Vault-13

CRINETICS PHARMACEUTICALS IN CRNX

COM · Common Stock · CUSIP 22663K107 · ISIN US22663K1079

229 institutional holders -20 vs Q4 2024
102,032,939102.0m shares reported held*
$3.4bnreported value*
36 new 90 added 71 reduced 55 sold out net bought ≈ $85.7m (+2.6m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($8.4m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $33.56. Options: 5 managers hold calls ($1.4m notional), 5 hold puts ($5.4m).

Trends to Q1 2025

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 122Q4 22: 122Q1 23: 130Q2 23: 141Q3 23: 173Q4 23: 182Q1 24: 204Q2 24: 236Q3 24: 237Q4 24: 249Q1 25: 229229Q3 22Q1 23Q3 23Q1 24Q3 24Q1 25
Numbers
QuarterHolders
Q3 2022122
Q4 2022122
Q1 2023130
Q2 2023141
Q3 2023173
Q4 2023182
Q1 2024204
Q2 2024236
Q3 2024237
Q4 2024249
Q1 2025229

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q2 23: 82 bought or addedQ2 23: 50 cut or sold outQ3 23: 132 bought or addedQ3 23: 47 cut or sold outQ3 23Q4 23: 102 bought or addedQ4 23: 82 cut or sold outQ1 24: 128 bought or addedQ1 24: 82 cut or sold outQ1 24Q2 24: 148 bought or addedQ2 24: 74 cut or sold outQ3 24: 121 bought or addedQ3 24: 101 cut or sold outQ3 24Q4 24: 137 bought or addedQ4 24: 89 cut or sold outQ1 25: 126 bought or addedQ1 25: 126 cut or sold outQ1 25
Numbers
QuarterBought or addedCut or sold out
Q2 20238250
Q3 202313247
Q4 202310282
Q1 202412882
Q2 202414874
Q3 2024121101
Q4 202413789
Q1 2025126126

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5m$10m$15mQ2 24 calls: $13.5mQ2 24 puts: $8.8mQ2 24P/C 0.65Q3 24 calls: $1.6mQ3 24 puts: $2.3mQ3 24P/C 1.42Q4 24 calls: $1.7mQ4 24 puts: $654.2kQ4 24P/C 0.39Q1 25 calls: $1.4mQ1 25 puts: $5.4mQ1 25P/C 3.89
Numbers
QuarterCallsPutsP/C
Q2 2024$13.5m$8.8m0.65
Q3 2024$1.6m$2.3m1.42
Q4 2024$1.7m$654.2k0.39
Q1 2025$1.4m$5.4m3.89

Biggest buyers

FMR LLC Added +5,103,183+5.1m
Vestal Point Capital, LP New +1,500,000+1.5m
JANUS HENDERSON GROUP PLC Added +629,001+629.0k
FARALLON CAPITAL MANAGEMENT, L.L.C. Added +530,000+530.0k
Candriam S.C.A. New +488,911+488.9k
Logos Global Management LP New +350,000+350.0k
VOYA INVESTMENT MANAGEMENT LLC Added +327,850+327.9k
NOVO HOLDINGS A/S Added +314,785+314.8k
STATE STREET CORP Added +292,437+292.4k
M&G PLC New +281,822+281.8k

Biggest sellers

Point72 Asset Management, L.P. Reduced -2,010,541-2.0m
LORD, ABBETT & CO. LLC Sold out -724,625-724.6k
FRANKLIN RESOURCES INC Reduced -628,385-628.4k
EVENTIDE ASSET MANAGEMENT, LLC Sold out -609,014-609.0k
JENNISON ASSOCIATES LLC Reduced -588,584-588.6k
First Turn Management, LLC Sold out -453,376-453.4k
Schonfeld Strategic Advisors LLC Reduced -426,754-426.8k
Cormorant Asset Management, LP Reduced -400,000-400.0k
UBS Group AG Reduced -392,071-392.1k
STEMPOINT CAPITAL LP Sold out -317,060-317.1k

