Vault-13

DAY ONE BIOPHARMACEUTICALS I

COM · Common Stock · CUSIP 23954D109 · ISIN US23954D1090

176 institutional holders -10 vs Q1 2025
86,257,94486.3m shares reported held*
$560.7mreported value*
26 new 71 added 55 reduced 34 sold out net sold ≈ $50.0m (-7.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.6m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $6.50. Options: 7 managers hold calls ($902.0k notional), 4 hold puts ($581.1k).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 93Q4 22: 110Q1 23: 127Q2 23: 141Q3 23: 132Q4 23: 142Q1 24: 150Q2 24: 159Q3 24: 168Q4 24: 166Q1 25: 186Q2 25: 176176Q3 22Q2 23Q1 24Q4 24Q2 25
Numbers
QuarterHolders
Q3 202293
Q4 2022110
Q1 2023127
Q2 2023141
Q3 2023132
Q4 2023142
Q1 2024150
Q2 2024159
Q3 2024168
Q4 2024166
Q1 2025186
Q2 2025176

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q3 23: 69 bought or addedQ3 23: 56 cut or sold outQ4 23: 71 bought or addedQ4 23: 52 cut or sold outQ4 23Q1 24: 74 bought or addedQ1 24: 61 cut or sold outQ2 24: 80 bought or addedQ2 24: 71 cut or sold outQ2 24Q3 24: 97 bought or addedQ3 24: 58 cut or sold outQ4 24: 85 bought or addedQ4 24: 70 cut or sold outQ4 24Q1 25: 109 bought or addedQ1 25: 64 cut or sold outQ2 25: 97 bought or addedQ2 25: 89 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q3 20236956
Q4 20237152
Q1 20247461
Q2 20248071
Q3 20249758
Q4 20248570
Q1 202510964
Q2 20259789

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$2m$4m$6mQ3 24 calls: $2.2mQ3 24 puts: $4.2mQ3 24P/C 1.91Q4 24 calls: $2.1mQ4 24 puts: $3.4mQ4 24P/C 1.61Q1 25 calls: $1.2mQ1 25 puts: $1.8mQ1 25P/C 1.43Q2 25 calls: $902.0kQ2 25 puts: $581.1kQ2 25P/C 0.64
Numbers
QuarterCallsPutsP/C
Q3 2024$2.2m$4.2m1.91
Q4 2024$2.1m$3.4m1.61
Q1 2025$1.2m$1.8m1.43
Q2 2025$902.0k$581.1k0.64

Biggest buyers

BlackRock, Inc. Added +3,072,502+3.1m
DEERFIELD MANAGEMENT COMPANY, L.P. Added +762,391+762.4k
Qube Research & Technologies Ltd Added +663,418+663.4k
RENAISSANCE TECHNOLOGIES LLC Added +652,100+652.1k
MORGAN STANLEY Added +643,733+643.7k
J. Goldman & Co LP New +557,480+557.5k
ALGERT GLOBAL LLC Added +534,662+534.7k
Vestal Point Capital, LP Added +401,873+401.9k
Point72 Asset Management, L.P. New +391,280+391.3k
ExodusPoint Capital Management, LP Added +296,480+296.5k

Biggest sellers

RA CAPITAL MANAGEMENT, L.P. Sold out -5,755,577-5.8m
Estuary Capital Management LP Sold out -3,326,849-3.3m
FMR LLC Reduced -2,357,749-2.4m
BRAIDWELL LP Reduced -1,355,255-1.4m
Boxer Capital Management, LLC Sold out -1,189,943-1.2m
Alyeska Investment Group, L.P. Reduced -1,047,577-1.0m
MARSHALL WACE, LLP Sold out -887,177-887.2k
CITADEL ADVISORS LLC Reduced -635,374-635.4k
Parkman Healthcare Partners LLC Reduced -543,162-543.2k
AQR CAPITAL MANAGEMENT LLC Reduced -338,777-338.8k

Biggest calls

CITIGROUP INC Unchanged $403.0k62.0k shares
Caption Management, LLC Unchanged $260.0k40.0k shares
CITADEL ADVISORS LLC Added $127.4k19.6k shares
SIMPLEX TRADING, LLC Reduced $55.0k8.6k shares
SteelPeak Wealth, LLC Unchanged $35.8k5.5k shares
GROUP ONE TRADING LLC Added $20.8k3.2k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITIGROUP INC Unchanged $403.0k62.0k shares
CITADEL ADVISORS LLC Reduced $152.8k23.5k shares
GROUP ONE TRADING LLC Reduced $25.4k3.9k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution +1.1 pts · filed 2025-07-17 5.8% +1.1 pts 5.8m 2025-07-17
GLAZER CAPITAL, LLC 13G · passive investor new · filed 2026-03-19 5.4% new 5.6m 2026-03-19

