DISC MEDICINE INC IRON
COM · Common Stock · CUSIP 254604101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWatertown, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($60.6k this quarter). Holder counts are more reliable. Shares outstanding: 34.6m as of 2025-04-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $49.76. Options: 5 managers hold calls ($1.6m notional), 3 hold puts ($332.6k).
Trends to Q1 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2022 | 35 |
| Q1 2023 | 46 |
| Q2 2023 | 91 |
| Q3 2023 | 92 |
| Q4 2023 | 113 |
| Q1 2024 | 132 |
| Q2 2024 | 123 |
| Q3 2024 | 134 |
| Q4 2024 | 154 |
| Q1 2025 | 159 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2023 | 71 | 20 |
| Q3 2023 | 58 | 36 |
| Q4 2023 | 67 | 39 |
| Q1 2024 | 90 | 40 |
| Q2 2024 | 82 | 67 |
| Q3 2024 | 80 | 40 |
| Q4 2024 | 79 | 60 |
| Q1 2025 | 98 | 52 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2024 | $1.6m | $986.2k | 0.62 |
| Q3 2024 | $437.3k | $883.7k | 2.02 |
| Q4 2024 | $3.7m | $2.2m | 0.61 |
| Q1 2025 | $1.6m | $332.6k | 0.21 |
Biggest buyers
| RA CAPITAL MANAGEMENT, L.P. | New | +1.6m |
| FMR LLC | Added | +1.4m |
| Siren, L.L.C. | New | +1.1m |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +948.1k |
| JPMORGAN CHASE & CO | Added | +698.3k |
| VANGUARD GROUP INC | Added | +236.8k |
| BlackRock, Inc. | Added | +234.8k |
| JANUS HENDERSON GROUP PLC | Added | +205.4k |
| Logos Global Management LP | Added | +194.3k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Added | +181.8k |
Biggest sellers
| CITADEL ADVISORS LLC | Reduced | -529.1k |
| ORBIMED ADVISORS LLC | Reduced | -370.6k |
| MPM BIOIMPACT LLC | Sold out | -346.4k |
| Paradigm Biocapital Advisors LP | Reduced | -286.7k |
| Catalio Capital Management, LP | Sold out | -179.8k |
| Atlas Venture Life Science Advisors, LLC | Reduced | -125.0k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -50.0k |
| VICTORY CAPITAL MANAGEMENT INC | Reduced | -42.6k |
| GOLDMAN SACHS GROUP INC | Reduced | -41.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -36.4k |
Biggest calls
| Caption Management, LLC | New | $948.1k19.1k shares |
| Ikarian Capital, LLC | New | $590.7k11.9k shares |
| CITADEL ADVISORS LLC | Reduced | $44.7k900 shares |
| SIMPLEX TRADING, LLC | Reduced | $19.0k400 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $307.8k6.2k shares |
| CITADEL ADVISORS LLC | Added | $24.8k500 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution -1.3 pts · filed 2026-08-06 | 12.8% |
| AI DMI LLC 13D · may seek influence -1.4 pts · filed 2026-10-26 | 6.6% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-01-07 | 5.9% |
Fell to 5% or below in the last year: Atlas Venture Fund X, L.P. (2.2%, 2025-12-17)
Insider purchases and sales in Q1 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2023 | 0 | — | 3 | $1.4m | $1.4m |
| Q3 2023 | 0 | — | 3 | $4.9m | $1.1m |
| Q4 2023 | 0 | — | 6 | $40.5m | $1.1m |
| Q1 2024 | 0 | — | 1 | $10.1m | — |
| Q2 2024 | 3 | $11.0m | 1 | $157.8k | $157.8k |
| Q3 2024 | 0 | — | 2 | $262.1k | $262.1k |
| Q4 2024 | 0 | — | 3 | $4.9m | $4.9m |
| Q1 2025 | 0 | — | 8 | $21.9m | $887.2k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-03-24 | Ashiya Mona Director · See Footnotes | Sold | $310.5k5.7k shares |
| 2025-03-24 | ORBIMED ADVISORS LLC +3 Director · See Footnotes | Sold | $310.5k5.7k shares |
| 2025-03-21 | ORBIMED ADVISORS LLC +3 Director · See Footnotes | Sold | $540.6k10.0k shares |
| 2025-03-21 | Ashiya Mona Director · See Footnotes | Sold | $540.6k10.0k shares |
| 2025-03-20 | ORBIMED ADVISORS LLC +3 Director · See Footnotes | Sold | $149.2k2.8k shares |
| 2025-03-20 | Ashiya Mona Director · See Footnotes | Sold | $149.2k2.8k shares |
| 2025-03-19 | ORBIMED ADVISORS LLC +3 Director · See Footnotes | Sold | $2.1m39.7k shares |
| 2025-03-19 | Ashiya Mona Director · See Footnotes | Sold | $2.1m39.7k shares |
| 2025-03-12 | ORBIMED ADVISORS LLC +3 Director · See Footnotes | Sold | $4.5m83.2k shares |
| 2025-03-12 | Ashiya Mona Director · See Footnotes | Sold | $4.5m83.2k shares |
| 2025-03-11 | Ashiya Mona Director · See Footnotes | Sold | $1.5m27.1k shares |
| 2025-03-11 | ORBIMED ADVISORS LLC +3 Director · See Footnotes | Sold | $1.5m27.1k shares |
| 2025-03-10 | ORBIMED ADVISORS LLC +3 Director · See Footnotes | Sold | $11.0m202.1k shares |
| 2025-03-10 | Ashiya Mona Director · See Footnotes | Sold | $11.0m202.1k shares |