Biggest calls

JANE STREET GROUP, LLC New $724.5k21.6k shares
CITADEL ADVISORS LLC Added $617.1k18.4k shares
GROUP ONE TRADING LLC Added $33.5k1.0k shares
SIMPLEX TRADING, LLC Reduced $26.0k800 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

Caption Management, LLC New $5.0m150.0k shares
CITADEL ADVISORS LLC Added $389.1k11.6k shares
GROUP ONE TRADING LLC New $16.8k500 shares
SIMPLEX TRADING, LLC Reduced $13.0k400 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-03 8.5% 9.0m≈ $336.4m 2026-08-03
Farallon Capital Partners, L.P. 13G · passive investor +2.5 pts · filed 2026-02-05 8.5% +2.5 pts 8.0m≈ $300.3m 2026-02-05
WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.0 pts · filed 2026-08-13 6.8% -1.0 pts 7.1m≈ $266.8m 2026-08-13
DRIEHAUS CAPITAL MANAGEMENT LLC 13G · institution filed 2026-05-15 6.1% 6.4m≈ $239.3m 2026-05-15
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 5.2% new 5.4m≈ $203.6m 2026-04-29
PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution filed 2026-05-15 5.1% 5.4m≈ $200.4m 2026-05-15

Fell to 5% or below in the last year: FMR LLC (1.4%, 2026-08-07), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)

