Vault-13

89BIO INC ETNB

COM · Common Stock · CUSIP 282559103

106 institutional holders +20 vs Q3 2022
46,014,13146.0m shares reported held*
$585.7mreported value*
38 new 32 added 20 reduced 18 sold out net bought ≈ $84.6m (+6.6m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.7m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $12.73. Options: 11 managers hold calls ($5.8m notional), 7 hold puts ($852.4k).

Trends to Q4 2022

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 86Q4 22: 106106Q3 22Q4 22
Numbers
QuarterHolders
Q3 202286
Q4 2022106

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$2m$4m$6mQ3 22 calls: $2.5mQ3 22 puts: $476.0kQ3 22P/C 0.19Q4 22 calls: $5.8mQ4 22 puts: $852.4kQ4 22P/C 0.15
Numbers
QuarterCallsPutsP/C
Q3 2022$2.5m$476.0k0.19
Q4 2022$5.8m$852.4k0.15

Biggest buyers

Cormorant Asset Management, LP New +2,550,000+2.5m
Holocene Advisors, LP New +1,900,532+1.9m
Deep Track Capital, LP Added +1,214,000+1.2m
RA CAPITAL MANAGEMENT, L.P. Added +1,172,741+1.2m
MARSHALL WACE, LLP Added +1,037,931+1.0m
Point72 Asset Management, L.P. New +1,024,614+1.0m
Commodore Capital LP New +758,244+758.2k
MILLENNIUM MANAGEMENT LLC Added +706,686+706.7k
Artal Group S.A. New +400,000+400.0k
Octagon Capital Advisors LP New +380,000+380.0k

Biggest sellers

BVF INC/IL Sold out -3,143,682-3.1m
Rubric Capital Management LP Sold out -989,388-989.4k
GREAT POINT PARTNERS LLC Sold out -955,000-955.0k
JANUS HENDERSON GROUP PLC Reduced -556,605-556.6k
SPHERA FUNDS MANAGEMENT LTD. Reduced -478,184-478.2k
DAFNA Capital Management LLC Reduced -330,689-330.7k
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -262,408-262.4k
SILVERARC CAPITAL MANAGEMENT, LLC Sold out -250,000-250.0k
CITADEL ADVISORS LLC Reduced -184,110-184.1k
Pekin Hardy Strauss, Inc. Reduced -132,398-132.4k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $2.6m207.6k shares
J. Goldman & Co LP New $859.3k67.5k shares
CITADEL ADVISORS LLC Reduced $753.6k59.2k shares
PURA VIDA INVESTMENTS, LLC New $649.2k51.0k shares
SIMPLEX TRADING, LLC Reduced $644.0k50.6k shares
Walleye Trading LLC New $115.8k9.1k shares
Walleye Capital LLC New $72.6k5.7k shares
SPHERA FUNDS MANAGEMENT LTD. New $45.8k3.6k shares
GROUP ONE TRADING LLC Added $6.4k500 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $597.0k46.9k shares
CITADEL ADVISORS LLC Reduced $110.8k8.7k shares
Belvedere Trading LLC New $44.6k3.5k shares
SIMPLEX TRADING, LLC Reduced $39.0k3.1k shares
Walleye Capital LLC New $36.9k2.9k shares
Walleye Trading LLC New $24.2k1.9k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
VANGUARD GROUP INC 13G · institution new · filed 2025-07-29 5.6% new 8.2m 2025-07-29
SUVRETTA CAPITAL MANAGEMENT, LLC 13G · institution -4.3 pts · filed 2025-11-13 5.6% -4.3 pts 8.3m 2025-11-13

Fell to 5% or below in the last year: Deep Track Capital, LP (0.0%, 2026-02-13), Pentwater Capital Management LP (0.0%, 2025-11-14)

