Vault-13

DICE THERAPEUTICS INC

COM · CUSIP 23345J104

109 institutional holders +30 vs Q3 2022
47,458,39047.5m shares reported held*
$1.5bnreported value*
39 new 43 added 20 reduced 12 sold out net bought ≈ $251.1m (+8.0m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($198.5k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $31.20. Options: 5 managers hold calls ($411.7k notional), 6 hold puts ($3.5m).

Trends to Q4 2022

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 79Q4 22: 109109Q3 22Q4 22
Numbers
QuarterHolders
Q3 202279
Q4 2022109

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ3 22 calls: $55.9mQ3 22 puts: $21.3mQ3 22P/C 0.38Q4 22 calls: $411.7kQ4 22 puts: $3.5mQ4 22P/C 8.50
Numbers
QuarterCallsPutsP/C
Q3 2022$55.9m$21.3m0.38
Q4 2022$411.7k$3.5m8.50

Biggest buyers

FMR LLC Added +1,774,433+1.8m
RA CAPITAL MANAGEMENT, L.P. Added +1,640,000+1.6m
Avoro Capital Advisors LLC Added +1,450,555+1.5m
BlackRock Inc. Added +1,145,411+1.1m
ALKEON CAPITAL MANAGEMENT LLC New +1,038,125+1.0m
Deep Track Capital, LP Added +734,143+734.1k
D. E. Shaw & Co., Inc. New +682,934+682.9k
PRICE T ROWE ASSOCIATES INC /MD/ Added +666,503+666.5k
VANGUARD GROUP INC Added +516,658+516.7k
Woodline Partners LP Added +511,385+511.4k

Biggest sellers

JANUS HENDERSON GROUP PLC Reduced -2,177,878-2.2m
CITADEL ADVISORS LLC Reduced -455,611-455.6k
Logos Global Management LP Reduced -425,251-425.3k
Sands Capital Alternatives, LLC Reduced -400,000-400.0k
PERCEPTIVE ADVISORS LLC Reduced -394,062-394.1k
Soleus Capital Management, L.P. Reduced -361,911-361.9k
OUP Management Co., LLC Reduced -268,347-268.3k
ArrowMark Colorado Holdings LLC Reduced -216,302-216.3k
New Leaf Venture Partners, L.L.C. Reduced -185,000-185.0k
Miller Investment Management, LP Sold out -180,901-180.9k

Biggest calls

CITADEL ADVISORS LLC Reduced $259.0k8.3k shares
SIMPLEX TRADING, LLC Reduced $134.0k4.3k shares
GROUP ONE TRADING LLC Reduced $18.7k600 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares
Cutler Group LLC / CA Reduced $0200 shares

