Vault-13

CATALYST PHARMACEUTICALS INC CPRX

COM · Common Stock · CUSIP 14888U101 · ISIN US14888U1016

366 institutional holders -5 vs Q1 2025
101,402,729101.4m shares reported held*
$2.2bnreported value*
42 new 159 added 124 reduced 48 sold out net bought ≈ $80.4m (+3.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.7m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $21.70. Options: 3 managers hold calls ($402.6k notional), 6 hold puts ($6.2m).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

0200400Q3 22: 230Q4 22: 259Q1 23: 261Q2 23: 249Q3 23: 257Q4 23: 260Q1 24: 269Q2 24: 272Q3 24: 317Q4 24: 336Q1 25: 371Q2 25: 366366Q3 22Q2 23Q1 24Q4 24Q2 25
Numbers
QuarterHolders
Q3 2022230
Q4 2022259
Q1 2023261
Q2 2023249
Q3 2023257
Q4 2023260
Q1 2024269
Q2 2024272
Q3 2024317
Q4 2024336
Q1 2025371
Q2 2025366

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
4000400Q3 23: 112 bought or addedQ3 23: 116 cut or sold outQ4 23: 105 bought or addedQ4 23: 119 cut or sold outQ4 23Q1 24: 157 bought or addedQ1 24: 109 cut or sold outQ2 24: 125 bought or addedQ2 24: 120 cut or sold outQ2 24Q3 24: 159 bought or addedQ3 24: 128 cut or sold outQ4 24: 183 bought or addedQ4 24: 130 cut or sold outQ4 24Q1 25: 191 bought or addedQ1 25: 157 cut or sold outQ2 25: 201 bought or addedQ2 25: 172 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q3 2023112116
Q4 2023105119
Q1 2024157109
Q2 2024125120
Q3 2024159128
Q4 2024183130
Q1 2025191157
Q2 2025201172

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$2m$4m$6m$8mQ3 24 calls: $609.5kQ3 24 puts: $1.6mQ3 24P/C 2.59Q4 24 calls: $489.9kQ4 24 puts: $248.2kQ4 24P/C 0.51Q1 25 calls: $2.5mQ1 25 puts: $547.2kQ1 25P/C 0.22Q2 25 calls: $402.6kQ2 25 puts: $6.2mQ2 25P/C 15.41
Numbers
QuarterCallsPutsP/C
Q3 2024$609.5k$1.6m2.59
Q4 2024$489.9k$248.2k0.51
Q1 2025$2.5m$547.2k0.22
Q2 2025$402.6k$6.2m15.41

Biggest buyers

AMERICAN CENTURY COMPANIES INC Added +1,231,419+1.2m
MORGAN STANLEY Added +788,968+789.0k
Fundsmith LLP Added +557,812+557.8k
BANK OF AMERICA CORP /DE/ Added +554,200+554.2k
JANUS HENDERSON GROUP PLC Added +431,733+431.7k
ORBIMED ADVISORS LLC New +416,900+416.9k
RAYMOND JAMES FINANCIAL INC Added +404,525+404.5k
Allianz Asset Management GmbH Added +343,686+343.7k
ALGERT GLOBAL LLC Added +329,981+330.0k
RENAISSANCE TECHNOLOGIES LLC Added +295,200+295.2k

Biggest sellers

GOLDMAN SACHS GROUP INC Reduced -723,813-723.8k
DEERFIELD MANAGEMENT COMPANY, L.P. Reduced -542,673-542.7k
CITADEL ADVISORS LLC Reduced -425,424-425.4k
New Vernon Capital Holdings II LLC Reduced -314,340-314.3k
DIMENSIONAL FUND ADVISORS LP Reduced -279,901-279.9k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -241,925-241.9k
Skandinaviska Enskilda Banken AB (publ) Reduced -234,200-234.2k
NORTHERN TRUST CORP Reduced -211,108-211.1k
Pacer Advisors, Inc. Reduced -209,235-209.2k
VICTORY CAPITAL MANAGEMENT INC Reduced -202,978-203.0k

Biggest calls

GROUP ONE TRADING LLC Reduced $301.6k13.9k shares
SIMPLEX TRADING, LLC Reduced $101.0k4.7k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $4.6m211.9k shares
JANE STREET GROUP, LLC New $928.8k42.8k shares
CITADEL ADVISORS LLC Added $486.1k22.4k shares
SIMPLEX TRADING, LLC Added $173.0k8.0k shares
GROUP ONE TRADING LLC Added $17.4k800 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-04-28 13.9% 16.9m≈ $530.9m 2025-04-28
STATE STREET CORP 13G · institution new · filed 2025-11-10 5.2% new 6.4m≈ $201.3m 2025-11-10

Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 BlackRock, Inc. 0.01% of their portfolio New York, NY 18,900,43818.9m $410.1m $410.1m 0.01% Added +96.1k +96,103
2 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 8,765,8358.8m $190.2m $190.2m 0.00% Added +270.3k +270,255
3 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 5,478,3885.5m $118.9m $118.9m 0.00% Reduced -52.0k -52,049
4 RENAISSANCE TECHNOLOGIES LLC 0.09% of their portfolio NEW YORK, NY 3,251,5163.3m $70.6m $70.6m 0.09% Added +295.2k +295,200
5 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 3,183,5233.2m $69.1m $69.1m 0.00% Added +789.0k +788,968
6 DEERFIELD MANAGEMENT COMPANY, L.P. 1.13% of their portfolio New York, NY 2,879,4762.9m $62.5m $62.5m 1.13% Reduced -542.7k -542,673
7 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 2,866,6832.9m $62.2m $62.2m 0.00% Added +101.1k +101,127
8 Fundsmith LLP 0.26% of their portfolio LONDON, X0 2,709,0862.7m $58.8m $58.8m 0.26% Added +557.8k +557,812
9 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 2,411,6602.4m $52.3m $52.3m 0.01% Reduced -723.8k -723,813
10 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 2,365,6752.4m $51.3m $51.3m 0.00% Added +554.2k +554,200
11 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 1,907,5211.9m $41.4m $41.4m 0.01% Reduced -279.9k -279,901
12 AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio KANSAS CITY, MO 1,757,9881.8m $38.1m $38.1m 0.02% Added +1.2m +1,231,419
13 ROYCE & ASSOCIATES LP 0.35% of their portfolio New York, NY 1,582,8621.6m $34.3m $34.3m 0.35% Reduced -15.5k -15,498
14 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 1,436,1121.4m $31.2m $31.2m 0.01% Added +109.3k +109,341
15 Boston Partners 0.03% of their portfolio BOSTON, MA 1,282,7221.3m $27.9m $27.9m 0.03% Added +7.4k +7,397
16 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 1,275,0901.3m $27.7m $27.7m 0.00% Reduced -211.1k -211,108
17 ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.02% of their portfolio BOSTON, MA 1,223,6231.2m $26.6m $26.6m 0.02% Added +188.6k +188,594
18 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 1,213,7001.2m $26.3m $26.3m 0.00% Added +14.1k +14,073
19 Allianz Asset Management GmbH 0.03% of their portfolio MUNICH, 2M 1,037,8111.0m $22.5m $22.5m 0.03% Added +343.7k +343,686
20 Qube Research & Technologies Ltd 0.03% of their portfolio LONDON, X0 1,014,4101.0m $22.0m $22.0m 0.03% Added +254.1k +254,114
21 KENNEDY CAPITAL MANAGEMENT LLC 0.52% of their portfolio ST LOUIS, MO 1,009,4611.0m $21.9m $21.9m 0.52% Reduced -51.9k -51,862