| 2025-02-18 | Quisel John D Chief Executive Officer, director | Sold | $304.2k5.6k shares |
| 2025-02-18 | Stephenson Pamela Chief Commercial Officer | Sold | $171.2k3.1k shares |
| 2025-02-18 | Franchi Jean M. Chief Financial Officer | Sold | $171.2k3.1k shares |
| 2025-02-18 | Savage William Jacob Chief Medical Officer | Sold | $89.4k1.6k shares |
| 2025-02-18 | Yu Jonathan Yen-Wen Chief Operating Officer | Sold | $87.9k1.6k shares |
| 2025-02-18 | Khara Rahul Chief Legal Officer | Sold | $63.4k1.2k shares |
| 2025-02-03 | Khara Rahul Chief Legal Officer | Sold plan | $416.6k7.5k shares |
| 2025-01-02 | Khara Rahul Chief Legal Officer | Sold plan | $470.6k7.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2025
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.01% of their portfolio | 3.2m $160.1m | Added +1.4m |
| Atlas Venture Life Science Advisors, LLC 22.69% of their portfolio | 2.4m $118.4m | Reduced -125.0k |
| WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio | 2.3m $116.3m | Added +948.1k |
| BlackRock, Inc. 0.00% of their portfolio | 2.1m $104.0m | Added +234.8k |
| Frazier Life Sciences Management, L.P. 3.98% of their portfolio | 1.8m $87.1m | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. 1.31% of their portfolio | 1.6m $78.3m | New |
| JANUS HENDERSON GROUP PLC 0.04% of their portfolio | 1.4m $74.5m | Added +205.4k |
| ORBIMED ADVISORS LLC 1.69% of their portfolio | 1.4m $70.2m | Reduced -370.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 1.4m $67.4m | Reduced -36.4k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.3m $64.8m | Added +236.8k |
| Paradigm Biocapital Advisors LP 2.77% of their portfolio | 1.2m $60.1m | Reduced -286.7k |
| Siren, L.L.C. 3.00% of their portfolio | 1.1m $53.2m | New |
| Bain Capital Life Sciences Investors, LLC 7.22% of their portfolio | 983.5k $48.8m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 918.6k $45.6m | Added +149.8k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.77% of their portfolio | 782.3k $38.8m | Added +181.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 759.3k $37.7m | Added +698.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 572.0k $28.4m | Added +99.3k |
| Saturn V Capital Management LP 12.98% of their portfolio | 518.2k $25.7m | Added +8.8k |
| Woodline Partners LP 0.16% of their portfolio | 502.2k $24.9m | Added +105.6k |
| TCG Crossover Management, LLC 3.15% of their portfolio | 465.3k $23.1m | Reduced -21.7k |
| ARMISTICE CAPITAL, LLC 0.58% of their portfolio | 436.0k $21.6m | Added +80.0k |
| Logos Global Management LP 3.48% of their portfolio | 394.3k $19.6m | Added +194.3k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio | 300.0k $14.9m | Reduced -50.0k |
| Foresite Capital Management V, LLC 16.94% of their portfolio | 299.1k $14.8m | Unchanged |
| Checkpoint Capital L.P. 6.63% of their portfolio | 243.3k $12.1m | Added +58.3k |
| SILVERARC CAPITAL MANAGEMENT, LLC 2.45% of their portfolio | 236.5k $11.7m | Added +126.1k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 219.6k $10.9m | Added +138.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 208.8k $10.4m | Added +21.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 194.7k $9.7m | Added +29.7k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 193.7k $9.6m | Reduced -42.6k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 191.2k $9.5m | Added +104.8k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.18% of their portfolio | 181.8k $9.0m | New |
| MORGAN STANLEY 0.00% of their portfolio | 170.2k $8.4m | Added +20.2k |
| PERCEPTIVE ADVISORS LLC 0.26% of their portfolio | 150.0k $7.4m | New |
| Nantahala Capital Management, LLC 0.61% of their portfolio | 148.4k $7.4m | Reduced -1.6k |
| Blue Owl Capital Holdings LP 2.25% of their portfolio | 140.3k $7.0m | Added +20.0k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 139.4k $6.9m | Reduced -327 |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 130.8k $6.5m | Reduced -41.1k |
| Pictet Asset Management Holding SA 0.01% of their portfolio | 130.4k $6.5m | Added +904 |
| Nuveen, LLC 0.00% of their portfolio | 112.7k $5.6m | First filing |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 108.5k $5.4m | Added +100.6k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 96.6k $4.8m | Added +3.5k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 87.3k $4.6m | Reduced -4.2k |
| Opaleye Management Inc. 0.94% of their portfolio | 85.0k $4.2m | New |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 83.3k $4.1m | Reduced -4.7k |
