Vault-13

DESIGN THERAPEUTICS INC DSGN

COM · Common Stock · CUSIP 25056L103

98 institutional holders +1 vs Q1 2023
38,775,91038.8m shares reported held*
69.3% of all shares outstanding*
$244.3mreported value*
10 new 30 added 43 reduced 9 sold out net sold ≈ $5.4m (-863.3k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($67.4k this quarter). Holder counts are more reliable. Shares outstanding: 56.0m as of 2023-08-09, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $6.30. Options: 4 managers hold calls ($12.0k notional), 4 hold puts ($35.8k).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 79Q4 22: 83Q1 23: 97Q2 23: 9898Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 202279
Q4 202283
Q1 202397
Q2 202398

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 46 bought or addedQ4 22: 37 cut or sold outQ4 22Q1 23: 56 bought or addedQ1 23: 44 cut or sold outQ1 23Q2 23: 40 bought or addedQ2 23: 52 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20224637
Q1 20235644
Q2 20234052

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$2m$4m$6m$8mQ3 22 calls: $7.9mQ3 22 puts: $1.1mQ3 22P/C 0.14Q4 22 calls: $5.8mQ4 22 puts: $1.2mQ4 22P/C 0.21Q1 23 calls: $1.1mQ1 23 puts: $282.7kQ1 23P/C 0.26Q2 23 calls: $12.0kQ2 23 puts: $35.8kQ2 23P/C 2.99
Numbers
QuarterCallsPutsP/C
Q3 2022$7.9m$1.1m0.14
Q4 2022$5.8m$1.2m0.21
Q1 2023$1.1m$282.7k0.26
Q2 2023$12.0k$35.8k2.99

Biggest buyers

RTW INVESTMENTS, LP New +1,563,031+1.6m
Candriam S.C.A. New +185,000+185.0k
GOLDMAN SACHS GROUP INC Added +146,792+146.8k
GSA CAPITAL PARTNERS LLP Added +140,300+140.3k
Assenagon Asset Management S.A. Added +133,473+133.5k
MORGAN STANLEY Added +121,391+121.4k
ExodusPoint Capital Management, LP Added +109,246+109.2k
BANK OF MONTREAL /CAN/ New +99,240+99.2k
NORTHERN TRUST CORP Added +48,970+49.0k
STATE OF WISCONSIN INVESTMENT BOARD Added +40,900+40.9k

Biggest sellers

FMR LLC Reduced -1,278,036-1.3m
MILLENNIUM MANAGEMENT LLC Reduced -510,334-510.3k
VANGUARD GROUP INC Reduced -299,769-299.8k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced -247,275-247.3k
BlackRock Inc. Reduced -191,840-191.8k
Ergoteles LLC Sold out -177,337-177.3k
JANE STREET GROUP, LLC Reduced -169,390-169.4k
BAKER BROS. ADVISORS LP Reduced -126,884-126.9k
STATE STREET CORP Reduced -125,493-125.5k
Cubist Systematic Strategies, LLC Reduced -111,598-111.6k

Biggest calls

CITADEL ADVISORS LLC Reduced $7.6k1.2k shares
GROUP ONE TRADING LLC New $4.4k700 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares
SIMPLEX TRADING, LLC Reduced $0100 shares

Biggest puts

CITADEL ADVISORS LLC Reduced $26.5k4.2k shares
GROUP ONE TRADING LLC Added $6.3k1.0k shares
SIMPLEX TRADING, LLC New $3.0k500 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
SR One Capital Fund I Aggregator LP 13D · may seek influence filed 2026-03-11
Stated purposeNot applicable. Full filing
10.7% 6.6m≈ $95.6m 2026-03-11
Sirenia Capital Management LP 13G · institution new · filed 2026-08-14 9.5% new 6.0m≈ $86.3m 2026-08-14
Light Irrevocable Trust #1 dated April 22, 2019 13G · exempt (held before listing) filed 2025-02-07 6.9% 3.8m≈ $55.5m 2025-02-07
Star Irrevocable Trust #1 dated April 22, 2019 13G · exempt (held before listing) filed 2025-02-07 6.9% 3.8m≈ $55.5m 2025-02-07

Fell to 5% or below in the last year: Point72 Asset Management, L.P. (3.8%, 2026-08-14), Logos Global Management LP (4.4%, 2025-11-18)

