DYNE THERAPEUTICS INC DYN
COM · Common Stock · CUSIP 26818M108
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWaltham, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($435.9k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $18.11. Options: 4 managers hold calls ($768.7k notional), 6 hold puts ($4.5m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 102 |
| Q4 2022 | 114 |
| Q1 2023 | 128 |
| Q2 2023 | 119 |
| Q3 2023 | 115 |
| Q4 2023 | 125 |
| Q1 2024 | 170 |
| Q2 2024 | 194 |
| Q3 2024 | 201 |
| Q4 2024 | 201 |
| Q1 2025 | 206 |
| Q2 2025 | 199 |
| Q3 2025 | 207 |
| Q4 2025 | 233 |
| Q1 2026 | 228 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 124 | 66 |
| Q3 2024 | 113 | 88 |
| Q4 2024 | 98 | 97 |
| Q1 2025 | 127 | 86 |
| Q2 2025 | 117 | 83 |
| Q3 2025 | 146 | 65 |
| Q4 2025 | 146 | 87 |
| Q1 2026 | 136 | 103 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $390.0k | $822.9k | 2.11 |
| Q3 2025 | $2.5m | $3.2m | 1.31 |
| Q4 2025 | $4.4m | $8.2m | 1.87 |
| Q1 2026 | $768.7k | $4.5m | 5.82 |
Biggest buyers
| T. Rowe Price Investment Management, Inc. | Added | +10.4m |
| Vestal Point Capital, LP | Added | +3.9m |
| FMR LLC | Added | +2.3m |
| Orbis Allan Gray Ltd | Added | +2.0m |
| Fiera Capital Corp | New | +1.4m |
| PERCEPTIVE ADVISORS LLC | Added | +1.2m |
| DIMENSIONAL FUND ADVISORS LP | Added | +853.5k |
| ORBIMED ADVISORS LLC | Added | +715.7k |
| Squarepoint Ops LLC | Added | +579.0k |
| BANK OF AMERICA CORP /DE/ | Added | +560.4k |
Biggest sellers
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -4.2m |
| Siren, L.L.C. | Reduced | -1.3m |
| Vivo Capital, LLC | Reduced | -1.1m |
| Candriam S.C.A. | Sold out | -1.1m |
| CITADEL ADVISORS LLC | Reduced | -970.5k |
| Saturn V Capital Management LP | Reduced | -822.0k |
| FCPM III SERVICES B.V. | Reduced | -818.5k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -745.8k |
| EVENTIDE ASSET MANAGEMENT, LLC | Sold out | -680.3k |
| Deep Track Capital, LP | Reduced | -650.0k |
Biggest calls
| CITADEL ADVISORS LLC | Reduced | $250.2k13.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $250.2k13.8k shares |
| JANE STREET GROUP, LLC | Reduced | $195.8k10.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $72.5k4.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $2.0m111.9k shares |
| JANE STREET GROUP, LLC | Reduced | $1.2m66.8k shares |
| Caption Management, LLC | Added | $645.4k35.6k shares |
| CITADEL ADVISORS LLC | Added | $464.1k25.6k shares |
| SIMPLEX TRADING, LLC | Reduced | $107.0k5.9k shares |
| GROUP ONE TRADING LLC | Reduced | $16.3k900 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| T. Rowe Price Investment Management, Inc. 13G · institution +2.5 pts · filed 2026-05-15 | 18.7% |
| Janus Henderson Group Ltd. 13G · institution -1.0 pts · filed 2026-08-13 | 7.3% |
| BlackRock, Inc. 13G · institution +1.2 pts · filed 2026-07-28 | 7.0% |
| FMR LLC 13G · institution +1.4 pts · filed 2026-08-06 | 6.8% |
Fell to 5% or below in the last year: Atlas Venture Fund XI, L.P. (2.4%, 2026-08-13), VANGUARD GROUP INC (0.0%, 2026-03-26), RA CAPITAL MANAGEMENT, L.P. (0.0%, 2025-11-14)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 5 | $7.0m | $6.9m |
| Q3 2024 | 1 | $1.1m | 6 | $88.1m | $84.0m |
| Q4 2024 | 0 | — | 5 | $15.8m | $4.0m |
| Q1 2025 | 0 | — | 5 | $200.2k | $200.2k |
| Q2 2025 | 0 | — | 3 | $74.1k | $74.1k |
| Q3 2025 | 1 | $911.0k | 3 | $108.0k | $108.0k |
| Q4 2025 | 0 | — | 3 | $76.4k | $76.4k |
| Q1 2026 | 1 | $118.0k | 4 | $15.7m | $15.7m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-03-30 | Posner Brian S Director | Bought | $34.2k2.0k shares |
| 2026-03-11 | Kersten Dirk Director · See footnote | Sold plan | $2.5m129.7k shares |
| 2026-03-11 | Posner Brian S Director | Bought | $38.7k2.0k shares |
| 2026-03-10 | Kersten Dirk Director · See footnote | Sold plan | $10.0m511.1k shares |
| 2026-03-09 | Kersten Dirk Director · See footnote | Sold plan | $3.1m177.7k shares |
| 2026-03-06 | Posner Brian S Director | Bought | $45.2k3.0k shares |
| 2026-03-05 | Cox John CEO & President, director | Sold plan | $40.7k2.7k shares |
| 2026-03-05 | Kerr Douglas Chief Medical Officer | Sold plan | $13.5k904 shares |
