Vault-13

CABALETTA BIO INC CABA

COM · Common Stock · CUSIP 12674W109

87 institutional holders -7 vs Q1 2025
72,481,29372.5m shares reported held*
79.2% of all shares outstanding*
$110.2mreported value*
26 new 23 added 28 reduced 33 sold out net bought ≈ $55.4m (+36.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($431.7k this quarter). Holder counts are more reliable. Shares outstanding: 91.5m as of 2025-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.52. Options: 6 managers hold calls ($1.8m notional), 5 hold puts ($152.0k).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 54Q4 22: 62Q1 23: 73Q2 23: 85Q3 23: 98Q4 23: 129Q1 24: 160Q2 24: 143Q3 24: 121Q4 24: 110Q1 25: 94Q2 25: 8787Q3 22Q2 23Q1 24Q4 24Q2 25
Numbers
QuarterHolders
Q3 202254
Q4 202262
Q1 202373
Q2 202385
Q3 202398
Q4 2023129
Q1 2024160
Q2 2024143
Q3 2024121
Q4 2024110
Q1 202594
Q2 202587

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q3 23: 73 bought or addedQ3 23: 22 cut or sold outQ4 23: 76 bought or addedQ4 23: 40 cut or sold outQ4 23Q1 24: 91 bought or addedQ1 24: 61 cut or sold outQ2 24: 71 bought or addedQ2 24: 84 cut or sold outQ2 24Q3 24: 63 bought or addedQ3 24: 77 cut or sold outQ4 24: 60 bought or addedQ4 24: 62 cut or sold outQ4 24Q1 25: 42 bought or addedQ1 25: 61 cut or sold outQ2 25: 49 bought or addedQ2 25: 61 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q3 20237322
Q4 20237640
Q1 20249161
Q2 20247184
Q3 20246377
Q4 20246062
Q1 20254261
Q2 20254961

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$500k$1m$1.5m$2mQ3 24 calls: $991.6kQ3 24 puts: $603.8kQ3 24P/C 0.61Q4 24 calls: $1.1mQ4 24 puts: $371.2kQ4 24P/C 0.35Q1 25 calls: $463.5kQ1 25 puts: $307.1kQ1 25P/C 0.66Q2 25 calls: $1.8mQ2 25 puts: $152.0kQ2 25P/C 0.08
Numbers
QuarterCallsPutsP/C
Q3 2024$991.6k$603.8k0.61
Q4 2024$1.1m$371.2k0.35
Q1 2025$463.5k$307.1k0.66
Q2 2025$1.8m$152.0k0.08

Biggest buyers

Bain Capital Life Sciences Investors, LLC Added +6,916,237+6.9m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +5,195,285+5.2m
Cormorant Asset Management, LP New +5,000,000+5.0m
Alyeska Investment Group, L.P. New +4,800,000+4.8m
JENNISON ASSOCIATES LLC Added +3,586,439+3.6m
HEIGHTS CAPITAL MANAGEMENT, INC New +3,144,106+3.1m
T. Rowe Price Investment Management, Inc. Added +2,823,762+2.8m
Jefferies Financial Group Inc. New +1,997,208+2.0m
Burkehill Global Management, LP New +1,900,000+1.9m
Anson Funds Management LP New +1,822,830+1.8m

Biggest sellers

BlackRock, Inc. Reduced -2,481,546-2.5m
CANTOR FITZGERALD, L. P. Reduced -952,085-952.1k
Integral Health Asset Management, LLC Sold out -850,000-850.0k
STATE STREET CORP Reduced -720,751-720.8k
ACADIAN ASSET MANAGEMENT LLC Reduced -667,529-667.5k
GEODE CAPITAL MANAGEMENT, LLC Reduced -587,835-587.8k
BANK OF AMERICA CORP /DE/ Reduced -485,852-485.9k
Nuveen, LLC Sold out -434,389-434.4k
FRED ALGER MANAGEMENT, LLC Reduced -417,397-417.4k
MORGAN STANLEY Reduced -384,082-384.1k

