CASTLE BIOSCIENCES INC CSTL
COM · Common Stock · CUSIP 14843C105 · ISIN US14843C1053
- SectorHealth care
- IndustryServices-Medical Laboratories
- HeadquartersFriendswood, TX
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.0m this quarter). Holder counts are more reliable. Shares outstanding: 29.0m as of 2025-07-28, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $20.42. Options: 2 managers hold calls ($22.5k notional), 2 hold puts ($4.0k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 157 |
| Q4 2022 | 154 |
| Q1 2023 | 149 |
| Q2 2023 | 131 |
| Q3 2023 | 136 |
| Q4 2023 | 154 |
| Q1 2024 | 152 |
| Q2 2024 | 160 |
| Q3 2024 | 186 |
| Q4 2024 | 197 |
| Q1 2025 | 181 |
| Q2 2025 | 153 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 73 | 57 |
| Q4 2023 | 88 | 62 |
| Q1 2024 | 71 | 72 |
| Q2 2024 | 82 | 73 |
| Q3 2024 | 114 | 63 |
| Q4 2024 | 100 | 92 |
| Q1 2025 | 102 | 98 |
| Q2 2025 | 84 | 87 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $9.0m | $1.3m | 0.15 |
| Q4 2024 | $3.8m | $1.3m | 0.33 |
| Q1 2025 | $200.2k | $112.1k | 0.56 |
| Q2 2025 | $22.5k | $4.0k | 0.18 |
Biggest buyers
| CITADEL ADVISORS LLC | Added | +630.1k |
| BRAIDWELL LP | Added | +457.5k |
| Nuveen, LLC | Added | +401.3k |
| PRINCIPAL FINANCIAL GROUP INC | Added | +331.1k |
| UBS Group AG | Added | +315.1k |
| Portolan Capital Management, LLC | Added | +224.3k |
| DIMENSIONAL FUND ADVISORS LP | Added | +177.8k |
| MILLENNIUM MANAGEMENT LLC | Added | +173.6k |
| BlackRock, Inc. | Added | +171.1k |
| VANGUARD GROUP INC | Added | +122.5k |
Biggest sellers
| Park West Asset Management LLC | Sold out | -556.5k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -421.3k |
| Bellevue Group AG | Sold out | -301.1k |
| Cubist Systematic Strategies, LLC | Sold out | -237.7k |
| Point72 Asset Management, L.P. | Sold out | -236.2k |
| SHELTON CAPITAL MANAGEMENT | Sold out | -164.0k |
| ACADIAN ASSET MANAGEMENT LLC | Reduced | -131.8k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -111.5k |
| TUDOR INVESTMENT CORP ET AL | Reduced | -94.9k |
| AQR CAPITAL MANAGEMENT LLC | Reduced | -87.8k |
Biggest calls
| GROUP ONE TRADING LLC | Added | $22.5k1.1k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SIMPLEX TRADING, LLC | Added | $4.0k200 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| RTW INVESTMENTS, LP 13G · institution +2.1 pts · filed 2026-05-15 | 9.3% |
| BlackRock, Inc. 13G · institution filed 2025-04-23 | 8.2% |
Fell to 5% or below in the last year: Portolan Capital Management, LLC (4.5%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-26), DIMENSIONAL FUND ADVISORS LP (3.9%, 2026-01-21)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 2 | $2.1m | $281.9k |
| Q4 2023 | 0 | — | 2 | $4.0m | $3.3m |
| Q1 2024 | 0 | — | 2 | $1.8m | $1.8m |
| Q2 2024 | 0 | — | 2 | $1.8m | $1.8m |
| Q3 2024 | 0 | — | 4 | $1.9m | $1.9m |
| Q4 2024 | 0 | — | 4 | $3.0m | $3.0m |
| Q1 2025 | 0 | — | 4 | $1.9m | $1.9m |
| Q2 2025 | 0 | — | 1 | $693.7k | $693.7k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-27 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By Derek Maetzold 2020 Irrevocable Trust | Sold plan | $163.8k8.1k shares |
| 2025-06-27 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk | Sold plan | $140.6k6.9k shares |
| 2025-06-27 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director | Sold plan | $100.4k4.9k shares |
| 2025-06-27 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director | Sold plan | $13.4k660 shares |
| 2025-06-27 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold | Sold plan | $13.4k660 shares |
| 2025-06-27 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO John Derek Maetzold | Sold plan | $13.4k660 shares |
| 2025-06-27 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold | Sold plan | $13.4k660 shares |
| 2025-04-21 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By Derek Maetzold 2020 Irrevocable Trust | Sold plan | $43.4k2.0k shares |
| 2025-04-21 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk | Sold plan | $37.3k1.7k shares |
| 2025-04-21 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director | Sold plan | $26.6k1.2k shares |
| 2025-04-21 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director | Sold plan | $3.6k165 shares |
| 2025-04-21 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO John Derek Maetzold | Sold plan | $3.6k165 shares |
| 2025-04-21 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold | Sold plan | $3.6k165 shares |
| 2025-04-21 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold | Sold plan | $3.6k165 shares |
| 2025-04-09 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk | Sold plan | $33.7k1.7k shares |
| 2025-04-09 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold | Sold plan | $29.0k1.4k shares |
| 2025-04-09 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director | Sold plan | $20.7k1.0k shares |
| 2025-04-09 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director | Sold plan | $5.5k274 shares |
| 2025-04-09 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold | Sold plan | $2.8k137 shares |
| 2025-04-09 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO John Derek Maetzold | Sold plan | $2.7k135 shares |
| 2025-04-08 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By Derek Maetzold 2020 Irrevocable Trust | Sold plan | $7.0k348 shares |
| 2025-04-08 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk | Sold plan | $6.0k299 shares |
| 2025-04-08 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director | Sold plan | $4.3k213 shares |
| 2025-04-08 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold | Sold plan | $60130 shares |
| 2025-04-08 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO John Derek Maetzold | Sold plan | $56128 shares |
| 2025-04-08 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold | Sold plan | $56128 shares |
| 2025-04-08 | MAETZOLD DEREK J Pres. & Chief Exec. Officer, director · By The Maetzold Descendants 2020 Trust | Sold plan | $56128 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 3.2m $64.4m | Added +171.1k |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.2m $44.3m | Added +122.5k |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 1.8m $36.7m | Added +331.1k |
| Portolan Capital Management, LLC 1.91% of their portfolio | 1.5m $30.4m | Added +224.3k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 1.4m $28.1m | Added +177.8k |
| Nuveen, LLC 0.01% of their portfolio | 1.1m $21.9m | Added +401.3k |
| WASATCH ADVISORS LP 0.11% of their portfolio | 1.0m $21.4m | Added +51.3k |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 888.5k $18.1m | Added +630.1k |
| BRAIDWELL LP 0.57% of their portfolio | 822.7k $16.8m | Added +457.5k |
| Allianz Asset Management GmbH 0.02% of their portfolio | 713.7k $14.6m | Added +74.3k |
| STATE STREET CORP 0.00% of their portfolio | 707.7k $14.5m | Reduced -7.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 689.9k $14.1m | Added +40.1k |
| RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio | 670.5k $13.7m | Reduced -30.7k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 648.6k $13.2m | Added +51.5k |
| PALISADE CAPITAL MANAGEMENT, LP 0.33% of their portfolio | 575.1k $11.7m | Added +85.1k |
| ACADIAN ASSET MANAGEMENT LLC 0.02% of their portfolio | 544.2k $11.1m | Reduced -131.8k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 428.4k $8.7m | Added +173.6k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 407.2k $8.3m | Reduced -421.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 382.7k $7.8m | Added +7.4k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 372.5k $7.6m | Added +46.8k |
| UBS Group AG 0.00% of their portfolio | 363.8k $7.4m | Added +315.1k |
| Parkman Healthcare Partners LLC 0.83% of their portfolio | 352.3k $7.2m | Added +1.7k |
| Trexquant Investment LP 0.07% of their portfolio | 318.1k $6.5m | Added +69.1k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.04% of their portfolio | 280.0k $5.7m | Added +81.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 279.8k $5.7m | Added +6.4k |
| KORNITZER CAPITAL MANAGEMENT INC /KS 0.11% of their portfolio | 278.3k $5.7m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 273.4k $5.6m | Added +98.1k |
| Advisors Capital Management, LLC 0.07% of their portfolio | 245.9k $5.0m | Added +44.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 235.0k $4.8m | Reduced -7.2k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio | 215.8k $4.4m | Added +52.7k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 192.6k $3.9m | Reduced -86.8k |
| ALGERT GLOBAL LLC 0.08% of their portfolio | 185.2k $3.8m | Added +40.9k |
| MORGAN STANLEY 0.00% of their portfolio | 167.6k $3.4m | Reduced -44.2k |
| Allspring Global Investments Holdings, LLC 0.01% of their portfolio | 161.2k $3.3m | Reduced -56.6k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 148.2k $3.0m | Reduced -41.0k |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 126.4k $2.6m | Reduced -50.5k |
| Squarepoint Ops LLC 0.01% of their portfolio | 125.7k $2.6m | Added +28.4k |
| Birchview Capital, LP 2.24% of their portfolio | 110.6k $2.3m | Added +22.2k |
| BARCLAYS PLC 0.00% of their portfolio | 109.7k $2.2m | Added +66.9k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 102.7k $2.1m | Added +34.7k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 99.3k $2.0m | Added +54.1k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 99.2k $2.0m | Added +161 |