22 Nuveen, LLC 0.01% of their portfolio CHARLOTTE, NC 986,271986.3k $21.4m $21.4m 0.01% Added +218.3k +218,259
23 MACQUARIE GROUP LTD 0.02% of their portfolio Sydney, NSW 2000, C3 905,285905.3k $19.6m $19.6m 0.02% Reduced -29.3k -29,327
24 RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio ST. PETERSBURG, FL 845,048845.0k $18.3m $18.3m 0.01% Added +404.5k +404,525
25 UBS Group AG 0.00% of their portfolio ZURICH, V8 844,777844.8k $18.3m $18.3m 0.00% Added +85.4k +85,373
26 JANUS HENDERSON GROUP PLC 0.01% of their portfolio LONDON, X0 751,562751.6k $16.3m $16.3m 0.01% Added +431.7k +431,733
27 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 735,698735.7k $16.0m $16.0m 0.00% Reduced -241.9k -241,925
28 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 719,747719.7k $15.6m $15.6m 0.00% Added +9.8k +9,822
29 Aberdeen Group plc 0.03% of their portfolio EDINBURGH, X0 688,760688.8k $14.9m $14.9m 0.03% Reduced -76.5k -76,534
30 Legal & General Group Plc 0.00% of their portfolio London, X0 663,595663.6k $14.4m $14.4m 0.00% Added +90.0k +89,958
31 Pacer Advisors, Inc. 0.04% of their portfolio Malvern, PA 645,132645.1k $14.0m $14.0m 0.04% Reduced -209.2k -209,235
32 PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio DES MOINES, IA 623,967624.0k $13.5m $13.5m 0.01% Added +6.5k +6,461
33 Swedbank AB 0.02% of their portfolio STOCKHOLM, V7 616,132616.1k $13.4m $13.4m 0.02% First filing
34 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 585,671585.7k $12.7m $12.7m 0.00% Added +59.4k +59,374
35 MetLife Investment Management, LLC 0.07% of their portfolio Whippany, NJ 582,721582.7k $12.6m $12.6m 0.07% Reduced -141.4k -141,370
36 LSV ASSET MANAGEMENT 0.03% of their portfolio CHICAGO, IL 577,700577.7k $12.5m $12.5m 0.03% Reduced -126.1k -126,102
37 Skandinaviska Enskilda Banken AB (publ) 0.05% of their portfolio STOCKHOLM, V7 552,700552.7k $12.0m $12.0m 0.05% Reduced -234.2k -234,200
38 JUPITER ASSET MANAGEMENT LTD 0.09% of their portfolio London, X0 517,666517.7k $11.2m $11.2m 0.09% Added +29.1k +29,079
39 FMR LLC 0.00% of their portfolio BOSTON, MA 509,113509.1k $11.0m $11.0m 0.00% Added +189.2k +189,234
40 OBERWEIS ASSET MANAGEMENT INC/ 0.44% of their portfolio LISLE, IL 468,200468.2k $10.2m $10.2m 0.44% Added +600 +600
41 Public Sector Pension Investment Board 0.04% of their portfolio MONTREAL, A8 466,402466.4k $10.1m $10.1m 0.04% Added +55.6k +55,640
42 JACOBS LEVY EQUITY MANAGEMENT, INC 0.04% of their portfolio FLORHAM PARK, NJ 457,836457.8k $9.9m $9.9m 0.04% Reduced -48.6k -48,609
43 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 433,722433.7k $9.4m $9.4m 0.00% Added +81.2k +81,188
44 Man Group plc 0.02% of their portfolio LONDON, X0 430,904430.9k $9.4m $9.4m 0.02% Added +135.2k +135,162
45 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 430,130430.1k $9.3m $9.3m 0.01% Added +126.6k +126,597
46 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 426,444426.4k $9.3m $9.3m 0.00% Added +213.0k +212,975
47 ORBIMED ADVISORS LLC 0.23% of their portfolio New York, NY 416,900416.9k $9.0m $9.0m 0.23% New
