Vault-13

CRINETICS PHARMACEUTICALS IN CRNX

COM · Common Stock · CUSIP 22663K107 · ISIN US22663K1079

244 institutional holders +2 vs Q4 2025
122,753,333122.8m shares reported held*
$4.5bnreported value*
40 new 117 added 59 reduced 41 sold out net bought ≈ $359.1m (+9.9m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($793.0k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $36.30. Options: 6 managers hold calls ($2.6m notional), 5 hold puts ($3.1m).

Trends to Q1 2026

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 122Q4 22: 122Q1 23: 130Q2 23: 141Q3 23: 173Q4 23: 182Q1 24: 204Q2 24: 236Q3 24: 237Q4 24: 249Q1 25: 229Q2 25: 224Q3 25: 226Q4 25: 242Q1 26: 244244Q3 22Q3 23Q3 24Q3 25Q1 26
Numbers
QuarterHolders
Q3 2022122
Q4 2022122
Q1 2023130
Q2 2023141
Q3 2023173
Q4 2023182
Q1 2024204
Q2 2024236
Q3 2024237
Q4 2024249
Q1 2025229
Q2 2025224
Q3 2025226
Q4 2025242
Q1 2026244

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q2 24: 148 bought or addedQ2 24: 74 cut or sold outQ3 24: 121 bought or addedQ3 24: 101 cut or sold outQ3 24Q4 24: 137 bought or addedQ4 24: 89 cut or sold outQ1 25: 126 bought or addedQ1 25: 126 cut or sold outQ1 25Q2 25: 129 bought or addedQ2 25: 102 cut or sold outQ3 25: 124 bought or addedQ3 25: 107 cut or sold outQ3 25Q4 25: 132 bought or addedQ4 25: 102 cut or sold outQ1 26: 157 bought or addedQ1 26: 100 cut or sold outQ1 26
Numbers
QuarterBought or addedCut or sold out
Q2 202414874
Q3 2024121101
Q4 202413789
Q1 2025126126
Q2 2025129102
Q3 2025124107
Q4 2025132102
Q1 2026157100

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ2 25 calls: $3.1mQ2 25 puts: $427.8kQ2 25P/C 0.14Q3 25 calls: $45.9mQ3 25 puts: $8.9mQ3 25P/C 0.19Q4 25 calls: $26.4mQ4 25 puts: $27.6mQ4 25P/C 1.05Q1 26 calls: $2.6mQ1 26 puts: $3.1mQ1 26P/C 1.21
Numbers
QuarterCallsPutsP/C
Q2 2025$3.1m$427.8k0.14
Q3 2025$45.9m$8.9m0.19
Q4 2025$26.4m$27.6m1.05
Q1 2026$2.6m$3.1m1.21

Biggest buyers

Bellevue Group AG Added +3,275,960+3.3m
T. Rowe Price Investment Management, Inc. Added +1,852,416+1.9m
FMR LLC Added +1,466,024+1.5m
FARALLON CAPITAL MANAGEMENT, L.L.C. Added +1,405,000+1.4m
MONTANOVA CAPITAL, LLC New +1,043,879+1.0m
ADAR1 Capital Management, LLC Added +829,963+830.0k
BAKER BROS. ADVISORS LP Added +702,596+702.6k
MARSHALL WACE, LLP New +684,108+684.1k
BlackRock, Inc. Added +490,267+490.3k
Siren, L.L.C. Added +396,000+396.0k

