Vault-13

CRINETICS PHARMACEUTICALS IN CRNX

COM · Common Stock · CUSIP 22663K107 · ISIN US22663K1079

267 institutional holders +23 vs Q1 2026
123,638,254123.6m shares reported held*
$4.6bnreported value*
54 new 98 added 71 reduced 30 sold out net bought ≈ $32.2m (+860.7k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($857.3k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $37.41. Options: 4 managers hold calls ($2.3m notional), 3 hold puts ($1.7m).

Trends to Q2 2026

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 122Q4 22: 122Q1 23: 130Q2 23: 141Q3 23: 173Q4 23: 182Q1 24: 204Q2 24: 236Q3 24: 237Q4 24: 249Q1 25: 229Q2 25: 224Q3 25: 226Q4 25: 242Q1 26: 244Q2 26: 267267Q3 22Q3 23Q3 24Q3 25Q2 26
Numbers
QuarterHolders
Q3 2022122
Q4 2022122
Q1 2023130
Q2 2023141
Q3 2023173
Q4 2023182
Q1 2024204
Q2 2024236
Q3 2024237
Q4 2024249
Q1 2025229
Q2 2025224
Q3 2025226
Q4 2025242
Q1 2026244
Q2 2026267

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q3 24: 121 bought or addedQ3 24: 101 cut or sold outQ4 24: 137 bought or addedQ4 24: 89 cut or sold outQ4 24Q1 25: 126 bought or addedQ1 25: 126 cut or sold outQ2 25: 129 bought or addedQ2 25: 102 cut or sold outQ2 25Q3 25: 124 bought or addedQ3 25: 107 cut or sold outQ4 25: 132 bought or addedQ4 25: 102 cut or sold outQ4 25Q1 26: 157 bought or addedQ1 26: 100 cut or sold outQ2 26: 152 bought or addedQ2 26: 101 cut or sold outQ2 26
Numbers
QuarterBought or addedCut or sold out
Q3 2024121101
Q4 202413789
Q1 2025126126
Q2 2025129102
Q3 2025124107
Q4 2025132102
Q1 2026157100
Q2 2026152101

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ3 25 calls: $45.9mQ3 25 puts: $8.9mQ3 25P/C 0.19Q4 25 calls: $26.4mQ4 25 puts: $27.6mQ4 25P/C 1.05Q1 26 calls: $2.6mQ1 26 puts: $3.1mQ1 26P/C 1.21Q2 26 calls: $2.3mQ2 26 puts: $1.7mQ2 26P/C 0.73
Numbers
QuarterCallsPutsP/C
Q3 2025$45.9m$8.9m0.19
Q4 2025$26.4m$27.6m1.05
Q1 2026$2.6m$3.1m1.21
Q2 2026$2.3m$1.7m0.73

Biggest buyers

Polar Capital Holdings Plc New +2,274,411+2.3m
BlackRock, Inc. Added +1,280,123+1.3m
PRICE T ROWE ASSOCIATES INC /MD/ Added +857,185+857.2k
FARALLON CAPITAL MANAGEMENT, L.L.C. Added +651,000+651.0k
BANK OF AMERICA CORP /DE/ Added +616,946+616.9k
GOLDMAN SACHS GROUP INC Added +476,843+476.8k
MARSHALL WACE, LLP Added +442,531+442.5k
MORGAN STANLEY Added +418,845+418.8k
DIMENSIONAL FUND ADVISORS LP Added +418,273+418.3k
KENNEDY CAPITAL MANAGEMENT LLC New +365,714+365.7k