Insider purchases and sales in Q2 2023

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
404Q3 21: 0 buyingQ3 21: 0 sellingQ4 21: 0 buyingQ4 21: 0 sellingQ4 21Q1 22: 1 buyingQ1 22: 1 sellingQ2 22: 0 buyingQ2 22: 0 sellingQ2 22Q3 22: 0 buyingQ3 22: 0 sellingQ4 22: 3 buyingQ4 22: 0 sellingQ4 22Q1 23: 0 buyingQ1 23: 0 sellingQ2 23: 0 buyingQ2 23: 0 sellingQ2 23
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20210—0——
Q4 20210—0——
Q1 20221$474.7k1$11.3m—
Q2 20220—0——
Q3 20220—0——
Q4 20223$7.8m0——
Q1 20230—0——
Q2 20230—0——

None reported in Q2 2023.

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 SR One Capital Management, LP 17.73% of their portfolio Redwood City, CA 6,526,4766.5m $41.1m $41.1m 17.73% Unchanged
2 Cormorant Asset Management, LP 1.85% of their portfolio BOSTON, MA 5,150,0005.2m $32.4m $32.4m 1.85% Unchanged
3 Avoro Capital Advisors LLC 0.30% of their portfolio NEW YORK, NY 3,500,0003.5m $22.1m $22.1m 0.30% Unchanged
4 BlackRock Inc. 0.00% of their portfolio New York, NY 2,994,0513.0m $18.9m $18.9m 0.00% Reduced -191.8k -191,840
5 RA CAPITAL MANAGEMENT, L.P. 0.35% of their portfolio BOSTON, MA 2,971,2313.0m $18.7m $18.7m 0.35% Unchanged
6 CITADEL ADVISORS LLC 0.02% of their portfolio MIAMI, FL 2,856,1062.9m $18.0m $18.0m 0.02% Reduced -9.1k -9,061
7 Logos Global Management LP 2.43% of their portfolio San Francisco, CA 2,797,5012.8m $17.6m $17.6m 2.43% Unchanged
8 RTW INVESTMENTS, LP 0.19% of their portfolio NEW YORK, NY 1,563,0311.6m $9.8m $9.8m 0.19% New
9 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 983,274983.3k $6.2m $6.2m 0.00% Reduced -299.8k -299,769
10 JANUS HENDERSON GROUP PLC 0.00% of their portfolio LONDON, X0 829,425829.4k $5.2m $5.2m 0.00% Reduced -14.3k -14,293
11 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 728,221728.2k $4.6m $4.6m 0.00% Added +8.3k +8,284
12 FMR LLC 0.00% of their portfolio BOSTON, MA 637,770637.8k $4.0m $4.0m 0.00% Reduced -1.3m -1,278,036
13 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 636,845636.8k $4.0m $4.0m 0.00% Added +3.8k +3,837
14 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 586,035586.0k $3.7m $3.7m 0.00% Reduced -125.5k -125,493
15 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 502,375502.4k $3.2m $3.2m 0.00% Reduced -48.0k -47,957
16 BAKER BROS. ADVISORS LP 0.02% of their portfolio NEW YORK, NY 500,000500.0k $3.1m $3.1m 0.02% Reduced -126.9k -126,884
17 Rock Springs Capital Management LP 0.07% of their portfolio Baltimore, MD 460,391460.4k $2.9m $2.9m 0.07% Unchanged
18 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 447,416447.4k $2.8m $2.8m 0.00% Added +146.8k +146,792
19 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 324,738324.7k $2.0m $2.0m 0.00% Added +49.0k +48,970
20 Assenagon Asset Management S.A. 0.01% of their portfolio SENNINGERBERG, N4 301,688301.7k $1.9m $1.9m 0.01% Added +133.5k +133,473
21 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 279,879279.9k $1.8m $1.8m 0.00% Reduced -510.3k -510,334
22 ExodusPoint Capital Management, LP 0.02% of their portfolio NEW YORK, NY 265,384265.4k $1.7m $1.7m 0.02% Added +109.2k +109,246
23 GSA CAPITAL PARTNERS LLP 0.15% of their portfolio LONDON, X0 238,200238.2k $1.5m $1.5m 0.15% Added +140.3k +140,300
24 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 228,806228.8k $1.4m $1.4m 0.00% Reduced -1.5k -1,541
25 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 190,768190.8k $1.2m $1.2m 0.00% Added +121.4k +121,391
26 Candriam S.C.A. 0.01% of their portfolio STRASSEN, N4 185,000185.0k $1.2m $1.2m 0.01% New
27 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 154,539154.5k $973.6k $973.6k 0.00% Added +38.7k +38,739
28 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 135,280135.3k $852.3k $852.3k 0.00% Added +24.0k +23,982
