CHARLES RIV LABS INTL INC CRL
COM · Common Stock · CUSIP 159864107 · ISIN US1598641074
Major US biomedical company
- SectorHealth care
- IndustryServices-Commercial Physical & Biological Research
- HeadquartersWilmington, MA
- Founded1947
- Websitecriver.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($23.5m this quarter). Holder counts are more reliable. Shares outstanding: 49.2m as of 2025-07-26, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $151.87. Options: 16 managers hold calls ($219.2m notional), 16 hold puts ($217.4m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 584 |
| Q4 2022 | 629 |
| Q1 2023 | 623 |
| Q2 2023 | 613 |
| Q3 2023 | 623 |
| Q4 2023 | 634 |
| Q1 2024 | 675 |
| Q2 2024 | 666 |
| Q3 2024 | 629 |
| Q4 2024 | 637 |
| Q1 2025 | 564 |
| Q2 2025 | 520 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 303 | 281 |
| Q4 2023 | 265 | 328 |
| Q1 2024 | 341 | 274 |
| Q2 2024 | 330 | 316 |
| Q3 2024 | 263 | 370 |
| Q4 2024 | 248 | 362 |
| Q1 2025 | 246 | 374 |
| Q2 2025 | 256 | 329 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $59.0m | $94.8m | 1.61 |
| Q4 2024 | $28.5m | $44.2m | 1.55 |
| Q1 2025 | $105.6m | $121.9m | 1.15 |
| Q2 2025 | $219.2m | $217.4m | 0.99 |
Biggest buyers
| HARRIS ASSOCIATES L P | New | +1.2m |
| NOMURA HOLDINGS INC | Added | +967.7k |
| D. E. Shaw & Co., Inc. | New | +607.0k |
| Allspring Global Investments Holdings, LLC | Added | +516.5k |
| FULLER & THALER ASSET MANAGEMENT, INC. | New | +445.8k |
| MILLENNIUM MANAGEMENT LLC | Added | +432.8k |
| NATIONAL BANK OF CANADA /FI/ | Added | +400.9k |
| Balyasny Asset Management L.P. | Added | +381.4k |
| Iron Triangle Partners LP | New | +320.0k |
| ARIEL INVESTMENTS, LLC | Added | +314.6k |
Biggest sellers
| KAYNE ANDERSON RUDNICK INVESTMENT MANAGEMENT LLC | Reduced | -2.0m |
| UBS Group AG | Reduced | -1.7m |
| Impactive Capital LP | Sold out | -1.2m |
| D1 Capital Partners L.P. | Sold out | -777.5k |
| GOLDMAN SACHS GROUP INC | Reduced | -618.4k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -517.2k |
| AMERIPRISE FINANCIAL INC | Reduced | -506.3k |
| JPMORGAN CHASE & CO | Reduced | -481.3k |
| EMINENCE CAPITAL, LP | Sold out | -435.5k |
| WELLS FARGO & COMPANY/MN | Reduced | -389.2k |
Biggest calls
| NOMURA HOLDINGS INC | Added | $168.8m1.1m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $16.1m106.2k shares |
| MILLENNIUM MANAGEMENT LLC | New | $7.1m46.5k shares |
| CITADEL ADVISORS LLC | Added | $6.6m43.3k shares |
| Squarepoint Ops LLC | New | $4.7m31.0k shares |
| Twin Tree Management, LP | New | $4.0m26.3k shares |
| Cubist Systematic Strategies, LLC | Added | $3.3m21.9k shares |
| WOLVERINE TRADING, LLC | Added | $1.9m12.5k shares |
| IMC-Chicago, LLC | New | $1.8m12.1k shares |
| TUDOR INVESTMENT CORP ET AL | Added | $1.6m10.4k shares |
Biggest puts
| NOMURA HOLDINGS INC | Added | $166.9m1.1m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $18.7m123.1k shares |
| JANE STREET GROUP, LLC | Added | $7.3m48.0k shares |
| CITADEL ADVISORS LLC | Reduced | $6.4m42.4k shares |
| Cubist Systematic Strategies, LLC | Added | $5.7m37.6k shares |
| Twin Tree Management, LP | New | $5.7m37.4k shares |
| SIMPLEX TRADING, LLC | New | $1.8m12.0k shares |
| Squarepoint Ops LLC | New | $1.6m10.5k shares |
| WOLVERINE TRADING, LLC | Reduced | $1.3m8.6k shares |
| TUDOR INVESTMENT CORP ET AL | Added | $667.6k4.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +1.4 pts · filed 2026-09-08 | 10.2% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 7.4% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 6.9% |
| Invesco Ltd. 13G · institution +1.3 pts · filed 2026-08-13 | 6.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC), WELLINGTON MANAGEMENT GROUP LLP (3.6%, 2026-02-10), NOMURA HOLDINGS INC (1.6%, 2025-11-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 1 | $198.8k | 3 | $1.7m | — |
| Q4 2023 | 2 | $1.2m | 2 | $3.2m | $1.2m |
| Q1 2024 | 0 | — | 5 | $5.8m | $1.4m |
| Q2 2024 | 0 | — | 2 | $374.2k | $78.2k |
| Q3 2024 | 0 | — | 2 | $6.6m | $6.2m |
| Q4 2024 | 0 | — | 1 | $1.6m | — |
| Q1 2025 | 2 | $1.3m | 1 | $715.0k | — |
| Q2 2025 | 0 | — | 2 | $111.7k | $39.0k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-05-15 | MASSARO GEORGE Director | Sold plan | $19.3k140 shares |
| 2025-05-14 | MASSARO GEORGE Director | Sold plan | $19.7k140 shares |
| 2025-05-13 | LaPlume Joseph W EVP, Corp Strategy & Develop | Sold | $72.7k500 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| VANGUARD GROUP INC 0.01% of their portfolio | 5.8m $881.8m | Reduced -293.7k |
| WELLINGTON MANAGEMENT GROUP LLP 0.10% of their portfolio | 3.8m $571.7m | Reduced -517.2k |
| BlackRock, Inc. 0.01% of their portfolio | 3.7m $554.7m | Reduced -14.7k |
| Allspring Global Investments Holdings, LLC 0.59% of their portfolio | 2.3m $353.7m | Added +516.5k |
| STATE STREET CORP 0.01% of their portfolio | 1.9m $282.0m | Reduced -43.8k |
| NOMURA HOLDINGS INC 1.92% of their portfolio | 1.6m $238.1m | Added +967.7k |
| ARIEL INVESTMENTS, LLC 2.43% of their portfolio | 1.4m $214.8m | Added +314.6k |
| Invesco Ltd. 0.03% of their portfolio | 1.2m $187.7m | Added +128.8k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.2m $186.6m | Reduced -31.4k |
| HARRIS ASSOCIATES L P 0.29% of their portfolio | 1.2m $176.5m | New |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 1.0m $155.7m | Added +232.0k |
| DIMENSIONAL FUND ADVISORS LP 0.04% of their portfolio | 1.0m $153.4m | Added +148.4k |
| MACKENZIE FINANCIAL CORP 0.20% of their portfolio | 1.0m $152.0m | Reduced -902 |
| EARNEST PARTNERS LLC 0.68% of their portfolio | 998.3k $151.5m | Reduced -6.3k |
| MORGAN STANLEY 0.01% of their portfolio | 754.9k $114.5m | Added +295.9k |
| UBS Group AG 0.02% of their portfolio | 735.3k $111.6m | Reduced -1.7m |
| SEI INVESTMENTS CO 0.13% of their portfolio | 714.7k $108.4m | Added +46.5k |
| NEUBERGER BERMAN GROUP LLC 0.08% of their portfolio | 694.7k $105.4m | Added +103.7k |
| D. E. Shaw & Co., Inc. 0.09% of their portfolio | 607.0k $92.1m | New |
| COOKE & BIELER LP 0.91% of their portfolio | 598.8k $90.9m | Added +179.1k |
| ROYAL BANK OF CANADA 0.01% of their portfolio | 585.7k $88.9m | Reduced -42.1k |
| Assenagon Asset Management S.A. 0.14% of their portfolio | 581.5k $88.2m | Added +11.4k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.06% of their portfolio | 578.6k $87.8m | Added +225.0k |
| CITADEL ADVISORS LLC 0.07% of their portfolio | 564.6k $85.7m | Added +282.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 545.7k $82.8m | Reduced -31.6k |
| DEUTSCHE BANK AG\ 0.03% of their portfolio | 539.7k $81.9m | Added +128.3k |
| MILLENNIUM MANAGEMENT LLC 0.07% of their portfolio | 507.3k $77.0m | Added +432.8k |
| NORGES BANK 0.01% of their portfolio | 507.2k $77.0m | Added +69.4k |
| Van Berkom & Associates Inc. 2.20% of their portfolio | 486.9k $73.9m | Added +39.9k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 477.2k $72.4m | Reduced -15.3k |
| FULLER & THALER ASSET MANAGEMENT, INC. 0.25% of their portfolio | 445.8k $67.6m | New |
| NATIONAL BANK OF CANADA /FI/ 0.07% of their portfolio | 434.9k $66.0m | Added +400.9k |
| Balyasny Asset Management L.P. 0.15% of their portfolio | 434.2k $65.9m | Added +381.4k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 386.0k $58.6m | Added +40.7k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 379.0k $57.5m | Reduced -618.4k |
| Clearbridge Investments, LLC 0.04% of their portfolio | 352.5k $53.5m | Reduced -336.1k |
| Iron Triangle Partners LP 7.68% of their portfolio | 320.0k $48.6m | New |
| Alyeska Investment Group, L.P. 0.16% of their portfolio | 292.7k $44.4m | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 283.7k $43.0m | Added +37.1k |
| Burgundy Asset Management Ltd. 0.41% of their portfolio | 280.2k $42.5m | Added +277.4k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 277.1k $42.0m | Reduced -481.3k |
| PRIMECAP MANAGEMENT CO/CA/ 0.03% of their portfolio | 270.6k $41.1m | Reduced -2.3k |
| Gotham Asset Management, LLC 0.24% of their portfolio | 269.2k $40.8m | Added +114.4k |
| Point72 Asset Management, L.P. 0.08% of their portfolio | 236.4k $35.9m | New |
| Amundi 0.01% of their portfolio | 226.3k $35.6m | Added +209.9k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 225.6k $34.2m | Reduced -272.2k |
| Boston Trust Walden Corp 0.24% of their portfolio | 225.2k $34.2m | Added +19.8k |
| Nearwater Capital Markets, Ltd 0.51% of their portfolio | 210.0k $31.9m | New |
| Woodline Partners LP 0.17% of their portfolio | 208.6k $31.6m | New |
| BANK OF NOVA SCOTIA 0.06% of their portfolio | 203.3k $30.8m | Added +201.5k |
| Connor, Clark & Lunn Investment Management Ltd. 0.10% of their portfolio | 191.3k $29.0m | Added +166.4k |
| SNYDER CAPITAL MANAGEMENT L P 0.58% of their portfolio | 181.1k $27.5m | Added +6.8k |
| BARCLAYS PLC 0.01% of their portfolio | 179.9k $27.3m | Added +60.1k |
| TUDOR INVESTMENT CORP ET AL 0.19% of their portfolio | 169.8k $25.8m | Added +100.7k |
| DF DENT & CO INC 0.31% of their portfolio | 162.5k $24.7m | Added +47.5k |
| Quantinno Capital Management LP 0.10% of their portfolio | 156.1k $23.7m | Added +38.3k |
| Nuveen, LLC 0.01% of their portfolio | 152.9k $23.2m | Added +29.8k |
| Man Group plc 0.05% of their portfolio | 148.5k $22.5m | Added +27.4k |
| CITIGROUP INC 0.02% of their portfolio | 146.6k $22.2m | Reduced -87.9k |
| LAKEWOOD CAPITAL MANAGEMENT, LP 1.62% of their portfolio | 140.2k $21.3m | Unchanged |
| RIVERBRIDGE PARTNERS LLC 0.33% of their portfolio | 133.6k $20.3m | Reduced -89.1k |
| FEDERATED HERMES, INC. 0.04% of their portfolio | 126.1k $19.1m | Added +125.8k |
| NORRIS PERNE & FRENCH LLP/MI 1.27% of their portfolio | 120.3k $18.3m | Reduced -8.8k |
| Meridiem Capital Partners LP 1.31% of their portfolio | 120.0k $18.2m | New |
| Integral Health Asset Management, LLC 1.63% of their portfolio | 115.0k $17.4m | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.02% of their portfolio | 111.0k $16.8m | Reduced -20.8k |
| Legal & General Group Plc 0.00% of their portfolio | 106.2k $16.1m | Added +11.6k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.01% of their portfolio | 105.0k $15.9m | Reduced -300 |
| PERCEPTIVE ADVISORS LLC 0.57% of their portfolio | 100.0k $15.2m | New |
| Junto Capital Management LP 0.32% of their portfolio | 99.9k $15.2m | New |
| CONFLUENCE INVESTMENT MANAGEMENT LLC 0.21% of their portfolio | 97.2k $14.8m | Added +700 |
| Aristotle Capital Boston, LLC 0.74% of their portfolio | 96.4k $14.6m | Reduced -8.1k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 95.1k $14.4m | Added +8.4k |
| Swiss National Bank 0.01% of their portfolio | 93.8k $14.2m | Reduced -5.3k |
| TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio | 93.7k $14.2m | Reduced -69.7k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.05% of their portfolio | 91.8k $13.9m | Reduced -44.9k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 89.7k $13.6m | Reduced -5.0k |
| GW&K Investment Management, LLC 0.12% of their portfolio | 88.3k $13.4m | Reduced -97 |
| Laurus Global Equity Management Inc. 8.57% of their portfolio | 86.5k $13.1m | Reduced -3.7k |
| ROYCE & ASSOCIATES LP 0.13% of their portfolio | 85.6k $13.0m | Added +81.5k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 85.5k $13.0m | Reduced -135.7k |
| NATIXIS ADVISORS, LLC 0.02% of their portfolio | 84.9k $12.9m | Reduced -138 |
| California Public Employees Retirement System 0.01% of their portfolio | 84.6k $12.8m | Added +3.2k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 78.8k $12.0m | Reduced -389.2k |
| FMR LLC 0.00% of their portfolio | 78.3k $11.9m | Reduced -23.4k |
| Cubist Systematic Strategies, LLC 0.13% of their portfolio | 77.1k $11.7m | New |
| HSBC HOLDINGS PLC 0.01% of their portfolio | 76.5k $11.6m | Reduced -5.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 74.5k $11.3m | Reduced -1.5k |
| ALGERT GLOBAL LLC 0.23% of their portfolio | 73.3k $11.1m | Added +51.0k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 66.1k $10.0m | Added +11.1k |
| Schonfeld Strategic Advisors LLC 0.07% of their portfolio | 63.6k $9.6m | Added +61.7k |
| Trexquant Investment LP 0.11% of their portfolio | 61.3k $9.3m | Added +39.6k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 56.8k $8.6m | Reduced -852 |
| Mitsubishi UFJ Asset Management Co., Ltd. 0.01% of their portfolio | 55.9k $8.5m | Added +1.5k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.19% of their portfolio | 53.3k $8.1m | Reduced -30.0k |
| KING LUTHER CAPITAL MANAGEMENT CORP 0.03% of their portfolio | 52.2k $7.9m | Added +6.8k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.07% of their portfolio | 51.8k $7.9m | Reduced -19.3k |
| OMERS ADMINISTRATION Corp 0.06% of their portfolio | 50.5k $7.7m | Unchanged |
| LAWSON KROEKER INVESTMENT MANAGEMENT INC/NE 1.42% of their portfolio | 50.5k $7.7m | Reduced -5.5k |
| IRIDIAN ASSET MANAGEMENT LLC/CT 2.50% of their portfolio | 47.6k $7.2m | Reduced -12.9k |