Biggest sellers

EcoR1 Capital, LLC Sold out -4,288,120-4.3m
RTW INVESTMENTS, LP Sold out -1,451,326-1.5m
WELLINGTON MANAGEMENT GROUP LLP Reduced -1,026,120-1.0m
JENNISON ASSOCIATES LLC Reduced -742,811-742.8k
Bellevue Group AG Reduced -660,000-660.0k
Siren, L.L.C. Reduced -482,848-482.8k
AMERIPRISE FINANCIAL INC Reduced -301,129-301.1k
VOYA INVESTMENT MANAGEMENT LLC Reduced -286,220-286.2k
Fiera Capital Corp Reduced -250,813-250.8k
Sio Capital Management, LLC Sold out -249,887-249.9k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $1.5m41.4k shares
CITADEL ADVISORS LLC Added $714.7k19.1k shares
GROUP ONE TRADING LLC Added $29.9k800 shares
SIMPLEX TRADING, LLC Reduced $26.2k700 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $1.0m27.6k shares
JANE STREET GROUP, LLC Reduced $437.8k11.7k shares
CITADEL ADVISORS LLC Reduced $232.0k6.2k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-03 8.5% 9.0m≈ $336.4m 2026-08-03
Farallon Capital Partners, L.P. 13G · passive investor +2.5 pts · filed 2026-02-05 8.5% +2.5 pts 8.0m≈ $300.3m 2026-02-05
WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.0 pts · filed 2026-08-13 6.8% -1.0 pts 7.1m≈ $266.8m 2026-08-13
DRIEHAUS CAPITAL MANAGEMENT LLC 13G · institution filed 2026-05-15 6.1% 6.4m≈ $239.3m 2026-05-15
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 5.2% new 5.4m≈ $203.6m 2026-04-29
PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution filed 2026-05-15 5.1% 5.4m≈ $200.4m 2026-05-15

Fell to 5% or below in the last year: FMR LLC (1.4%, 2026-08-07), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)