29 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 122,665122.7k $772.8k $772.8k 0.00% Reduced -1.4k -1,388
30 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 115,782115.8k $729.4k $729.4k 0.00% Reduced -63.3k -63,314
31 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 112,922112.9k $711.4k $711.4k 0.00% Reduced -68.0k -67,997
32 BANK OF MONTREAL /CAN/ 0.00% of their portfolio TORONTO, A6 99,24099.2k $629.2k $629.2k 0.00% New
33 HRT FINANCIAL LP 0.01% of their portfolio NEW YORK, NY 95,26495.3k $600.0k $600.0k 0.01% Reduced -29.7k -29,699
34 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 95,10895.1k $599.0k $599.0k 0.00% Reduced -6.6k -6,643
35 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 84,00084.0k $529.2k $529.2k 0.00% Added +40.9k +40,900
36 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 79,00079.0k $497.7k $497.7k 0.00% Added +32.3k +32,300
37 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 77,87877.9k $490.6k $490.6k 0.00% Added +21.6k +21,635
38 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 66,68666.7k $420.1k $420.1k 0.00% Reduced -111.6k -111,598
39 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 59,63559.6k $374.9k $374.9k 0.00% Reduced -16.9k -16,850
40 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 56,79456.8k $357.8k $357.8k 0.00% Reduced -247.3k -247,275
41 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 51,98352.0k $327.5k $327.5k 0.00% Added +26.0k +26,027
42 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 51,59051.6k $325.0k $325.0k 0.00% Reduced -98 -98
43 PDT Partners, LLC 0.04% of their portfolio New York, NY 47,51247.5k $299.3k $299.3k 0.04% Reduced -12.5k -12,457
44 Trexquant Investment LP 0.01% of their portfolio STAMFORD, CT 46,52446.5k $293.1k $293.1k 0.01% Reduced -4.3k -4,315
45 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 41,59041.6k $262.0k $262.0k 0.00% Reduced -67.6k -67,624
46 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 41,40041.4k $260.8k $260.8k 0.00% Added +10.2k +10,200
47 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 33,33433.3k $210.0k $210.0k 0.00% Reduced -169.4k -169,390
48 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 26,21526.2k $165.2k $165.2k 0.00% New
49 UBS Group AG 0.00% of their portfolio ZURICH, V8 24,16224.2k $152.2k $152.2k 0.00% Added +24.0k +23,956
50 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 22,04522.0k $138.9k $138.9k 0.00% Unchanged
51 TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio STAMFORD, CT 20,56120.6k $129.5k $129.5k 0.00% Reduced -7.1k -7,078
52 VIRTUS ADVISERS, LLC 0.08% of their portfolio HARTFORD, CT 20,13720.1k $126.9k $126.9k 0.08% Added +8.7k +8,741
53 ALGERT GLOBAL LLC 0.01% of their portfolio SAN FRANCISCO, CA 19,43019.4k $122.4k $122.4k 0.01% New
54 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 18,49918.5k $116.5k $116.5k 0.00% New
55 Corton Capital Inc. 0.05% of their portfolio Carrying Place, A6 17,32317.3k $109.1k $109.1k 0.05% New
56 JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio FLORHAM PARK, NJ 16,10016.1k $101.4k $101.4k 0.00% New
57 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 15,90115.9k $100.2k $100.2k 0.00% Reduced -9.0k -8,955
58 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 15,82015.8k $99.7k $99.7k 0.00% Reduced -1.4k -1,397
59 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 15,77315.8k $99.4k $99.4k 0.00% Reduced -580 -580
60 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 15,39815.4k $97.0k $97.0k 0.00% Reduced -114 -114
61 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 15,17315.2k $95.6k $95.6k 0.00% Added +1.5k +1,546
62 Schonfeld Strategic Advisors LLC 0.00% of their portfolio NEW YORK, NY 14,10014.1k $88.8k $88.8k 0.00% Added +700 +700