Holders, Q4 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 2.31% of their portfolio BOSTON, MA 8,955,4109.0m $114.0m $114.0m 2.31% Added +1.2m +1,172,741
2 Deep Track Capital, LP 2.14% of their portfolio GREENWICH, CT 3,850,0003.9m $49.0m $49.0m 2.14% Added +1.2m +1,214,000
3 ORBIMED ADVISORS LLC 0.89% of their portfolio New York, NY 3,658,8693.7m $46.6m $46.6m 0.89% Unchanged
4 Cormorant Asset Management, LP 2.18% of their portfolio BOSTON, MA 2,550,0002.5m $32.5m $32.5m 2.18% New
5 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.06% of their portfolio Boston, MA 1,987,5922.0m $25.3m $25.3m 0.06% Reduced -262.4k -262,408
6 Holocene Advisors, LP 0.15% of their portfolio New York, NY 1,900,5321.9m $24.2m $24.2m 0.15% New
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,578,2951.6m $20.1m $20.1m 0.00% Reduced -93.3k -93,289
8 MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio NEW YORK, NY 1,556,2331.6m $19.8m $19.8m 0.02% Added +706.7k +706,686
9 MARSHALL WACE, LLP 0.05% of their portfolio LONDON, X0 1,487,3111.5m $18.9m $18.9m 0.05% Added +1.0m +1,037,931
10 Boxer Capital, LLC 0.94% of their portfolio San Diego, CA 1,400,0001.4m $17.8m $17.8m 0.94% Unchanged
11 BlackRock Inc. 0.00% of their portfolio New York, NY 1,069,5811.1m $13.6m $13.6m 0.00% Added +159.5k +159,539
12 Point72 Asset Management, L.P. 0.05% of their portfolio STAMFORD, CT 1,024,6141.0m $13.0m $13.0m 0.05% New
13 JANUS HENDERSON GROUP PLC 0.01% of their portfolio LONDON, X0 1,019,3791.0m $13.0m $13.0m 0.01% Reduced -556.6k -556,605
14 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 950,312950.3k $12.1m $12.1m 0.01% Reduced -184.1k -184,110
15 TWO SIGMA ADVISERS, LP 0.03% of their portfolio NEW YORK, NY 819,400819.4k $10.4m $10.4m 0.03% Added +262.5k +262,500
16 Commodore Capital LP 1.45% of their portfolio NEW YORK, NY 758,244758.2k $9.7m $9.7m 1.45% New
17 TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio NEW YORK, NY 714,165714.2k $9.1m $9.1m 0.03% Added +224.6k +224,641
18 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 659,924659.9k $8.4m $8.4m 0.00% Added +271.3k +271,344
19 Orchard Capital Management, LLC 2.35% of their portfolio CHICAGO, IL 551,879551.9k $7.0m $7.0m 2.35% Unchanged
20 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 538,679538.7k $6.9m $6.9m 0.01% Added +128.0k +128,032
21 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 513,064513.1k $6.5m $6.5m 0.00% Reduced -60.9k -60,900
22 Schonfeld Strategic Advisors LLC 0.05% of their portfolio NEW YORK, NY 480,043480.0k $6.1m $6.1m 0.05% Added +130.2k +130,183
23 Walleye Capital LLC 0.13% of their portfolio NEW YORK, NY 479,756479.8k $6.1m $6.1m 0.13% Added +45.6k +45,635
24 Ikarian Capital, LLC 2.40% of their portfolio DALLAS, TX 454,000454.0k $5.8m $5.8m 2.40% Added +254.0k +254,000
25 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 409,145409.1k $5.2m $5.2m 0.00% First filing
26 Artal Group S.A. 0.29% of their portfolio LUXEMBOURG, N4 400,000400.0k $5.1m $5.1m 0.29% New
27 Octagon Capital Advisors LP 0.75% of their portfolio NEW YORK, NY 380,000380.0k $4.8m $4.8m 0.75% New
28 Soleus Capital Management, L.P. 0.69% of their portfolio GREENWICH, CT 379,000379.0k $4.8m $4.8m 0.69% Added +49.0k +49,000
29 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 343,856343.9k $4.4m $4.4m 0.00% Added +102.1k +102,148
30 Parkman Healthcare Partners LLC 1.13% of their portfolio STAMFORD, CT 332,880332.9k $4.2m $4.2m 1.13% Added +107.9k +107,880
31 DAFNA Capital Management LLC 1.16% of their portfolio LOS ANGELES, CA 324,173324.2k $4.1m $4.1m 1.16% Reduced -330.7k -330,689
32 Newtyn Management, LLC 0.81% of their portfolio NEW YORK, NY 310,000310.0k $3.9m $3.9m 0.81% Unchanged