48 GABLES CAPITAL MANAGEMENT INC. 4.20% of their portfolio MIAMI, FL 409,021409.0k $8.9m $8.9m 4.20% Reduced -7.3k -7,350
49 AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio Greenwich, CT 398,422398.4k $8.6m $8.6m 0.01% Reduced -47.1k -47,088
50 Clark Capital Management Group, Inc. 0.06% of their portfolio PHILADELPHIA, PA 392,368392.4k $8.5m $8.5m 0.06% Added +147.4k +147,373
51 JW Asset Management, LLC 4.15% of their portfolio MIAMI BEACH, FL 388,392388.4k $8.4m $8.4m 4.15% Reduced -25.0k -25,000
52 ALGERT GLOBAL LLC 0.17% of their portfolio SAN FRANCISCO, CA 378,371378.4k $8.2m $8.2m 0.17% Added +330.0k +329,981
53 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 376,384376.4k $8.2m $8.2m 0.01% Reduced -4.8k -4,800
54 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 368,836368.8k $8.0m $8.0m 0.00% Added +170.8k +170,755
55 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 356,901356.9k $7.7m $7.7m 0.01% Added +233.5k +233,537
56 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 336,804336.8k $7.3m $7.3m 0.00% Reduced -203.0k -202,978
57 RHUMBLINE ADVISERS 0.01% of their portfolio BOSTON, MA 329,078329.1k $7.1m $7.1m 0.01% Added +18.5k +18,510
58 RENAISSANCE GROUP LLC 0.28% of their portfolio Covington, KY 329,057329.1k $7.1m $7.1m 0.28% Added +76.8k +76,772
59 FIRST TRUST ADVISORS LP 0.01% of their portfolio Wheaton, IL 302,280302.3k $6.6m $6.6m 0.01% Added +60.1k +60,114
60 GLOBEFLEX CAPITAL L P 0.54% of their portfolio SAN DIEGO, CA 298,087298.1k $6.5m $6.5m 0.54% Added +43.9k +43,901
61 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 270,171270.2k $5.9m $5.9m 0.01% Added +34.3k +34,299
62 Hillsdale Investment Management Inc. 0.21% of their portfolio Toronto, A6 264,800264.8k $5.7m $5.7m 0.21% Added +67.7k +67,700
63 NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio NEW YORK, NY 261,417261.4k $5.7m $5.7m 0.00% Added +56.1k +56,098
64 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 259,992260.0k $5.6m $5.6m 0.00% Reduced -425.4k -425,424
65 FEDERATED HERMES, INC. 0.01% of their portfolio PITTSBURGH, PA 254,780254.8k $5.5m $5.5m 0.01% Added +180.3k +180,296
66 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 250,149250.1k $5.4m $5.4m 0.00% Reduced -19.0k -19,029
67 Swiss National Bank 0.00% of their portfolio ZURICH, V8 221,300221.3k $4.8m $4.8m 0.00% Added +13.4k +13,400
68 Ikarian Capital, LLC 1.51% of their portfolio DALLAS, TX 209,649209.6k $4.5m $4.5m 1.51% Reduced -40.0k -40,000
69 SYSTEMATIC FINANCIAL MANAGEMENT LP 0.11% of their portfolio TEANECK, NJ 194,630194.6k $4.2m $4.2m 0.11% Added +13.2k +13,240
70 Advisors Asset Management, Inc. 0.07% of their portfolio Monument, CO 191,516191.5k $4.2m $4.2m 0.07% Added +12.7k +12,650
71 LOS ANGELES CAPITAL MANAGEMENT LLC 0.01% of their portfolio LOS ANGELES, CA 184,375184.4k $4.0m $4.0m 0.01% Reduced -3.9k -3,941
72 DekaBank Deutsche Girozentrale 0.01% of their portfolio FRANKFURT, 2M 183,376183.4k $4.0m $4.0m 0.01% Added +12.0k +12,000
73 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 176,586176.6k $3.8m $3.8m 0.00% Reduced -10.2k -10,215
74 Knott David M Jr 1.73% of their portfolio SYOSSET, NY 176,000176.0k $3.8m $3.8m 1.73% Reduced -36.0k -36,000
