CARIBOU BIOSCIENCES INC CRBU
COM · Common Stock · CUSIP 142038108 · ISIN US1420381089
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersBerkeley, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($475.1k this quarter). Holder counts are more reliable. Shares outstanding: 93.1m as of 2025-08-05, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.27. Options: 5 managers hold calls ($170.2k notional), 5 hold puts ($114.4k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 114 |
| Q4 2022 | 135 |
| Q1 2023 | 128 |
| Q2 2023 | 123 |
| Q3 2023 | 128 |
| Q4 2023 | 146 |
| Q1 2024 | 152 |
| Q2 2024 | 141 |
| Q3 2024 | 130 |
| Q4 2024 | 135 |
| Q1 2025 | 132 |
| Q2 2025 | 130 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 84 | 39 |
| Q4 2023 | 82 | 43 |
| Q1 2024 | 69 | 67 |
| Q2 2024 | 65 | 80 |
| Q3 2024 | 58 | 60 |
| Q4 2024 | 71 | 49 |
| Q1 2025 | 53 | 61 |
| Q2 2025 | 61 | 78 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $344.0k | $166.4k | 0.48 |
| Q4 2024 | $240.3k | $175.5k | 0.73 |
| Q1 2025 | $135.8k | $100.2k | 0.74 |
| Q2 2025 | $170.2k | $114.4k | 0.67 |
Biggest buyers
| ROYAL BANK OF CANADA | Added | +1.2m |
| MILLENNIUM MANAGEMENT LLC | Added | +729.5k |
| RENAISSANCE TECHNOLOGIES LLC | New | +532.1k |
| Aberdeen Group plc | Added | +486.4k |
| &PARTNERS | New | +336.6k |
| Cubist Systematic Strategies, LLC | New | +308.0k |
| ENVESTNET ASSET MANAGEMENT INC | Added | +274.8k |
| CITADEL ADVISORS LLC | New | +240.2k |
| JANE STREET GROUP, LLC | Added | +189.9k |
| Brevan Howard Capital Management LP | New | +155.5k |
Biggest sellers
| BlackRock, Inc. | Reduced | -4.5m |
| STATE STREET CORP | Reduced | -1.3m |
| PFM Health Sciences, LP | Reduced | -1.1m |
| GEODE CAPITAL MANAGEMENT, LLC | Reduced | -1.1m |
| JPMORGAN CHASE & CO | Reduced | -803.8k |
| FMR LLC | Reduced | -730.7k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Reduced | -485.1k |
| Elmwood Wealth Management, Inc. | Sold out | -468.2k |
| NORTHERN TRUST CORP | Reduced | -450.1k |
| VANGUARD GROUP INC | Reduced | -432.2k |
Biggest calls
| SIMPLEX TRADING, LLC | Reduced | $118.0k93.8k shares |
| GROUP ONE TRADING LLC | Reduced | $20.7k16.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $18.0k14.3k shares |
| CITADEL ADVISORS LLC | Reduced | $13.5k10.7k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $49.0k38.9k shares |
| GROUP ONE TRADING LLC | Added | $47.4k37.6k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $18.0k14.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| SIMPLEX TRADING, LLC | Reduced | $0400 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +5.2 pts · filed 2026-07-27 | 7.2% |
Haurwitz Rachel E.
