CUE BIOPHARMA INC CUE
COM · Common Stock · CUSIP 22978P205
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSomerville, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 7.3m as of 2026-08-12, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $31.56. Options: 3 managers hold calls ($113.8k notional), 1 hold puts ($315.6k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2026 | 2 |
| Q2 2026 | 49 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $0 | $0 | — |
| Q4 2025 | $0 | $0 | — |
| Q1 2026 | $0 | $0 | — |
| Q2 2026 | $113.8k | $315.6k | 2.77 |
Biggest buyers
| Bleichroeder LP | New | +370.7k |
| Driehaus Capital Management LLC | New | +292.1k |
| VANGUARD CAPITAL MANAGEMENT LLC | New | +161.7k |
| Ikarian Capital, LLC | New | +104.4k |
| Tetragon Partners GP Ltd | New | +93.8k |
| STEMPOINT CAPITAL LP | New | +67.0k |
| BlackRock, Inc. | New | +57.8k |
| ADAR1 Capital Management, LLC | New | +55.2k |
| Lion Point Capital, LP | New | +52.9k |
| Squadron Capital Management LLC | New | +50.0k |
Biggest sellers
| Tidemark, LLC | Reduced | -1.4k |
| Advisory Services Network, LLC | Sold out | -200 |
Biggest calls
| GROUP ONE TRADING LLC | New | $78.9k2.5k shares |
| Belvedere Trading LLC | New | $34.9k34.9k shares |
| DIADEMA PARTNERS LP | New | $66 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $315.6k10.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-08-14 | 7.0% |
Lin Shao-Lee
13D · may seek influence
new · filed 2026-08-21
Stated purposeThe Reporting Person intends to review her investment in the Common Stock and the Issuer's securities on a regular basis and, as a result thereof, may, directly or through one or more affiliates, at any time or from time to time determine, either alone or as part of a group, (i) to acquire additional securities of the Issuer, through open market purchases, privately negotiated transactions, or otherwise, (ii) to dispose of all or a portion of the securities of the Issuer beneficially owned by her in the open market, in privately negotiated transactions, or otherwise, or (iii) to take any other available course of action, which could involve one or more of the types of transactions or have one or more of the results specified in clauses (a) through (j) of Item 4 of Schedule 13D of the Secur… Full filing |
6.2% |
Fell to 5% or below in the last year: STROME MARK E (8.5%, 2026-10-08)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 1 | $30.9k | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 1 | $99.7k | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 3 | $2.0m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-08-13 | Lin Shao-Lee Chief Executive Officer, director | Sold | $522.6k18.3k shares |
| 2026-08-13 | Ray Sumita Chief Legal Compliance Officer | Sold | $265.6k8.8k shares |
| 2026-08-13 | Meluzio Michael Vincent VP, Prin. Accounting Officer | Sold | $169.3k5.6k shares |
| 2026-08-12 | Lin Shao-Lee Chief Executive Officer, director | Sold | $1.1m40.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Bleichroeder LP 2.09% of their portfolio | 370.7k $11.7m | New |
| Driehaus Capital Management LLC 0.05% of their portfolio | 292.1k $9.2m | New |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 161.7k $5.1m | New |
| Ikarian Capital, LLC 0.54% of their portfolio | 104.4k $3.3m | New |
| Tetragon Partners GP Ltd 0.48% of their portfolio | 93.8k $3.0m | New |
| STEMPOINT CAPITAL LP 0.37% of their portfolio | 67.0k $2.1m | New |
| BlackRock, Inc. 0.00% of their portfolio | 57.8k $1.8m | New |
| ADAR1 Capital Management, LLC 0.08% of their portfolio | 55.2k $1.7m | New |
| Lion Point Capital, LP 7.99% of their portfolio | 52.9k $1.7m | New |
| Squadron Capital Management LLC 0.54% of their portfolio | 50.0k $1.6m | New |
| DIADEMA PARTNERS LP 0.54% of their portfolio | 48.4k $1.5m | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 47.8k $1.5m | New |
| BOOTHBAY FUND MANAGEMENT, LLC 0.02% of their portfolio | 31.5k $992.8k | New |
| UBS Group AG 0.00% of their portfolio | 26.7k $842.7k | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 25.6k $809.0k | New |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 24.5k $772.5k | New |
| Texas Capital Bank Wealth Management Services Inc 0.04% of their portfolio | 22.9k $722.1k | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 14.7k $463.6k | New |
| Persistent Asset Partners Ltd 0.12% of their portfolio | 12.3k $389.2k | New |
| Robertson Stephens Wealth Management, LLC 0.01% of their portfolio | 11.1k $351.4k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 11.0k $347.3k | New |
| Seven Fleet Capital Management LP 0.06% of their portfolio | 10.7k $337.8k | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 9.1k $287.9k | New |
| ADVISORY RESEARCH INC 0.03% of their portfolio | 8.6k $270.6k | New |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 8.2k $259.4k | New |
| ANGELES WEALTH MANAGEMENT, LLC 0.01% of their portfolio | 7.0k $220.9k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 6.9k $218.7k | New |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 2.6k $83.1k | New |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 1.6k $51.7k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 1.1k $35.3k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 869 $27.4k | New |
| MORGAN STANLEY 0.00% of their portfolio | 674 $21.3k | New |
| BARCLAYS PLC 0.00% of their portfolio | 479 $15.1k | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 300 $9.5k | New |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 213 $5.4k | New |
| Gleason Group, Inc. 0.00% of their portfolio | 200 $6.3k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 163 $5.0k | New |
| NFSG Corp 0.00% of their portfolio | 99 $3.1k | New |
| Golden State Wealth Management, LLC 0.00% of their portfolio | 66 $2.1k | New |
| Tidemark, LLC 0.00% of their portfolio | 50 $1.6k | Reduced -1.4k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 48 $1.5k | New |
| MATHER GROUP, LLC. 0.00% of their portfolio | 33 $1.0k | New |
| Physician Wealth Advisors, Inc. 0.00% of their portfolio | 33 $1.0k | New |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 30 $947 | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 26 $821 | New |
| IFP Advisors, Inc 0.00% of their portfolio | 3 $95 | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 2 $0 | New |
| CITIGROUP INC 0.00% of their portfolio | 1 $32 | New |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 1 $32 | New |