CARIS LIFE SCIENCES INC CAI
COM · Common Stock · CUSIP 142152107 · ISIN US1421521071
Company in Irving, United States
- SectorHealth care
- IndustryServices-Medical Laboratories
- HeadquartersIrving, TX
- Founded2008
- Websitecarislifesciences.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($7.3m this quarter). Holder counts are more reliable. Shares outstanding: 282.6m as of 2026-02-26, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $26.95. Options: 8 managers hold calls ($14.4m notional), 7 hold puts ($5.1m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q2 2025 | 117 |
| Q3 2025 | 138 |
| Q4 2025 | 186 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2025 | 98 | 44 |
| Q4 2025 | 134 | 57 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $0 | $0 | — |
| Q2 2025 | $26.0k | $2.1m | 79.10 |
| Q3 2025 | $13.0m | $1.6m | 0.13 |
| Q4 2025 | $14.4m | $5.1m | 0.35 |
Biggest buyers
| T. Rowe Price Investment Management, Inc. | Added | +5.0m |
| FMR LLC | Added | +4.6m |
| CITADEL ADVISORS LLC | New | +3.1m |
| PointState Capital LP | Added | +2.8m |
| UBS Group AG | Added | +1.9m |
| BlackRock, Inc. | Added | +1.7m |
| Balyasny Asset Management L.P. | Added | +1.7m |
| Point72 Asset Management, L.P. | Added | +1.6m |
| Champlain Investment Partners, LLC | New | +939.4k |
| MARSHALL WACE, LLP | Added | +919.8k |
Biggest sellers
| Silver Lake Group, L.L.C. | Sold out | -5.3m |
| Sixth Street Partners Management Company, L.P. | Reduced | -5.0m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -2.1m |
| ALLIANCEBERNSTEIN L.P. | Reduced | -1.2m |
| Alyeska Investment Group, L.P. | Sold out | -1.1m |
| LORD, ABBETT & CO. LLC | Sold out | -850.0k |
| JANUS HENDERSON GROUP PLC | Sold out | -664.4k |
| NEUBERGER BERMAN GROUP LLC | Reduced | -544.1k |
| First Light Asset Management, LLC | Sold out | -403.9k |
| COATUE MANAGEMENT LLC | Reduced | -322.2k |
Biggest calls
| MILLENNIUM MANAGEMENT LLC | New | $5.4m200.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $3.2m117.9k shares |
| WELLS FARGO & COMPANY/MN | New | $3.1m113.5k shares |
| CITADEL ADVISORS LLC | Added | $1.2m43.1k shares |
| JANE STREET GROUP, LLC | Reduced | $798.6k29.6k shares |
| IMC-Chicago, LLC | New | $353.4k13.1k shares |
| SIMPLEX TRADING, LLC | Added | $256.3k9.5k shares |
| GROUP ONE TRADING LLC | Reduced | $229.3k8.5k shares |
Biggest puts
| Caption Management, LLC | New | $2.0m75.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.2m44.8k shares |
| CITADEL ADVISORS LLC | Added | $644.8k23.9k shares |
| GROUP ONE TRADING LLC | Added | $358.8k13.3k shares |
| IMC-Chicago, LLC | New | $356.1k13.2k shares |
| SIMPLEX TRADING, LLC | Added | $294.1k10.9k shares |
| JANE STREET GROUP, LLC | New | $205.0k7.6k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| HALBERT DAVID D 13G · exempt (held before listing) new · filed 2025-08-13 | 44.1% |
| FMR LLC 13G · institution +5.8 pts · filed 2026-04-07 | 10.8% |
Fell to 5% or below in the last year: J H Whitney VI L P (4.0%, 2026-08-12), TSSP Sub-Fund HoldCo LLC (2.6%, 2026-08-07)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 2 | $787.5k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 2 | $110.3k | 1 | $1.7m | $1.7m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-11 | Power Luke Thomas Officer | Sold plan | $1.7m62.2k shares |
| 2025-11-07 | Denton John Russel Officer · By Trust | Bought | $100.8k4.2k shares |
| 2025-11-07 | Spetzler David Baxley President | Bought | $9.5k400 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| J. H. Whitney Equity Partners VI, LLC 100.00% of their portfolio | 20.3m $546.5m | First filing |
| Sixth Street Partners Management Company, L.P. 53.72% of their portfolio | 19.4m $523.0m | Reduced -5.0m |
| FMR LLC 0.02% of their portfolio | 14.2m $383.6m | Added +4.6m |
| T. Rowe Price Investment Management, Inc. 0.14% of their portfolio | 13.0m $351.9m | Added +5.0m |
