Vault-13

DAY ONE BIOPHARMACEUTICALS I

COM · Common Stock · CUSIP 23954D109 · ISIN US23954D1090

110 institutional holders +17 vs Q3 2022
60,642,78360.6m shares reported held*
$1.3bnreported value*
21 new 38 added 25 reduced 6 sold out net sold ≈ $30.8m (-1.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.2m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $21.42. Options: 5 managers hold calls ($3.0m notional), 5 hold puts ($4.4m).

Trends to Q4 2022

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 93Q4 22: 110110Q3 22Q4 22
Numbers
QuarterHolders
Q3 202293
Q4 2022110

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$2m$4m$6mQ3 22 calls: $2.9mQ3 22 puts: $4.1mQ3 22P/C 1.41Q4 22 calls: $3.0mQ4 22 puts: $4.4mQ4 22P/C 1.49
Numbers
QuarterCallsPutsP/C
Q3 2022$2.9m$4.1m1.41
Q4 2022$3.0m$4.4m1.49

Biggest buyers

PATHWAY CAPITAL MANAGEMENT, LP Added +592,559+592.6k
LORD, ABBETT & CO. LLC Added +508,105+508.1k
VANGUARD GROUP INC Added +493,532+493.5k
GREAT POINT PARTNERS LLC Added +473,830+473.8k
Point72 Asset Management, L.P. New +461,631+461.6k
STATE STREET CORP Added +414,797+414.8k
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +260,000+260.0k
FMR LLC Added +210,820+210.8k
Polar Capital Holdings Plc Added +163,973+164.0k
Woodline Partners LP New +151,028+151.0k

Biggest sellers

Canaan Partners XI LLC Reduced -4,415,898-4.4m
Atlas Venture Life Science Advisors, LLC Reduced -600,854-600.9k
TANG CAPITAL MANAGEMENT LLC Sold out -400,000-400.0k
BlackRock Inc. Reduced -105,967-106.0k
Cubist Systematic Strategies, LLC Reduced -82,028-82.0k
DEERFIELD MANAGEMENT COMPANY, L.P. Reduced -67,967-68.0k
VOLORIDGE INVESTMENT MANAGEMENT, LLC Reduced -61,224-61.2k
CITIGROUP INC Reduced -41,733-41.7k
CITADEL ADVISORS LLC Reduced -41,077-41.1k
PRUDENTIAL FINANCIAL INC Sold out -38,315-38.3k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $1.4m64.2k shares
GROUP ONE TRADING LLC Added $996.4k46.3k shares
CITADEL ADVISORS LLC New $572.4k26.6k shares
SIMPLEX TRADING, LLC Reduced $27.0k1.3k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

GROUP ONE TRADING LLC Reduced $3.8m176.9k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $486.4k22.6k shares
CITADEL ADVISORS LLC Reduced $124.8k5.8k shares
SIMPLEX TRADING, LLC Reduced $10.0k500 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution +1.1 pts · filed 2025-07-17 5.8% +1.1 pts 5.8m 2025-07-17
GLAZER CAPITAL, LLC 13G · passive investor new · filed 2026-03-19 5.4% new 5.6m 2026-03-19

Fell to 5% or below in the last year: Vestal Point Capital, LP (0.0%, 2026-05-15), Atlas Venture Fund XI, L.P. (0.0%, 2026-05-14), AI Day1 LLC (0.0%, 2026-04-27), FMR LLC (0.0%, 2026-04-07), VANGUARD GROUP INC (0.0%, 2026-03-26)