33 Cubist Systematic Strategies, LLC 0.03% of their portfolio STAMFORD, CT 291,025291.0k $3.7m $3.7m 0.03% Added +248.2k +248,208
34 Informed Momentum Co LLC 0.73% of their portfolio SOLANA BEACH, CA 275,943275.9k $3.5m $3.5m 0.73% Added +85.2k +85,225
35 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 231,250231.2k $2.9m $2.9m 0.01% New
36 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 215,167215.2k $2.7m $2.7m 0.00% Reduced -18.6k -18,600
37 Pekin Hardy Strauss, Inc. 0.39% of their portfolio CHICAGO, IL 194,938194.9k $2.5m $2.5m 0.39% Reduced -132.4k -132,398
38 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 191,544191.5k $2.4m $2.4m 0.00% Added +60.4k +60,358
39 Laurion Capital Management LP 0.07% of their portfolio NEW YORK, NY 187,100187.1k $2.4m $2.4m 0.07% Unchanged
40 SPHERA FUNDS MANAGEMENT LTD. 0.72% of their portfolio TEL AVIV, L3 180,600180.6k $2.3m $2.3m 0.72% Reduced -478.2k -478,184
41 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 143,929143.9k $1.8m $1.8m 0.00% Reduced -79.8k -79,809
42 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 130,877130.9k $1.7m $1.7m 0.00% New
43 Global IMC LLC 0.41% of their portfolio SOLANA BEACH, CA 125,394125.4k $1.6m $1.6m 0.41% New
44 PICTON MAHONEY ASSET MANAGEMENT 0.07% of their portfolio Toronto, A6 111,600111.6k $1.4m $1.4m 0.07% Added +2.0k +2,000
45 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 105,111105.1k $1.3m $1.3m 0.00% Reduced -27.3k -27,254
46 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 105,010105.0k $1.3m $1.3m 0.00% Added +42.1k +42,100
47 Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio ST. PETERSBURG, FL 102,777102.8k $1.3m $1.3m 0.00% Reduced -57.4k -57,417
48 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 101,241101.2k $1.3m $1.3m 0.00% Added +81.4k +81,441
49 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.03% of their portfolio HOUSTON, TX 92,30092.3k $1.2m $1.2m 0.03% Unchanged
50 BOOTHBAY FUND MANAGEMENT, LLC 0.03% of their portfolio NEW YORK, NY 88,53588.5k $1.1m $1.1m 0.03% Added +52.8k +52,775
51 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 79,44879.4k $1.0m $1.0m 0.00% Unchanged
52 1492 Capital Management LLC 0.65% of their portfolio MILWAUKEE, WI 78,46578.5k $998.9k $998.9k 0.65% New
53 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 71,02671.0k $904.0k $904.0k 0.00% Unchanged
54 SIMPLEX TRADING, LLC 0.04% of their portfolio CHICAGO, IL 69,68369.7k $887.0k $887.0k 0.04% New
55 Alpha Paradigm Partners, LLC 0.35% of their portfolio CHICAGO, IL 67,43367.4k $858.0k $858.0k 0.35% New
56 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 64,32664.3k $818.9k $818.9k 0.00% Reduced -4.4k -4,351
57 Trexquant Investment LP 0.02% of their portfolio STAMFORD, CT 62,03462.0k $789.7k $789.7k 0.02% New
58 Walleye Trading LLC 0.02% of their portfolio NEW YORK, NY 61,94961.9k $788.6k $788.6k 0.02% Added +39.3k +39,347
59 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 56,67656.7k $721.5k $721.5k 0.00% Added +39.9k +39,893
60 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 56,22756.2k $715.8k $715.8k 0.00% Reduced -54.8k -54,841
61 HRT FINANCIAL LP 0.01% of their portfolio NEW YORK, NY 56,19456.2k $715.0k $715.0k 0.01% New
62 J. Goldman & Co LP 0.05% of their portfolio NEW YORK, NY 54,06054.1k $688.2k $688.2k 0.05% New
63 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.00% of their portfolio JUPITER, FL 53,04053.0k $675.2k $675.2k 0.00% New
64 ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio Boston, MA 51,86151.9k $660.0k $660.0k 0.00% Reduced -71.2k -71,244
65 PURA VIDA INVESTMENTS, LLC 0.11% of their portfolio NEW YORK, NY 50,00050.0k $636.5k $636.5k 0.11% New