| COATUE MANAGEMENT LLC 0.66% of their portfolio | 9.8m $264.9m | Reduced -322.2k |
| BRAIDWELL LP 6.74% of their portfolio | 7.8m $210.9m | Added +500.0k |
| PointState Capital LP 3.10% of their portfolio | 6.7m $181.3m | Added +2.8m |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 4.8m $130.3m | Reduced -2.1m |
| NEUBERGER BERMAN GROUP LLC 0.08% of their portfolio | 3.8m $102.5m | Reduced -544.1k |
| MILLENNIUM MANAGEMENT LLC 0.07% of their portfolio | 3.7m $98.5m | Reduced -285.4k |
| ORBIMED ADVISORS LLC 1.72% of their portfolio | 3.1m $84.1m | Added +81.2k |
| CITADEL ADVISORS LLC 0.06% of their portfolio | 3.1m $84.0m | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 2.4m $66.0m | Added +729.1k |
| BlackRock, Inc. 0.00% of their portfolio | 2.4m $64.0m | Added +1.7m |
| UBS Group AG 0.01% of their portfolio | 2.2m $58.9m | Added +1.9m |
| Point72 Asset Management, L.P. 0.08% of their portfolio | 1.9m $50.3m | Added +1.6m |
| MORGAN STANLEY 0.00% of their portfolio | 1.8m $48.4m | Added +260.6k |
| Balyasny Asset Management L.P. 0.08% of their portfolio | 1.7m $44.8m | Added +1.7m |
| Longaeva Partners L.P. 4.84% of their portfolio | 1.5m $40.7m | Added +223.8k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 1.5m $40.6m | Reduced -174.4k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 1.5m $39.7m | Added +354.1k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.03% of their portfolio | 1.5m $39.5m | Added +141.8k |
| Clearbridge Investments, LLC 0.03% of their portfolio | 1.4m $38.2m | Added +35.0k |
| PERCEPTIVE ADVISORS LLC 0.56% of their portfolio | 1.1m $30.7m | Added +38.0k |
| FIL Ltd 0.02% of their portfolio | 1.1m $30.3m | Added +896.9k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.1m $30.3m | Added +693.3k |
| Invesco Ltd. 0.00% of their portfolio | 1.0m $27.9m | Added +229.3k |
| MARSHALL WACE, LLP 0.03% of their portfolio | 1.0m $27.1m | Added +919.8k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 941.6k $25.4m | Reduced -29.7k |
| Champlain Investment Partners, LLC 0.26% of their portfolio | 939.4k $25.3m | New |
| Ghisallo Capital Management LLC 1.02% of their portfolio | 845.3k $22.8m | Reduced -202.8k |
| TD Asset Management Inc 0.02% of their portfolio | 773.9k $20.9m | Added +551.5k |
| Woodline Partners LP 0.08% of their portfolio | 723.2k $19.5m | Unchanged |
| Rock Springs Capital Management LP 0.95% of their portfolio | 687.5k $18.5m | Reduced -106.2k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 685.8k $18.5m | Added +684.6k |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC 0.33% of their portfolio | 543.2k $14.7m | New |
| SEVEN GRAND MANAGERS, LLC 1.02% of their portfolio | 495.1k $13.4m | Added +395.1k |
| ARK Investment Management LLC 0.07% of their portfolio | 408.7k $11.0m | Added +163.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 373.0k $10.1m | Reduced -25.3k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 350.1k $9.4m | Added +67.9k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 329.9k $8.9m | Added +104.8k |
| Meridiem Capital Partners LP 0.47% of their portfolio | 278.1k $7.5m | New |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 268.6k $7.2m | Added +51.7k |
| STATE STREET CORP 0.00% of their portfolio | 260.6k $7.0m | Added +105.3k |
| Schonfeld Strategic Advisors LLC 0.03% of their portfolio | 247.4k $6.7m | New |
| LAZARD ASSET MANAGEMENT LLC 0.01% of their portfolio | 242.8k $6.6m | Reduced -34.8k |
| Holocene Advisors, LP 0.01% of their portfolio | 237.9k $6.4m | Added +66.8k |
| PICTON MAHONEY ASSET MANAGEMENT 0.06% of their portfolio | 218.3k $5.9m | Added +212.1k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 207.0k $5.6m | Added +174.2k |
| WORLDQUANT MILLENNIUM ADVISORS LLC 0.02% of their portfolio | 188.9k $5.1m | Added +178.8k |