63 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 14,09014.1k $88.8k $88.8k 0.00% Added +928 +928
64 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 12,63012.6k $79.6k $79.6k 0.00% Unchanged
65 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 12,46312.5k $78.5k $78.5k 0.00% Added +6.5k +6,469
66 Jump Financial, LLC 0.00% of their portfolio Chicago, IL 12,13912.1k $76.5k $76.5k 0.00% Reduced -46.7k -46,661
67 Verition Fund Management LLC 0.00% of their portfolio GREENWICH, CT 11,78611.8k $74.3k $74.3k 0.00% Reduced -32.4k -32,394
68 Walleye Capital LLC 0.00% of their portfolio NEW YORK, NY 11,13811.1k $70.2k $70.2k 0.00% New
69 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 10,90110.9k $68.7k $68.7k 0.00% Reduced -1.7k -1,697
70 XTX Topco Ltd 0.01% of their portfolio LONDON, X0 10,79910.8k $68.0k $68.0k 0.01% New
71 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 10,71610.7k $67.5k $67.5k 0.00% Added +7.3k +7,309
72 Point72 Middle East FZE 0.00% of their portfolio DUBAI, C0 9,0859.1k $57.2k $57.2k 0.00% Reduced -279 -279
73 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 5,3495.3k $33.7k $33.7k 0.00% Reduced -4.8k -4,781
74 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 5,3005.3k $33.4k $33.4k 0.00% Added +3.2k +3,201
75 Quantbot Technologies LP 0.00% of their portfolio NEW YORK, NY 4,7054.7k $29.6k $29.6k 0.00% Reduced -6.1k -6,148
76 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 3,5743.6k $23.0k $23.0k 0.00% Added +1.5k +1,508
77 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 3,2803.3k $21.0k $21.0k 0.00% Reduced -226 -226
78 Legal & General Group Plc 0.00% of their portfolio London, X0 3,1273.1k $19.7k $19.7k 0.00% Unchanged
79 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 2,5702.6k $16.2k $16.2k 0.00% Unchanged
80 Metropolitan Life Insurance Co/NY 0.00% of their portfolio New York, NY 2,0162.0k $12.7k $12.7k 0.00% Unchanged
81 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 1,9942.0k $12.6k $12.6k 0.00% Reduced -15.6k -15,640
82 ASSETMARK, INC 0.00% of their portfolio CONCORD, CA 1,8741.9k $11.8k $11.8k 0.00% Added +216 +216
83 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 1,3941.4k $8.8k $8.8k 0.00% Added +402 +402
84 SIGNATUREFD, LLC 0.00% of their portfolio ATLANTA, GA 1,2111.2k $7.6k $7.6k 0.00% Reduced -138 -138
85 China Universal Asset Management Co., Ltd. 0.00% of their portfolio SHANGHAI, F4 733733 $4.6k $4.6k 0.00% Reduced -25 -25
86 Clearstead Advisors, LLC 0.00% of their portfolio CLEVELAND, OH 610610 $3.8k $3.8k 0.00% Unchanged
87 Lindbrook Capital, LLC 0.00% of their portfolio CALABASAS, CA 607607 $3.8k $3.8k 0.00% Reduced -928 -928
88 FEDERATED HERMES, INC. 0.00% of their portfolio PITTSBURGH, PA 508508 $3.2k $3.2k 0.00% Reduced -133 -133
89 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 438438 $2.8k $2.8k 0.00% Reduced -41 -41
90 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 382382 $2.0k $2.0k 0.00% Reduced -155 -155
91 QUADRANT CAPITAL GROUP LLC 0.00% of their portfolio CINCINNATI, OH 362362 $2.3k $2.3k 0.00% Reduced -254 -254
92 Allworth Financial LP 0.00% of their portfolio FOLSOM, CA 336336 $2.1k $2.1k 0.00% Added +300 +300
93 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 232232 $1.5k $1.5k 0.00% Added +29 +29
94 Daiwa Securities Group Inc. 0.00% of their portfolio CHIYODA-KU,TOKYO, M0 162162 $1.0k $1.0k 0.00% Unchanged
95 Parallel Advisors, LLC 0.00% of their portfolio SAN FRANCISCO, CA 102102 $643 $643 0.00% Added +52 +52
96 Covestor Ltd 0.00% of their portfolio LONDON, X0 2020 $0 $0 0.00% Added +12 +12
97 Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio ZURICH, V8 11 $6 $6 0.00% Unchanged
98 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged