,961868.0k $13.2m $13.2m 0.04% Added +153.8k +153,796
25 WESTFIELD CAPITAL MANAGEMENT CO LP 0.08% of their portfolio BOSTON, MA 755,210755.2k $11.5m $11.5m 0.08% New
26 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 710,832710.8k $10.8m $10.8m 0.01% New
27 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio BALA CYNWYD, PA 644,101644.1k $9.8m $9.8m 0.02% Added +412.9k +412,851
28 EVENTIDE ASSET MANAGEMENT, LLC 0.18% of their portfolio Boston, MA 642,073642.1k $9.8m $9.8m 0.18% New
29 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.04% of their portfolio JUPITER, FL 574,780574.8k $8.8m $8.8m 0.04% Added +521.7k +521,740
30 Orchard Capital Management, LLC 2.81% of their portfolio CHICAGO, IL 551,879551.9k $8.4m $8.4m 2.81% Unchanged
31 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 544,529544.5k $8.3m $8.3m 0.00% Added +31.5k +31,465
32 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 534,105534.1k $8.1m $8.1m 0.00% Added +390.2k +390,176
33 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 503,945503.9k $7.7m $7.7m 0.00% Added +160.1k +160,089
34 Artal Group S.A. 0.45% of their portfolio LUXEMBOURG, N4 500,000500.0k $7.6m $7.6m 0.45% Added +100.0k +100,000
35 ALKEON CAPITAL MANAGEMENT LLC 0.05% of their portfolio New York, NY 500,000500.0k $7.6m $7.6m 0.05% New
36 Soleus Capital Management, L.P. 0.93% of their portfolio GREENWICH, CT 494,000494.0k $7.5m $7.5m 0.93% Added +115.0k +115,000
37 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 468,191468.2k $7.1m $7.1m 0.00% Reduced -191.7k -191,733
38 SILVERARC CAPITAL MANAGEMENT, LLC 3.00% of their portfolio BOSTON, MA 438,215438.2k $6.7m $6.7m 3.00% New
39 Laurion Capital Management LP 0.30% of their portfolio NEW YORK, NY 436,885436.9k $6.7m $6.7m 0.30% Added +249.8k +249,785
40 Octagon Capital Advisors LP 0.88% of their portfolio NEW YORK, NY 400,000400.0k $6.1m $6.1m 0.88% Added +20.0k +20,000
41 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 383,588383.6k $5.8m $5.8m 0.01% Reduced -155.1k -155,091
42 Schonfeld Strategic Advisors LLC 0.05% of their portfolio NEW YORK, NY 353,246353.2k $5.4m $5.4m 0.05% Reduced -126.8k -126,797
43 Hudson Bay Capital Management LP 0.03% of their portfolio STAMFORD, CT 343,670343.7k $5.2m $5.2m 0.03% New
44 Alyeska Investment Group, L.P. 0.04% of their portfolio CHICAGO, IL 333,485333.5k $5.1m $5.1m 0.04% New
45 Rafferty Asset Management, LLC 0.03% of their portfolio New York, NY 319,498319.5k $4.9m $4.9m 0.03% New
46 Driehaus Capital Management LLC 0.06% of their portfolio Chicago, IL 301,581301.6k $4.6m $4.6m 0.06% New
47 Informed Momentum Co LLC 0.86% of their portfolio SOLANA BEACH, CA 286,420286.4k $4.4m $4.4m 0.86% Added +10.5k +10,477
48 Caption Management, LLC 0.85% of their portfolio OKLAHOMA CITY, OK 260,638260.6k $4.0m $4.0m 0.85% New
49 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 251,984252.0k $3.8m $3.8m 0.00% New
50 GREAT POINT PARTNERS LLC 0.75% of their portfolio Greenwich, CT 250,000250.0k $3.8m $3.8m 0.75% New
51 Parkman Healthcare Partners LLC 0.82% of their portfolio STAMFORD, CT 246,956247.0k $3.8m $3.8m 0.82% Reduced -85.9k -85,924
52 ExodusPoint Capital Management, LP 0.04% of their portfolio NEW YORK, NY 227,089227.1k $3.5m $3.5m 0.04% New
53 JANE STREET GROUP, LLC 0.01% of their portfolio NEW YORK, NY 218,376218.4k $3.3m $3.3m 0.01% Added +117.1k +117,135
54 Newtyn Management, LLC 0.60% of their portfolio NEW YORK, NY 200,000200.0k $3.0m $3.0m 0.60% Reduced -110.0k -110,000
55 Ghost Tree Capital, LLC 1.15% of their portfolio NEW YORK, NY 200,000200.0k $3.0m $3.0m 1.15% New
56 Affinity Asset Advisors, LLC 1.17% of their portfolio NEW YORK, NY 200,000200.0k $3.0m $3.0m 1.17% New
57 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 199,836199.8k $3.0m $3.0m 0.00% Added +8.3k +8,292
58 PICTON MAHONEY ASSET MANAGEMENT 0.15% of their portfolio Toronto, A6 197,441197.4k $3.0m $3.0m 0.15% Added +85.8k +85,841
59 Pekin Hardy Strauss, Inc. 0.44% of their portfolio CHICAGO, IL 186,644186.6k $2.8m $2.8m 0.44% Reduced -8.3k -8,294
60 Candriam S.C.A. 0.02% of their portfolio STRASSEN, N4 160,000160.0k $2.2m $2.2m 0.02% New
61 SIMPLEX TRADING, LLC 0.11% of their portfolio CHICAGO, IL 157,700157.7k $2.4m $2.4m 0.11% Added +88.0k +88,017