13D · may seek influence
new · filed 2025-04-25
Stated purposeThe Reporting Persons intend to continuously review their investment in the Issuer, and may in the future determine to (1) acquire additional securities of the Issuer, through open market purchases, private agreements, or otherwise (subject to the Issuer's Insider Trading Policy); (2) dispose of all or a portion of the securities of the Issuer owned by them (including through 10b5-1 plans) (subject to the Issuer's Insider Trading Policy); or (3) take any other available course of action. Notwithstanding anything contained herein, the Reporting Persons specifically reserve the right to change their intention with respect to any or all of such matters. Dr. Haurwitz is the President and Chief Executive Officer and serves as a member of the Board of Directors of the Issuer and acquired her se… Full filing |
5.0% |
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 2 | $45.1k | 3 | $4.8k | — |
| Q2 2025 | 0 | — | 0 | — | — |
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| Pfizer Inc 1.03% of their portfolio | 4.7m $5.9m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.1m $5.2m | Reduced -432.2k |
| Kynam Capital Management, LP 0.42% of their portfolio | 3.1m $3.9m | Reduced -201.4k |
| Schonfeld Strategic Advisors LLC 0.02% of their portfolio | 2.3m $2.9m | Reduced -78.7k |
| BlackRock, Inc. 0.00% of their portfolio | 1.9m $2.4m | Reduced -4.5m |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 1.6m $2.0m | Added +729.5k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 1.4m $1.8m | Reduced -59.4k |
| PFM Health Sciences, LP 0.15% of their portfolio | 1.4m $1.7m | Reduced -1.1m |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 1.3m $1.6m | Reduced -77.3k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 1.2m $1.5m | Added +1.2m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 980.9k $1.2m | Reduced -1.1m |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 957.0k $1.2m | Reduced -485.1k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 928.5k $1.2m | Reduced -52.8k |
| Aberdeen Group plc 0.00% of their portfolio | 897.6k $1.1m | Added +486.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 808.9k $1.0m | Reduced -291.6k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 791.6k $997.4k | Reduced -31.2k |
| Pale Fire Capital SE 0.10% of their portfolio | 775.1k $976.6k | Reduced -11.7k |
| FMR LLC 0.00% of their portfolio | 729.4k $919.1k | Reduced -730.7k |
| MAVERICK CAPITAL LTD 0.01% of their portfolio | 652.5k $822.2k | Unchanged |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 647.1k $815.4k | Added +121.2k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 584.4k $736.0k | Reduced -28.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 532.1k $670.5k | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 529.4k $667.1k | Reduced -197.8k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 483.6k $609.3k | Added +189.9k |
| 72 Investment Holdings, LLC 1.56% of their portfolio | 474.1k $597.3k | Unchanged |
| Green Alpha Advisors, LLC 0.51% of their portfolio | 425.7k $536.4k | Reduced -6.6k |
| MILESTONE ASSET MANAGEMENT, LLC 0.11% of their portfolio | 409.6k $516.0k | Added +80.5k |
| STATE STREET CORP 0.00% of their portfolio | 358.2k $451.3k | Reduced -1.3m |
| &PARTNERS 0.00% of their portfolio | 336.6k $424.1k | New |
| MORGAN STANLEY 0.00% of their portfolio | 331.5k $417.7k | Reduced -151.3k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 318.7k $401.5k | Added +274.8k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 309.0k $389.3k | Reduced -99.1k |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 308.0k $388.1k | New |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 289.7k $365.1k | Added +60.9k |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 274.5k $346.0k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 264.6k $333.4k | Added +62.4k |
| Bruce & Co., Inc. 0.10% of their portfolio | 250.0k $315.0k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 249.1k $313.9k | Reduced -333.8k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 240.2k $302.7k | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 212.0k $267.1k | Reduced -450.1k |
| GSA CAPITAL PARTNERS LLP 0.01% of their portfolio | 166.4k $210.0k | Added +148.8k |
| Brevan Howard Capital Management LP 0.00% of their portfolio | 155.5k $196.0k | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 148.5k $187.1k | Added +40.0k |
