CABALETTA BIO INC CABA
COM · Common Stock · CUSIP 12674W109
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersPhiladelphia, PA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($431.7k this quarter). Holder counts are more reliable. Shares outstanding: 91.5m as of 2025-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.52. Options: 6 managers hold calls ($1.8m notional), 5 hold puts ($152.0k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 54 |
| Q4 2022 | 62 |
| Q1 2023 | 73 |
| Q2 2023 | 85 |
| Q3 2023 | 98 |
| Q4 2023 | 129 |
| Q1 2024 | 160 |
| Q2 2024 | 143 |
| Q3 2024 | 121 |
| Q4 2024 | 110 |
| Q1 2025 | 94 |
| Q2 2025 | 87 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 73 | 22 |
| Q4 2023 | 76 | 40 |
| Q1 2024 | 91 | 61 |
| Q2 2024 | 71 | 84 |
| Q3 2024 | 63 | 77 |
| Q4 2024 | 60 | 62 |
| Q1 2025 | 42 | 61 |
| Q2 2025 | 49 | 61 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $991.6k | $603.8k | 0.61 |
| Q4 2024 | $1.1m | $371.2k | 0.35 |
| Q1 2025 | $463.5k | $307.1k | 0.66 |
| Q2 2025 | $1.8m | $152.0k | 0.08 |
Biggest buyers
| Bain Capital Life Sciences Investors, LLC | Added | +6.9m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +5.2m |
| Cormorant Asset Management, LP | New | +5.0m |
| Alyeska Investment Group, L.P. | New | +4.8m |
| JENNISON ASSOCIATES LLC | Added | +3.6m |
| HEIGHTS CAPITAL MANAGEMENT, INC | New | +3.1m |
| T. Rowe Price Investment Management, Inc. | Added | +2.8m |
| Jefferies Financial Group Inc. | New | +2.0m |
| Burkehill Global Management, LP | New | +1.9m |
| Anson Funds Management LP | New | +1.8m |
Biggest sellers
| BlackRock, Inc. | Reduced | -2.5m |
| CANTOR FITZGERALD, L. P. | Reduced | -952.1k |
| Integral Health Asset Management, LLC | Sold out | -850.0k |
| STATE STREET CORP | Reduced | -720.8k |
| ACADIAN ASSET MANAGEMENT LLC | Reduced | -667.5k |
| GEODE CAPITAL MANAGEMENT, LLC | Reduced | -587.8k |
| BANK OF AMERICA CORP /DE/ | Reduced | -485.9k |
| Nuveen, LLC | Sold out | -434.4k |
| FRED ALGER MANAGEMENT, LLC | Reduced | -417.4k |
| MORGAN STANLEY | Reduced | -384.1k |
Biggest calls
| GROUP ONE TRADING LLC | Added | $647.7k426.1k shares |
| SIMPLEX TRADING, LLC | Added | $540.0k355.7k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $380.0k250.0k shares |
| JANE STREET GROUP, LLC | New | $120.5k79.3k shares |
| CITADEL ADVISORS LLC | Added | $116.3k76.5k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $94.4k62.1k shares |
| CITADEL ADVISORS LLC | Reduced | $43.8k28.8k shares |
| GROUP ONE TRADING LLC | Reduced | $10.8k7.1k shares |
| SIMPLEX TRADING, LLC | Added | $3.0k2.2k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| T. Rowe Price Investment Management, Inc. 13G · institution +1.4 pts · filed 2026-08-14 | 11.6% |
| PRUDENTIAL FINANCIAL INC 13G · institution +2.5 pts · filed 2026-06-05 | 11.4% |
| JENNISON ASSOCIATES LLC 13G · institution +2.5 pts · filed 2026-06-04 | 11.4% |
| Bain Capital Life Sciences Opportunities III, LP 13G · passive investor no change · filed 2026-08-14 | 10.0% |
| Adage Capital Management, L.P. 13G · institution -1.6 pts · filed 2026-08-12 | 8.4% |
| BlackRock, Inc. 13G · institution +1.8 pts · filed 2026-10-27 | 7.7% |
| Cormorant Asset Management, LP 13G · institution -3.1 pts · filed 2026-08-14 | 6.0% |
| NORGES BANK 13G · institution new · filed 2026-08-12 | 5.4% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.1% |
Fell to 5% or below in the last year: MILLENNIUM MANAGEMENT LLC (1.3%, 2026-07-23), Alyeska Investment Group, L.P. (4.7%, 2026-02-17), CITADEL ADVISORS LLC (3.4%, 2025-11-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 1 | $492.9k | $492.9k |