| 2026-03-05 | Friedl-Naderer Johanna Chief Commercial Officer | Sold plan | $2.2k148 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| T. Rowe Price Investment Management, Inc. 0.38% of their portfolio | 30.8m $558.1m | Added +10.4m |
| JANUS HENDERSON GROUP PLC 0.12% of their portfolio | 13.6m $247.4m | Reduced -240.3k |
| BlackRock, Inc. 0.00% of their portfolio | 11.7m $212.1m | Added +509.0k |
| Atlas Venture Life Science Advisors, LLC 20.95% of their portfolio | 9.1m $165.5m | Unchanged |
| FMR LLC 0.01% of their portfolio | 8.9m $161.5m | Added +2.3m |
| Orbis Allan Gray Ltd 0.52% of their portfolio | 6.8m $122.6m | Added +2.0m |
| STATE STREET CORP 0.00% of their portfolio | 6.7m $120.6m | Reduced -39.0k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 6.4m $116.1m | First filing |
| PERCEPTIVE ADVISORS LLC 1.67% of their portfolio | 4.7m $84.6m | Added +1.2m |
| FCPM III SERVICES B.V. 11.66% of their portfolio | 4.6m $84.2m | Reduced -818.5k |
| TCG Crossover Management, LLC 2.39% of their portfolio | 4.6m $83.7m | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 4.2m $75.5m | First filing |
| Vestal Point Capital, LP 2.03% of their portfolio | 4.0m $72.5m | Added +3.9m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 3.5m $63.5m | Added +240.7k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 3.3m $55.6m | Reduced -296.4k |
| ARMISTICE CAPITAL, LLC 1.90% of their portfolio | 3.2m $57.6m | Reduced -74.6k |
| Frazier Life Sciences Management, L.P. 1.47% of their portfolio | 3.2m $57.2m | Unchanged |
| ORBIMED ADVISORS LLC 1.15% of their portfolio | 2.9m $52.9m | Added +715.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 2.3m $42.2m | Added +4.6k |
| Siren, L.L.C. 1.12% of their portfolio | 2.2m $40.4m | Reduced -1.3m |
| Venrock Adviser, LLC 1.47% of their portfolio | 2.2m $39.4m | Unchanged |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 2.0m $36.4m | Added +2.4k |
| Deep Track Capital, LP 0.75% of their portfolio | 2.0m $36.3m | Reduced -650.0k |
| SAMLYN CAPITAL, LLC 0.60% of their portfolio | 1.9m $34.9m | Added +429.5k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.7m $31.2m | Reduced -560.1k |
| BRAIDWELL LP 1.02% of their portfolio | 1.7m $30.5m | Added +203.7k |
| Palo Alto Investors LP 4.58% of their portfolio | 1.7m $30.0m | Added +180.8k |
| Sofinnova Investments, Inc. 1.48% of their portfolio | 1.6m $29.6m | Reduced -620.3k |
| Vivo Capital, LLC 2.35% of their portfolio | 1.6m $28.2m | Reduced -1.1m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.4m $26.2m | Added +560.4k |
| Aberdeen Group plc 0.04% of their portfolio | 1.4m $25.9m | Added +322.2k |
| MPM BIOIMPACT LLC 1.97% of their portfolio | 1.4m $25.5m | Added +2.8k |
| Logos Global Management LP 1.31% of their portfolio | 1.4m $25.4m | Added +150.0k |
| Fiera Capital Corp 0.09% of their portfolio | 1.4m $25.0m | New |
| Polar Capital Holdings Plc 0.11% of their portfolio | 1.4m $24.6m | Added +90.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.2m $21.7m | Added +106.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.2m $21.0m | Added +7.1k |
| STEMPOINT CAPITAL LP 1.78% of their portfolio | 1.0m $18.4m | Added +176.9k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio | 1.0m $18.1m | Reduced -4.2m |
| Rock Springs Capital Management LP 1.04% of their portfolio | 972.2k $17.6m | Added +59.2k |
| Saturn V Capital Management LP 3.17% of their portfolio | 966.6k $17.5m | Reduced -822.0k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 951.6k $17.2m | Added +853.5k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 947.4k $17.2m | First filing |
| MORGAN STANLEY 0.00% of their portfolio | 929.0k $16.8m | Reduced -284.6k |
| Squarepoint Ops LLC 0.03% of their portfolio | 834.2k $15.1m | Added +579.0k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.15% of their portfolio | 821.8k $14.9m | Reduced -317.0k |
| BAKER BROS. ADVISORS LP 0.08% of their portfolio | 813.4k $14.7m | Unchanged |
| Nuveen, LLC 0.00% of their portfolio | 718.3k $13.0m | Added +97.0k |
| ArrowMark Colorado Holdings LLC 0.32% of their portfolio | 673.9k $12.2m | Reduced -26.7k |
| Artisan Partners Limited Partnership 0.02% of their portfolio | 619.5k $11.2m | Reduced -30.2k |
| RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio | 533.6k $9.7m | Added +63.0k |
| TD Asset Management Inc 0.01% of their portfolio | 529.3k $9.6m | Added +109.6k |
| Ensign Peak Advisors, Inc 0.02% of their portfolio | 496.6k $9.0m | Unchanged |
| University of Wisconsin Foundation 7.80% of their portfolio | 484.7k $8.8m | Added +68.0k |
| ALGERT GLOBAL LLC 0.12% of their portfolio | 454.5k $8.2m | Added +183.2k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 451.6k $8.2m | Reduced -78.7k |
| WASATCH ADVISORS LP 0.05% of their portfolio | 443.7k $8.0m | Added +36.7k |
| Clearbridge Investments, LLC 0.01% of their portfolio | 403.2k $7.3m | Reduced -4.6k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 401.6k $7.3m | Added +48.1k |
| UBS Group AG 0.00% of their portfolio | 380.6k $6.9m | Reduced -417 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio | 333.5k $6.0m | Added +254.2k |
| Fisher Asset Management, LLC 0.00% of their portfolio | 323.1k $5.9m | Added +73.0k |
| Catalio Capital Management, LP 1.07% of their portfolio | 283.0k $5.1m | Reduced -236.8k |
| Tetragon Partners GP Ltd 0.92% of their portfolio | 258.1k $4.7m | Added +10.1k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 253.2k $4.6m | Reduced -159.3k |
| Invesco Ltd. 0.00% of their portfolio | 248.9k $4.5m | Added +111.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 239.3k $4.3m | Added +24.8k |
| Swiss National Bank 0.00% of their portfolio | 228.1k $4.1m | Added +5.6k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 221.1k $4.0m | Added +25.0k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 201.1k $3.6m | Reduced -970.5k |
| SummitTX Capital, L.P. 0.11% of their portfolio | 196.2k $3.6m | Reduced -47.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 187.2k $3.4m | Added +12.2k |
| PDT Partners, LLC 0.20% of their portfolio | 183.0k $3.3m | Unchanged |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 183.0k $3.3m | Reduced -50.9k |
| HighVista Strategies LLC 0.92% of their portfolio | 182.9k $3.3m | Added +123.3k |
| Neo Ivy Capital Management 0.81% of their portfolio | 168.8k $3.1m | Reduced -68.7k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.00% of their portfolio | 164.9k $3.0m | Reduced -805 |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 163.0k $3.0m | Reduced -34.7k |
| SPHERA FUNDS MANAGEMENT LTD. 0.50% of their portfolio | 160.6k $2.9m | Reduced -232.3k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 158.5k $2.9m | Reduced -745.8k |
| Burkehill Global Management, LP 0.14% of their portfolio | 155.0k $2.8m | Unchanged |
| Darwin Wealth Management, LLC 0.87% of their portfolio | 154.9k $2.8m | Added +39.6k |
| Woodline Partners LP 0.01% of their portfolio | 149.4k $2.7m | Added +28.6k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 145.5k $2.6m | Reduced -2.3k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 139.7k $2.5m | Added +18.9k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 135.9k $2.7m | Added +1.7k |
| Aegis Wealth Management LLC 1.40% of their portfolio | 135.0k $2.4m | Added +59.1k |
| SG Americas Securities, LLC 0.00% of their portfolio | 112.6k $2.0m | Reduced -152.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 108.7k $2.0m | Added +10.5k |
| Legal & General Group Plc 0.00% of their portfolio | 96.5k $1.7m | Reduced -21.7k |
| Man Group plc 0.00% of their portfolio | 95.7k $1.7m | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 86.6k $1.6m | Added +171 |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 84.2k $1.5m | Added +13.6k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 83.1k $1.5m | Reduced -593.8k |
| PROFUND ADVISORS LLC 0.05% of their portfolio | 82.1k $1.5m | Reduced -4.6k |
| MOORE CAPITAL MANAGEMENT, LP 0.05% of their portfolio | 78.8k $1.4m | New |
| TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio | 77.0k $1.4m | Reduced -70.6k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 75.5k $1.4m | Added +4.3k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 73.3k $1.3m | First filing |
| MetLife Investment Management, LLC 0.01% of their portfolio | 72.8k $1.3m | Added +3.2k |