CRYOPORT INC CYRX
COM PAR $0.001 · Common Stock · CUSIP 229050307 · ISIN US2290503075
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBrentwood, TN
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($155.8k this quarter). Holder counts are more reliable. Shares outstanding: 50.1m as of 2025-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $9.59. Options: 8 managers hold calls ($15.9m notional), 5 hold puts ($1.9m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 195 |
| Q4 2022 | 172 |
| Q1 2023 | 181 |
| Q2 2023 | 180 |
| Q3 2023 | 160 |
| Q4 2023 | 146 |
| Q1 2024 | 152 |
| Q2 2024 | 162 |
| Q3 2024 | 154 |
| Q4 2024 | 162 |
| Q1 2025 | 154 |
| Q2 2025 | 161 |
| Q3 2025 | 160 |
| Q4 2025 | 172 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 69 | 65 |
| Q2 2024 | 80 | 78 |
| Q3 2024 | 73 | 75 |
| Q4 2024 | 84 | 66 |
| Q1 2025 | 68 | 77 |
| Q2 2025 | 95 | 57 |
| Q3 2025 | 76 | 72 |
| Q4 2025 | 78 | 70 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $2.0m | $1.8m | 0.91 |
| Q2 2025 | $4.5m | $3.9m | 0.85 |
| Q3 2025 | $13.8m | $5.5m | 0.40 |
| Q4 2025 | $15.9m | $1.9m | 0.12 |
Biggest buyers
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | New | +635.1k |
| MILLENNIUM MANAGEMENT LLC | Added | +623.9k |
| MAK CAPITAL ONE LLC | Added | +381.1k |
| First Eagle Investment Management, LLC | New | +312.1k |
| GROUP ONE TRADING LLC | Added | +255.9k |
| Empire Financial Management Company, LLC | Added | +236.9k |
| FEDERATED HERMES, INC. | Added | +124.0k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | Added | +121.8k |
| Brandywine Global Investment Management, LLC | New | +114.4k |
| INTRINSIC EDGE CAPITAL MANAGEMENT LLC | New | +100.0k |
Biggest sellers
| BROWN CAPITAL MANAGEMENT LLC | Reduced | -1.5m |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Reduced | -428.8k |
| BANK OF AMERICA CORP /DE/ | Reduced | -265.9k |
| JPMORGAN CHASE & CO | Reduced | -229.5k |
| FRANKLIN RESOURCES INC | Reduced | -220.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -211.6k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -163.2k |
| CITADEL ADVISORS LLC | Reduced | -156.2k |
| D. E. Shaw & Co., Inc. | Reduced | -137.5k |
| Nuveen, LLC | Reduced | -121.9k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $6.3m653.9k shares |
| GROUP ONE TRADING LLC | Reduced | $2.3m243.3k shares |
| Caption Management, LLC | Unchanged | $2.2m225.2k shares |
| PEAK6 LLC | Reduced | $1.5m159.0k shares |
| CITADEL ADVISORS LLC | Reduced | $1.5m152.3k shares |
| JANE STREET GROUP, LLC | Added | $1.2m130.1k shares |
| Walleye Trading LLC | New | $689.3k71.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $246.7k25.7k shares |
Biggest puts
| Caption Management, LLC | Unchanged | $1.2m125.0k shares |
| CITADEL ADVISORS LLC | Reduced | $330.2k34.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $221.8k23.1k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $150.7k15.7k shares |
| GROUP ONE TRADING LLC | Reduced | $32.6k3.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| CADIAN CAPITAL MANAGEMENT, LP 13G · institution -4.2 pts · filed 2026-08-14 | 5.8% |
Fell to 5% or below in the last year: MORGAN STANLEY (4.5%, 2026-08-13), INTEGRATED CORE STRATEGIES (US) LLC (3.4%, 2026-07-29), VANGUARD GROUP INC (0.0%, 2026-03-26), BROWN CAPITAL MANAGEMENT LLC (2.2%, 2026-02-17)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 4 | $1.1m | — |
| Q2 2024 | 0 | — | 2 | $154.7k | — |
| Q3 2024 | 0 | — | 2 | $60.4k | $33.5k |
| Q4 2024 | 0 | — | 3 | $1.6m | $1.5m |
| Q1 2025 | 0 | — | 4 | $131.5k | — |
| Q2 2025 | 0 | — | 4 | $3.0m | — |
| Q3 2025 | 0 | — | 3 | $661.3k | — |
| Q4 2025 | 0 | — | 1 | $115.6k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-10 | Mandalam Ramkumar Director | Sold | $115.6k11.6k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| CADIAN CAPITAL MANAGEMENT, LP 3.44% of their portfolio | 5.0m $47.6m | Reduced -21.5k |
| MORGAN STANLEY 0.00% of their portfolio | 4.6m $44.0m | Reduced -23.5k |