| Q4 2023 | 0 | — | 1 | $583.7k | — |
| Q1 2024 | 0 | — | 1 | $215.5k | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| Bain Capital Life Sciences Investors, LLC 1.84% of their portfolio | 9.7m $14.7m | Added +6.9m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio | 8.8m $13.4m | Added +5.2m |
| T. Rowe Price Investment Management, Inc. 0.01% of their portfolio | 6.8m $10.3m | Added +2.8m |
| JENNISON ASSOCIATES LLC 0.01% of their portfolio | 6.0m $9.2m | Added +3.6m |
| Cormorant Asset Management, LP 0.57% of their portfolio | 5.0m $7.6m | New |
| Alyeska Investment Group, L.P. 0.03% of their portfolio | 4.8m $7.3m | New |
| VANGUARD GROUP INC 0.00% of their portfolio | 3.5m $5.2m | Added +606.5k |
| HEIGHTS CAPITAL MANAGEMENT, INC 1.50% of their portfolio | 3.1m $4.8m | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 2.2m $3.3m | Added +1.7m |
| Jefferies Financial Group Inc. 0.05% of their portfolio | 2.0m $3.0m | New |
| Burkehill Global Management, LP 0.21% of their portfolio | 1.9m $2.9m | New |
| Anson Funds Management LP 0.51% of their portfolio | 1.8m $2.8m | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 1.7m $2.6m | Added +1.7m |
| Schonfeld Strategic Advisors LLC 0.02% of their portfolio | 1.5m $2.3m | Reduced -177.6k |
| MORGAN STANLEY 0.00% of their portfolio | 1.3m $2.0m | Reduced -384.1k |
| Woodline Partners LP 0.01% of their portfolio | 1.2m $1.9m | New |
| Blue Owl Capital Holdings LP 0.55% of their portfolio | 1.1m $1.7m | New |
| SUPERSTRING CAPITAL MANAGEMENT LP 2.01% of their portfolio | 1.1m $1.6m | Added +601.8k |
| BlackRock, Inc. 0.00% of their portfolio | 970.6k $1.5m | Reduced -2.5m |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 855.3k $1.3m | Added +686.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 553.5k $841.6k | Reduced -587.8k |
| CANTOR FITZGERALD, L. P. 0.02% of their portfolio | 532.5k $809.4k | Reduced -952.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 498.2k $757.3k | Reduced -485.9k |
| UBS Group AG 0.00% of their portfolio | 472.0k $717.5k | Reduced -18.2k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 413.6k $628.7k | Reduced -57.9k |
| Almitas Capital LLC 0.14% of their portfolio | 367.5k $558.6k | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 353.3k $537.0k | Added +22.8k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 344.5k $523.7k | Added +1.1k |
| Raiffeisen Bank International AG 0.01% of their portfolio | 300.0k $531.0k | Unchanged |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 284.0k $431.7k | Reduced -3.5k |
| AXA S.A. 0.00% of their portfolio | 270.5k $411.2k | Added +439 |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 252.4k $383.6k | Reduced -69.1k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 238.3k $362.3k | New |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 235.3k $357.6k | New |
| STATE STREET CORP 0.00% of their portfolio | 218.0k $331.3k | Reduced -720.8k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 191.0k $290.3k | Added +157.5k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 133.0k $202.2k | Reduced -266.7k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 126.1k $191.7k | Added +115.2k |
| HRT FINANCIAL LP 0.00% of their portfolio | 124.4k $189.0k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 123.6k $187.9k | Added +65.8k |