Biggest sellers

Point72 Asset Management, L.P. Sold out -2,337,034-2.3m
Paradigm Biocapital Advisors LP Sold out -2,210,774-2.2m
JENNISON ASSOCIATES LLC Reduced -376,929-376.9k
UBS Group AG Reduced -336,293-336.3k
MILLENNIUM MANAGEMENT LLC Reduced -237,967-238.0k
Balyasny Asset Management L.P. Sold out -233,197-233.2k
Skandinaviska Enskilda Banken AB (publ) Sold out -213,891-213.9k
Ensign Peak Advisors, Inc Reduced -200,192-200.2k
NEUBERGER BERMAN GROUP LLC Reduced -175,150-175.2k
First Light Asset Management, LLC Reduced -104,593-104.6k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $1.2m32.6k shares
CITADEL ADVISORS LLC Reduced $653.8k18.0k shares
JANE STREET GROUP, LLC Added $468.5k12.9k shares
SIMPLEX TRADING, LLC New $174.3k4.8k shares
Walleye Capital LLC New $54.5k1.5k shares
GROUP ONE TRADING LLC Reduced $18.2k500 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $1.4m38.3k shares
JANE STREET GROUP, LLC Added $719.1k19.8k shares
SIMPLEX TRADING, LLC New $395.9k10.9k shares
CITADEL ADVISORS LLC Added $370.5k10.2k shares
IMC-Chicago, LLC New $225.2k6.2k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-03 8.5% 9.0m≈ $336.4m 2026-08-03
Farallon Capital Partners, L.P. 13G · passive investor +2.5 pts · filed 2026-02-05 8.5% +2.5 pts 8.0m≈ $300.3m 2026-02-05
WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.0 pts · filed 2026-08-13 6.8% -1.0 pts 7.1m≈ $266.8m 2026-08-13
DRIEHAUS CAPITAL MANAGEMENT LLC 13G · institution filed 2026-05-15 6.1% 6.4m≈ $239.3m 2026-05-15
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 5.2% new 5.4m≈ $203.6m 2026-04-29
PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution filed 2026-05-15 5.1% 5.4m≈ $200.4m 2026-05-15

Fell to 5% or below in the last year: FMR LLC (1.4%, 2026-08-07), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)