Biggest puts

CITADEL ADVISORS LLC Reduced $1.3m40.5k shares
Caption Management, LLC New $1.1m36.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $574.1k18.4k shares
SIMPLEX TRADING, LLC Added $496.0k15.9k shares
GROUP ONE TRADING LLC Reduced $40.6k1.3k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Holders, Q4 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 4.33% of their portfolio BOSTON, MA 6,848,9116.8m $213.7m $213.7m 4.33% Added +1.6m +1,640,000
2 FMR LLC 0.02% of their portfolio BOSTON, MA 5,197,3575.2m $162.2m $162.2m 0.02% Added +1.8m +1,774,433
3 Northpond Ventures, LLC 55.73% of their portfolio Bethesda, MD 3,292,8713.3m $102.7m $102.7m 55.73% Unchanged
4 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 3,219,9603.2m $100.5m $100.5m 0.02% Added +666.5k +666,503
5 BlackRock Inc. 0.00% of their portfolio New York, NY 3,052,1023.1m $95.2m $95.2m 0.00% Added +1.1m +1,145,411
6 Sands Capital Alternatives, LLC 23.49% of their portfolio ARLINGTON, VA 2,748,9702.7m $85.8m $85.8m 23.49% Reduced -400.0k -400,000
7 Avoro Capital Advisors LLC 1.18% of their portfolio NEW YORK, NY 2,525,5552.5m $78.8m $78.8m 1.18% Added +1.5m +1,450,555
8 Driehaus Capital Management LLC 0.91% of their portfolio Chicago, IL 1,953,7062.0m $61.0m $61.0m 0.91% Reduced -18.1k -18,087
9 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,903,4161.9m $59.4m $59.4m 0.00% Added +516.7k +516,658
10 Deep Track Capital, LP 2.36% of their portfolio GREENWICH, CT 1,734,1431.7m $54.1m $54.1m 2.36% Added +734.1k +734,143
11 JANUS HENDERSON GROUP PLC 0.02% of their portfolio LONDON, X0 1,093,4181.1m $34.1m $34.1m 0.02% Reduced -2.2m -2,177,878
12 ALKEON CAPITAL MANAGEMENT LLC 0.24% of their portfolio New York, NY 1,038,1251.0m $32.4m $32.4m 0.24% New
13 Woodline Partners LP 0.43% of their portfolio San Francisco, CA 995,129995.1k $31.0m $31.0m 0.43% Added +511.4k +511,385
14 BAKER BROS. ADVISORS LP 0.16% of their portfolio NEW YORK, NY 862,207862.2k $26.9m $26.9m 0.16% Added +274.0k +273,972
15 BRAIDWELL LP 0.88% of their portfolio STAMFORD, CT 839,075839.1k $26.2m $26.2m 0.88% First filing
16 Venrock Adviser, LLC 4.30% of their portfolio NEW YORK, NY 819,000819.0k $25.6m $25.6m 4.30% Added +54.0k +54,021
17 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 793,952794.0k $24.8m $24.8m 0.00% Added +299.6k +299,623
18 D. E. Shaw & Co., Inc. 0.04% of their portfolio New York, NY 682,934682.9k $21.3m $21.3m 0.04% New
19 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 666,826666.8k $20.8m $20.8m 0.00% Added +182.2k +182,224
20 Logos Global Management LP 2.41% of their portfolio San Francisco, CA 660,000660.0k $20.6m $20.6m 2.41% Reduced -425.3k -425,251
21 NOVO HOLDINGS A/S 0.91% of their portfolio HELLERUP, G7 465,000465.0k $14.5m $14.5m 0.91% New
22 ArrowMark Colorado Holdings LLC 0.15% of their portfolio Denver, CO 414,831414.8k $12.9m $12.9m 0.15% Reduced -216.3k -216,302
23 Balyasny Asset Management L.P. 0.04% of their portfolio Chicago, IL 398,477398.5k $12.4m $12.4m 0.04% Reduced -61.2k -61,200
24 New Leaf Venture Partners, L.L.C. 8.40% of their portfolio New York, NY 371,693371.7k $11.6m $11.6m 8.40% Reduced -185.0k -185,000
25 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 336,358336.4k $10.5m $10.5m 0.01% New
26 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 309,137309.1k $9.6m $9.6m 0.00% Added +78.7k +78,657
27 PERCEPTIVE ADVISORS LLC 0.26% of their portfolio NEW YORK, NY 293,362293.4k $9.2m $9.2m 0.26% Reduced -394.1k -394,062
28 OUP Management Co., LLC 13.67% of their portfolio Bala Cynwyd, PA 268,346268.3k $8.4m $8.4m 13.67% Reduced -268.3k -268,347
29 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 253,277253.3k $7.9m $7.9m 0.00% Added +64.6k +64,601
30 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 210,312210.3k $6.6m $6.6m 0.01% Added +33.8k +33,811
31 Candriam S.C.A. 0.04% of their portfolio STRASSEN, N4 210,000210.0k $6.6m $6.6m 0.04% New
32 SAMSARA BIOCAPITAL, LLC 1.36% of their portfolio PALO ALTO, CA 202,773202.8k $6.3m $6.3m 1.36% Reduced -50.7k -50,693
33 Soleus Capital Management, L.P. 0.78% of their portfolio GREENWICH, CT 173,447173.4k $5.4m $5.4m 0.78% Reduced -361.9k -361,911
34 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 171,007171.0k $5.3m $5.3m 0.00% Added +128.6k +128,646
35 Casdin Capital, LLC 0.40% of their portfolio New York, NY 165,000165.0k $5.1m $5.1m 0.40% New
36 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 149,555149.6k $4.7m $4.7m 0.01% Reduced -455.6k -455,611
37 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio JUPITER, FL 148,194148.2k $4.6m $4.6m 0.03% New
38 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 143,739143.7k $4.5m $4.5m 0.00% Added +55.2k +55,240
39 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 136,982137.0k $4.3m $4.3m 0.00% Added +42.1k +42,118
40 DAFNA Capital Management LLC 1.09% of their portfolio LOS ANGELES, CA 123,500123.5k $3.9m $3.9m 1.09% Added +45.0k +45,000
41 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 121,300121.3k $3.8m $3.8m 0.01% New
42 Graham Capital Management, L.P. 0.14% of their portfolio ROWAYTON, CT 116,341116.3k $3.6m $3.6m 0.14% Added +106.2k +106,170
43 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 84,02584.0k $2.6m $2.6m 0.00% Added +46.0k +45,968
44 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 78,59078.6k $2.5m $2.5m 0.01% New
45 Swiss National Bank 0.00% of their portfolio ZURICH, V8 72,80072.8k $2.3m $2.3m 0.00% Added +50.3k +50,300
46 KENNEDY CAPITAL MANAGEMENT LLC 0.05% of their portfolio ST LOUIS, MO 62,43562.4k $1.9m $1.9m 0.05% New
47 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 60,73960.7k $1.9m $1.9m 0.00% Added +3.5k +3,513
48 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 55,30955.3k $1.7m $1.7m 0.00% Added +2.3k +2,298
49 Informed Momentum Co LLC 0.34% of their portfolio SOLANA BEACH, CA 53,40853.4k $1.7m $1.7m 0.34% New
50 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 51,59051.6k $1.6m $1.6m 0.00% Added +9.1k +9,099
51 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 46,07946.1k $1.4m $1.4m 0.01% New
52 SVB FINANCIAL GROUP 3.61% of their portfolio Dallas, TX 42,35842.4k $1.3m $1.3m 3.61% First filing
53 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 40,39040.4k $1.3m $1.3m 0.00% Added +21.0k +20,957
54 HighVista Strategies LLC 0.72% of their portfolio BOSTON, MA 39,06439.1k $1.2m $1.2m 0.72% New
55 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 37,58237.6k $1.2m $1.2m 0.00% Added +12.7k +12,728
56 Global IMC LLC 0.29% of their portfolio SOLANA BEACH, CA 36,42036.4k $1.1m $1.1m 0.29% New
57 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 30,07830.1k $938.4k $938.4k 0.00% Added +13.6k +13,611
58 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 29,95730.0k $934.7k $934.7k 0.00% New
59 Jump Financial, LLC 0.05% of their portfolio Chicago, IL 29,60029.6k $923.5k $923.5k 0.05% New
60 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 29,56329.6k $922.4k $922.4k 0.00% New
61 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 29,29329.3k $913.9k $913.9k 0.00% Added +18.1k +18,074
62 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 26,90026.9k $839.3k $839.3k 0.00% Added +800 +800
63 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 26,39526.4k $823.5k $823.5k 0.00% Added +17.4k +17,399
64 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 22,64822.6k $706.6k $706.6k 0.00% Reduced -2.8k -2,783
