Vault-13

CUE BIOPHARMA INC CUE

COM · Common Stock · CUSIP 22978P205

49 institutional holders +47 vs Q1 2026
1,641,3511.6m shares reported held*
22.6% of all shares outstanding*
$51.8mreported value*
48 new 0 added 1 reduced 1 sold out net bought ≈ $51.7m (+1.6m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 7.3m as of 2026-08-12, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $31.56. Options: 3 managers hold calls ($113.8k notional), 1 hold puts ($315.6k).

Trends to Q2 2026

Institutional holders

Managers reporting a position, each quarter

0204060Q1 26: 2Q2 26: 4949Q1 26Q2 26
Numbers
QuarterHolders
Q1 20262
Q2 202649

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100k$200k$300k$400kQ3 25 calls: $0Q3 25 puts: $0Q3 25P/C —Q4 25 calls: $0Q4 25 puts: $0Q4 25P/C —Q1 26 calls: $0Q1 26 puts: $0Q1 26P/C —Q2 26 calls: $113.8kQ2 26 puts: $315.6kQ2 26P/C 2.77
Numbers
QuarterCallsPutsP/C
Q3 2025$0$0—
Q4 2025$0$0—
Q1 2026$0$0—
Q2 2026$113.8k$315.6k2.77

Biggest buyers

Bleichroeder LP New +370,682+370.7k
Driehaus Capital Management LLC New +292,144+292.1k
VANGUARD CAPITAL MANAGEMENT LLC New +161,700+161.7k
Ikarian Capital, LLC New +104,364+104.4k
Tetragon Partners GP Ltd New +93,819+93.8k
STEMPOINT CAPITAL LP New +66,995+67.0k
BlackRock, Inc. New +57,807+57.8k
ADAR1 Capital Management, LLC New +55,193+55.2k
Lion Point Capital, LP New +52,928+52.9k
Squadron Capital Management LLC New +50,000+50.0k

Biggest sellers

Tidemark, LLC Reduced -1,450-1.4k
Advisory Services Network, LLC Sold out -200-200

Biggest calls

GROUP ONE TRADING LLC New $78.9k2.5k shares
Belvedere Trading LLC New $34.9k34.9k shares
DIADEMA PARTNERS LP New $66 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $315.6k10.0k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
DRIEHAUS CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-08-14 7.0% new 292.1k≈ $9.2m 2026-08-14
Lin Shao-Lee 13D · may seek influence new · filed 2026-08-21
Stated purposeThe Reporting Person intends to review her investment in the Common Stock and the Issuer's securities on a regular basis and, as a result thereof, may, directly or through one or more affiliates, at any time or from time to time determine, either alone or as part of a group, (i) to acquire additional securities of the Issuer, through open market purchases, privately negotiated transactions, or otherwise, (ii) to dispose of all or a portion of the securities of the Issuer beneficially owned by her in the open market, in privately negotiated transactions, or otherwise, or (iii) to take any other available course of action, which could involve one or more of the types of transactions or have one or more of the results specified in clauses (a) through (j) of Item 4 of Schedule 13D of the Secur… Full filing
6.2% new 467.2k≈ $14.7m 2026-08-21

Fell to 5% or below in the last year: STROME MARK E (8.5%, 2026-10-08)