Fell to 5% or below in the last year: Vestal Point Capital, LP (0.0%, 2026-05-15), Atlas Venture Fund XI, L.P. (0.0%, 2026-05-14), AI Day1 LLC (0.0%, 2026-04-27), FMR LLC (0.0%, 2026-04-07), VANGUARD GROUP INC (0.0%, 2026-03-26)

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.00% of their portfolio BOSTON, MA 11,342,69911.3m $73.7m $73.7m 0.00% Reduced -2.4m -2,357,749
2 BlackRock, Inc. 0.00% of their portfolio New York, NY 9,830,4319.8m $63.9m $63.9m 0.00% Added +3.1m +3,072,502
3 Atlas Venture Life Science Advisors, LLC 6.31% of their portfolio CAMBRIDGE, MA 6,430,2576.4m $41.8m $41.8m 6.31% Unchanged
4 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 6,176,4956.2m $40.1m $40.1m 0.00% Added +233.3k +233,252
5 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 4,097,6254.1m $26.6m $26.6m 0.01% Added +79.3k +79,255
6 DEERFIELD MANAGEMENT COMPANY, L.P. 0.44% of their portfolio New York, NY 3,723,1313.7m $24.2m $24.2m 0.44% Added +762.4k +762,391
7 Pictet Asset Management Holding SA 0.02% of their portfolio CAROUGE, V8 3,722,7323.7m $24.2m $24.2m 0.02% Added +87.2k +87,152
8 Alyeska Investment Group, L.P. 0.07% of their portfolio CHICAGO, IL 3,012,1873.0m $19.6m $19.6m 0.07% Reduced -1.0m -1,047,577
9 Vestal Point Capital, LP 1.03% of their portfolio NEW YORK, NY 3,000,0003.0m $19.5m $19.5m 1.03% Added +401.9k +401,873
10 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,689,6862.7m $17.5m $17.5m 0.00% Reduced -17.0k -17,013
11 BRAIDWELL LP 0.48% of their portfolio STAMFORD, CT 2,181,5982.2m $14.2m $14.2m 0.48% Reduced -1.4m -1,355,255
12 Polar Capital Holdings Plc 0.07% of their portfolio London, X0 2,109,1772.1m $13.7m $13.7m 0.07% Reduced -240.8k -240,823
13 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,712,4291.7m $11.1m $11.1m 0.00% Added +172.0k +171,964
14 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 1,691,2861.7m $11.0m $11.0m 0.00% Added +121.4k +121,368
15 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 1,416,5531.4m $9.2m $9.2m 0.00% Added +113.6k +113,588
16 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,353,1481.4m $8.8m $8.8m 0.00% Added +643.7k +643,733
17 Hudson Bay Capital Management LP 0.06% of their portfolio STAMFORD, CT 1,296,7001.3m $8.4m $8.4m 0.06% Added +146.3k +146,300
18 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 1,207,8021.2m $7.9m $7.9m 0.01% Reduced -112.3k -112,293
19 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 1,120,6311.1m $7.3m $7.3m 0.00% Reduced -52.5k -52,463
20 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 1,000,5401.0m $6.5m $6.5m 0.01% Added +652.1k +652,100
21 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 965,423965.4k $6.3m $6.3m 0.00% Reduced -81.3k -81,333
22 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 944,202944.2k $6.1m $6.1m 0.01% Added +663.4k +663,418
23 ALGERT GLOBAL LLC 0.12% of their portfolio SAN FRANCISCO, CA 906,042906.0k $5.9m $5.9m 0.12% Added +534.7k +534,662
24 DAFNA Capital Management LLC 1.58% of their portfolio LOS ANGELES, CA 879,163879.2k $5.7m $5.7m 1.58% Added +147.8k +147,800
25 EcoR1 Capital, LLC 0.33% of their portfolio San Francisco, CA 862,068862.1k $5.6m $5.6m 0.33% Unchanged
26 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 703,644703.6k $4.6m $4.6m 0.00% Reduced -635.4k -635,374
27 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 611,161611.2k $4.0m $4.0m 0.00% Added +75.2k +75,164
28 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 578,763578.8k $3.8m $3.8m 0.00% Added +50.6k +50,615
29 J. Goldman & Co LP 0.11% of their portfolio NEW YORK, NY 557,480557.5k $3.6m $3.6m 0.11% New
30 Parkman Healthcare Partners LLC 0.38% of their portfolio STAMFORD, CT 500,000500.0k $3.2m $3.2m 0.38% Reduced -543.2k -543,162
31 KENNEDY CAPITAL MANAGEMENT LLC 0.07% of their portfolio ST LOUIS, MO 453,520453.5k $2.9m $2.9m 0.07% Added +125.8k +125,829
32 Stonepine Capital Management, LLC 2.88% of their portfolio Bend, OR 450,000450.0k $2.9m $2.9m 2.88% Added +101.2k +101,180