Holders, Q1 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.03% of their portfolio BOSTON, MA 15,759,79915.8m $572.4m $572.4m 0.03% Added +1.5m +1,466,024
2 BlackRock, Inc. 0.01% of their portfolio New York, NY 8,478,8158.5m $308.0m $308.0m 0.01% Added +490.3k +490,267
3 FARALLON CAPITAL MANAGEMENT, L.L.C. 1.80% of their portfolio SAN FRANCISCO, CA 8,338,0988.3m $302.8m $302.8m 1.80% Added +1.4m +1,405,000
4 WELLINGTON MANAGEMENT GROUP LLP 0.06% of their portfolio Boston, MA 8,157,2048.2m $296.3m $296.3m 0.06% Added +119.3k +119,315
5 Driehaus Capital Management LLC 1.71% of their portfolio Chicago, IL 6,395,9226.4m $232.3m $232.3m 1.71% Added +8.2k +8,182
6 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 5,355,4965.4m $194.5m $194.5m 0.02% Added +131.1k +131,109
7 VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio MALVERN, PA 4,673,9354.7m $169.8m $169.8m 0.00% First filing
8 VANGUARD PORTFOLIO MANAGEMENT LLC 0.01% of their portfolio MALVERN, PA 4,638,5114.6m $168.5m $168.5m 0.01% First filing
9 JANUS HENDERSON GROUP PLC 0.08% of their portfolio LONDON, X0 4,520,2514.5m $164.2m $164.2m 0.08% Added +79.6k +79,560
10 EcoR1 Capital, LLC 6.66% of their portfolio San Francisco, CA 4,288,1204.3m $155.7m $155.7m 6.66% Unchanged
11 Bellevue Group AG 2.84% of their portfolio ZURICH, V8 3,280,0003.3m $119.1m $119.1m 2.84% Added +3.3m +3,275,960
12 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 2,480,7632.5m $90.1m $90.1m 0.01% Added +238.1k +238,132
13 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,403,0462.4m $87.3m $87.3m 0.00% Added +241.7k +241,668
14 BAKER BROS. ADVISORS LP 0.49% of their portfolio NEW YORK, NY 2,351,4652.4m $85.4m $85.4m 0.49% Added +702.6k +702,596
15 T. Rowe Price Investment Management, Inc. 0.05% of their portfolio BALTIMORE, MD 1,940,6221.9m $70.5m $70.5m 0.05% Added +1.9m +1,852,416
16 Siren, L.L.C. 1.92% of their portfolio New York, NY 1,903,6361.9m $69.1m $69.1m 1.92% Added +396.0k +396,000
17 Pictet Asset Management Holding SA 0.07% of their portfolio CAROUGE, V8 1,884,2811.9m $68.2m $68.2m 0.07% Added +324.0k +323,981
18 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.07% of their portfolio Paris, I0 1,716,4451.7m $62.3m $62.3m 0.07% Added +389.1k +389,063
19 GW&K Investment Management, LLC 0.52% of their portfolio BOSTON, MA 1,618,6861.6m $58.8m $58.8m 0.52% Added +142.4k +142,361
20 NOVO HOLDINGS A/S 4.56% of their portfolio HELLERUP, G7 1,550,0001.6m $56.3m $56.3m 4.56% Reduced -75.0k -75,000
21 RTW INVESTMENTS, LP 0.52% of their portfolio NEW YORK, NY 1,451,3261.5m $52.7m $52.7m 0.52% Added +100.0k +100,000
22 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 1,324,6681.3m $45.4m $45.4m 0.00% Added +170.0k +169,958
23 ADAR1 Capital Management, LLC 2.49% of their portfolio AUSTIN, TX 1,139,3311.1m $41.4m $41.4m 2.49% Added +830.0k +829,963
24 First Light Asset Management, LLC 3.55% of their portfolio Edina, MN 1,089,6701.1m $39.6m $39.6m 3.55% Reduced -104.6k -104,593
25 AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio KANSAS CITY, MO 1,052,8581.1m $38.2m $38.2m 0.02% Reduced -16.0k -16,020
26 MONTANOVA CAPITAL, LLC 1.03% of their portfolio New York, NY 1,043,8791.0m $37.9m $37.9m 1.03% New
27 ORBIMED ADVISORS LLC 0.79% of their portfolio New York, NY 999,000999.0k $36.3m $36.3m 0.79% Unchanged
28 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 919,686919.7k $33.4m $33.4m 0.00% Added +150.9k +150,860
29 Hood River Capital Management LLC 0.33% of their portfolio PALM BEACH GARDENS, FL 907,412907.4k $33.0m $33.0m 0.33% Added +10.0k +10,009
30 JENNISON ASSOCIATES LLC 0.02% of their portfolio NEW YORK, NY 904,672904.7k $32.9m $32.9m 0.02% Reduced -376.9k -376,929
31 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 852,258852.3k $30.9m $30.9m 0.01% Added +303.3k +303,281
32 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 841,301841.3k $30.6m $30.6m 0.00% Added +71.5k +71,478
