Vault-13

CRINETICS PHARMACEUTICALS IN CRNX

COM · Common Stock · CUSIP 22663K107 · ISIN US22663K1079

224 institutional holders -5 vs Q1 2025
104,540,135104.5m shares reported held*
$3.0bnreported value*
34 new 95 added 65 reduced 37 sold out net bought ≈ $72.7m (+2.5m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($5.8m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $28.76. Options: 6 managers hold calls ($3.1m notional), 3 hold puts ($427.8k).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 122Q4 22: 122Q1 23: 130Q2 23: 141Q3 23: 173Q4 23: 182Q1 24: 204Q2 24: 236Q3 24: 237Q4 24: 249Q1 25: 229Q2 25: 224224Q3 22Q2 23Q1 24Q4 24Q2 25
Numbers
QuarterHolders
Q3 2022122
Q4 2022122
Q1 2023130
Q2 2023141
Q3 2023173
Q4 2023182
Q1 2024204
Q2 2024236
Q3 2024237
Q4 2024249
Q1 2025229
Q2 2025224

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q3 23: 132 bought or addedQ3 23: 47 cut or sold outQ4 23: 102 bought or addedQ4 23: 82 cut or sold outQ4 23Q1 24: 128 bought or addedQ1 24: 82 cut or sold outQ2 24: 148 bought or addedQ2 24: 74 cut or sold outQ2 24Q3 24: 121 bought or addedQ3 24: 101 cut or sold outQ4 24: 137 bought or addedQ4 24: 89 cut or sold outQ4 24Q1 25: 126 bought or addedQ1 25: 126 cut or sold outQ2 25: 129 bought or addedQ2 25: 102 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q3 202313247
Q4 202310282
Q1 202412882
Q2 202414874
Q3 2024121101
Q4 202413789
Q1 2025126126
Q2 2025129102

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$2m$4m$6mQ3 24 calls: $1.6mQ3 24 puts: $2.3mQ3 24P/C 1.42Q4 24 calls: $1.7mQ4 24 puts: $654.2kQ4 24P/C 0.39Q1 25 calls: $1.4mQ1 25 puts: $5.4mQ1 25P/C 3.89Q2 25 calls: $3.1mQ2 25 puts: $427.8kQ2 25P/C 0.14
Numbers
QuarterCallsPutsP/C
Q3 2024$1.6m$2.3m1.42
Q4 2024$1.7m$654.2k0.39
Q1 2025$1.4m$5.4m3.89
Q2 2025$3.1m$427.8k0.14

Biggest buyers

Point72 Asset Management, L.P. Added +1,219,763+1.2m
CITADEL ADVISORS LLC Added +615,084+615.1k
PRICE T ROWE ASSOCIATES INC /MD/ Added +478,144+478.1k
RTW INVESTMENTS, LP New +467,000+467.0k
GOLDMAN SACHS GROUP INC Added +401,293+401.3k
Paradigm Biocapital Advisors LP Added +397,385+397.4k
MILLENNIUM MANAGEMENT LLC Added +350,989+351.0k
ROYAL BANK OF CANADA Added +318,222+318.2k
Prosight Management, LP New +298,123+298.1k
BAKER BROS. ADVISORS LP New +280,000+280.0k

Biggest sellers

WELLINGTON MANAGEMENT GROUP LLP Reduced -1,084,089-1.1m
VOYA INVESTMENT MANAGEMENT LLC Reduced -668,113-668.1k
SG Americas Securities, LLC Reduced -501,984-502.0k
Logos Global Management LP Sold out -350,000-350.0k
FRANKLIN RESOURCES INC Reduced -314,143-314.1k
BlackRock, Inc. Reduced -237,854-237.9k
Qube Research & Technologies Ltd Reduced -230,146-230.1k
MPM BIOIMPACT LLC Reduced -202,989-203.0k
Cormorant Asset Management, LP Reduced -200,000-200.0k
Ensign Peak Advisors, Inc Reduced -199,245-199.2k

Biggest calls

GROUP ONE TRADING LLC Added $1.3m46.7k shares
CITADEL ADVISORS LLC Added $1.1m39.7k shares
Caption Management, LLC New $575.2k20.0k shares
Rosalind Advisors, Inc. New $58.0k52.7k shares
SIMPLEX TRADING, LLC Unchanged $23.0k800 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITADEL ADVISORS LLC Added $422.8k14.7k shares
SIMPLEX TRADING, LLC Reduced $5.0k200 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-03 8.5% 9.0m≈ $336.4m 2026-08-03
Farallon Capital Partners, L.P. 13G · passive investor +2.5 pts · filed 2026-02-05 8.5% +2.5 pts 8.0m≈ $300.3m 2026-02-05
WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.0 pts · filed 2026-08-13 6.8% -1.0 pts 7.1m≈ $266.8m 2026-08-13
DRIEHAUS CAPITAL MANAGEMENT LLC 13G · institution filed 2026-05-15 6.1% 6.4m≈ $239.3m 2026-05-15
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 5.2% new 5.4m≈ $203.6m 2026-04-29
PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution filed 2026-05-15 5.1% 5.4m≈ $200.4m 2026-05-15