| Y-Intercept (Hong Kong) Ltd 0.00% of their portfolio | 137.2k $172.9k | New |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 130.0k $723.0k | Unchanged |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio | 128.4k $161.8k | Reduced -40.2k |
| Woodline Partners LP 0.00% of their portfolio | 122.8k $154.8k | Added +698 |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 114.6k $147.3k | Added +66.7k |
| HRT FINANCIAL LP 0.00% of their portfolio | 105.9k $133.0k | New |
| Siren, L.L.C. 0.01% of their portfolio | 105.3k $132.7k | Unchanged |
| XTX Topco Ltd 0.01% of their portfolio | 105.2k $132.6k | New |
| Aster Capital Management (DIFC) Ltd 0.03% of their portfolio | 105.0k $132.3k | New |
| Jain Global LLC 0.00% of their portfolio | 101.2k $127.5k | New |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 100.2k $126.2k | Added +42.0k |
| Quadrature Capital Ltd 0.00% of their portfolio | 91.1k $114.3k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 87.8k $110.6k | Reduced -47.1k |
| Nelson Capital Management, LLC 0.01% of their portfolio | 85.0k $107.1k | Unchanged |
| RBF Capital, LLC 0.00% of their portfolio | 80.0k $100.8k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 74.1k $93.3k | Added +63.1k |
| Keystone Financial Group 0.01% of their portfolio | 64.0k $80.6k | Added +7.6k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 60.0k $76.0k | Reduced -1.3k |
| Point72 Asia (Singapore) Pte. Ltd. 0.01% of their portfolio | 59.5k $75.0k | New |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 40.8k $51.4k | Added +16.7k |
| Catalyst Funds Management Pty Ltd 0.01% of their portfolio | 38.7k $48.8k | New |
| Prime Capital Investment Advisors, LLC 0.00% of their portfolio | 38.0k $47.9k | Reduced -16.0k |
| CWM, LLC 0.00% of their portfolio | 33.8k $43.0k | Added +11.8k |
| Freedom Investment Management, Inc. 0.00% of their portfolio | 32.5k $41.0k | Reduced -2.0k |
| Thrive Wealth Management, LLC 0.01% of their portfolio | 32.0k $40.3k | Unchanged |
| Cerity Partners LLC 0.00% of their portfolio | 31.8k $40.1k | Reduced -8.9k |
| CITIGROUP INC 0.00% of their portfolio | 31.4k $39.5k | Reduced -32.6k |
| Squarepoint Ops LLC 0.00% of their portfolio | 29.7k $37.5k | New |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 25.9k $32.7k | Added +2.6k |
| Invesco Ltd. 0.00% of their portfolio | 24.7k $31.2k | Reduced -34.2k |
| Hudson Bay Capital Management LP 0.00% of their portfolio | 23.7k $29.9k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 22.6k $28.4k | Reduced -1.1k |
| DRW Securities, LLC 0.00% of their portfolio | 22.2k $28.0k | New |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 22.1k $30.3k | Added +4.1k |
| BARCLAYS PLC 0.00% of their portfolio | 21.7k $27.3k | Reduced -82.7k |
| Creative Planning 0.00% of their portfolio | 20.2k $25.4k | New |
| Next Capital Management LLC 0.01% of their portfolio | 20.0k $25.2k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 19.4k $24.4k | Reduced -20.3k |
| HighTower Advisors, LLC 0.00% of their portfolio | 17.1k $21.6k | Added +3.9k |
| Ground Swell Capital, LLC 0.03% of their portfolio | 16.3k $20.5k | New |
| Engineers Gate Manager LP 0.00% of their portfolio | 15.8k $19.9k | New |
| Focus Partners Advisor Solutions, LLC 0.00% of their portfolio | 15.6k $19.6k | Added +2.5k |
| Jump Financial, LLC 0.00% of their portfolio | 14.2k $17.9k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 14.0k $17.7k | Reduced -210.4k |
| Pathstone Holdings, LLC 0.00% of their portfolio | 13.0k $16.4k | Reduced -9.2k |
| PINNACLE ASSOCIATES LTD 0.00% of their portfolio | 12.9k $16.3k | Unchanged |
| Pinnacle Wealth Management Advisory Group, LLC 0.00% of their portfolio | 12.9k $16.3k | Unchanged |
| Cetera Investment Advisers 0.00% of their portfolio | 12.7k $15.9k | Reduced -1.8k |
| HBK Sorce Advisory LLC 0.00% of their portfolio | 12.3k $15.6k | New |
| J.W. COLE ADVISORS, INC. 0.00% of their portfolio | 12.0k $15.1k | Unchanged |
| CAPITAL ADVISORY GROUP ADVISORY SERVICES, LLC 0.01% of their portfolio | 11.5k $14.5k | New |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 10.6k $13.4k | New |
| NewEdge Advisors, LLC 0.00% of their portfolio | 10.4k $13.1k | Unchanged |
| Chevy Chase Trust Holdings, LLC 0.00% of their portfolio | 10.0k $12.6k | Unchanged |
| Modern Wealth Management, LLC 0.00% of their portfolio | 10.0k $12.6k | Unchanged |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 8.8k $11.1k | Added +1.8k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 8.7k $11.0k | New |