Holders, Q2 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.03% of their portfolio BOSTON, MA 15,840,21915.8m $592.7m $592.7m 0.03% Added +80.4k +80,420
2 BlackRock, Inc. 0.01% of their portfolio New York, NY 9,758,9389.8m $365.2m $365.2m 0.01% Added +1.3m +1,280,123
3 FARALLON CAPITAL MANAGEMENT, L.L.C. 1.97% of their portfolio SAN FRANCISCO, CA 8,989,0989.0m $336.4m $336.4m 1.97% Added +651.0k +651,000
4 WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio Boston, MA 7,131,0847.1m $266.8m $266.8m 0.05% Reduced -1.0m -1,026,120
5 Driehaus Capital Management LLC 1.40% of their portfolio Chicago, IL 6,463,5516.5m $241.9m $241.9m 1.40% Added +67.6k +67,629
6 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 6,212,6816.2m $232.5m $232.5m 0.02% Added +857.2k +857,185
7 VANGUARD PORTFOLIO MANAGEMENT LLC 0.01% of their portfolio MALVERN, PA 4,832,6144.8m $180.8m $180.8m 0.01% Added +194.1k +194,103
8 VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio MALVERN, PA 4,745,2624.7m $177.6m $177.6m 0.00% Added +71.3k +71,327
9 Jupiter Topco LLC 0.07% of their portfolio NEW YORK, NY 4,557,6894.6m $170.5m $170.5m 0.07% First filing
10 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 2,727,6332.7m $102.1m $102.1m 0.01% Added +246.9k +246,870
11 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,689,3502.7m $100.6m $100.6m 0.00% Added +286.3k +286,304
12 Bellevue Group AG 2.06% of their portfolio ZURICH, V8 2,620,0002.6m $98.0m $98.0m 2.06% Reduced -660.0k -660,000
13 BAKER BROS. ADVISORS LP 0.44% of their portfolio NEW YORK, NY 2,351,4652.4m $88.0m $88.0m 0.44% Unchanged
14 Polar Capital Holdings Plc 0.24% of their portfolio London, X0 2,274,4112.3m $85.1m $85.1m 0.24% New
15 Pictet Asset Management Holding SA 0.07% of their portfolio CAROUGE, V8 2,075,3752.1m $77.6m $77.6m 0.07% Added +191.1k +191,094
16 T. Rowe Price Investment Management, Inc. 0.05% of their portfolio BALTIMORE, MD 2,010,2882.0m $75.2m $75.2m 0.05% Added +69.7k +69,666
17 GW&K Investment Management, LLC 0.51% of their portfolio BOSTON, MA 1,731,1401.7m $64.8m $64.8m 0.51% Added +112.5k +112,454
18 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.06% of their portfolio Paris, I0 1,678,4901.7m $62.8m $62.8m 0.06% Reduced -38.0k -37,955
19 Siren, L.L.C. 1.08% of their portfolio New York, NY 1,420,7881.4m $53.2m $53.2m 1.08% Reduced -482.8k -482,848
20 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 1,365,0301.4m $50.6m $50.6m 0.00% Added +40.4k +40,362
21 First Light Asset Management, LLC 3.10% of their portfolio Edina, MN 1,360,8661.4m $50.9m $50.9m 3.10% Added +271.2k +271,196
22 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,338,5311.3m $50.1m $50.1m 0.00% Added +418.8k +418,845
23 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 1,333,0711.3m $49.9m $49.9m 0.00% Added +616.9k +616,946
24 NOVO HOLDINGS A/S 2.87% of their portfolio HELLERUP, G7 1,320,0001.3m $49.4m $49.4m 2.87% Reduced -230.0k -230,000
25 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 1,270,5311.3m $47.5m $47.5m 0.01% Added +418.3k +418,273
26 AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio KANSAS CITY, MO 1,262,5621.3m $47.2m $47.2m 0.02% Added +209.7k +209,704
27 ADAR1 Capital Management, LLC 2.15% of their portfolio AUSTIN, TX 1,222,0801.2m $45.7m $45.7m 2.15% Added +82.7k +82,749
28 MONTANOVA CAPITAL, LLC 0.93% of their portfolio New York, NY 1,186,2791.2m $44.4m $44.4m 0.93% Added +142.4k +142,400
29 MARSHALL WACE, LLP 0.04% of their portfolio LONDON, X0 1,126,6391.1m $42.2m $42.2m 0.04% Added +442.5k +442,531
30 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 1,104,9981.1m $41.3m $41.3m 0.00% Added +476.8k +476,843
31 ORBIMED ADVISORS LLC 0.71% of their portfolio New York, NY 999,000999.0k $37.4m $37.4m 0.71% Unchanged
32 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 974,781974.8k $36.5m $36.5m 0.00% Added +133.5k +133,480