33 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 833,418833.4k $30.3m $30.3m 0.00% Added +51.4k +51,437
34 Candriam S.C.A. 0.16% of their portfolio STRASSEN, N4 830,961831.0k $30.2m $30.2m 0.16% Unchanged
35 Aberdeen Group plc 0.05% of their portfolio EDINBURGH, X0 820,395820.4k $29.8m $29.8m 0.05% Added +145.9k +145,862
36 AMERIPRISE FINANCIAL INC 0.01% of their portfolio MINNEAPOLIS, MN 798,334798.3k $29.0m $29.0m 0.01% Added +197.1k +197,144
37 Fisher Asset Management, LLC 0.01% of their portfolio PLANO, TX 762,702762.7k $27.7m $27.7m 0.01% Added +4.0k +4,043
38 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 716,125716.1k $26.0m $26.0m 0.00% Reduced -85.2k -85,189
39 VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio MALVERN, PA 708,473708.5k $25.7m $25.7m 0.01% First filing
40 MARSHALL WACE, LLP 0.03% of their portfolio LONDON, X0 684,108684.1k $24.8m $24.8m 0.03% New
41 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 628,155628.2k $22.8m $22.8m 0.00% Added +61.0k +61,028
42 Fiera Capital Corp 0.07% of their portfolio MONTREAL, A8 589,654589.7k $21.4m $21.4m 0.07% Added +11.2k +11,199
43 UBS Group AG 0.00% of their portfolio ZURICH, V8 571,899571.9k $20.8m $20.8m 0.00% Reduced -336.3k -336,293
44 Nuveen, LLC 0.01% of their portfolio CHARLOTTE, NC 551,464551.5k $20.0m $20.0m 0.01% Added +29.0k +28,998
45 Universal- Beteiligungs- und Servicegesellschaft mbH 0.03% of their portfolio FRANKFURT AM MAIN, 2M 425,616425.6k $15.5m $15.5m 0.03% Added +17.3k +17,304
46 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 382,363382.4k $13.1m $13.1m 0.01% Added +194.9k +194,930
47 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 358,719358.7k $13.0m $13.0m 0.00% Reduced -46.3k -46,291
48 Prosight Management, LP 2.08% of their portfolio DALLAS, TX 350,000350.0k $12.7m $12.7m 2.08% Added +87.1k +87,096
49 Impax Asset Management Group plc 0.09% of their portfolio LONDON, X0 350,000350.0k $12.7m $12.7m 0.09% Added +75.0k +75,000
50 BRAUN STACEY ASSOCIATES INC 0.39% of their portfolio NEW YORK, NY 324,808324.8k $11.8m $11.8m 0.39% New
51 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 317,934317.9k $11.5m $11.5m 0.01% Added +63.2k +63,214
52 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 306,039306.0k $11.1m $11.1m 0.01% Added +4.0k +4,038
53 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 257,525257.5k $9.4m $9.4m 0.00% Added +22.5k +22,507
54 Cormorant Asset Management, LP 0.46% of their portfolio BOSTON, MA 250,000250.0k $9.1m $9.1m 0.46% Reduced -50.0k -50,000
55 Sio Capital Management, LLC 1.31% of their portfolio NEW YORK, NY 249,887249.9k $9.1m $9.1m 1.31% Added +125.0k +125,046
56 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 234,892234.9k $8.5m $8.5m 0.01% Added +44.4k +44,414
57 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 230,128230.1k $8.4m $8.4m 0.00% Added +4.3k +4,286
58 SEB Asset Management AB 0.03% of their portfolio STOCKHOLM, V7 213,891213.9k $7.8m $7.8m 0.03% First filing
59 Foresite Capital Management VI LLC 1.67% of their portfolio WEST HOLLYWOOD, CA 212,010212.0k $7.7m $7.7m 1.67% New
60 RICE HALL JAMES & ASSOCIATES, LLC 0.40% of their portfolio San Diego, CA 195,701195.7k $7.1m $7.1m 0.40% Added +23.9k +23,871
61 Moody Aldrich Partners LLC 1.20% of their portfolio MARBLEHEAD, MA 183,438183.4k $6.7m $6.7m 1.20% Added +73.0k +73,023
62 SEGALL BRYANT & HAMILL, LLC 0.09% of their portfolio CHICAGO, IL 180,112180.1k $6.5m $6.5m 0.09% Reduced -9.4k -9,365
63 Swiss National Bank 0.00% of their portfolio ZURICH, V8 176,500176.5k $6.4m $6.4m 0.00% Unchanged
64 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 170,949170.9k $8.0m $8.0m 0.00% Added +77.9k +77,929
65 SILVERCREST ASSET MANAGEMENT GROUP LLC 0.04% of their portfolio NEW YORK, NY 163,633163.6k $5.9m $5.9m 0.04% Added +19.4k +19,394