Holders, Q1 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.03% of their portfolio BOSTON, MA 14,031,26914.0m $470.6m $470.6m 0.03% Added +5.1m +5,103,183
2 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 9,311,6009.3m $312.3m $312.3m 0.01% Added +222.2k +222,209
3 BlackRock, Inc. 0.01% of their portfolio New York, NY 7,656,5697.7m $256.8m $256.8m 0.01% Added +141.4k +141,376
4 WELLINGTON MANAGEMENT GROUP LLP 0.04% of their portfolio Boston, MA 6,891,3976.9m $231.1m $231.1m 0.04% Reduced -59.2k -59,170
5 Driehaus Capital Management LLC 2.02% of their portfolio Chicago, IL 6,239,9026.2m $209.3m $209.3m 2.02% Added +98.9k +98,888
6 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 5,112,3605.1m $171.5m $171.5m 0.02% Reduced -302.1k -302,145
7 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.83% of their portfolio SAN FRANCISCO, CA 4,605,0984.6m $154.5m $154.5m 0.83% Added +530.0k +530,000
8 EcoR1 Capital, LLC 8.54% of their portfolio San Francisco, CA 4,288,1204.3m $143.8m $143.8m 8.54% Unchanged
9 JANUS HENDERSON GROUP PLC 0.07% of their portfolio LONDON, X0 3,424,4423.4m $118.9m $118.9m 0.07% Added +629.0k +629,001
10 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 3,283,2753.3m $110.1m $110.1m 0.00% Added +292.4k +292,437
11 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 2,190,9322.2m $73.5m $73.5m 0.01% Added +92.1k +92,091
12 JENNISON ASSOCIATES LLC 0.05% of their portfolio NEW YORK, NY 2,119,7672.1m $71.1m $71.1m 0.05% Reduced -588.6k -588,584
13 Paradigm Biocapital Advisors LP 3.00% of their portfolio NEW YORK, NY 1,946,1681.9m $65.3m $65.3m 3.00% Added +35.4k +35,407
14 Siren, L.L.C. 3.19% of their portfolio New York, NY 1,688,6111.7m $56.6m $56.6m 3.19% Added +79.0k +78,959
15 Vestal Point Capital, LP 3.59% of their portfolio NEW YORK, NY 1,500,0001.5m $50.3m $50.3m 3.59% New
16 NOVO HOLDINGS A/S 3.25% of their portfolio HELLERUP, G7 1,275,0001.3m $42.8m $42.8m 3.25% Added +314.8k +314,785
17 Pictet Asset Management Holding SA 0.04% of their portfolio CAROUGE, V8 1,047,0151.0m $35.1m $35.1m 0.04% Added +199.0k +198,965
18 ORBIMED ADVISORS LLC 0.80% of their portfolio New York, NY 999,000999.0k $33.5m $33.5m 0.80% Unchanged
19 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 963,281963.3k $32.3m $32.3m 0.01% Reduced -628.4k -628,385
20 GW&K Investment Management, LLC 0.29% of their portfolio BOSTON, MA 920,020920.0k $30.9m $30.9m 0.29% Added +240.9k +240,897
21 Hood River Capital Management LLC 0.50% of their portfolio PALM BEACH GARDENS, FL 872,635872.6k $29.3m $29.3m 0.50% Added +21.2k +21,235
22 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 857,081857.1k $28.7m $28.7m 0.00% Reduced -22.7k -22,733
23 First Light Asset Management, LLC 3.28% of their portfolio Edina, MN 855,419855.4k $28.7m $28.7m 3.28% Reduced -30.0k -30,034
24 Point72 Asset Management, L.P. 0.07% of their portfolio STAMFORD, CT 778,398778.4k $26.1m $26.1m 0.07% Reduced -2.0m -2,010,541
25 Fisher Asset Management, LLC 0.01% of their portfolio PLANO, TX 773,347773.3k $25.9m $25.9m 0.01% Added +214.1k +214,060
26 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 753,527753.5k $25.3m $25.3m 0.00% Reduced -5.6k -5,599
27 AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio KANSAS CITY, MO 719,578719.6k $24.1m $24.1m 0.01% Added +242.3k +242,280
28 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 717,070717.1k $24.1m $24.1m 0.01% Added +327.9k +327,850
29 T. Rowe Price Investment Management, Inc. 0.02% of their portfolio BALTIMORE, MD 689,265689.3k $23.1m $23.1m 0.02% Reduced -313.6k -313,617
30 MPM BIOIMPACT LLC 3.64% of their portfolio BOSTON, MA 631,964632.0k $21.2m $21.2m 3.64% Added +14.9k +14,929
31 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.05% of their portfolio Paris, I0 610,839610.8k $20.5m $20.5m 0.05% Added +34.8k +34,771
32 Cormorant Asset Management, LP 1.52% of their portfolio BOSTON, MA 600,000600.0k $20.1m $20.1m 1.52% Reduced -400.0k -400,000
33 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 562,935562.9k $15.9m $15.9m 0.00% First filing
34 Ikarian Capital, LLC 5.72% of their portfolio DALLAS, TX 523,431523.4k $17.6m $17.6m 5.72% Added +7.0k +7,000
35 SG Americas Securities, LLC 0.06% of their portfolio NEW YORK, NY 522,266522.3k $17.5m $17.5m 0.06% Reduced -20.2k -20,180
36 Ensign Peak Advisors, Inc 0.03% of their portfolio SALT LAKE CITY, UT 514,809514.8k $17.3m $17.3m 0.03% Added +12.1k +12,119
37 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 514,684514.7k $17.3m $17.3m 0.00% Added +9.6k +9,644
38 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 499,594499.6k $16.8m $16.8m 0.00% Reduced -221.7k -221,675
39 Candriam S.C.A. 0.10% of their portfolio STRASSEN, N4 488,911488.9k $16.4m $16.4m 0.10% New
40 Fiera Capital Corp 0.05% of their portfolio MONTREAL, A8 438,337438.3k $14.7m $14.7m 0.05% Reduced -16.6k -16,645
41 Qube Research & Technologies Ltd 0.02% of their portfolio LONDON, X0 429,063429.1k $14.4m $14.4m 0.02% Added +209.5k +209,539
42 Logos Global Management LP 2.09% of their portfolio San Francisco, CA 350,000350.0k $11.7m $11.7m 2.09% New
43 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 347,581347.6k $11.7m $11.7m 0.00% Added +22.3k +22,305
44 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 344,579344.6k $11.6m $11.6m 0.00% Reduced -186 -186
45 Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio FRANKFURT AM MAIN, 2M 342,734342.7k $11.5m $11.5m 0.02% Added +8.0k +7,951
46 UBS Group AG 0.00% of their portfolio ZURICH, V8 315,659315.7k $10.6m $10.6m 0.00% Reduced -392.1k -392,071
47 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 304,926304.9k $10.2m $10.2m 0.00% Added +69.6k +69,645
48 M&G PLC 0.05% of their portfolio London, X0 281,822281.8k $9.6m $9.6m 0.05% New
49 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 265,495265.5k $8.9m $8.9m 0.00% Reduced -4.0k -4,048
50 VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio San Antonio, TX 251,331251.3k $8.4m $8.4m 0.01% Reduced -30.1k -30,120
51 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 242,875242.9k $8.3m $8.3m 0.01% Reduced -34.5k -34,495
52 Aberdeen Group plc 0.01% of their portfolio EDINBURGH, X0 208,059208.1k $7.0m $7.0m 0.01% Added +164.7k +164,670
53 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 205,054205.1k $6.9m $6.9m 0.00% Reduced -150.1k -150,120
54 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 204,122204.1k $6.8m $6.8m 0.00% Reduced -7.2k -7,192
55 Decheng Capital LLC 1.67% of their portfolio MENLO PARK, CA 177,958178.0k $6.0m $6.0m 1.67% Added +10.0k +10,000
56 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 174,694174.7k $5.9m $5.9m 0.01% Reduced -54.3k -54,310
57 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 166,338166.3k $5.6m $5.6m 0.01% Added +132.1k +132,138
58 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 165,911165.9k $5.6m $5.6m 0.00% Reduced -16.0k -16,030
59 Swiss National Bank 0.00% of their portfolio ZURICH, V8 161,800161.8k $5.4m $5.4m 0.00% Added +2.4k +2,400
60 Affinity Asset Advisors, LLC 0.80% of their portfolio NEW YORK, NY 152,252152.3k $5.1m $5.1m 0.80% Reduced -307.7k -307,748
61 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 150,050150.1k $5.0m $5.0m 0.00% Added +29.3k +29,291
62 SEGALL BRYANT & HAMILL, LLC 0.08% of their portfolio CHICAGO, IL 146,274146.3k $4.9m $4.9m 0.08% Reduced -4.1k -4,124
63 New Leaf Venture Partners, L.L.C. 10.53% of their portfolio New York, NY 141,000141.0k $4.7m $4.7m 10.53% Unchanged
64 BOOTHBAY FUND MANAGEMENT, LLC 0.16% of their portfolio NEW YORK, NY 139,973140.0k $4.7m $4.7m 0.16% Added +2.2k +2,221
65 Moody Aldrich Partners LLC 0.98% of their portfolio MARBLEHEAD, MA 139,905139.9k $4.7m $4.7m 0.98% Reduced -4.5k -4,461