62 Tri Locum Partners LP 0.73% of their portfolio NEW YORK, NY 157,225157.2k $2.4m $2.4m 0.73% New
63 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 156,503156.5k $2.4m $2.4m 0.00% New
64 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 152,876152.9k $2.3m $2.3m 0.00% Reduced -256.3k -256,269
65 Squarepoint Ops LLC 0.02% of their portfolio NEW YORK, NY 142,662142.7k $2.2m $2.2m 0.02% Added +103.1k +103,076
66 UBS Group AG 0.00% of their portfolio ZURICH, V8 141,124141.1k $2.1m $2.1m 0.00% Added +131.0k +131,005
67 Resolute Capital Asset Partners LLC 1.39% of their portfolio DENVER, CO 125,000125.0k $1.9m $1.9m 1.39% New
68 Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio ST. PETERSBURG, FL 108,966109.0k $1.7m $1.7m 0.00% Added +6.2k +6,189
69 Tekla Capital Management LLC 0.06% of their portfolio Boston, MA 105,898105.9k $1.6m $1.6m 0.06% New
70 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 101,592101.6k $1.5m $1.5m 0.00% Added +37.3k +37,266
71 Velan Capital Investment Management LP 1.33% of their portfolio ALPHARETTA, GA 98,50098.5k $1.5m $1.5m 1.33% New
72 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 89,53489.5k $1.4m $1.4m 0.00% Added +18.5k +18,508
73 Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio VANCOUVER, A1 89,33989.3k $1.4m $1.4m 0.01% New
74 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 79,44879.4k $1.2m $1.2m 0.00% Unchanged
75 1492 Capital Management LLC 0.74% of their portfolio MILWAUKEE, WI 78,44078.4k $1.2m $1.2m 0.74% Reduced -25 -25
76 GILDER GAGNON HOWE & CO LLC 0.02% of their portfolio New York, NY 76,00376.0k $1.2m $1.2m 0.02% Added +26.1k +26,126
77 Monashee Investment Management LLC 0.32% of their portfolio Boston, MA 75,00075.0k $1.1m $1.1m 0.32% New
78 RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio ST PETERSBURG, FL 70,10370.1k $1.1m $1.1m 0.00% Added +30.1k +30,150
79 Pentwater Capital Management LP 0.02% of their portfolio Naples, FL 70,00070.0k $1.1m $1.1m 0.02% New
80 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 68,53168.5k $1.0m $1.0m 0.01% Added +11.9k +11,855
81 Bellevue Group AG 0.01% of their portfolio ZURICH, V8 67,00067.0k $1.0m $1.0m 0.01% New
82 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 60,91660.9k $927.8k $927.8k 0.00% New
83 PROFUND ADVISORS LLC 0.05% of their portfolio BETHESDA, MD 58,07658.1k $884.5k $884.5k 0.05% New
84 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 56,96057.0k $867.5k $867.5k 0.00% New
85 Virtu Financial LLC 0.09% of their portfolio New York, NY 56,61856.6k $862.0k $862.0k 0.09% New
86 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% of their portfolio CHICAGO, IL 55,93955.9k $852.0k $852.0k 0.02% New
87 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 53,42453.4k $813.6k $813.6k 0.00% Added +53.2k +53,202
88 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 49,91649.9k $760.2k $760.2k 0.00% Reduced -6.3k -6,311
89 Walleye Trading LLC 0.03% of their portfolio NEW YORK, NY 48,95149.0k $745.5k $745.5k 0.03% Reduced -13.0k -12,998
90 Belvedere Trading LLC 0.32% of their portfolio CHICAGO, IL 47,94947.9k $730.3k $730.3k 0.32% Added +33.9k +33,945
91 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 45,27745.3k $689.6k $689.6k 0.00% Added +18.2k +18,194
92 LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 0.09% of their portfolio Englewood, NJ 43,29543.3k $659.4k $659.4k 0.09% New
93 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio HOUSTON, TX 42,50042.5k $647.3k $647.3k 0.02% Reduced -49.8k -49,800
94 Jump Financial, LLC 0.02% of their portfolio Chicago, IL 37,67537.7k $573.8k $573.8k 0.02% Reduced -1.1k -1,107
95 ALGERT GLOBAL LLC 0.03% of their portfolio SAN FRANCISCO, CA 36,96537.0k $563.0k $563.0k 0.03% New
96 ALPS ADVISORS INC 0.00% of their portfolio Denver, CO 33,31233.3k $507.3k $507.3k 0.00% Added +1.7k +1,729
97 Verition Fund Management LLC 0.01% of their portfolio GREENWICH, CT 32,66532.7k $497.5k $497.5k 0.01% New
98 BAILARD, INC. 0.02% of their portfolio Foster City, CA 28,89228.9k $440.0k $440.0k 0.02% Unchanged
99 STEPHENS INC /AR/ 0.01% of their portfolio LITTLE ROCK, AR 26,37426.4k $401.7k $401.7k 0.01% Reduced -16.8k -16,846
100 LMR Partners LLP 0.01% of their portfolio LONDON, X0 25,43125.4k $387.3k $387.3k 0.01% Added +8.6k +8,639