| Patient Square Capital LP 1.70% of their portfolio | 83.0k $4.1m | Added +26.6k |
| MONTANOVA CAPITAL, LLC 0.16% of their portfolio | 80.0k $4.0m | New |
| BAKER BROS. ADVISORS LP 0.04% of their portfolio | 77.0k $3.8m | Unchanged |
| Sio Capital Management, LLC 1.11% of their portfolio | 73.5k $3.6m | Unchanged |
| UBS Group AG 0.00% of their portfolio | 72.6k $3.6m | Added +48.3k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 72.5k $3.6m | Added +32.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 70.9k $3.5m | Added +42.1k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 67.9k $3.4m | Added +62.6k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 63.5k $3.2m | Added +6.2k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 62.2k $3.1m | Reduced -529.1k |
| Exome Asset Management LLC 2.74% of their portfolio | 61.7k $3.1m | Reduced -7.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 53.8k $2.7m | Added +18.5k |
| BARCLAYS PLC 0.00% of their portfolio | 45.7k $2.3m | Added +5.6k |
| TWINBEECH CAPITAL LP 0.04% of their portfolio | 45.4k $2.3m | New |
| CITIGROUP INC 0.00% of their portfolio | 43.0k $2.1m | Added +340 |
| Zimmer Partners, LP 0.04% of their portfolio | 42.9k $2.1m | Added +9.8k |
| TD Asset Management Inc 0.00% of their portfolio | 42.4k $2.1m | Reduced -2.5k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 40.6k $2.0m | Added +2.1k |
| Swiss National Bank 0.00% of their portfolio | 35.9k $1.8m | Added +3.7k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 34.0k $1.7m | Added +6.3k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 32.1k $1.6m | Added +3.1k |
| ALPS ADVISORS INC 0.01% of their portfolio | 25.5k $1.3m | Added +1.4k |
| Ghisallo Capital Management LLC 0.11% of their portfolio | 25.0k $1.2m | New |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 23.7k $1.2m | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 22.8k $1.1m | Added +2.1k |
| Atom Investors LP 0.14% of their portfolio | 22.6k $1.1m | New |
| Walleye Capital LLC 0.01% of their portfolio | 22.1k $1.1m | Reduced -4.9k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 21.1k $1.0m | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 20.4k $1.0m | Added +2.7k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 20.2k $1.0m | Added +4.6k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.09% of their portfolio | 18.2k $903.4k | Added +44 |
| Engineers Gate Manager LP 0.01% of their portfolio | 16.8k $834.4k | Added +4.0k |
| ALGERT GLOBAL LLC 0.02% of their portfolio | 16.3k $811.0k | Unchanged |
| Harvest Investment Services, LLC 0.21% of their portfolio | 15.4k $763.6k | Reduced -232 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 15.1k $755.8k | Added +2.8k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 14.7k $730.0k | Reduced -1.4k |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio | 14.6k $726.0k | Reduced -2.4k |
| SG Americas Securities, LLC 0.00% of their portfolio | 14.3k $711.0k | Added +6.3k |
| Invesco Ltd. 0.00% of their portfolio | 13.8k $686.7k | Added +3.0k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% of their portfolio | 13.6k $676.1k | Reduced -636 |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 13.6k $673.0k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 13.5k $667.9k | Added +1.3k |
| Aquatic Capital Management LLC 0.02% of their portfolio | 12.2k $605.0k | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 12.0k $594.8k | Reduced -230 |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 11.9k $590.8k | Added +6.0k |
| Corebridge Financial, Inc. 0.00% of their portfolio | 11.2k $555.0k | Added +1.4k |
| INTECH INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 10.9k $543.5k | Added +3.1k |
| Lion Point Capital, LP 3.36% of their portfolio | 10.6k $526.2k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 10.3k $510.6k | First filing |
| Trexquant Investment LP 0.00% of their portfolio | 8.6k $424.7k | Reduced -4.3k |
| Quantbot Technologies LP 0.01% of their portfolio | 7.6k $375.5k | Added +7.6k |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 7.6k $374.9k | Added +2.7k |
| Sofinnova Investments, Inc. 0.03% of their portfolio | 7.5k $371.6k | Reduced -15.3k |
| PROFUND ADVISORS LLC 0.02% of their portfolio | 7.2k $355.4k | Added +1.6k |
| STRS OHIO 0.00% of their portfolio | 7.0k $347.5k | Added +6.1k |