75 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 172,421172.4k $3.7m $3.7m 0.00% Reduced -11.7k -11,664
76 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 171,395171.4k $3.7m $3.7m 0.00% Added +29.6k +29,642
77 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 163,715163.7k $3.6m $3.6m 0.00% Added +66.3k +66,320
78 BFSG, LLC 0.39% of their portfolio IRVINE, CA 161,621161.6k $3.5m $3.5m 0.39% Reduced -242 -242
79 Woodline Partners LP 0.02% of their portfolio San Francisco, CA 150,478150.5k $3.3m $3.3m 0.02% Reduced -56.0k -56,000
80 Integral Health Asset Management, LLC 0.30% of their portfolio New York, NY 150,000150.0k $3.3m $3.3m 0.30% Unchanged
81 NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio ALBANY, NY 149,887149.9k $3.3m $3.3m 0.01% Added +577 +577
82 HUSSMAN STRATEGIC ADVISORS, INC. 0.73% of their portfolio ELLICOTT CITY, MD 147,000147.0k $3.2m $3.2m 0.73% Added +63.0k +63,000
83 Universal- Beteiligungs- und Servicegesellschaft mbH 0.01% of their portfolio FRANKFURT AM MAIN, 2M 145,662145.7k $3.2m $3.2m 0.01% Reduced -25.2k -25,174
84 Stanley-Laman Group, Ltd. 0.46% of their portfolio Berwyn, PA 144,019144.0k $3.1m $3.1m 0.46% Reduced -409 -409
85 JANE STREET GROUP, LLC 0.01% of their portfolio NEW YORK, NY 143,838143.8k $3.1m $3.1m 0.01% Reduced -139.4k -139,366
86 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 140,823140.8k $3.1m $3.1m 0.00% New
87 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 140,182140.2k $3.0m $3.0m 0.00% Added +61.2k +61,155
88 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 127,760127.8k $2.8m $2.8m 0.00% Reduced -124.6k -124,628
89 CANADA LIFE ASSURANCE Co 0.00% of their portfolio WINNIPEG, A2 127,700127.7k $2.8m $2.8m 0.00% Added +5.7k +5,677
90 Linden Thomas Advisory Services, LLC 0.30% of their portfolio Charlotte, NC 127,426127.4k $2.8m $2.8m 0.30% Added +92.2k +92,193
91 Nilsine Partners, LLC 0.28% of their portfolio GREENWOOD VILLAGE, CO 127,139127.1k $2.8m $2.8m 0.28% Added +71.9k +71,890
92 Neo Ivy Capital Management 0.87% of their portfolio NEW YORK, NY 125,627125.6k $2.7m $2.7m 0.87% New
93 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 123,230123.2k $2.7m $2.7m 0.00% Added +3.1k +3,100
94 Moody Aldrich Partners LLC 0.51% of their portfolio MARBLEHEAD, MA 120,703120.7k $2.6m $2.6m 0.51% Reduced -61.9k -61,868
95 Cyndeo Wealth Partners, LLC 0.15% of their portfolio ST. PETERSBURG, FL 118,444118.4k $2.6m $2.6m 0.15% Unchanged
96 Bridge City Capital, LLC 0.71% of their portfolio LAKE OSWEGO, OR 115,881115.9k $2.5m $2.5m 0.71% Reduced -1.5k -1,493
97 CLARK ESTATES INC/NY 0.55% of their portfolio NEW YORK, NY 113,918113.9k $2.5m $2.5m 0.55% Reduced -20.5k -20,500
98 MARTINGALE ASSET MANAGEMENT L P 0.06% of their portfolio BOSTON, MA 112,340112.3k $2.4m $2.4m 0.06% Added +23 +23
99 Gotham Asset Management, LLC 0.01% of their portfolio NEW YORK, NY 109,725109.7k $2.4m $2.4m 0.01% Added +62.4k +62,416
100 Assenagon Asset Management S.A. 0.00% of their portfolio SENNINGERBERG, N4 104,375104.4k $2.3m $2.3m 0.00% Added +7.7k +7,746