33 Point72 Asset Management, L.P. 0.01% of their portfolio STAMFORD, CT 391,280391.3k $2.5m $2.5m 0.01% New
34 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 349,948349.9k $2.3m $2.3m 0.00% Added +164.2k +164,215
35 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 348,109348.1k $2.3m $2.3m 0.00% Added +192.9k +192,900
36 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 325,288325.3k $2.1m $2.1m 0.00% Reduced -9.2k -9,234
37 ExodusPoint Capital Management, LP 0.03% of their portfolio NEW YORK, NY 320,217320.2k $2.1m $2.1m 0.03% Added +296.5k +296,480
38 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 307,853307.9k $2.0m $2.0m 0.00% Added +59.5k +59,473
39 Y-Intercept (Hong Kong) Ltd 0.04% of their portfolio HONG KONG, K3 281,528281.5k $1.8m $1.8m 0.04% New
40 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 279,850279.9k $1.8m $1.8m 0.00% Reduced -338.8k -338,777
41 Parkwood LLC 0.16% of their portfolio CLEVELAND, OH 275,000275.0k $1.8m $1.8m 0.16% Unchanged
42 SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.05% of their portfolio BALA CYNWYD, PA 263,313263.3k $1.7m $1.7m 0.05% Reduced -59.6k -59,562
43 Fisher Asset Management, LLC 0.00% of their portfolio PLANO, TX 221,983222.0k $1.4m $1.4m 0.00% Reduced -53.2k -53,224
44 Cubist Systematic Strategies, LLC 0.01% of their portfolio STAMFORD, CT 193,857193.9k $1.3m $1.3m 0.01% New
45 SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio London, X0 180,133180.1k $1.2m $1.2m 0.00% New
46 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 175,416175.4k $1.1m $1.1m 0.00% Added +63.1k +63,137
47 SPHERA FUNDS MANAGEMENT LTD. 0.30% of their portfolio TEL AVIV, L3 175,371175.4k $1.1m $1.1m 0.30% Reduced -159.6k -159,616
48 NORGES BANK 0.00% of their portfolio OSLO, Q8 169,000169.0k $1.1m $1.1m 0.00% Unchanged
49 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 150,372150.4k $977.4k $977.4k 0.00% Added +10.7k +10,714
50 National Philanthropic Trust 0.01% of their portfolio Jenkintown, PA 150,000150.0k $975.0k $975.0k 0.01% New
51 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 143,453143.5k $932.4k $932.4k 0.00% Added +127.1k +127,113
52 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 136,276136.3k $885.8k $885.8k 0.00% Added +53.0k +53,018
53 HSBC HOLDINGS PLC 0.00% of their portfolio LONDON, X0 131,668131.7k $846.0k $846.0k 0.00% Added +81.5k +81,491
54 Swiss National Bank 0.00% of their portfolio ZURICH, V8 125,800125.8k $817.7k $817.7k 0.00% Added +18.3k +18,300
55 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 125,462125.5k $815.5k $815.5k 0.00% Reduced -36.5k -36,542
56 NEOS Investment Management LLC 0.01% of their portfolio Westport, CT 124,310124.3k $808.0k $808.0k 0.01% Added +33.2k +33,187
57 Tema ETFs LLC 0.21% of their portfolio New York, NY 124,310124.3k $808.0k $808.0k 0.21% Added +33.2k +33,187
58 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 116,060116.1k $754.4k $754.4k 0.00% Added +34.2k +34,216
59 Trexquant Investment LP 0.01% of their portfolio STAMFORD, CT 115,427115.4k $750.3k $750.3k 0.01% Reduced -89.4k -89,355
60 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 110,000110.0k $715.0k $715.0k 0.00% Unchanged
61 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 108,371108.4k $704.4k $704.4k 0.00% Reduced -56.3k -56,305
62 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% of their portfolio CHICAGO, IL 107,249107.2k $697.1k $697.1k 0.02% Reduced -6.0k -6,001
63 Woodline Partners LP 0.00% of their portfolio San Francisco, CA 100,516100.5k $653.4k $653.4k 0.00% Reduced -112.6k -112,638
64 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 100,502100.5k $653.3k $653.3k 0.00% Reduced -8.1k -8,066
65 Schonfeld Strategic Advisors LLC 0.00% of their portfolio NEW YORK, NY 99,59099.6k $647.3k $647.3k 0.00% Added +34.1k +34,065
66 Rafferty Asset Management, LLC 0.00% of their portfolio New York, NY 98,69198.7k $641.5k $641.5k 0.00% Reduced -20.5k -20,469
67 Hennion & Walsh Asset Management, Inc. 0.03% of their portfolio Parsippany, NJ 96,82196.8k $629.3k $629.3k 0.03% Reduced -41.1k -41,147
68 UBS Group AG 0.00% of their portfolio ZURICH, V8 89,47589.5k $581.6k $581.6k 0.00% Reduced -34.7k -34,701
69 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 89,10289.1k $579.2k $579.2k 0.00% Added +27.6k +27,566
70 Dynamic Technology Lab Private Ltd 0.07% of their portfolio SINGAPORE, U0 83,22383.2k $541.0k $541.0k 0.07% Added +34.8k +34,766
71 LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio LOS ANGELES, CA 82,25782.3k $534.7k $534.7k 0.00% Added +27.3k +27,335
72 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 81,30381.3k $528.5k $528.5k 0.00% Reduced -1.8k -1,767
73 GC Wealth Management RIA, LLC 0.04% of their portfolio Cambridge, MA 80,00080.0k $520.0k $520.0k 0.04% New
74 DARK FOREST CAPITAL MANAGEMENT LP 0.02% of their portfolio NEW YORK, NY 78,42278.4k $509.7k $509.7k 0.02% New
75 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 72,56772.6k $471.7k $471.7k 0.00% Added +18.9k +18,871
76 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 68,50768.5k $445.3k $445.3k 0.00% Added +22.1k +22,083
77 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 67,79067.8k $440.6k $440.6k 0.00% Unchanged
78 Virtus Investment Advisers, LLC 0.15% of their portfolio HARTFORD, CT 66,42766.4k $431.8k $431.8k 0.15% Added +38.4k +38,397
79 GSA CAPITAL PARTNERS LLP 0.03% of their portfolio LONDON, X0 63,54663.5k $413.0k $413.0k 0.03% Added +19.8k +19,843
80 Nebula Research & Development LLC 0.03% of their portfolio New York, NY 60,66560.7k $394.3k $394.3k 0.03% Added +3.5k +3,533
81 DRW Securities, LLC 0.03% of their portfolio CHICAGO, IL 57,80457.8k $375.7k $375.7k 0.03% New
82 Legal & General Group Plc 0.00% of their portfolio London, X0 56,86456.9k $369.6k $369.6k 0.00% Reduced -3.7k -3,701
83 Man Group plc 0.00% of their portfolio LONDON, X0 56,86256.9k $369.6k $369.6k 0.00% Added +17.9k +17,950
84 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 56,12056.1k $364.8k $364.8k 0.00% Added +650 +650
85 ALPS ADVISORS INC 0.00% of their portfolio Denver, CO 54,70854.7k $355.6k $355.6k 0.00% Reduced -18.6k -18,635
86 Erste Asset Management GmbH 0.00% of their portfolio VIENNA, C4 51,20051.2k $331.3k $331.3k 0.00% Unchanged
87 Diametric Capital, LP 0.17% of their portfolio BOSTON, MA 49,94149.9k $324.6k $324.6k 0.17% Added +25.5k +25,465
88 INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio WEST PALM BEACH, FL 45,39745.4k $295.1k $295.1k 0.00% Reduced -5.8k -5,767
89 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 44,44244.4k $288.9k $288.9k 0.00% Added +10.8k +10,832
90 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 44,24444.2k $287.4k $287.4k 0.00% Added +6.3k +6,252
91 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 38,20438.2k $248.3k $248.3k 0.00% Added +8.5k +8,496
92 TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio STAMFORD, CT 36,39336.4k $236.6k $236.6k 0.00% Reduced -14.4k -14,401
93 MARTINGALE ASSET MANAGEMENT L P 0.01% of their portfolio BOSTON, MA 35,00035.0k $227.5k $227.5k 0.01% Reduced -26.6k -26,597
94 Pale Fire Capital SE 0.02% of their portfolio Prague, 2N 34,84334.8k $226.5k $226.5k 0.02% Added +3.1k +3,150
95 Knott David M Jr 0.10% of their portfolio SYOSSET, NY 33,71433.7k $219.1k $219.1k 0.10% New
96 Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio ZURICH, V8 32,93932.9k $214.1k $214.1k 0.00% Added +18.7k +18,670
97 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 32,88132.9k $213.7k $213.7k 0.00% Reduced -32.4k -32,430
98 Bayesian Capital Management, LP 0.03% of their portfolio Brooklyn, NY 28,10028.1k $182.7k $182.7k 0.03% Added +10.1k +10,100
99 ADAR1 Capital Management, LLC 0.03% of their portfolio AUSTIN, TX 28,02328.0k $182.2k $182.2k 0.03% Unchanged
100 IEQ CAPITAL, LLC 0.00% of their portfolio Foster City, CA 27,94827.9k $181.7k $181.7k 0.00% Reduced -9.1k -9,064