DESIGN THERAPEUTICS INC DSGN
COM · Common Stock · CUSIP 25056L103
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCarlsbad, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($67.4k this quarter). Holder counts are more reliable. Shares outstanding: 56.0m as of 2023-08-09, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $6.30. Options: 4 managers hold calls ($12.0k notional), 4 hold puts ($35.8k).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 79 |
| Q4 2022 | 83 |
| Q1 2023 | 97 |
| Q2 2023 | 98 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 46 | 37 |
| Q1 2023 | 56 | 44 |
| Q2 2023 | 40 | 52 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $7.9m | $1.1m | 0.14 |
| Q4 2022 | $5.8m | $1.2m | 0.21 |
| Q1 2023 | $1.1m | $282.7k | 0.26 |
| Q2 2023 | $12.0k | $35.8k | 2.99 |
Biggest buyers
| RTW INVESTMENTS, LP | New | +1.6m |
| Candriam S.C.A. | New | +185.0k |
| GOLDMAN SACHS GROUP INC | Added | +146.8k |
| GSA CAPITAL PARTNERS LLP | Added | +140.3k |
| Assenagon Asset Management S.A. | Added | +133.5k |
| MORGAN STANLEY | Added | +121.4k |
| ExodusPoint Capital Management, LP | Added | +109.2k |
| BANK OF MONTREAL /CAN/ | New | +99.2k |
| NORTHERN TRUST CORP | Added | +49.0k |
| STATE OF WISCONSIN INVESTMENT BOARD | Added | +40.9k |
Biggest sellers
| FMR LLC | Reduced | -1.3m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -510.3k |
| VANGUARD GROUP INC | Reduced | -299.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -247.3k |
| BlackRock Inc. | Reduced | -191.8k |
| Ergoteles LLC | Sold out | -177.3k |
| JANE STREET GROUP, LLC | Reduced | -169.4k |
| BAKER BROS. ADVISORS LP | Reduced | -126.9k |
| STATE STREET CORP | Reduced | -125.5k |
| Cubist Systematic Strategies, LLC | Reduced | -111.6k |
Biggest calls
| CITADEL ADVISORS LLC | Reduced | $7.6k1.2k shares |
| GROUP ONE TRADING LLC | New | $4.4k700 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| SIMPLEX TRADING, LLC | Reduced | $0100 shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $26.5k4.2k shares |
| GROUP ONE TRADING LLC | Added | $6.3k1.0k shares |
| SIMPLEX TRADING, LLC | New | $3.0k500 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
SR One Capital Fund I Aggregator LP
13D · may seek influence
filed 2026-03-11
Stated purposeNot applicable. Full filing |
10.7% |
| Sirenia Capital Management LP 13G · institution new · filed 2026-08-14 | 9.5% |
| Light Irrevocable Trust #1 dated April 22, 2019 13G · exempt (held before listing) filed 2025-02-07 | 6.9% |
| Star Irrevocable Trust #1 dated April 22, 2019 13G · exempt (held before listing) filed 2025-02-07 | 6.9% |
Fell to 5% or below in the last year: Point72 Asset Management, L.P. (3.8%, 2026-08-14), Logos Global Management LP (4.4%, 2025-11-18)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 0 | — | — |
| Q1 2022 | 1 | $474.7k | 1 | $11.3m | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 3 | $7.8m | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
None reported in Q2 2023.
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| SR One Capital Management, LP 17.73% of their portfolio | 6.5m $41.1m | Unchanged |
| Cormorant Asset Management, LP 1.85% of their portfolio | 5.2m $32.4m | Unchanged |
| Avoro Capital Advisors LLC 0.30% of their portfolio | 3.5m $22.1m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 3.0m $18.9m | Reduced -191.8k |
| RA CAPITAL MANAGEMENT, L.P. 0.35% of their portfolio | 3.0m $18.7m | Unchanged |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 2.9m $18.0m | Reduced -9.1k |
| Logos Global Management LP 2.43% of their portfolio | 2.8m $17.6m | Unchanged |
| RTW INVESTMENTS, LP 0.19% of their portfolio | 1.6m $9.8m | New |
| VANGUARD GROUP INC 0.00% of their portfolio | 983.3k $6.2m | Reduced -299.8k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 829.4k $5.2m | Reduced -14.3k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 728.2k $4.6m | Added +8.3k |
| FMR LLC 0.00% of their portfolio | 637.8k $4.0m | Reduced -1.3m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 636.8k $4.0m | Added +3.8k |
| STATE STREET CORP 0.00% of their portfolio | 586.0k $3.7m | Reduced -125.5k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 502.4k $3.2m | Reduced -48.0k |
| BAKER BROS. ADVISORS LP 0.02% of their portfolio | 500.0k $3.1m | Reduced -126.9k |
| Rock Springs Capital Management LP 0.07% of their portfolio | 460.4k $2.9m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 447.4k $2.8m | Added +146.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 324.7k $2.0m | Added +49.0k |
| Assenagon Asset Management S.A. 0.01% of their portfolio | 301.7k $1.9m | Added +133.5k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 279.9k $1.8m | Reduced -510.3k |
| ExodusPoint Capital Management, LP 0.02% of their portfolio | 265.4k $1.7m | Added +109.2k |
| GSA CAPITAL PARTNERS LLP 0.15% of their portfolio | 238.2k $1.5m | Added +140.3k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 228.8k $1.4m | Reduced -1.5k |
| MORGAN STANLEY 0.00% of their portfolio | 190.8k $1.2m | Added +121.4k |
| Candriam S.C.A. 0.01% of their portfolio | 185.0k $1.2m | New |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 154.5k $973.6k | Added +38.7k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 135.3k $852.3k | Added +24.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 122.7k $772.8k | Reduced -1.4k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 115.8k $729.4k | Reduced -63.3k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 112.9k $711.4k | Reduced -68.0k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 99.2k $629.2k | New |
| HRT FINANCIAL LP 0.01% of their portfolio | 95.3k $600.0k | Reduced -29.7k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 95.1k $599.0k | Reduced -6.6k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 84.0k $529.2k | Added +40.9k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 79.0k $497.7k | Added +32.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 77.9k $490.6k | Added +21.6k |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 66.7k $420.1k | Reduced -111.6k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 59.6k $374.9k | Reduced -16.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 56.8k $357.8k | Reduced -247.3k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 52.0k $327.5k | Added +26.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 51.6k $325.0k | Reduced -98 |
| PDT Partners, LLC 0.04% of their portfolio | 47.5k $299.3k | Reduced -12.5k |
| Trexquant Investment LP 0.01% of their portfolio | 46.5k $293.1k | Reduced -4.3k |
| Squarepoint Ops LLC 0.00% of their portfolio | 41.6k $262.0k | Reduced -67.6k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 41.4k $260.8k | Added +10.2k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 33.3k $210.0k | Reduced -169.4k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 26.2k $165.2k | New |
| UBS Group AG 0.00% of their portfolio | 24.2k $152.2k | Added +24.0k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 22.0k $138.9k | Unchanged |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 20.6k $129.5k | Reduced -7.1k |
| VIRTUS ADVISERS, LLC 0.08% of their portfolio | 20.1k $126.9k | Added +8.7k |
| ALGERT GLOBAL LLC 0.01% of their portfolio | 19.4k $122.4k | New |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 18.5k $116.5k | New |
| Corton Capital Inc. 0.05% of their portfolio | 17.3k $109.1k | New |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 16.1k $101.4k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 15.9k $100.2k | Reduced -9.0k |
| BARCLAYS PLC 0.00% of their portfolio | 15.8k $99.7k | Reduced -1.4k |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 15.8k $99.4k | Reduced -580 |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 15.4k $97.0k | Reduced -114 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 15.2k $95.6k | Added +1.5k |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 14.1k $88.8k | Added +700 |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 14.1k $88.8k | Added +928 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 12.6k $79.6k | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 12.5k $78.5k | Added +6.5k |
| Jump Financial, LLC 0.00% of their portfolio | 12.1k $76.5k | Reduced -46.7k |
| Verition Fund Management LLC 0.00% of their portfolio | 11.8k $74.3k | Reduced -32.4k |
| Walleye Capital LLC 0.00% of their portfolio | 11.1k $70.2k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 10.9k $68.7k | Reduced -1.7k |
| XTX Topco Ltd 0.01% of their portfolio | 10.8k $68.0k | New |
| CITIGROUP INC 0.00% of their portfolio | 10.7k $67.5k | Added +7.3k |
| Point72 Middle East FZE 0.00% of their portfolio | 9.1k $57.2k | Reduced -279 |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 5.3k $33.7k | Reduced -4.8k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 5.3k $33.4k | Added +3.2k |
| Quantbot Technologies LP 0.00% of their portfolio | 4.7k $29.6k | Reduced -6.1k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 3.6k $23.0k | Added +1.5k |
| AMALGAMATED BANK 0.00% of their portfolio | 3.3k $21.0k | Reduced -226 |
| Legal & General Group Plc 0.00% of their portfolio | 3.1k $19.7k | Unchanged |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 2.6k $16.2k | Unchanged |
| Metropolitan Life Insurance Co/NY 0.00% of their portfolio | 2.0k $12.7k | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 2.0k $12.6k | Reduced -15.6k |
| ASSETMARK, INC 0.00% of their portfolio | 1.9k $11.8k | Added +216 |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 1.4k $8.8k | Added +402 |
| SIGNATUREFD, LLC 0.00% of their portfolio | 1.2k $7.6k | Reduced -138 |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 733 $4.6k | Reduced -25 |
| Clearstead Advisors, LLC 0.00% of their portfolio | 610 $3.8k | Unchanged |
| Lindbrook Capital, LLC 0.00% of their portfolio | 607 $3.8k | Reduced -928 |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 508 $3.2k | Reduced -133 |
| US BANCORP \DE\ 0.00% of their portfolio | 438 $2.8k | Reduced -41 |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 382 $2.0k | Reduced -155 |
| QUADRANT CAPITAL GROUP LLC 0.00% of their portfolio | 362 $2.3k | Reduced -254 |
| Allworth Financial LP 0.00% of their portfolio | 336 $2.1k | Added +300 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 232 $1.5k | Added +29 |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 162 $1.0k | Unchanged |
| Parallel Advisors, LLC 0.00% of their portfolio | 102 $643 | Added +52 |
| Covestor Ltd 0.00% of their portfolio | 20 $0 | Added +12 |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 1 $6 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |