CHARLES RIV LABS INTL INC CRL
COM · Common Stock · CUSIP 159864107 · ISIN US1598641074
Major US biomedical company
- SectorHealth care
- IndustryServices-Commercial Physical & Biological Research
- HeadquartersWilmington, MA
- Founded1947
- Websitecriver.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($13.2m this quarter). Holder counts are more reliable. Shares outstanding: 48.2m as of 2026-04-24, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $172.65. Options: 9 managers hold calls ($40.9m notional), 10 hold puts ($33.4m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 584 |
| Q4 2022 | 629 |
| Q1 2023 | 623 |
| Q2 2023 | 613 |
| Q3 2023 | 623 |
| Q4 2023 | 634 |
| Q1 2024 | 675 |
| Q2 2024 | 666 |
| Q3 2024 | 629 |
| Q4 2024 | 637 |
| Q1 2025 | 564 |
| Q2 2025 | 520 |
| Q3 2025 | 556 |
| Q4 2025 | 583 |
| Q1 2026 | 561 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 330 | 316 |
| Q3 2024 | 263 | 370 |
| Q4 2024 | 248 | 362 |
| Q1 2025 | 246 | 374 |
| Q2 2025 | 256 | 329 |
| Q3 2025 | 285 | 243 |
| Q4 2025 | 273 | 285 |
| Q1 2026 | 252 | 286 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $219.2m | $217.4m | 0.99 |
| Q3 2025 | $35.1m | $28.0m | 0.80 |
| Q4 2025 | $33.4m | $21.4m | 0.64 |
| Q1 2026 | $40.9m | $33.4m | 0.82 |
Biggest buyers
| FMR LLC | Added | +1.7m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +1.1m |
| CITADEL ADVISORS LLC | Added | +794.6k |
| MILLENNIUM MANAGEMENT LLC | Added | +603.9k |
| Van Berkom & Associates Inc. | Added | +551.6k |
| Amundi | Added | +492.3k |
| HARRIS ASSOCIATES L P | Added | +475.7k |
| UBS Group AG | Added | +342.6k |
| COOKE & BIELER LP | Added | +260.4k |
| Meridiem Capital Partners LP | Added | +229.2k |
Biggest sellers
| Woodline Partners LP | Reduced | -343.0k |
| Invesco Ltd. | Reduced | -298.9k |
| AMERIPRISE FINANCIAL INC | Reduced | -275.0k |
| Walleye Capital LLC | Reduced | -249.2k |
| D. E. Shaw & Co., Inc. | Reduced | -237.6k |
| Point72 Asset Management, L.P. | Sold out | -221.6k |
| Balyasny Asset Management L.P. | Reduced | -196.5k |
| MACKENZIE FINANCIAL CORP | Reduced | -186.7k |
| Empyrean Capital Partners, LP | Sold out | -121.5k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -119.8k |
Biggest calls
| Caption Management, LLC | New | $24.0m139.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $6.5m37.4k shares |
| CITADEL ADVISORS LLC | Added | $4.9m28.3k shares |
| JANE STREET GROUP, LLC | Added | $2.2m12.8k shares |
| Walleye Trading LLC | Added | $1.5m8.5k shares |
| IMC-Chicago, LLC | Reduced | $1.2m7.0k shares |
| Walleye Capital LLC | New | $345.0k2.0k shares |
| TUDOR INVESTMENT CORP ET AL | New | $241.5k1.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $120.8k700 shares |
Biggest puts
| Walleye Trading LLC | Added | $10.4m60.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $7.5m43.7k shares |
| Caption Management, LLC | New | $5.2m30.0k shares |
| IMC-Chicago, LLC | New | $4.3m24.9k shares |
| CITADEL ADVISORS LLC | Added | $1.7m9.6k shares |
| JANE STREET GROUP, LLC | New | $1.5m8.6k shares |
| LOGAN CAPITAL MANAGEMENT INC | New | $1.3m7.6k shares |
| TUDOR INVESTMENT CORP ET AL | New | $707.2k4.1k shares |
| Walleye Capital LLC | Added | $431.2k2.5k shares |
| SIMPLEX TRADING, LLC | Added | $345.0k2.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +1.4 pts · filed 2026-09-08 | 10.2% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 7.4% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 6.9% |
| Invesco Ltd. 13G · institution +1.3 pts · filed 2026-08-13 | 6.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC), WELLINGTON MANAGEMENT GROUP LLP (3.6%, 2026-02-10), NOMURA HOLDINGS INC (1.6%, 2025-11-14)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 2 | $374.2k | $78.2k |
| Q3 2024 | 0 | — | 2 | $6.6m | $6.2m |
| Q4 2024 | 0 | — | 1 | $1.6m | — |
| Q1 2025 | 2 | $1.3m | 1 | $715.0k | — |
| Q2 2025 | 0 | — | 2 | $111.7k | $39.0k |
| Q3 2025 | 0 | — | 1 | $251.6k | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 1 | $4.4k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-03-03 | LaPlume Joseph W EVP, Corp Strategy & Develop | Bought | $4.4k25 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.01% of their portfolio | 3.9m $665.7m | Added +104.7k |
