DISC MEDICINE INC IRON
COM · Common Stock · CUSIP 254604101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWatertown, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($361.6k this quarter). Holder counts are more reliable. Shares outstanding: 34.8m as of 2025-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $52.96. Options: 4 managers hold calls ($23.4m notional), 3 hold puts ($1.1m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2022 | 35 |
| Q1 2023 | 46 |
| Q2 2023 | 91 |
| Q3 2023 | 92 |
| Q4 2023 | 113 |
| Q1 2024 | 132 |
| Q2 2024 | 123 |
| Q3 2024 | 134 |
| Q4 2024 | 154 |
| Q1 2025 | 159 |
| Q2 2025 | 153 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 58 | 36 |
| Q4 2023 | 67 | 39 |
| Q1 2024 | 90 | 40 |
| Q2 2024 | 82 | 67 |
| Q3 2024 | 80 | 40 |
| Q4 2024 | 79 | 60 |
| Q1 2025 | 98 | 52 |
| Q2 2025 | 92 | 69 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $437.3k | $883.7k | 2.02 |
| Q4 2024 | $3.7m | $2.2m | 0.61 |
| Q1 2025 | $1.6m | $332.6k | 0.21 |
| Q2 2025 | $23.4m | $1.1m | 0.05 |
Biggest buyers
| Woodline Partners LP | Added | +364.7k |
| Logos Global Management LP | Added | +305.7k |
| First Turn Management, LLC | New | +299.5k |
| BAKER BROS. ADVISORS LP | Added | +260.0k |
| Sio Capital Management, LLC | Added | +211.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +157.4k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +150.0k |
| Palo Alto Investors LP | New | +145.7k |
| Vestal Point Capital, LP | New | +140.0k |
| Nantahala Capital Management, LLC | Added | +139.4k |
Biggest sellers
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -911.4k |
| Bain Capital Life Sciences Investors, LLC | Reduced | -400.0k |
| SILVERARC CAPITAL MANAGEMENT, LLC | Sold out | -236.5k |
| D. E. Shaw & Co., Inc. | Sold out | -219.6k |
| PERCEPTIVE ADVISORS LLC | Sold out | -150.0k |
| Pictet Asset Management Holding SA | Sold out | -130.4k |
| Saturn V Capital Management LP | Reduced | -122.1k |
| Frazier Life Sciences Management, L.P. | Reduced | -100.0k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -94.8k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -86.9k |
Biggest calls
| Caption Management, LLC | Added | $22.6m426.3k shares |
| MILLENNIUM MANAGEMENT LLC | New | $794.4k15.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $5.0k100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $1.1m20.5k shares |
| SIMPLEX TRADING, LLC | New | $26.0k500 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution -1.3 pts · filed 2026-08-06 | 12.8% |
| AI DMI LLC 13D · may seek influence -1.4 pts · filed 2026-10-26 | 6.6% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-01-07 | 5.9% |
Fell to 5% or below in the last year: Atlas Venture Fund X, L.P. (2.2%, 2025-12-17)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 3 | $4.9m | $1.1m |
| Q4 2023 | 0 | — | 6 | $40.5m | $1.1m |
| Q1 2024 | 0 | — | 1 | $10.1m | — |
| Q2 2024 | 3 | $11.0m | 1 | $157.8k | $157.8k |
| Q3 2024 | 0 | — | 2 | $262.1k | $262.1k |
| Q4 2024 | 0 | — | 3 | $4.9m | $4.9m |
| Q1 2025 | 0 | — | 8 | $21.9m | $887.2k |
| Q2 2025 | 0 | — | 2 | $693.8k | $693.8k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-16 | Franchi Jean M. Chief Financial Officer | Sold plan | $104.5k2.0k shares |
| 2025-06-06 | Savage William Jacob Chief Medical Officer | Sold plan | $149.8k3.0k shares |
| 2025-05-20 | Savage William Jacob Chief Medical Officer | Sold plan | $334.1k6.7k shares |
| 2025-05-02 | Savage William Jacob Chief Medical Officer | Sold plan | $105.4k2.1k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.01% of their portfolio | 3.2m $171.9m | Added +21.3k |
| Atlas Venture Life Science Advisors, LLC 19.07% of their portfolio | 2.4m $126.3m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 2.0m $108.3m | Reduced -49.7k |
| Frazier Life Sciences Management, L.P. 3.50% of their portfolio | 1.7m $87.6m | Reduced -100.0k |