| TUDOR INVESTMENT CORP ET AL 0.03% of their portfolio | 182.4k $4.9m | Reduced -82.2k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 171.0k $4.6m | Added +156.4k |
| Walleye Capital LLC 0.03% of their portfolio | 162.9k $4.4m | Reduced -157.8k |
| ODDO BHF ASSET MANAGEMENT SAS 0.16% of their portfolio | 162.3k $4.4m | Not comparable |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 150.0k $4.0m | Unchanged |
| Creative Planning 0.00% of their portfolio | 149.9k $4.0m | New |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 146.1k $0 | New |
| Parkman Healthcare Partners LLC 0.32% of their portfolio | 125.0k $3.4m | New |
| HRT FINANCIAL LP 0.01% of their portfolio | 122.9k $3.3m | New |
| NORGES BANK 0.00% of their portfolio | 110.3k $3.0m | Not comparable |
| Jump Financial, LLC 0.03% of their portfolio | 103.0k $2.8m | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 101.8k $2.8m | Reduced -8.3k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 97.5k $2.6m | Added +2.6k |
| TD Waterhouse Canada Inc. 0.02% of their portfolio | 92.7k $2.5m | New |
| PURA VIDA INVESTMENTS, LLC 9.07% of their portfolio | 89.9k $2.4m | Unchanged |
| Trexquant Investment LP 0.02% of their portfolio | 82.7k $2.2m | New |
| DARK FOREST CAPITAL MANAGEMENT LP 0.10% of their portfolio | 78.2k $2.1m | Added +46.5k |
| Sumitomo Mitsui Trust Group, Inc. 0.00% of their portfolio | 75.3k $2.0m | Added +15.8k |
| Burkehill Global Management, LP 0.13% of their portfolio | 75.0k $2.0m | Unchanged |
| Engineers Gate Manager LP 0.02% of their portfolio | 71.4k $1.9m | Added +49.4k |
| Gotham Asset Management, LLC 0.01% of their portfolio | 67.2k $1.8m | Added +34.0k |
| Quantinno Capital Management LP 0.00% of their portfolio | 64.9k $1.8m | Reduced -7.3k |
| Squarepoint Ops LLC 0.00% of their portfolio | 64.4k $1.7m | New |
| HAMILTON LANE ADVISORS LLC 0.87% of their portfolio | 58.7k $1.6m | New |
| Amova Asset Management Americas, Inc. 0.02% of their portfolio | 54.7k $1.5m | Added +7.3k |
| BARCLAYS PLC 0.00% of their portfolio | 54.1k $1.5m | Added +50.9k |
| Caption Management, LLC 0.06% of their portfolio | 50.9k $1.4m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 50.4k $1.4m | Added +25.5k |
| ELEMENT CAPITAL MANAGEMENT LLC 0.70% of their portfolio | 50.0k $1.3m | New |
| PEAK6 LLC 0.02% of their portfolio | 49.6k $1.3m | New |
| China Universal Asset Management Co., Ltd. 0.10% of their portfolio | 46.0k $1.2m | New |
| MANGROVE PARTNERS IM, LLC 0.09% of their portfolio | 42.5k $1.1m | New |
| VARCOV Co. 0.43% of their portfolio | 40.0k $1.1m | First filing |
| Maven Securities LTD 0.14% of their portfolio | 40.0k $1.1m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 36.9k $996.9k | Reduced -8.6k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.00% of their portfolio | 35.0k $945.6k | New |
| VANGUARD GROUP INC 0.00% of their portfolio | 33.5k $904.0k | Reduced -142.0k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 31.0k $837.2k | New |
| CITIGROUP INC 0.00% of their portfolio | 30.7k $829.0k | Reduced -17.7k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 30.2k $813.6k | New |
| BESSEMER GROUP INC 0.00% of their portfolio | 26.7k $719.0k | New |
| GROUP ONE TRADING LLC 0.02% of their portfolio | 26.3k $710.7k | New |
| LPL Financial LLC 0.00% of their portfolio | 25.7k $693.7k | Added +9.7k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 25.3k $682.3k | Unchanged |
| SEI INVESTMENTS CO 0.00% of their portfolio | 24.5k $659.7k | New |
| Sandia Investment Management LP 1.59% of their portfolio | 23.6k $636.7k | Added +15.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 23.4k $630.8k | Added +1.9k |
| WPWealth LLP 0.10% of their portfolio | 23.0k $621.2k | Reduced -11 |
| Nuveen, LLC 0.00% of their portfolio | 22.4k $604.7k | Unchanged |
| PDT Partners, LLC 0.04% of their portfolio | 22.0k $594.0k | New |