33 Hood River Capital Management LLC 0.26% of their portfolio PALM BEACH GARDENS, FL 968,996969.0k $36.3m $36.3m 0.26% Added +61.6k +61,584
34 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 877,643877.6k $32.8m $32.8m 0.00% Added +44.2k +44,225
35 Aberdeen Group plc 0.04% of their portfolio EDINBURGH, X0 820,395820.4k $30.7m $30.7m 0.04% Unchanged
36 Candriam S.C.A. 0.14% of their portfolio STRASSEN, N4 819,032819.0k $30.6m $30.6m 0.14% Reduced -11.9k -11,929
37 VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio MALVERN, PA 754,436754.4k $28.2m $28.2m 0.01% Added +46.0k +45,963
38 Fisher Asset Management, LLC 0.01% of their portfolio PLANO, TX 741,553741.6k $27.7m $27.7m 0.01% Reduced -21.1k -21,149
39 UBS Group AG 0.00% of their portfolio ZURICH, V8 561,165561.2k $21.0m $21.0m 0.00% Reduced -10.7k -10,734
40 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 555,381555.4k $20.8m $20.8m 0.00% Added +3.9k +3,917
41 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 497,205497.2k $18.6m $18.6m 0.00% Reduced -301.1k -301,129
42 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 480,504480.5k $17.7m $17.7m 0.01% Added +98.1k +98,141
43 Impax Asset Management Group plc 0.11% of their portfolio LONDON, X0 435,000435.0k $16.3m $16.3m 0.11% Added +85.0k +85,000
44 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 393,688393.7k $14.7m $14.7m 0.00% Added +35.0k +34,969
45 Prosight Management, LP 2.42% of their portfolio DALLAS, TX 374,666374.7k $14.0m $14.0m 2.42% Added +24.7k +24,666
46 Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio FRANKFURT AM MAIN, 2M 373,910373.9k $14.0m $14.0m 0.02% Reduced -51.7k -51,706
47 KENNEDY CAPITAL MANAGEMENT LLC 0.24% of their portfolio ST LOUIS, MO 365,714365.7k $13.7m $13.7m 0.24% New
48 BRAUN STACEY ASSOCIATES INC 0.37% of their portfolio NEW YORK, NY 348,143348.1k $13.0m $13.0m 0.37% Added +23.3k +23,335
49 Fiera Capital Corp 0.05% of their portfolio MONTREAL, A8 338,841338.8k $12.7m $12.7m 0.05% Reduced -250.8k -250,813
50 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 283,727283.7k $10.6m $10.6m 0.00% Added +26.2k +26,202
51 Defilade Capital Management, L.P. 1.20% of their portfolio EMERYVILLE, CA 239,440239.4k $9.0m $9.0m 1.20% New
52 SEB Asset Management AB 0.03% of their portfolio STOCKHOLM, V7 213,891213.9k $8.0m $8.0m 0.03% Unchanged
53 Foresite Capital Management VI LLC 1.23% of their portfolio WEST HOLLYWOOD, CA 212,010212.0k $7.9m $7.9m 1.23% Unchanged
54 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 202,395202.4k $7.6m $7.6m 0.00% Reduced -27.7k -27,733
55 RICE HALL JAMES & ASSOCIATES, LLC 0.36% of their portfolio San Diego, CA 196,318196.3k $7.3m $7.3m 0.36% Added +617 +617
56 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 191,142191.1k $7.2m $7.2m 0.01% Reduced -43.8k -43,750
57 Swiss National Bank 0.00% of their portfolio ZURICH, V8 183,800183.8k $6.9m $6.9m 0.00% Added +7.3k +7,300
58 SEGALL BRYANT & HAMILL, LLC 0.08% of their portfolio CHICAGO, IL 183,199183.2k $6.9m $6.9m 0.08% Added +3.1k +3,087
59 JENNISON ASSOCIATES LLC 0.00% of their portfolio NEW YORK, NY 161,861161.9k $6.1m $6.1m 0.00% Reduced -742.8k -742,811
60 SILVERCREST ASSET MANAGEMENT GROUP LLC 0.04% of their portfolio NEW YORK, NY 156,738156.7k $5.9m $5.9m 0.04% Reduced -6.9k -6,895
61 Foresite Capital Management IV, LLC 1.93% of their portfolio WEST HOLLYWOOD, CA 150,000150.0k $5.6m $5.6m 1.93% New
62 NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio ALBANY, NY 147,218147.2k $5.5m $5.5m 0.01% Added +5.6k +5,600
63 ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio Berwyn, PA 146,216146.2k $5.5m $5.5m 0.00% Reduced -4.4k -4,443
64 Moody Aldrich Partners LLC 0.98% of their portfolio MARBLEHEAD, MA 146,077146.1k $5.5m $5.5m 0.98% Reduced -37.4k -37,361
65 Ishara Investments LP 3.95% of their portfolio LOS ANGELES, CA 143,500143.5k $5.4m $5.4m 3.95% New