| FMR LLC 0.03% of their portfolio | 3.5m $596.2m | Added +1.7m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 3.2m $552.4m | First filing |
| Invesco Ltd. 0.04% of their portfolio | 2.4m $413.5m | Reduced -298.9k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.02% of their portfolio | 2.3m $395.8m | First filing |
| HARRIS ASSOCIATES L P 0.50% of their portfolio | 2.2m $371.4m | Added +475.7k |
| Allspring Global Investments Holdings, LLC 0.58% of their portfolio | 2.0m $348.6m | Reduced -2.3k |
| STATE STREET CORP 0.01% of their portfolio | 1.9m $323.2m | Added +1.9k |
| DIMENSIONAL FUND ADVISORS LP 0.06% of their portfolio | 1.7m $285.0m | Added +210.3k |
| WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio | 1.6m $281.1m | Reduced -119.8k |
| ARIEL INVESTMENTS, LLC 2.79% of their portfolio | 1.4m $249.1m | Added +16.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.3m $224.8m | Added +29.2k |
| CITADEL ADVISORS LLC 0.15% of their portfolio | 1.2m $209.1m | Added +794.6k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 1.1m $195.8m | Added +54.5k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio | 1.1m $194.1m | Added +1.1m |
| AMERIPRISE FINANCIAL INC 0.04% of their portfolio | 1.1m $191.4m | Reduced -275.0k |
| Van Berkom & Associates Inc. 2.83% of their portfolio | 1.0m $172.9m | Added +551.6k |
| EARNEST PARTNERS LLC 0.69% of their portfolio | 971.4k $167.6m | Reduced -16.9k |
| MILLENNIUM MANAGEMENT LLC 0.12% of their portfolio | 934.0k $161.1m | Added +603.9k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.05% of their portfolio | 908.9k $158.8m | Added +24.2k |
| NEUBERGER BERMAN GROUP LLC 0.11% of their portfolio | 874.4k $150.7m | Added +14.2k |
| COOKE & BIELER LP 1.69% of their portfolio | 867.9k $149.7m | Added +260.4k |
| MORGAN STANLEY 0.01% of their portfolio | 825.7k $142.4m | Added +32.8k |
| Amundi 0.04% of their portfolio | 773.3k $133.4m | Added +492.3k |
| SEI INVESTMENTS CO 0.12% of their portfolio | 757.1k $130.6m | Added +371 |
| VICTORY CAPITAL MANAGEMENT INC 0.08% of their portfolio | 743.3k $128.2m | Added +51.9k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.07% of their portfolio | 737.0k $127.1m | Reduced -99.2k |
| UBS Group AG 0.02% of their portfolio | 731.5k $126.2m | Added +342.6k |
| Clearbridge Investments, LLC 0.09% of their portfolio | 632.6k $109.1m | Added +121.0k |
| MACKENZIE FINANCIAL CORP 0.12% of their portfolio | 594.8k $102.6m | Reduced -186.7k |
| Alyeska Investment Group, L.P. 0.27% of their portfolio | 558.6k $96.4m | Reduced -86.1k |
| LSV ASSET MANAGEMENT 0.18% of their portfolio | 486.6k $83.9m | Added +10.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 469.0k $80.9m | Added +14.8k |
| BANK OF MONTREAL /CAN/ 0.03% of their portfolio | 445.9k $76.9m | Added +58.0k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 445.4k $76.8m | Added +6.2k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 414.7k $71.5m | Added +97.1k |
| Meridiem Capital Partners LP 4.11% of their portfolio | 362.1k $62.5m | Added +229.2k |
| Gotham Asset Management, LLC 0.19% of their portfolio | 358.5k $61.8m | Added +69.0k |
| ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio | 302.0k $60.2m | Added +1.6k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 295.9k $51.0m | Reduced -36.3k |
| Boston Trust Walden Corp 0.40% of their portfolio | 285.4k $49.2m | Reduced -19.5k |
| VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio | 277.0k $47.8m | First filing |
| DEUTSCHE BANK AG\ 0.02% of their portfolio | 275.4k $47.5m | Added +87.3k |
| PRIMECAP MANAGEMENT CO/CA/ 0.04% of their portfolio | 266.9k $46.0m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 264.4k $42.2m | Added +89.6k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.07% of their portfolio | 256.0k $44.2m | Reduced -55.6k |
| BNP PARIBAS FINANCIAL MARKETS 0.03% of their portfolio | 252.2k $43.5m | Added +89.4k |
| SNYDER CAPITAL MANAGEMENT L P 0.80% of their portfolio | 237.7k $41.0m | Reduced -3.3k |
| BARCLAYS PLC 0.01% of their portfolio | 234.9k $40.5m | Added +175.8k |
| Quantinno Capital Management LP 0.07% of their portfolio | 227.1k $39.2m | Reduced -22.7k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 218.9k $37.8m | Added +10.0k |