66 ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio Berwyn, PA 150,659150.7k $5.5m $5.5m 0.00% Added +20.3k +20,296
67 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 147,680147.7k $5.4m $5.4m 0.00% Reduced -809 -809
68 NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio ALBANY, NY 141,618141.6k $5.1m $5.1m 0.01% Reduced -4.5k -4,505
69 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 133,466133.5k $4.8m $4.8m 0.00% Reduced -24.6k -24,623
70 GordonMD Global Investments LP 3.21% of their portfolio Beverely Hills, CA 126,985127.0k $4.6m $4.6m 3.21% Reduced -97.2k -97,150
71 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 118,420118.4k $4.3m $4.3m 0.00% Added +2.7k +2,668
72 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 107,875107.9k $3.9m $3.9m 0.00% Reduced -12.0k -12,030
73 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 106,734106.7k $3.9m $3.9m 0.00% Reduced -78.9k -78,943
74 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 105,563105.6k $3.8m $3.8m 0.00% Added +20.0k +19,995
75 AWM Investment Company, Inc. 0.40% of their portfolio NEW YORK, NY 100,000100.0k $3.6m $3.6m 0.40% Unchanged
76 Burkehill Global Management, LP 0.18% of their portfolio NEW YORK, NY 100,000100.0k $3.6m $3.6m 0.18% New
77 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 99,36499.4k $3.6m $3.6m 0.00% Reduced -39.3k -39,321
78 ALGERT GLOBAL LLC 0.05% of their portfolio SAN FRANCISCO, CA 97,80297.8k $3.6m $3.6m 0.05% New
79 XTX Topco Ltd 0.06% of their portfolio LONDON, X0 97,16697.2k $3.5m $3.5m 0.06% New
80 SECTOR GAMMA AS 0.81% of their portfolio OSLO, Q8 94,19594.2k $3.4m $3.4m 0.81% Reduced -20.8k -20,805
81 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 87,29987.3k $3.2m $3.2m 0.00% Added +37.6k +37,600
82 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 85,23285.2k $3.1m $3.1m 0.01% Added +7.5k +7,467
83 Campbell & CO Investment Adviser LLC 0.17% of their portfolio BALTIMORE, MD 83,61783.6k $3.0m $3.0m 0.17% New
84 VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio London, EC4N 8AF, X0 80,52680.5k $2.9m $2.9m 0.00% First filing
85 Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio VANCOUVER, A1 79,75579.8k $2.9m $2.9m 0.01% Reduced -20.8k -20,812
86 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 75,42475.4k $2.7m $2.7m 0.01% Reduced -200.2k -200,192
87 Affinity Asset Advisors, LLC 0.16% of their portfolio NEW YORK, NY 75,00075.0k $2.7m $2.7m 0.16% Unchanged
88 Legal & General Group Plc 0.00% of their portfolio London, X0 74,35574.4k $2.7m $2.7m 0.00% Reduced -13.4k -13,447
89 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 73,96174.0k $2.7m $2.7m 0.00% Added +1.9k +1,916
90 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 73,65273.7k $2.7m $2.7m 0.00% Reduced -65.8k -65,809
91 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 65,23265.2k $2.4m $2.4m 0.01% Added +9.7k +9,671
92 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 62,36862.4k $2.3m $2.3m 0.00% Reduced -238.0k -237,967
93 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 54,32654.3k $2.0m $2.0m 0.01% Added +4.5k +4,508
94 Creative Planning 0.00% of their portfolio OVERLAND PARK, KS 53,63753.6k $1.9m $1.9m 0.00% Added +6.3k +6,316
95 FIRST TRUST ADVISORS LP 0.00% of their portfolio Wheaton, IL 51,36551.4k $1.9m $1.9m 0.00% Added +18.2k +18,215
96 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 49,77849.8k $1.8m $1.8m 0.00% Added +2.5k +2,483
97 Vestmark Advisory Solutions, Inc. 0.02% of their portfolio Wakefield, MA 48,72448.7k $1.8m $1.8m 0.02% Added +2.2k +2,172
98 Man Group plc 0.00% of their portfolio LONDON, X0 47,58047.6k $1.7m $1.7m 0.00% Reduced -15.0k -14,980
99 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 46,25346.3k $1.7m $1.7m 0.00% Added +12.7k +12,742
100 TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio STAMFORD, CT 46,02146.0k $1.7m $1.7m 0.01% New