66 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 139,492139.5k $4.7m $4.7m 0.01% New
67 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 138,035138.0k $4.6m $4.6m 0.01% Added +87.8k +87,784
68 NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio ALBANY, NY 137,918137.9k $4.6m $4.6m 0.01% Reduced -17.5k -17,508
69 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 134,793134.8k $4.5m $4.5m 0.00% Reduced -14.2k -14,163
70 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 131,950131.9k $4.4m $4.4m 0.00% Added +7.9k +7,872
71 Integral Health Asset Management, LLC 0.46% of their portfolio New York, NY 125,000125.0k $4.2m $4.2m 0.46% Reduced -175.0k -175,000
72 Walleye Capital LLC 0.05% of their portfolio NEW YORK, NY 123,982124.0k $4.2m $4.2m 0.05% Reduced -17.9k -17,856
73 Pier Capital, LLC 0.64% of their portfolio STAMFORD, CT 113,412113.4k $3.8m $3.8m 0.64% Added +1.4k +1,413
74 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 110,674110.7k $3.7m $3.7m 0.00% Added +9.0k +8,954
75 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 102,131102.1k $3.4m $3.4m 0.01% Added +20.9k +20,874
76 AWM Investment Company, Inc. 0.44% of their portfolio NEW YORK, NY 95,00095.0k $3.2m $3.2m 0.44% Added +40.0k +40,000
77 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 91,49491.5k $3.1m $3.1m 0.00% Reduced -9.4k -9,422
78 Legal & General Group Plc 0.00% of their portfolio London, X0 88,62788.6k $3.0m $3.0m 0.00% Reduced -312 -312
79 Caption Management, LLC 0.13% of their portfolio OKLAHOMA CITY, OK 86,71386.7k $2.9m $2.9m 0.13% New
80 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 81,18481.2k $2.7m $2.7m 0.00% Added +28 +28
81 SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio London, X0 77,46177.5k $2.7m $2.7m 0.00% Added +48.1k +48,100
82 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 74,99775.0k $2.5m $2.5m 0.00% Reduced -1.3k -1,267
83 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 69,95970.0k $2.3m $2.3m 0.00% Reduced -228.3k -228,295
84 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 67,30367.3k $2.3m $2.3m 0.01% Reduced -7.7k -7,682
85 Parkman Healthcare Partners LLC 0.25% of their portfolio STAMFORD, CT 63,94063.9k $2.1m $2.1m 0.25% Added +12.8k +12,807
86 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 63,55563.6k $2.1m $2.1m 0.01% Reduced -11.5k -11,548
87 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 59,31159.3k $2.0m $2.0m 0.00% Added +6.1k +6,148
88 Saturn V Capital Management LP 1.00% of their portfolio AUSTIN, TX 59,01759.0k $2.0m $2.0m 1.00% Reduced -108 -108
89 NEOS Investment Management LLC 0.04% of their portfolio Westport, CT 58,80758.8k $2.0m $2.0m 0.04% Added +874 +874
90 Tema ETFs LLC 0.59% of their portfolio New York, NY 58,80758.8k $2.0m $2.0m 0.59% Added +874 +874
91 INTECH INVESTMENT MANAGEMENT LLC 0.02% of their portfolio WEST PALM BEACH, FL 56,95057.0k $1.9m $1.9m 0.02% Added +13.8k +13,845
92 ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio Berwyn, PA 56,69156.7k $1.9m $1.9m 0.00% Reduced -6.4k -6,386
93 State of New Jersey Common Pension Fund D 0.01% of their portfolio TRENTON, NJ 55,87855.9k $1.9m $1.9m 0.01% Added +17.8k +17,829
94 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 54,71454.7k $1.8m $1.8m 0.00% Reduced -1.0k -1,013
95 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 53,41453.4k $1.8m $1.8m 0.01% Added +394 +394
96 ADAR1 Capital Management, LLC 0.34% of their portfolio AUSTIN, TX 53,12553.1k $1.8m $1.8m 0.34% Unchanged
97 Exome Asset Management LLC 1.54% of their portfolio NEW YORK, NY 51,29551.3k $1.7m $1.7m 1.54% New
98 NATIXIS ADVISORS, LLC 0.00% of their portfolio Boston, MA 46,50946.5k $1.6m $1.6m 0.00% Added +826 +826
99 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 44,90844.9k $1.5m $1.5m 0.00% Reduced -303 -303
100 Corebridge Financial, Inc. 0.01% of their portfolio HOUSTON, TX 44,89644.9k $1.5m $1.5m 0.01% Added +1.3k +1,297