66 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 138,329138.3k $5.2m $5.2m 0.00% Reduced -179.6k -179,605
67 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 137,576137.6k $5.1m $5.1m 0.00% Added +63.9k +63,924
68 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 131,680131.7k $4.8m $4.8m 0.00% Reduced -39.3k -39,269
69 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 129,908129.9k $4.9m $4.9m 0.00% Added +11.5k +11,488
70 GordonMD Global Investments LP 2.30% of their portfolio Beverely Hills, CA 126,985127.0k $4.8m $4.8m 2.30% Unchanged
71 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 125,948125.9k $4.7m $4.7m 0.00% Reduced -21.7k -21,732
72 Cormorant Asset Management, LP 0.24% of their portfolio BOSTON, MA 125,000125.0k $4.7m $4.7m 0.24% Reduced -125.0k -125,000
73 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 122,451122.5k $4.6m $4.6m 0.00% Added +15.7k +15,717
74 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 116,460116.5k $4.4m $4.4m 0.00% Reduced -17.0k -17,006
75 SECTOR GAMMA AS 0.93% of their portfolio OSLO, Q8 114,628114.6k $4.3m $4.3m 0.93% Added +20.4k +20,433
76 XTX Topco Ltd 0.05% of their portfolio LONDON, X0 111,292111.3k $4.2m $4.2m 0.05% Added +14.1k +14,126
77 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 106,409106.4k $4.0m $4.0m 0.02% Added +21.2k +21,177
78 FEDERATED HERMES, INC. 0.01% of their portfolio PITTSBURGH, PA 105,756105.8k $4.0m $4.0m 0.01% Added +89.5k +89,508
79 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 102,229102.2k $3.8m $3.8m 0.00% Reduced -3.3k -3,334
80 Burkehill Global Management, LP 0.14% of their portfolio NEW YORK, NY 100,000100.0k $3.7m $3.7m 0.14% Unchanged
81 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 93,11293.1k $3.5m $3.5m 0.00% Reduced -6.3k -6,252
82 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 87,29987.3k $3.3m $3.3m 0.00% Unchanged
83 VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio London, EC4N 8AF, X0 86,97987.0k $3.3m $3.3m 0.00% Added +6.5k +6,453
84 AWM Investment Company, Inc. 0.28% of their portfolio NEW YORK, NY 85,00085.0k $3.2m $3.2m 0.28% Reduced -15.0k -15,000
85 Odyssean, LLC 0.51% of their portfolio DARIEN, CT 84,45684.5k $3.2m $3.2m 0.51% New
86 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 83,22583.2k $3.1m $3.1m 0.00% Added +9.3k +9,264
87 Legal & General Group Plc 0.00% of their portfolio London, X0 77,56977.6k $2.9m $2.9m 0.00% Added +3.2k +3,214
88 Affinity Asset Advisors, LLC 0.14% of their portfolio NEW YORK, NY 75,00075.0k $2.8m $2.8m 0.14% Unchanged
89 ALGERT GLOBAL LLC 0.03% of their portfolio SAN FRANCISCO, CA 72,53272.5k $2.7m $2.7m 0.03% Reduced -25.3k -25,270
90 ExodusPoint Capital Management, LP 0.02% of their portfolio NEW YORK, NY 70,88270.9k $2.7m $2.7m 0.02% New
91 Ensign Peak Advisors, Inc 0.00% of their portfolio SALT LAKE CITY, UT 67,00467.0k $2.5m $2.5m 0.00% Reduced -8.4k -8,420
92 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 66,60366.6k $2.5m $2.5m 0.00% Added +41.5k +41,516
93 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 63,76863.8k $2.4m $2.4m 0.00% Reduced -44.1k -44,107
94 FIRST TRUST ADVISORS LP 0.00% of their portfolio Wheaton, IL 63,35263.4k $2.4m $2.4m 0.00% Added +12.0k +11,987
95 Man Group plc 0.00% of their portfolio LONDON, X0 61,04361.0k $2.3m $2.3m 0.00% Added +13.5k +13,463
96 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 60,36160.4k $2.3m $2.3m 0.01% Added +6.0k +6,035
97 Swedbank AB 0.00% of their portfolio STOCKHOLM, V7 59,60059.6k $2.2m $2.2m 0.00% New
98 Longaeva Partners L.P. 0.06% of their portfolio Chicago, IL 58,38858.4k $2.2m $2.2m 0.06% New
99 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 55,26555.3k $2.1m $2.1m 0.00% Reduced -10.0k -9,967
100 Jump Financial, LLC 0.02% of their portfolio Chicago, IL 51,40051.4k $1.9m $1.9m 0.02% Added +35.4k +35,400