Biggest calls

GROUP ONE TRADING LLC Added $647.7k426.1k shares
SIMPLEX TRADING, LLC Added $540.0k355.7k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $380.0k250.0k shares
JANE STREET GROUP, LLC New $120.5k79.3k shares
CITADEL ADVISORS LLC Added $116.3k76.5k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $94.4k62.1k shares
CITADEL ADVISORS LLC Reduced $43.8k28.8k shares
GROUP ONE TRADING LLC Reduced $10.8k7.1k shares
SIMPLEX TRADING, LLC Added $3.0k2.2k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
T. Rowe Price Investment Management, Inc. 13G · institution +1.4 pts · filed 2026-08-14 11.6% +1.4 pts 18.9m≈ $58.7m 2026-08-14
PRUDENTIAL FINANCIAL INC 13G · institution +2.5 pts · filed 2026-06-05 11.4% +2.5 pts 24.3m≈ $66.1m 2026-06-05
JENNISON ASSOCIATES LLC 13G · institution +2.5 pts · filed 2026-06-04 11.4% +2.5 pts 24.3m≈ $66.1m 2026-06-04
Bain Capital Life Sciences Opportunities III, LP 13G · passive investor no change · filed 2026-08-14 10.0% no change 17.2m≈ $53.6m 2026-08-14
Adage Capital Management, L.P. 13G · institution -1.6 pts · filed 2026-08-12 8.4% -1.6 pts 14.2m≈ $44.1m 2026-08-12
BlackRock, Inc. 13G · institution +1.8 pts · filed 2026-10-27 7.7% +1.8 pts 13.0m≈ $40.5m 2026-10-27
Cormorant Asset Management, LP 13G · institution -3.1 pts · filed 2026-08-14 6.0% -3.1 pts 10.0m≈ $31.1m 2026-08-14
NORGES BANK 13G · institution new · filed 2026-08-12 5.4% new 8.8m≈ $27.3m 2026-08-12
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 5.1% new 8.3m≈ $25.8m 2026-07-31

Fell to 5% or below in the last year: MILLENNIUM MANAGEMENT LLC (1.3%, 2026-07-23), Alyeska Investment Group, L.P. (4.7%, 2026-02-17), CITADEL ADVISORS LLC (3.4%, 2025-11-14)

Insider purchases and sales in Q2 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
101Q3 23: 0 buyingQ3 23: 1 sellingQ4 23: 0 buyingQ4 23: 1 sellingQ4 23Q1 24: 0 buyingQ1 24: 1 sellingQ2 24: 0 buyingQ2 24: 0 sellingQ2 24Q3 24: 0 buyingQ3 24: 0 sellingQ4 24: 0 buyingQ4 24: 0 sellingQ4 24Q1 25: 0 buyingQ1 25: 0 sellingQ2 25: 0 buyingQ2 25: 0 sellingQ2 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20230—1$492.9k$492.9k
Q4 20230—1$583.7k—
Q1 20240—1$215.5k—
Q2 20240—0——
Q3 20240—0——
Q4 20240—0——
Q1 20250—0——
Q2 20250—0——

None reported in Q2 2025.