65 Caption Management, LLC 0.12% of their portfolio OKLAHOMA CITY, OK 22,29922.3k $695.7k $695.7k 0.12% New
66 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 19,49519.5k $608.2k $608.2k 0.00% New
67 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 18,85118.9k $588.2k $588.2k 0.00% Added +2.9k +2,930
68 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 17,13617.1k $534.6k $534.6k 0.00% Added +5.6k +5,602
69 M&T Bank Corp 0.00% of their portfolio BUFFALO, NY 17,12217.1k $534.1k $534.1k 0.00% Reduced -11.4k -11,354
70 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 16,74216.7k $522.4k $522.4k 0.00% Added +3.3k +3,263
71 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 16,61516.6k $518.4k $518.4k 0.00% Added +4.8k +4,808
72 SG Americas Securities, LLC 0.01% of their portfolio NEW YORK, NY 16,60316.6k $518.0k $518.0k 0.01% New
73 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 16,11816.1k $502.9k $502.9k 0.00% New
74 Legal & General Group Plc 0.00% of their portfolio London, X0 14,33814.3k $447.3k $447.3k 0.00% Added +9.3k +9,256
75 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 13,13713.1k $409.9k $409.9k 0.00% First filing
76 GSA CAPITAL PARTNERS LLP 0.05% of their portfolio LONDON, X0 12,63712.6k $394.0k $394.0k 0.05% New
77 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 12,36912.4k $385.9k $385.9k 0.00% New
78 Aquatic Capital Management LLC 0.03% of their portfolio CHICAGO, IL 11,50011.5k $359.0k $359.0k 0.03% New
79 FOX RUN MANAGEMENT, L.L.C. 0.12% of their portfolio GREENWICH, CT 9,9019.9k $308.9k $308.9k 0.12% New
80 Trexquant Investment LP 0.01% of their portfolio STAMFORD, CT 9,8789.9k $308.2k $308.2k 0.01% Reduced -7.7k -7,727
81 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 9,7719.8k $304.8k $304.8k 0.00% New
82 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 9,5409.5k $297.6k $297.6k 0.00% Reduced -4.5k -4,540
83 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 9,3199.3k $290.8k $290.8k 0.00% New
84 UBS Group AG 0.00% of their portfolio ZURICH, V8 9,0869.1k $283.5k $283.5k 0.00% Added +9.0k +8,963
85 ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio PHOENIX, AZ 8,5158.5k $265.7k $265.7k 0.00% New
86 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 8,4988.5k $265.1k $265.1k 0.00% New
87 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 8,1868.2k $255.4k $255.4k 0.00% Reduced -136.4k -136,374
88 Aigen Investment Management, LP 0.04% of their portfolio NEW YORK, NY 8,1608.2k $254.6k $254.6k 0.04% New
89 Quantamental Technologies LLC 0.10% of their portfolio WHITE PLAINS, NY 7,0397.0k $219.6k $219.6k 0.10% New
90 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 6,4116.4k $200.0k $200.0k 0.00% Added +1.3k +1,258
91 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 5,0005.0k $156.0k $156.0k 0.00% New
92 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 4,6534.7k $145.0k $145.0k 0.00% Added +1.1k +1,057
93 Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio ZURICH, V8 4,6144.6k $144.0k $144.0k 0.00% New
94 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 4,5724.6k $143.0k $143.0k 0.00% Added +4.2k +4,226
95 VIRTUS ADVISERS, LLC 0.07% of their portfolio HARTFORD, CT 4,1274.1k $128.8k $128.8k 0.07% Reduced -3.4k -3,413
96 SIMPLEX TRADING, LLC 0.01% of their portfolio CHICAGO, IL 4,0184.0k $125.0k $125.0k 0.01% New
97 Quantbot Technologies LP 0.01% of their portfolio NEW YORK, NY 3,7323.7k $116.4k $116.4k 0.01% Added +2.9k +2,899
98 Amundi 0.00% of their portfolio Paris, I0 2,9933.0k $88.3k $88.3k 0.00% New
99 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 2,8322.8k $86.6k $86.6k 0.00% Added +703 +703
100 Metropolitan Life Insurance Co/NY 0.00% of their portfolio New York, NY 2,2232.2k $69.4k $69.4k 0.00% Added +375 +375