Insider purchases and sales since 1 Apr 2026

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
404Q4 24: 1 buyingQ4 24: 0 sellingQ1 25: 0 buyingQ1 25: 0 sellingQ1 25Q2 25: 0 buyingQ2 25: 0 sellingQ3 25: 0 buyingQ3 25: 0 sellingQ3 25Q4 25: 1 buyingQ4 25: 0 sellingQ1 26: 0 buyingQ1 26: 0 sellingQ1 26Q2 26: 0 buyingQ2 26: 0 sellingQ3 26: 0 buyingQ3 26: 3 sellingQ3 26
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20241$30.9k0——
Q1 20250—0——
Q2 20250—0——
Q3 20250—0——
Q4 20251$99.7k0——
Q1 20260—0——
Q2 20260—0——
Q3 20260—3$2.0m—
DateInsiderTradeSharesPrice ValueTheir holding
2026-08-13 Lin Shao-Lee Chief Executive Officer, director Sold 18,258 $28.62 $522.6k18.3k shares -2%
2026-08-13 Ray Sumita Chief Legal Compliance Officer Sold 8,829 $30.09 $265.6k8.8k shares -7%
2026-08-13 Meluzio Michael Vincent VP, Prin. Accounting Officer Sold 5,628 $30.09 $169.3k5.6k shares -10%
2026-08-12 Lin Shao-Lee Chief Executive Officer, director Sold 40,000 $27.10 $1.1m40.0k shares -5%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Bleichroeder LP 2.09% of their portfolio NEW YORK, NY 370,682370.7k $11.7m $11.7m 2.09% New
2 Driehaus Capital Management LLC 0.05% of their portfolio Chicago, IL 292,144292.1k $9.2m $9.2m 0.05% New
3 VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio MALVERN, PA 161,700161.7k $5.1m $5.1m 0.00% New
4 Ikarian Capital, LLC 0.54% of their portfolio DALLAS, TX 104,364104.4k $3.3m $3.3m 0.54% New
5 Tetragon Partners GP Ltd 0.48% of their portfolio GRAND CAYMAN, E9 93,81993.8k $3.0m $3.0m 0.48% New
6 STEMPOINT CAPITAL LP 0.37% of their portfolio NEW YORK, NY 66,99567.0k $2.1m $2.1m 0.37% New
7 BlackRock, Inc. 0.00% of their portfolio New York, NY 57,80757.8k $1.8m $1.8m 0.00% New
8 ADAR1 Capital Management, LLC 0.08% of their portfolio AUSTIN, TX 55,19355.2k $1.7m $1.7m 0.08% New
9 Lion Point Capital, LP 7.99% of their portfolio NEW YORK, NY 52,92852.9k $1.7m $1.7m 7.99% New
10 Squadron Capital Management LLC 0.54% of their portfolio OAK BROOK, IL 50,00050.0k $1.6m $1.6m 0.54% New
11 DIADEMA PARTNERS LP 0.54% of their portfolio MORRISTOWN, NJ 48,36948.4k $1.5m $1.5m 0.54% New
12 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 47,82447.8k $1.5m $1.5m 0.00% New
13 BOOTHBAY FUND MANAGEMENT, LLC 0.02% of their portfolio NEW YORK, NY 31,45931.5k $992.8k $992.8k 0.02% New
14 UBS Group AG 0.00% of their portfolio ZURICH, V8 26,70026.7k $842.7k $842.7k 0.00% New
15 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 25,63325.6k $809.0k $809.0k 0.00% New
16 VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio MALVERN, PA 24,47624.5k $772.5k $772.5k 0.00% New
17 Texas Capital Bank Wealth Management Services Inc 0.04% of their portfolio Dallas, TX 22,88122.9k $722.1k $722.1k 0.04% New
18 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 14,68914.7k $463.6k $463.6k 0.00% New
19 Persistent Asset Partners Ltd 0.12% of their portfolio HONG KONG, K3 12,33212.3k $389.2k $389.2k 0.12% New
20 Robertson Stephens Wealth Management, LLC 0.01% of their portfolio San Francisco, CA 11,13311.1k $351.4k $351.4k 0.01% New
21 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 11,00311.0k $347.3k $347.3k 0.00% New
22 Seven Fleet Capital Management LP 0.06% of their portfolio MOUNTAIN VIEW, CA 10,70210.7k $337.8k $337.8k 0.06% New
23 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 9,1229.1k $287.9k $287.9k 0.00% New
24 ADVISORY RESEARCH INC 0.03% of their portfolio CHICAGO, IL 8,5738.6k $270.6k $270.6k 0.03% New
25 STIFEL FINANCIAL CORP 0.00% of their portfolio ST. LOUIS, MO 8,2188.2k $259.4k $259.4k 0.00% New
26 ANGELES WEALTH MANAGEMENT, LLC 0.01% of their portfolio SANTA MONICA, CA 7,0007.0k $220.9k $220.9k 0.01% New
27 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 6,9296.9k $218.7k $218.7k 0.00% New
28 NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio MILWAUKEE, WI 2,6322.6k $83.1k $83.1k 0.00% New
29 Vanguard Global Advisers, LLC 0.00% of their portfolio MALVERN, PA 1,6371.6k $51.7k $51.7k 0.00% New
30 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 1,1171.1k $35.3k $35.3k 0.00% New
31 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 869869 $27.4k $27.4k 0.00% New
32 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 674674 $21.3k $21.3k 0.00% New
33 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 479479 $15.1k $15.1k 0.00% New
34 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 300300 $9.5k $9.5k 0.00% New
35 JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio DES PERES, MO 213213 $5.4k $5.4k 0.00% New
36 Gleason Group, Inc. 0.00% of their portfolio PROSPECT, KY 200200 $6.3k $6.3k 0.00% New
37 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 163163 $5.0k $5.0k 0.00% New
38 NFSG Corp 0.00% of their portfolio BOCA RATON, FL 9999 $3.1k $3.1k 0.00% New
39 Golden State Wealth Management, LLC 0.00% of their portfolio SANTA ANA, CA 6666 $2.1k $2.1k 0.00% New
40 Tidemark, LLC 0.00% of their portfolio SAN DIEGO, CA 5050 $1.6k $1.6k 0.00% Reduced -1.4k -1,450
41 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 4848 $1.5k $1.5k 0.00% New
42 MATHER GROUP, LLC. 0.00% of their portfolio CHICAGO, IL 3333 $1.0k $1.0k 0.00% New
43 Physician Wealth Advisors, Inc. 0.00% of their portfolio MIDVALE, UT 3333 $1.0k $1.0k 0.00% New
44 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 3030 $947 $947 0.00% New
45 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 2626 $821 $821 0.00% New
46 IFP Advisors, Inc 0.00% of their portfolio TAMPA, FL 33 $95 $95 0.00% New
47 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 22 $0 $0 0.00% New
48 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 11 $32 $32 0.00% New
49 Caitong International Asset Management Co., Ltd 0.00% of their portfolio HONG KONG, K3 11 $32 $32 0.00% New