66 GILDER GAGNON HOWE & CO LLC 0.01% of their portfolio New York, NY 49,87749.9k $634.9k $634.9k 0.01% New
67 GSA CAPITAL PARTNERS LLP 0.08% of their portfolio LONDON, X0 47,65347.7k $607.0k $607.0k 0.08% New
68 STEPHENS INC /AR/ 0.01% of their portfolio LITTLE ROCK, AR 43,22043.2k $550.2k $550.2k 0.01% New
69 RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio ST PETERSBURG, FL 39,95340.0k $508.6k $508.6k 0.00% Reduced -554 -554
70 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 39,58639.6k $503.9k $503.9k 0.00% New
71 Jump Financial, LLC 0.03% of their portfolio Chicago, IL 38,78238.8k $493.7k $493.7k 0.03% New
72 Endurant Capital Management LP 0.19% of their portfolio San Mateo, CA 36,78436.8k $468.3k $468.3k 0.19% New
73 BANK OF MONTREAL /CAN/ 0.00% of their portfolio TORONTO, A6 34,23334.2k $436.1k $436.1k 0.00% Reduced -5.7k -5,700
74 ALPS ADVISORS INC 0.00% of their portfolio Denver, CO 31,58331.6k $402.1k $402.1k 0.00% New
75 BAILARD, INC. 0.01% of their portfolio Foster City, CA 28,89228.9k $367.8k $367.8k 0.01% Unchanged
76 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 27,08327.1k $344.8k $344.8k 0.00% Added +10.6k +10,580
77 Dynamic Technology Lab Private Ltd 0.03% of their portfolio SINGAPORE, U0 22,36222.4k $285.0k $285.0k 0.03% Added +11.7k +11,683
78 683 Capital Management, LLC 0.03% of their portfolio NEW YORK, NY 22,17822.2k $282.3k $282.3k 0.03% New
79 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 22,15922.2k $282.1k $282.1k 0.00% New
80 Bayesian Capital Management, LP 0.03% of their portfolio Brooklyn, NY 18,00918.0k $229.3k $229.3k 0.03% Added +3.4k +3,400
81 Man Group plc 0.00% of their portfolio LONDON, X0 17,80417.8k $226.6k $226.6k 0.00% New
82 LMR Partners LLP 0.00% of their portfolio LONDON, X0 16,79216.8k $213.8k $213.8k 0.00% New
83 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 15,30215.3k $194.8k $194.8k 0.00% Unchanged
84 Belvedere Trading LLC 0.10% of their portfolio CHICAGO, IL 14,00414.0k $178.3k $178.3k 0.10% New
85 Quantbot Technologies LP 0.01% of their portfolio NEW YORK, NY 12,80012.8k $162.9k $162.9k 0.01% Added +6.9k +6,900
86 TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio STAMFORD, CT 11,14211.1k $142.0k $142.0k 0.00% New
87 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 10,61910.6k $135.0k $135.0k 0.00% New
88 UBS Group AG 0.00% of their portfolio ZURICH, V8 10,11910.1k $128.8k $128.8k 0.00% Reduced -70.5k -70,462
89 FOX RUN MANAGEMENT, L.L.C. 0.05% of their portfolio GREENWICH, CT 10,05310.1k $128.0k $128.0k 0.05% New
90 Gladstone Institutional Advisory LLC 0.01% of their portfolio Bedminster, NJ 10,00010.0k $127.3k $127.3k 0.01% New
91 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 9,8419.8k $125.3k $125.3k 0.00% Added +9.4k +9,441
92 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 8,4378.4k $107.4k $107.4k 0.00% Unchanged
93 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 3,0593.1k $39.0k $39.0k 0.00% Reduced -8.4k -8,393
94 Dorsey Wright & Associates 0.01% of their portfolio PASADENA, CA 2,9002.9k $36.9k $36.9k 0.01% First filing
95 FMR LLC 0.00% of their portfolio BOSTON, MA 2,0792.1k $26.5k $26.5k 0.00% Unchanged
96 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 1,5821.6k $21.0k $21.0k 0.00% Added +400 +400
97 BOURGEON CAPITAL MANAGEMENT LLC 0.00% of their portfolio Darien, CT 1,0001.0k $12.7k $12.7k 0.00% Reduced -1.5k -1,500
98 Capital Advisors, Ltd. LLC 0.00% of their portfolio SHAKER HEIGHTS, OH 798798 $10.0k $10.0k 0.00% Unchanged
99 China Universal Asset Management Co., Ltd. 0.00% of their portfolio SHANGHAI, F4 473473 $6.0k $6.0k 0.00% Added +107 +107
100 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 222222 $2.8k $2.8k 0.00% Added +40 +40