Holders, Q4 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.02% of their portfolio BOSTON, MA 9,002,3119.0m $193.7m $193.7m 0.02% Added +210.8k +210,820
2 Atlas Venture Life Science Advisors, LLC 19.62% of their portfolio CAMBRIDGE, MA 7,568,3177.6m $162.9m $162.9m 19.62% Reduced -600.9k -600,854
3 RA CAPITAL MANAGEMENT, L.P. 3.07% of their portfolio BOSTON, MA 7,040,6227.0m $151.5m $151.5m 3.07% Unchanged
4 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.17% of their portfolio Boston, MA 3,300,0003.3m $71.0m $71.0m 0.17% Added +260.0k +260,000
5 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 3,108,9733.1m $66.9m $66.9m 0.00% Added +493.5k +493,532
6 Canaan Partners XI LLC 43.06% of their portfolio MENLO PARK, CA 2,548,4032.5m $54.8m $54.8m 43.06% Reduced -4.4m -4,415,898
7 FRANKLIN RESOURCES INC 0.03% of their portfolio San Mateo, CA 2,472,8492.5m $53.2m $53.2m 0.03% Reduced -3.9k -3,857
8 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,456,5352.5m $52.9m $52.9m 0.00% Added +414.8k +414,797
9 BlackRock Inc. 0.00% of their portfolio New York, NY 2,435,2682.4m $52.4m $52.4m 0.00% Reduced -106.0k -105,967
10 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 2,182,5782.2m $47.0m $47.0m 0.01% Added +87.7k +87,665
11 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 1,768,1021.8m $38.0m $38.0m 0.01% Added +43.0k +42,960
12 VIKING GLOBAL INVESTORS LP 0.17% of their portfolio STAMFORD, CT 1,558,5631.6m $33.5m $33.5m 0.17% Unchanged
13 Polar Capital Holdings Plc 0.24% of their portfolio London, X0 1,399,5481.4m $30.1m $30.1m 0.24% Added +164.0k +163,973
14 BRAIDWELL LP 0.90% of their portfolio STAMFORD, CT 1,246,5391.2m $26.8m $26.8m 0.90% First filing
15 Boxer Capital, LLC 1.35% of their portfolio San Diego, CA 1,189,9431.2m $25.6m $25.6m 1.35% Unchanged
16 LORD, ABBETT & CO. LLC 0.04% of their portfolio JERSEY CITY, NJ 1,012,3561.0m $21.8m $21.8m 0.04% Added +508.1k +508,105
17 PATHWAY CAPITAL MANAGEMENT, LP 38.24% of their portfolio Irvine, CA 995,686995.7k $21.4m $21.4m 38.24% Added +592.6k +592,559
18 DEERFIELD MANAGEMENT COMPANY, L.P. 0.43% of their portfolio New York, NY 964,033964.0k $20.7m $20.7m 0.43% Reduced -68.0k -67,967
19 Nicholas Investment Partners, LP 1.48% of their portfolio RANCHO SANTA FE, CA 786,554786.6k $16.9m $16.9m 1.48% Added +29.1k +29,147
20 Commodore Capital LP 2.40% of their portfolio NEW YORK, NY 739,661739.7k $15.9m $15.9m 2.40% Unchanged
21 D. E. Shaw & Co., Inc. 0.02% of their portfolio New York, NY 601,322601.3k $12.9m $12.9m 0.02% Added +34.2k +34,174
22 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 580,484580.5k $12.5m $12.5m 0.00% Added +25.9k +25,854
23 GREAT POINT PARTNERS LLC 2.42% of their portfolio Greenwich, CT 544,451544.5k $11.7m $11.7m 2.42% Added +473.8k +473,830
24 Driehaus Capital Management LLC 0.15% of their portfolio Chicago, IL 483,484483.5k $10.4m $10.4m 0.15% Reduced -6.5k -6,488
25 Point72 Asset Management, L.P. 0.04% of their portfolio STAMFORD, CT 461,631461.6k $9.9m $9.9m 0.04% New
26 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 421,127421.1k $2.8m $2.8m 0.00% Reduced -27.6k -27,643
27 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 225,269225.3k $4.8m $4.8m 0.00% Added +219 +219
28 Parkman Healthcare Partners LLC 1.29% of their portfolio STAMFORD, CT 224,483224.5k $4.8m $4.8m 1.29% Added +12.3k +12,292
29 Rafferty Asset Management, LLC 0.04% of their portfolio New York, NY 205,446205.4k $4.4m $4.4m 0.04% Added +60.8k +60,812
30 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 203,905203.9k $4.4m $4.4m 0.00% Added +5.0k +4,953
31 SAMSARA BIOCAPITAL, LLC 0.91% of their portfolio PALO ALTO, CA 196,425196.4k $4.2m $4.2m 0.91% Unchanged
32 Woodline Partners LP 0.04% of their portfolio San Francisco, CA 151,028151.0k $3.3m $3.3m 0.04% New
33 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 147,426147.4k $3.2m $3.2m 0.00% Added +49.5k +49,526
34 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio JUPITER, FL 146,041146.0k $3.1m $3.1m 0.02% Reduced -61.2k -61,224
35 Alyeska Investment Group, L.P. 0.03% of their portfolio CHICAGO, IL 143,218143.2k $3.1m $3.1m 0.03% Added +1.1k +1,075
36 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 138,608138.6k $3.0m $3.0m 0.00% Added +87.2k +87,200
37 UBS Group AG 0.00% of their portfolio ZURICH, V8 129,857129.9k $2.8m $2.8m 0.00% Added +108.3k +108,251
38 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 124,473124.5k $2.7m $2.7m 0.00% Reduced -31.7k -31,732
39 Schonfeld Strategic Advisors LLC 0.02% of their portfolio NEW YORK, NY 115,500115.5k $2.5m $2.5m 0.02% Added +92.1k +92,113
40 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 110,000110.0k $2.4m $2.4m 0.00% Unchanged
41 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 109,552109.6k $2.4m $2.4m 0.00% First filing
42 NORGES BANK 0.00% of their portfolio OSLO, Q8 108,000108.0k $2.3m $2.3m 0.00% Not comparable
43 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 100,501100.5k $2.2m $2.2m 0.00% Reduced -1.7k -1,722
44 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 90,01390.0k $1.9m $1.9m 0.00% Reduced -41.7k -41,733
45 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 87,26587.3k $1.9m $1.9m 0.00% Reduced -20.1k -20,140
46 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 72,00672.0k $1.6m $1.6m 0.00% Reduced -5.3k -5,308
47 ExodusPoint Capital Management, LP 0.02% of their portfolio NEW YORK, NY 65,92965.9k $1.4m $1.4m 0.02% Added +53.0k +53,026
48 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 59,15459.2k $1.3m $1.3m 0.00% Added +1.7k +1,697
49 HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.01% of their portfolio TORONTO, A6 54,00054.0k $1.2m $1.2m 0.01% Unchanged
50 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 51,81351.8k $1.1m $1.1m 0.00% Added +23 +23
51 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 49,85649.9k $1.1m $1.1m 0.01% Added +9.7k +9,712
52 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 46,33246.3k $997.1k $997.1k 0.00% Unchanged
53 GROUP ONE TRADING LLC 0.03% of their portfolio CHICAGO, IL 45,58645.6k $981.0k $981.0k 0.03% Reduced -13.5k -13,537
54 Cubist Systematic Strategies, LLC 0.01% of their portfolio STAMFORD, CT 43,55843.6k $937.4k $937.4k 0.01% Reduced -82.0k -82,028
55 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 42,95343.0k $924.0k $924.0k 0.00% Added +711 +711
56 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 41,90041.9k $901.7k $901.7k 0.00% Added +3.9k +3,900
57 Fisher Asset Management, LLC 0.00% of their portfolio PLANO, TX 36,22636.2k $780.0k $780.0k 0.00% Reduced -9.3k -9,300
58 MARTINGALE ASSET MANAGEMENT L P 0.01% of their portfolio BOSTON, MA 32,04232.0k $689.5k $689.5k 0.01% New
59 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 30,81630.8k $663.2k $663.2k 0.00% New
60 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 27,89827.9k $600.4k $600.4k 0.00% Unchanged
61 Cheyne Capital Management (UK) LLP 1.03% of their portfolio LONDON, X0 27,22327.2k $585.8k $585.8k 1.03% New
62 Penn Mutual Asset Management 0.60% of their portfolio Conshohocken, PA 24,92024.9k $536.3k $536.3k 0.60% New
63 Legato Capital Management LLC 0.10% of their portfolio San Francisco, CA 23,77423.8k $511.6k $511.6k 0.10% New
64 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 20,72120.7k $445.9k $445.9k 0.00% Reduced -258 -258