| MACQUARIE GROUP LTD 0.21% of their portfolio | 201.6k $34.8m | Reduced -518 |
| Ilex Capital Partners (UK) LLP 0.84% of their portfolio | 196.5k $33.9m | New |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 193.5k $33.4m | Added +71.3k |
| D. E. Shaw & Co., Inc. 0.03% of their portfolio | 193.5k $33.4m | Reduced -237.6k |
| SG Americas Securities, LLC 0.04% of their portfolio | 186.2k $32.1m | Added +4.4k |
| LOOMIS SAYLES & CO L P 0.04% of their portfolio | 171.0k $29.5m | Added +108.4k |
| MARSHALL WACE, LLP 0.03% of their portfolio | 149.7k $25.8m | Added +25.5k |
| Nuveen, LLC 0.01% of their portfolio | 134.0k $23.1m | Added +7.2k |
| FEDERATED HERMES, INC. 0.04% of their portfolio | 129.3k $22.3m | Added +3.5k |
| NATIXIS ADVISORS, LLC 0.03% of their portfolio | 122.5k $21.1m | Added +8.1k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 120.8k $20.8m | Reduced -55 |
| JONES FINANCIAL COMPANIES LLLP 0.01% of their portfolio | 114.0k $18.2m | Added +113.2k |
| Aberdeen Group plc 0.03% of their portfolio | 113.8k $19.6m | Added +16.8k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.03% of their portfolio | 109.3k $18.9m | Reduced -2.1k |
| Vanguard Global Advisers, LLC 0.01% of their portfolio | 103.5k $17.9m | First filing |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 0.07% of their portfolio | 101.6k $17.5m | Added +18.0k |
| CONFLUENCE INVESTMENT MANAGEMENT LLC 0.27% of their portfolio | 100.5k $17.3m | Reduced -5.1k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 100.3k $17.3m | Reduced -23.3k |
| Aristotle Capital Boston, LLC 1.04% of their portfolio | 97.4k $16.8m | Added +11.2k |
| Swiss National Bank 0.01% of their portfolio | 97.3k $16.8m | Added +200 |
| Legal & General Group Plc 0.00% of their portfolio | 96.9k $16.7m | Reduced -9.5k |
| PICTON MAHONEY ASSET MANAGEMENT 0.17% of their portfolio | 95.4k $16.5m | Added +21.9k |
| GW&K Investment Management, LLC 0.14% of their portfolio | 95.2k $16.4m | Reduced -5.9k |
| Engineers Gate Manager LP 0.20% of their portfolio | 93.8k $16.2m | Added +66.2k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 91.7k $15.8m | Added +3.2k |
| California Public Employees Retirement System 0.01% of their portfolio | 88.8k $15.3m | Added +197 |
| Clark Capital Management Group, Inc. 0.09% of their portfolio | 86.5k $14.9m | Added +44.1k |
| Candriam S.C.A. 0.08% of their portfolio | 86.4k $14.9m | Added +53.1k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 83.3k $14.4m | Added +13.2k |
| CITIGROUP INC 0.01% of their portfolio | 81.3k $14.0m | Added +32.4k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 79.9k $13.8m | Added +2.5k |
| NICHOLAS COMPANY, INC. 0.24% of their portfolio | 71.9k $12.4m | New |
| Laurus Global Equity Management Inc. 12.11% of their portfolio | 71.7k $12.4m | Reduced -10.7k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 71.6k $11.8m | Reduced -48.5k |
| Ranger Investment Management, L.P. 0.88% of their portfolio | 70.7k $12.2m | New |
| HSBC HOLDINGS PLC 0.01% of their portfolio | 69.7k $12.0m | Reduced -54.5k |
| LAKEWOOD CAPITAL MANAGEMENT, LP 0.76% of their portfolio | 69.0k $11.9m | Reduced -71.2k |
| RIVERBRIDGE PARTNERS LLC 0.27% of their portfolio | 63.8k $11.0m | Reduced -35.5k |
| Mitsubishi UFJ Asset Management Co., Ltd. 0.01% of their portfolio | 63.8k $11.0m | Added +5.4k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 57.0k $9.8m | Added +10.2k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 56.2k $9.7m | Reduced -63.3k |
| NORDEA INVESTMENT MANAGEMENT AB 0.01% of their portfolio | 56.1k $9.2m | Added +1.4k |
| KING LUTHER CAPITAL MANAGEMENT CORP 0.04% of their portfolio | 55.1k $9.5m | Reduced -9.7k |
| Connor, Clark & Lunn Investment Management Ltd. 0.02% of their portfolio | 54.6k $9.4m | Reduced -79.6k |
| OMERS ADMINISTRATION Corp 0.06% of their portfolio | 54.4k $9.4m | Reduced -4.1k |
| Public Sector Pension Investment Board 0.03% of their portfolio | 53.9k $9.3m | Added +41.4k |
| Schonfeld Strategic Advisors LLC 0.07% of their portfolio | 53.0k $9.1m | Added +2.1k |
| ASSETMARK, INC 0.02% of their portfolio | 52.4k $9.0m | Added +8.6k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.09% of their portfolio | 48.1k $8.3m | Reduced -75.6k |