Fell to 5% or below in the last year: FMR LLC (1.4%, 2026-08-07), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.02% of their portfolio BOSTON, MA 14,125,99914.1m $406.3m $406.3m 0.02% Added +94.7k +94,730
2 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 9,256,1329.3m $266.2m $266.2m 0.00% Reduced -55.5k -55,468
3 BlackRock, Inc. 0.00% of their portfolio New York, NY 7,418,7157.4m $213.4m $213.4m 0.00% Reduced -237.9k -237,854
4 Driehaus Capital Management LLC 1.47% of their portfolio Chicago, IL 6,400,0256.4m $184.1m $184.1m 1.47% Added +160.1k +160,123
5 WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio Boston, MA 5,807,3085.8m $167.0m $167.0m 0.03% Reduced -1.1m -1,084,089
6 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 5,590,5045.6m $160.8m $160.8m 0.02% Added +478.1k +478,144
7 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.61% of their portfolio SAN FRANCISCO, CA 4,646,0984.6m $133.6m $133.6m 0.61% Added +41.0k +41,000
8 EcoR1 Capital, LLC 7.31% of their portfolio San Francisco, CA 4,288,1204.3m $123.3m $123.3m 7.31% Unchanged
9 JANUS HENDERSON GROUP PLC 0.05% of their portfolio LONDON, X0 3,410,3203.4m $98.1m $98.1m 0.05% Reduced -14.1k -14,122
10 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 3,224,3063.2m $92.7m $92.7m 0.00% Reduced -59.0k -58,969
11 Paradigm Biocapital Advisors LP 2.88% of their portfolio NEW YORK, NY 2,343,5532.3m $67.4m $67.4m 2.88% Added +397.4k +397,385
12 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 2,213,3252.2m $63.7m $63.7m 0.00% Added +22.4k +22,393
13 Point72 Asset Management, L.P. 0.14% of their portfolio STAMFORD, CT 1,998,1612.0m $57.5m $57.5m 0.14% Added +1.2m +1,219,763
14 JENNISON ASSOCIATES LLC 0.03% of their portfolio NEW YORK, NY 1,987,1182.0m $57.1m $57.1m 0.03% Reduced -132.6k -132,649
15 Siren, L.L.C. 2.51% of their portfolio New York, NY 1,688,6111.7m $48.6m $48.6m 2.51% Unchanged
16 NOVO HOLDINGS A/S 3.15% of their portfolio HELLERUP, G7 1,550,0001.6m $44.6m $44.6m 3.15% Added +275.0k +275,000
17 Vestal Point Capital, LP 2.27% of their portfolio NEW YORK, NY 1,500,0001.5m $43.1m $43.1m 2.27% Unchanged
18 Pictet Asset Management Holding SA 0.04% of their portfolio CAROUGE, V8 1,200,4771.2m $34.5m $34.5m 0.04% Added +153.5k +153,462
19 ORBIMED ADVISORS LLC 0.83% of their portfolio New York, NY 1,149,0001.1m $33.0m $33.0m 0.83% Added +150.0k +150,000
20 GW&K Investment Management, LLC 0.25% of their portfolio BOSTON, MA 970,810970.8k $27.9m $27.9m 0.25% Added +50.8k +50,790
21 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 900,887900.9k $25.9m $25.9m 0.00% Added +401.3k +401,293
22 Hood River Capital Management LLC 0.36% of their portfolio PALM BEACH GARDENS, FL 888,470888.5k $25.6m $25.6m 0.36% Added +15.8k +15,835
23 First Light Asset Management, LLC 3.22% of their portfolio Edina, MN 864,136864.1k $24.9m $24.9m 3.22% Added +8.7k +8,717
24 AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio KANSAS CITY, MO 848,638848.6k $24.4m $24.4m 0.01% Added +129.1k +129,060
25 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 784,213784.2k $22.6m $22.6m 0.00% Reduced -72.9k -72,868
26 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 766,228766.2k $22.0m $22.0m 0.00% Added +12.7k +12,701
27 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 760,022760.0k $21.9m $21.9m 0.00% Added +245.3k +245,338
28 Fisher Asset Management, LLC 0.01% of their portfolio PLANO, TX 737,084737.1k $21.2m $21.2m 0.01% Reduced -36.3k -36,263
29 T. Rowe Price Investment Management, Inc. 0.01% of their portfolio BALTIMORE, MD 716,172716.2k $20.6m $20.6m 0.01% Added +26.9k +26,907
30 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.05% of their portfolio Paris, I0 712,719712.7k $20.5m $20.5m 0.05% Added +101.9k +101,880
31 Candriam S.C.A. 0.12% of their portfolio STRASSEN, N4 693,869693.9k $20.0m $20.0m 0.12% Added +205.0k +204,958