65 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 20,56820.6k $442.6k $442.6k 0.00% Reduced -28.8k -28,800
66 Parkwood LLC 0.08% of their portfolio CLEVELAND, OH 19,35319.4k $416.0k $416.0k 0.08% Added +878 +878
67 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 16,81016.8k $361.8k $361.8k 0.00% Added +5.2k +5,212
68 Jump Financial, LLC 0.02% of their portfolio Chicago, IL 16,36416.4k $352.2k $352.2k 0.02% New
69 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 15,57315.6k $335.1k $335.1k 0.00% Unchanged
70 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 15,29215.3k $329.1k $329.1k 0.00% Added +3.3k +3,349
71 Laurion Capital Management LP 0.01% of their portfolio NEW YORK, NY 15,00015.0k $322.8k $322.8k 0.01% Added +763 +763
72 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 13,27013.3k $285.6k $285.6k 0.00% New
73 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 13,13913.1k $283.0k $283.0k 0.00% Added +3.5k +3,519
74 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 13,09713.1k $281.8k $281.8k 0.00% Reduced -48 -48
75 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 13,02813.0k $280.4k $280.4k 0.00% New
76 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 11,05411.1k $237.9k $237.9k 0.00% Added +125 +125
77 E Fund Management Co., Ltd. 0.02% of their portfolio GUANGZHOU, F4 10,76410.8k $232.0k $232.0k 0.02% New
78 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 10,65010.7k $229.2k $229.2k 0.00% Reduced -3.1k -3,110
79 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 9,8839.9k $212.7k $212.7k 0.00% New
80 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 9,6459.6k $207.6k $207.6k 0.00% New
81 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 9,5119.5k $204.7k $204.7k 0.00% New
82 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 6,8716.9k $147.9k $147.9k 0.00% Reduced -41.1k -41,077
83 VIRTUS ADVISERS, LLC 0.07% of their portfolio HARTFORD, CT 6,4826.5k $139.5k $139.5k 0.07% Reduced -119 -119
84 Quantbot Technologies LP 0.01% of their portfolio NEW YORK, NY 5,9005.9k $127.0k $127.0k 0.01% New
85 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 4,3394.3k $93.0k $93.0k 0.00% Added +2.8k +2,832
86 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 3,5773.6k $77.0k $77.0k 0.00% Unchanged
87 Legal & General Group Plc 0.00% of their portfolio London, X0 2,5852.6k $55.6k $55.6k 0.00% Unchanged
88 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 2,4362.4k $53.0k $53.0k 0.00% Added +250 +250
89 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 2,1712.2k $47.3k $47.3k 0.00% Unchanged
90 TCI Wealth Advisors, Inc. 0.01% of their portfolio Tucson, AZ 1,9742.0k $42.5k $42.5k 0.01% Unchanged
91 Metropolitan Life Insurance Co/NY 0.00% of their portfolio New York, NY 1,8251.8k $39.3k $39.3k 0.00% Unchanged
92 Capital Analysts, LLC 0.00% of their portfolio FORT WASHINGTON, PA 750750 $16.0k $16.0k 0.00% Unchanged
93 China Universal Asset Management Co., Ltd. 0.01% of their portfolio SHANGHAI, F4 747747 $16.1k $16.1k 0.01% Added +59 +59
94 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 425425 $9.1k $9.1k 0.00% New
95 Leonteq Securities AG 0.00% of their portfolio ZURICH, V8 350350 $7.5k $7.5k 0.00% New
96 Daiwa Securities Group Inc. 0.00% of their portfolio CHIYODA-KU,TOKYO, M0 296296 $6.0k $6.0k 0.00% Added +115 +115
97 Red Tortoise LLC 0.00% of their portfolio ATLANTA, GA 196196 $4.2k $4.2k 0.00% First filing
98 Washington Trust Advisors, Inc. 0.00% of their portfolio WELLESLEY, MA 163163 $3.5k $3.5k 0.00% Unchanged
99 BELLEVUE ASSET MANAGEMENT, LLC 0.00% of their portfolio BELLEVUE, WA 6262 $1.3k $1.3k 0.00% Unchanged
100 Spire Wealth Management 0.00% of their portfolio MCLEAN, VA 4040 $1.0k $1.0k 0.00% Unchanged