| RA CAPITAL MANAGEMENT, L.P. 1.41% of their portfolio | 1.6m $83.5m | Unchanged |
| JANUS HENDERSON GROUP PLC 0.04% of their portfolio | 1.6m $82.3m | Added +130.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 1.5m $80.3m | Added +157.4k |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 1.4m $75.8m | Reduced -911.4k |
| ORBIMED ADVISORS LLC 1.88% of their portfolio | 1.4m $74.9m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.4m $74.0m | Added +91.7k |
| Paradigm Biocapital Advisors LP 2.74% of their portfolio | 1.2m $64.1m | Unchanged |
| Siren, L.L.C. 3.01% of their portfolio | 1.1m $58.2m | Added +27.5k |
| STATE STREET CORP 0.00% of their portfolio | 929.8k $49.2m | Added +11.2k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.88% of their portfolio | 919.4k $48.7m | Added +137.1k |
| Woodline Partners LP 0.24% of their portfolio | 867.0k $45.9m | Added +364.7k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 843.6k $44.7m | Added +84.3k |
| Logos Global Management LP 4.95% of their portfolio | 700.0k $37.1m | Added +305.7k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 598.6k $31.7m | Added +26.6k |
| Bain Capital Life Sciences Investors, LLC 3.87% of their portfolio | 583.5k $30.9m | Reduced -400.0k |
| TCG Crossover Management, LLC 2.81% of their portfolio | 465.3k $24.6m | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.04% of their portfolio | 450.0k $23.8m | Added +150.0k |
| ARMISTICE CAPITAL, LLC 0.88% of their portfolio | 436.0k $23.1m | Unchanged |
| Saturn V Capital Management LP 8.50% of their portfolio | 396.1k $21.0m | Reduced -122.1k |
| BAKER BROS. ADVISORS LP 0.17% of their portfolio | 337.1k $17.9m | Added +260.0k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.29% of their portfolio | 308.0k $16.3m | Added +126.2k |
| First Turn Management, LLC 2.96% of their portfolio | 299.5k $15.9m | New |
| Foresite Capital Management V, LLC 19.62% of their portfolio | 299.1k $15.8m | Unchanged |
| Nantahala Capital Management, LLC 1.08% of their portfolio | 287.8k $15.2m | Added +139.4k |
| Sio Capital Management, LLC 6.05% of their portfolio | 284.8k $15.1m | Added +211.3k |
| Checkpoint Capital L.P. 6.54% of their portfolio | 265.0k $14.0m | Added +21.7k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 225.9k $12.0m | Added +95.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 219.1k $11.6m | Added +10.3k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 204.2k $10.8m | Added +9.5k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 197.8k $10.5m | Added +4.2k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 192.9k $10.2m | Added +53.5k |
| Opaleye Management Inc. 2.00% of their portfolio | 186.4k $9.9m | Added +101.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 168.8k $8.9m | Added +115.0k |
| Palo Alto Investors LP 1.64% of their portfolio | 145.7k $7.7m | New |
| UBS Group AG 0.00% of their portfolio | 145.5k $7.7m | Added +72.9k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 141.5k $7.5m | Added +69.0k |
| Vestal Point Capital, LP 0.39% of their portfolio | 140.0k $7.4m | New |
| Blue Owl Capital Holdings LP 2.09% of their portfolio | 122.3k $6.5m | Reduced -18.0k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 121.6k $6.4m | Added +25.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 121.5k $6.4m | Added +53.6k |
| MORGAN STANLEY 0.00% of their portfolio | 110.7k $5.9m | Reduced -59.5k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 96.4k $5.1m | Reduced -94.8k |
| Zimmer Partners, LP 0.11% of their portfolio | 90.2k $4.8m | Added +47.3k |
| BARCLAYS PLC 0.00% of their portfolio | 86.6k $4.6m | Added +40.9k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 86.5k $4.6m | Added +3.2k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 82.5k $4.5m | Reduced -4.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 76.0k $4.0m | Added +5.1k |