32 CITADEL ADVISORS LLC 0.02% of their portfolio MIAMI, FL 653,635653.6k $18.8m $18.8m 0.02% Added +615.1k +615,084
33 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 649,138649.1k $18.7m $18.7m 0.00% Reduced -314.1k -314,143
34 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 573,282573.3k $16.5m $16.5m 0.00% Added +268.4k +268,356
35 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 524,951525.0k $15.1m $15.1m 0.00% Reduced -38.0k -37,984
36 RTW INVESTMENTS, LP 0.19% of their portfolio NEW YORK, NY 467,000467.0k $13.4m $13.4m 0.19% New
37 Fiera Capital Corp 0.04% of their portfolio MONTREAL, A8 444,330444.3k $12.8m $12.8m 0.04% Added +6.0k +5,993
38 Ikarian Capital, LLC 4.12% of their portfolio DALLAS, TX 433,431433.4k $12.5m $12.5m 4.12% Reduced -90.0k -90,000
39 MPM BIOIMPACT LLC 2.14% of their portfolio BOSTON, MA 428,975429.0k $12.3m $12.3m 2.14% Reduced -203.0k -202,989
40 Cormorant Asset Management, LP 0.86% of their portfolio BOSTON, MA 400,000400.0k $11.5m $11.5m 0.86% Reduced -200.0k -200,000
41 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 357,677357.7k $10.3m $10.3m 0.01% Added +351.0k +350,989
42 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 345,928345.9k $9.9m $9.9m 0.00% Added +1.3k +1,349
43 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 344,958345.0k $9.9m $9.9m 0.00% Added +318.2k +318,222
44 Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio FRANKFURT AM MAIN, 2M 341,705341.7k $9.8m $9.8m 0.02% Reduced -1.0k -1,029
45 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 334,796334.8k $9.6m $9.6m 0.00% Reduced -12.8k -12,785
46 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 331,957332.0k $9.5m $9.5m 0.00% Added +66.5k +66,462
47 UBS Group AG 0.00% of their portfolio ZURICH, V8 320,545320.5k $9.2m $9.2m 0.00% Added +4.9k +4,886
48 Ensign Peak Advisors, Inc 0.02% of their portfolio SALT LAKE CITY, UT 315,564315.6k $9.1m $9.1m 0.02% Reduced -199.2k -199,245
49 Prosight Management, LP 2.09% of their portfolio DALLAS, TX 298,123298.1k $8.6m $8.6m 2.09% New
50 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 292,047292.0k $8.4m $8.4m 0.00% Added +126.1k +126,136
51 M&G PLC 0.05% of their portfolio London, X0 281,896281.9k $8.2m $8.2m 0.05% Added +74 +74
52 Aberdeen Group plc 0.01% of their portfolio EDINBURGH, X0 280,347280.3k $8.1m $8.1m 0.01% Added +72.3k +72,288
53 BAKER BROS. ADVISORS LP 0.08% of their portfolio NEW YORK, NY 280,000280.0k $8.1m $8.1m 0.08% New
54 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 261,531261.5k $7.5m $7.5m 0.00% Added +10.2k +10,200
55 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 238,610238.6k $6.9m $6.9m 0.00% Added +33.6k +33,556
56 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 202,482202.5k $5.8m $5.8m 0.00% Added +27.8k +27,788
57 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 198,917198.9k $5.7m $5.7m 0.01% Reduced -230.1k -230,146
58 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 195,196195.2k $5.6m $5.6m 0.00% Reduced -8.9k -8,926
59 Walleye Capital LLC 0.05% of their portfolio NEW YORK, NY 190,373190.4k $5.5m $5.5m 0.05% Added +66.4k +66,391
60 SEGALL BRYANT & HAMILL, LLC 0.07% of their portfolio CHICAGO, IL 176,517176.5k $5.1m $5.1m 0.07% Added +30.2k +30,243
61 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 175,257175.3k $5.0m $5.0m 0.00% Added +155.5k +155,534
62 Swiss National Bank 0.00% of their portfolio ZURICH, V8 168,800168.8k $4.9m $4.9m 0.00% Added +7.0k +7,000
63 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 157,515157.5k $4.7m $4.7m 0.01% Reduced -85.4k -85,360
64 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 156,383156.4k $4.5m $4.5m 0.01% Reduced -10.0k -9,955
65 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 154,980155.0k $4.5m $4.5m 0.00% Added +20.2k +20,187
66 Affinity Asset Advisors, LLC 0.65% of their portfolio NEW YORK, NY 152,252152.3k $4.4m $4.4m 0.65% Unchanged
67 Schonfeld Strategic Advisors LLC 0.03% of their portfolio NEW YORK, NY 147,923147.9k $4.3m $4.3m 0.03% Added +128.7k +128,731
68 Decheng Capital LLC 1.04% of their portfolio MENLO PARK, CA 143,000143.0k $4.1m $4.1m 1.04% Reduced -35.0k -34,958
69 Pier Capital, LLC 0.63% of their portfolio STAMFORD, CT 142,611142.6k $4.1m $4.1m 0.63% Added +29.2k +29,199
70 New Leaf Venture Partners, L.L.C. 7.66% of their portfolio New York, NY 141,000141.0k $4.1m $4.1m 7.66% Unchanged
71 SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio London, X0 140,978141.0k $4.1m $4.1m 0.00% Added +63.5k +63,517
72 NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio ALBANY, NY 140,918140.9k $4.1m $4.1m 0.01% Added +3.0k +3,000
73 Moody Aldrich Partners LLC 0.77% of their portfolio MARBLEHEAD, MA 137,796137.8k $4.0m $4.0m 0.77% Reduced -2.1k -2,109
74 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 135,307135.3k $3.9m $3.9m 0.00% Added +3.4k +3,357
75 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 127,664127.7k $3.7m $3.7m 0.01% Reduced -10.4k -10,371
76 BOOTHBAY FUND MANAGEMENT, LLC 0.10% of their portfolio NEW YORK, NY 108,969109.0k $3.1m $3.1m 0.10% Reduced -31.0k -31,004
77 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 103,296103.3k $3.0m $3.0m 0.00% New
78 Legal & General Group Plc 0.00% of their portfolio London, X0 97,53297.5k $2.8m $2.8m 0.00% Added +8.9k +8,905
79 Verition Fund Management LLC 0.02% of their portfolio GREENWICH, CT 95,33395.3k $2.7m $2.7m 0.02% Added +68.9k +68,875
80 AWM Investment Company, Inc. 0.31% of their portfolio NEW YORK, NY 95,00095.0k $2.7m $2.7m 0.31% Unchanged
81 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 93,02093.0k $2.7m $2.7m 0.00% Reduced -17.7k -17,654
82 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 90,75690.8k $2.6m $2.6m 0.01% Reduced -11.4k -11,375
83 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 90,06090.1k $2.6m $2.6m 0.00% Reduced -1.4k -1,434
84 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 78,14078.1k $2.2m $2.2m 0.00% Added +8.2k +8,181
85 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 75,48475.5k $2.2m $2.2m 0.00% Added +487 +487
86 Parkman Healthcare Partners LLC 0.24% of their portfolio STAMFORD, CT 73,41273.4k $2.1m $2.1m 0.24% Added +9.5k +9,472
87 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 67,30067.3k $1.9m $1.9m 0.00% Added +61.0k +61,000
88 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 64,58764.6k $1.9m $1.9m 0.00% Added +1.0k +1,032
89 Exome Asset Management LLC 1.53% of their portfolio NEW YORK, NY 62,70062.7k $1.8m $1.8m 1.53% Added +11.4k +11,405
90 State of New Jersey Common Pension Fund D 0.01% of their portfolio TRENTON, NJ 62,55262.6k $1.8m $1.8m 0.01% Added +6.7k +6,674
91 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 60,18060.2k $1.7m $1.7m 0.00% Added +5.5k +5,466
92 NEOS Investment Management LLC 0.02% of their portfolio Westport, CT 58,10158.1k $1.7m $1.7m 0.02% Reduced -706 -706
93 Tema ETFs LLC 0.44% of their portfolio New York, NY 58,10158.1k $1.7m $1.7m 0.44% Reduced -706 -706
94 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 56,77956.8k $1.6m $1.6m 0.00% Reduced -93.3k -93,271
95 ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio Berwyn, PA 54,25854.3k $1.6m $1.6m 0.00% Reduced -2.4k -2,433
96 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 53,99554.0k $1.6m $1.6m 0.00% Reduced -5.3k -5,316
97 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 53,41453.4k $1.5m $1.5m 0.01% Unchanged
98 ADAR1 Capital Management, LLC 0.25% of their portfolio AUSTIN, TX 53,12553.1k $1.5m $1.5m 0.25% Unchanged
99 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 52,77952.8k $1.5m $1.5m 0.00% New
100 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 50,52450.5k $1.5m $1.5m 0.01% Reduced -16.8k -16,779