| XTX Topco Ltd 0.01% of their portfolio | 97.3k $147.8k | New |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 95.3k $145.0k | Unchanged |
| TD Asset Management Inc 0.00% of their portfolio | 88.6k $134.7k | Unchanged |
| TCG Crossover Management, LLC 0.02% of their portfolio | 86.8k $131.9k | Unchanged |
| Invesco Ltd. 0.00% of their portfolio | 84.8k $128.9k | Added +23.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 80.8k $122.8k | Reduced -170.6k |
| Squarepoint Ops LLC 0.00% of their portfolio | 71.4k $108.6k | New |
| CITIGROUP INC 0.00% of their portfolio | 62.5k $95.0k | Added +31.0k |
| FRED ALGER MANAGEMENT, LLC 0.00% of their portfolio | 59.8k $90.9k | Reduced -417.4k |
| Jain Global LLC 0.00% of their portfolio | 56.2k $85.4k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 51.0k $77.6k | Added +44.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 50.6k $76.9k | Reduced -109.2k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 49.1k $74.6k | Reduced -12.3k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 47.8k $72.7k | Reduced -107.4k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 45.7k $69.4k | Unchanged |
| MYDA Advisors LLC 0.02% of their portfolio | 40.0k $60.8k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 39.8k $60.5k | Reduced -17.3k |
| Point72 Asia (Singapore) Pte. Ltd. 0.01% of their portfolio | 34.8k $52.8k | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 32.1k $48.8k | Reduced -41.8k |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 24.9k $37.9k | Added +5.6k |
| SG Americas Securities, LLC 0.00% of their portfolio | 24.0k $37.0k | Reduced -12.2k |
| Catalyst Funds Management Pty Ltd 0.01% of their portfolio | 21.0k $31.9k | New |
| TWO SIGMA SECURITIES, LLC 0.00% of their portfolio | 16.5k $25.1k | New |
| Rangeley Capital, LLC 0.03% of their portfolio | 16.0k $24.3k | New |
| FMR LLC 0.00% of their portfolio | 15.5k $23.5k | Added +11.3k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 15.1k $23.0k | Reduced -667.5k |
| Hudson Bay Capital Management LP 0.00% of their portfolio | 13.1k $19.9k | New |
| DRW Securities, LLC 0.00% of their portfolio | 12.8k $19.5k | New |
| CRA Financial Services, LLC 0.00% of their portfolio | 11.0k $16.7k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 9.7k $14.8k | Reduced -46.7k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 6.7k $10.2k | Reduced -25.3k |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 6.5k $9.9k | Added +3.6k |
| SUMMIT SECURITIES GROUP LLC 0.00% of their portfolio | 4.8k $7.3k | New |
| Point72 (DIFC) Ltd 0.00% of their portfolio | 2.4k $3.7k | New |
| Truvestments Capital LLC 0.00% of their portfolio | 2.0k $3.0k | Unchanged |
| CWM, LLC 0.00% of their portfolio | 1.6k $2.0k | Reduced -4.6k |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 1.3k $2.0k | Added +1.2k |
| Rise Advisors, LLC 0.00% of their portfolio | 1.1k $1.6k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 939 $1.4k | New |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 912 $1.4k | Added +718 |
| Federation des caisses Desjardins du Quebec 0.00% of their portfolio | 340 $517 | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 126 $0 | Reduced -2.2k |
| Mid-American Wealth Advisory Group, Inc. 0.00% of their portfolio | 91 $138 | New |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 41 $62 | Reduced -49 |
| Covestor Ltd 0.00% of their portfolio | 34 $0 | Reduced -3 |
| True Wealth Design, LLC 0.00% of their portfolio | 17 $26 | Reduced -46 |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio | 0 $0 | Unchanged |