| BlackRock, Inc. 0.00% of their portfolio | 4.0m $38.4m | Reduced -1.4k |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 3.2m $31.2m | Added +623.9k |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.9m $27.9m | Added +47.9k |
| FRED ALGER MANAGEMENT, LLC 0.07% of their portfolio | 1.8m $16.8m | Reduced -25.9k |
| Assenagon Asset Management S.A. 0.02% of their portfolio | 1.5m $14.3m | Reduced -11.4k |
| UBS Group AG 0.00% of their portfolio | 1.4m $13.7m | Added +90.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.2m $11.5m | Reduced -10.5k |
| MAK CAPITAL ONE LLC 1.55% of their portfolio | 1.2m $11.5m | Added +381.1k |
| BROWN CAPITAL MANAGEMENT LLC 0.88% of their portfolio | 1.1m $10.7m | Reduced -1.5m |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 996.0k $9.6m | Added +1.9k |
| STATE STREET CORP 0.00% of their portfolio | 971.0k $9.3m | Added +7.3k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 967.6k $9.3m | Added +32.8k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.06% of their portfolio | 840.5k $8.1m | Added +121.8k |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 681.8k $6.5m | Added +10.5k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.01% of their portfolio | 635.1k $6.1m | New |
| Meros Investment Management, LP 2.38% of their portfolio | 626.4k $6.0m | Added +76.7k |
| Blackstone Inc. 0.02% of their portfolio | 453.4k $4.4m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 452.3k $4.3m | Reduced -34.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 429.2k $4.1m | Reduced -271 |
| Empire Financial Management Company, LLC 0.84% of their portfolio | 403.9k $3.9m | Added +236.9k |
| Nuveen, LLC 0.00% of their portfolio | 374.8k $3.6m | Reduced -121.9k |
| TOCQUEVILLE ASSET MANAGEMENT L.P. 0.05% of their portfolio | 355.0k $3.4m | Unchanged |
| NEEDHAM INVESTMENT MANAGEMENT LLC 0.21% of their portfolio | 339.5k $3.3m | Added +32.0k |
| Archon Capital Management LLC 1.78% of their portfolio | 325.3k $3.1m | Added +75.0k |
| Bullseye Asset Management LLC 1.63% of their portfolio | 315.1k $3.0m | Added +18.5k |
| First Eagle Investment Management, LLC 0.01% of their portfolio | 312.1k $3.0m | New |
| TUDOR INVESTMENT CORP ET AL 0.02% of their portfolio | 300.4k $2.9m | Added +9.7k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 295.8k $2.8m | Added +5.6k |
| READYSTATE ASSET MANAGEMENT LP 0.12% of their portfolio | 287.7k $2.8m | Reduced -16.9k |
| GROUP ONE TRADING LLC 0.08% of their portfolio | 264.7k $2.5m | Added +255.9k |
| PHILADELPHIA TRUST CO 0.17% of their portfolio | 263.2k $2.5m | Added +19.7k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 255.2k $2.5m | Reduced -265.9k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 249.3k $2.4m | Reduced -137.5k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 232.9k $2.2m | Added +99.9k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 232.4k $2.2m | Reduced -156.2k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 226.0k $2.2m | Reduced -163.2k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 209.3k $2.0m | Added +43.2k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 208.9k $2.0m | Added +124.0k |
| PERKINS CAPITAL MANAGEMENT INC 1.56% of their portfolio | 204.0k $2.0m | Reduced -3.3k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 203.5k $2.0m | Reduced -229.5k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 203.5k $2.0m | Added +47.9k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 172.4k $1.7m | Reduced -1.6k |
| Conestoga Capital Advisors, LLC 0.03% of their portfolio | 159.9k $1.5m | Added +54.7k |
| Squarepoint Ops LLC 0.00% of their portfolio | 130.4k $1.3m | Added +50.6k |
| Trexquant Investment LP 0.01% of their portfolio | 124.2k $1.2m | Added +68.0k |
| SG Americas Securities, LLC 0.00% of their portfolio | 118.7k $1.1m | Reduced -8.6k |
| Brandywine Global Investment Management, LLC 0.01% of their portfolio | 114.4k $1.1m | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 114.0k $1.1m | Reduced -26.6k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 113.7k $1.1m | Added +4.1k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 107.3k $1.0m | Reduced -2.4k |
| BARCLAYS PLC 0.00% of their portfolio | 104.3k $1.0m | Added +14.3k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 103.7k $996.6k | Added +52.0k |
| INTRINSIC EDGE CAPITAL MANAGEMENT LLC 0.19% of their portfolio | 100.0k $960.0k | New |
| Invesco Ltd. 0.00% of their portfolio | 96.5k $926.8k | Added +15.6k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 95.5k $916.8k | Reduced -428.8k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 88.3k $847.2k | Reduced -3.4k |
| MARATHON CAPITAL MANAGEMENT 0.18% of their portfolio | 87.2k $837.4k | Reduced -22.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 84.7k $813.0k | Added +17.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 78.7k $755.4k | Reduced -12.7k |
| AlphaQuest LLC 0.04% of their portfolio | 70.6k $677.4k | Added +62.3k |
| CITIGROUP INC 0.00% of their portfolio | 65.5k $628.8k | Added +63.4k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 62.3k $597.9k | Reduced -1.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 61.1k $586.7k | Unchanged |
| Caption Management, LLC 0.03% of their portfolio | 60.0k $576.0k | Unchanged |
| Geneos Wealth Management Inc. 0.01% of their portfolio | 60.0k $576.0k | Unchanged |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 57.9k $556.0k | Reduced -220.0k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 56.0k $537.5k | Added +18.7k |
| Diametric Capital, LP 0.14% of their portfolio | 54.7k $525.1k | New |
| Penbrook Management LLC 0.35% of their portfolio | 52.8k $507.2k | Added +65 |
| Dedeker Financial LLC 0.00% of their portfolio | 52.2k $0 | First filing |
| Evanson Asset Management, LLC 0.03% of their portfolio | 50.0k $480.0k | Unchanged |
| Inspire Investing, LLC 0.04% of their portfolio | 48.7k $467.6k | Added +882 |
| Legato Capital Management LLC 0.04% of their portfolio | 46.2k $443.4k | New |
| Integrated Quantitative Investments LLC 0.10% of their portfolio | 46.2k $443.4k | New |
| SIERRA SUMMIT ADVISORS LLC 0.07% of their portfolio | 45.1k $432.6k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 44.9k $430.0k | Reduced -95.8k |
| XTX Topco Ltd 0.01% of their portfolio | 44.2k $423.9k | New |
| Granahan Investment Management, LLC 0.02% of their portfolio | 40.2k $385.9k | New |
| State of Wyoming 0.04% of their portfolio | 38.9k $373.3k | Added +13.3k |
| Campbell & CO Investment Adviser LLC 0.02% of their portfolio | 38.8k $372.9k | Added +21.6k |
| Marex Group Ltd 0.00% of their portfolio | 37.0k $355.2k | New |
| HARBOR CAPITAL ADVISORS, INC. 0.03% of their portfolio | 36.7k $352.0k | New |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 36.2k $348.0k | Added +2.8k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 35.7k $342.5k | Reduced -13.3k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 35.6k $341.8k | New |
| Aquatic Capital Management LLC 0.01% of their portfolio | 34.9k $335.0k | New |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 34.6k $331.9k | New |
| Quantinno Capital Management LP 0.00% of their portfolio | 33.6k $322.8k | Added +4.2k |
| Creative Planning 0.00% of their portfolio | 29.6k $284.2k | Added +3.5k |
| HRT FINANCIAL LP 0.00% of their portfolio | 29.4k $281.0k | New |
| Engineers Gate Manager LP 0.00% of their portfolio | 28.8k $276.8k | New |
| MARTINGALE ASSET MANAGEMENT L P 0.01% of their portfolio | 27.1k $260.4k | Added +5.6k |
| Corient Private Wealth LP 0.00% of their portfolio | 23.4k $225.1k | New |
| LPL Financial LLC 0.00% of their portfolio | 23.3k $223.7k | Added +1.4k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 23.1k $221.7k | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 22.7k $218.0k | Reduced -265 |
| FMR LLC 0.00% of their portfolio | 22.5k $215.7k | Added +1.8k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 21.6k $207.7k | Reduced -5.8k |