| Bank of New York Mellon Corp 0.00% of their portfolio | 89.9k $1.8m | Added +5.8k |
| Y-Intercept (Hong Kong) Ltd 0.04% of their portfolio | 78.9k $1.6m | New |
| Orion Porfolio Solutions, LLC 0.01% of their portfolio | 76.5k $1.6m | Reduced -1.9k |
| TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio | 76.5k $1.6m | Reduced -94.9k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 70.5k $1.4m | Added +707 |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 67.9k $1.4m | Added +8.3k |
| Engineers Gate Manager LP 0.02% of their portfolio | 67.3k $1.4m | Added +14.3k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 65.3k $1.3m | Reduced -8.8k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 61.7k $1.3m | Reduced -3.8k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 54.6k $1.1m | Added +42.9k |
| Swiss National Bank 0.00% of their portfolio | 54.3k $1.1m | Unchanged |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 49.2k $1.0m | Reduced -87.8k |
| XTX Topco Ltd 0.04% of their portfolio | 46.3k $945.5k | Added +26.7k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 45.4k $927.0k | Added +6.2k |
| Nebula Research & Development LLC 0.08% of their portfolio | 44.5k $908.1k | Added +6.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 42.9k $875.1k | Added +7.0k |
| Graham Capital Management, L.P. 0.03% of their portfolio | 41.8k $853.2k | Reduced -26.6k |
| Brevan Howard Capital Management LP 0.01% of their portfolio | 41.3k $843.4k | Added +29.1k |
| TRITONPOINT WEALTH, LLC 0.08% of their portfolio | 40.8k $832.7k | Reduced -860 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 40.8k $832.1k | New |
| Empowered Funds, LLC 0.01% of their portfolio | 40.8k $832.1k | New |
| Invesco Ltd. 0.00% of their portfolio | 40.4k $825.6k | Added +8.2k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.00% of their portfolio | 35.8k $731.0k | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 34.9k $712.8k | Added +9.0k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 34.0k $690.7k | Added +14.4k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 33.4k $681.4k | Unchanged |
| Verition Fund Management LLC 0.00% of their portfolio | 31.5k $644.0k | Added +868 |
| SEI INVESTMENTS CO 0.00% of their portfolio | 31.1k $635.7k | Reduced -41.9k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 28.2k $576.7k | Reduced -111.5k |
| PERKINS CAPITAL MANAGEMENT INC 0.57% of their portfolio | 28.0k $571.7k | Reduced -6.0k |
| Parallel Advisors, LLC 0.01% of their portfolio | 27.9k $569.6k | Added +300 |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 26.7k $544.5k | Reduced -3.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 26.4k $540.0k | Added +2.7k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 24.6k $502.7k | Unchanged |
| MACKENZIE FINANCIAL CORP 0.00% of their portfolio | 24.2k $494.2k | Reduced -3.3k |
| TRUIST FINANCIAL CORP 0.00% of their portfolio | 24.0k $490.6k | Added +1.7k |
| FMR LLC 0.00% of their portfolio | 24.0k $490.1k | Added +22.8k |
| Jump Financial, LLC 0.01% of their portfolio | 21.9k $446.3k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 21.1k $430.0k | Added +12.1k |
| HARBOR CAPITAL ADVISORS, INC. 0.02% of their portfolio | 20.4k $417.0k | Added +3.8k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 20.3k $414.5k | Added +4.0k |
| First Bank & Trust 0.07% of their portfolio | 20.0k $407.4k | Added +4.8k |
| Aquatic Capital Management LLC 0.01% of their portfolio | 19.3k $393.7k | New |
| Inspire Investing, LLC 0.04% of their portfolio | 19.1k $390.4k | Added +2.0k |
| HRT FINANCIAL LP 0.00% of their portfolio | 18.8k $384.0k | Reduced -9.5k |
| Oak Harvest Investment Services 0.04% of their portfolio | 16.9k $344.8k | Unchanged |
| Advantage Alpha Capital Partners LP 0.09% of their portfolio | 16.0k $327.1k | Reduced -3.8k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 15.9k $324.3k | Added +152 |
| Summit Global Investments 0.02% of their portfolio | 15.6k $320.0k | Reduced -15.0k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 15.6k $317.8k | Added +120 |
| CITIGROUP INC 0.00% of their portfolio | 14.1k $287.4k | Reduced -48.6k |
| SIMON QUICK ADVISORS, LLC 0.01% of their portfolio | 13.6k $276.9k | Reduced -33 |
| DIVERSIFY WEALTH MANAGEMENT, LLC 0.01% of their portfolio | 12.3k $238.3k | Reduced -780 |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 12.3k $250.9k | Reduced -3.8k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 12.1k $246.9k | Added +8 |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 12.0k $245.0k | Reduced -57.2k |
| STRS OHIO 0.00% of their portfolio | 11.7k $238.9k | Reduced -6.6k |
| STEPHENS INC /AR/ 0.00% of their portfolio | 11.4k $232.5k | Reduced -2.3k |