| Patient Square Capital LP 1.41% of their portfolio | 74.0k $3.9m | Reduced -9.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 71.5k $3.8m | Added +8.0k |
| Exome Asset Management LLC 2.76% of their portfolio | 61.4k $3.2m | Reduced -300 |
| ExodusPoint Capital Management, LP 0.04% of their portfolio | 57.9k $3.1m | Added +44.4k |
| Nicholas Investment Partners, LP 0.26% of their portfolio | 54.4k $2.9m | New |
| TD Asset Management Inc 0.00% of their portfolio | 53.0k $2.8m | Added +10.6k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 51.8k $2.7m | Added +11.3k |
| Nuveen, LLC 0.00% of their portfolio | 50.3k $2.7m | Reduced -62.4k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 45.2k $2.4m | Added +44.0k |
| Swiss National Bank 0.00% of their portfolio | 42.9k $2.3m | Added +7.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 35.8k $1.9m | Added +3.6k |
| Aberdeen Group plc 0.00% of their portfolio | 32.1k $1.7m | New |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 31.5k $1.7m | Reduced -2.6k |
| PFM Health Sciences, LP 0.14% of their portfolio | 30.8k $1.6m | New |
| Catalio Capital Management, LP 0.34% of their portfolio | 30.7k $1.6m | New |
| Bollard Group LLC 0.04% of their portfolio | 30.6k $1.6m | New |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 25.1k $1.3m | Added +1.4k |
| Atle Fund Management AB 0.56% of their portfolio | 24.7k $1.3m | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 24.1k $1.3m | Added +3.1k |
| Legal & General Group Plc 0.00% of their portfolio | 24.1k $1.3m | Added +3.7k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 22.5k $1.2m | Reduced -375 |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 21.6k $1.1m | Reduced -86.9k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 20.2k $1.1m | Added +98 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.00% of their portfolio | 19.7k $1.0m | New |
| ALPS ADVISORS INC 0.01% of their portfolio | 18.6k $986.4k | Reduced -6.9k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.09% of their portfolio | 18.2k $961.5k | Reduced -44 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 16.9k $892.5k | Added +10.6k |
| Invesco Ltd. 0.00% of their portfolio | 16.8k $890.6k | Added +3.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 16.7k $885.3k | Added +2.0k |
| CITIGROUP INC 0.00% of their portfolio | 16.1k $853.1k | Reduced -26.9k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 15.0k $798.9k | Reduced -97 |
| MetLife Investment Management, LLC 0.00% of their portfolio | 14.9k $786.7k | Added +1.4k |
| Harvest Investment Services, LLC 0.17% of their portfolio | 14.3k $758.2k | Reduced -1.1k |
| Walleye Capital LLC 0.01% of their portfolio | 14.1k $744.8k | Reduced -8.0k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 13.6k $722.9k | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 12.9k $682.6k | Added +906 |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio | 12.9k $681.0k | Reduced -1.8k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% of their portfolio | 12.3k $652.3k | Reduced -1.3k |
| INTECH INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 12.2k $647.3k | Added +1.3k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 11.0k $581.9k | Added +5.1k |
| Lion Point Capital, LP 3.81% of their portfolio | 10.6k $561.4k | Unchanged |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 10.2k $542.6k | New |
| Y-Intercept (Hong Kong) Ltd 0.01% of their portfolio | 9.4k $496.9k | New |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 9.1k $483.5k | Added +5.1k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 7.4k $390.6k | Added +985 |
| Sofinnova Investments, Inc. 0.03% of their portfolio | 7.3k $387.2k | Reduced -173 |
| Legato Capital Management LLC 0.05% of their portfolio | 7.2k $382.8k | New |
| China Universal Asset Management Co., Ltd. 0.03% of their portfolio | 7.0k $368.4k | Added +22 |
| HighVista Strategies LLC 0.13% of their portfolio | 6.7k $356.6k | Added +275 |