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Bain Capital Life Sciences Investors, LLC 1.84% of their portfolio Boston, MA 9,677,1259.7m $14.7m $14.7m 1.84% Added +6.9m +6,916,237
2 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio Boston, MA 8,829,7588.8m $13.4m $13.4m 0.02% Added +5.2m +5,195,285
3 T. Rowe Price Investment Management, Inc. 0.01% of their portfolio BALTIMORE, MD 6,793,7886.8m $10.3m $10.3m 0.01% Added +2.8m +2,823,762
4 JENNISON ASSOCIATES LLC 0.01% of their portfolio NEW YORK, NY 6,020,1676.0m $9.2m $9.2m 0.01% Added +3.6m +3,586,439
5 Cormorant Asset Management, LP 0.57% of their portfolio BOSTON, MA 5,000,0005.0m $7.6m $7.6m 0.57% New
6 Alyeska Investment Group, L.P. 0.03% of their portfolio CHICAGO, IL 4,800,0004.8m $7.3m $7.3m 0.03% New
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 3,450,7273.5m $5.2m $5.2m 0.00% Added +606.5k +606,488
8 HEIGHTS CAPITAL MANAGEMENT, INC 1.50% of their portfolio SAN FRANCISCO, CA 3,144,1063.1m $4.8m $4.8m 1.50% New
9 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 2,187,0392.2m $3.3m $3.3m 0.00% Added +1.7m +1,697,718
10 Jefferies Financial Group Inc. 0.05% of their portfolio NEW YORK, NY 1,997,2082.0m $3.0m $3.0m 0.05% New
11 Burkehill Global Management, LP 0.21% of their portfolio NEW YORK, NY 1,900,0001.9m $2.9m $2.9m 0.21% New
12 Anson Funds Management LP 0.51% of their portfolio DALLAS, TX 1,822,8301.8m $2.8m $2.8m 0.51% New
13 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 1,687,9801.7m $2.6m $2.6m 0.00% Added +1.7m +1,687,630
14 Schonfeld Strategic Advisors LLC 0.02% of their portfolio NEW YORK, NY 1,484,8361.5m $2.3m $2.3m 0.02% Reduced -177.6k -177,565
15 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,324,8061.3m $2.0m $2.0m 0.00% Reduced -384.1k -384,082
16 Woodline Partners LP 0.01% of their portfolio San Francisco, CA 1,218,4641.2m $1.9m $1.9m 0.01% New
17 Blue Owl Capital Holdings LP 0.55% of their portfolio New York, NY 1,125,0001.1m $1.7m $1.7m 0.55% New
18 SUPERSTRING CAPITAL MANAGEMENT LP 2.01% of their portfolio NEW YORK, NY 1,060,7641.1m $1.6m $1.6m 2.01% Added +601.8k +601,792
19 BlackRock, Inc. 0.00% of their portfolio New York, NY 970,601970.6k $1.5m $1.5m 0.00% Reduced -2.5m -2,481,546
20 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 855,330855.3k $1.3m $1.3m 0.00% Added +686.4k +686,431
21 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 553,462553.5k $841.6k $841.6k 0.00% Reduced -587.8k -587,835
22 CANTOR FITZGERALD, L. P. 0.02% of their portfolio NEW YORK, NY 532,500532.5k $809.4k $809.4k 0.02% Reduced -952.1k -952,085
23 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 498,243498.2k $757.3k $757.3k 0.00% Reduced -485.9k -485,852
24 UBS Group AG 0.00% of their portfolio ZURICH, V8 472,042472.0k $717.5k $717.5k 0.00% Reduced -18.2k -18,158
25 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 413,600413.6k $628.7k $628.7k 0.00% Reduced -57.9k -57,900
26 Almitas Capital LLC 0.14% of their portfolio SANTA MONICA, CA 367,491367.5k $558.6k $558.6k 0.14% Unchanged
27 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 353,307353.3k $537.0k $537.0k 0.00% Added +22.8k +22,766
28 FEDERATED HERMES, INC. 0.00% of their portfolio PITTSBURGH, PA 344,540344.5k $523.7k $523.7k 0.00% Added +1.1k +1,129
29 Raiffeisen Bank International AG 0.01% of their portfolio VIENNA, C4 300,000300.0k $531.0k $531.0k 0.01% Unchanged
30 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 284,000284.0k $431.7k $431.7k 0.00% Reduced -3.5k -3,490
31 AXA S.A. 0.00% of their portfolio PARIS, I0 270,516270.5k $411.2k $411.2k 0.00% Added +439 +439
32 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 252,357252.4k $383.6k $383.6k 0.00% Reduced -69.1k -69,054
33 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 238,325238.3k $362.3k $362.3k 0.00% New
34 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 235,270235.3k $357.6k $357.6k 0.00% New
35 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 217,967218.0k $331.3k $331.3k 0.00% Reduced -720.8k -720,751
36 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 190,957191.0k $290.3k $290.3k 0.00% Added +157.5k +157,497
37 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 133,020133.0k $202.2k $202.2k 0.00% Reduced -266.7k -266,746
38 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 126,100126.1k $191.7k $191.7k 0.00% Added +115.2k +115,200
39 HRT FINANCIAL LP 0.00% of their portfolio NEW YORK, NY 124,395124.4k $189.0k $189.0k 0.00% New
40 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 123,625123.6k $187.9k $187.9k 0.00% Added +65.8k +65,845
41 XTX Topco Ltd 0.01% of their portfolio LONDON, X0 97,26097.3k $147.8k $147.8k 0.01% New
42 Thrivent Financial for Lutherans 0.00% of their portfolio Minneapolis, MN 95,32795.3k $145.0k $145.0k 0.00% Unchanged
43 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 88,60088.6k $134.7k $134.7k 0.00% Unchanged
44 TCG Crossover Management, LLC 0.02% of their portfolio PALO ALTO, CA 86,79586.8k $131.9k $131.9k 0.02% Unchanged
45 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 84,83184.8k $128.9k $128.9k 0.00% Added +23.2k +23,156
46 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 80,79680.8k $122.8k $122.8k 0.00% Reduced -170.6k -170,641
47 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 71,44171.4k $108.6k $108.6k 0.00% New
48 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 62,49962.5k $95.0k $95.0k 0.00% Added +31.0k +31,037
49 FRED ALGER MANAGEMENT, LLC 0.00% of their portfolio NEW YORK, NY 59,81359.8k $90.9k $90.9k 0.00% Reduced -417.4k -417,397
50 Jain Global LLC 0.00% of their portfolio NEW YORK, NY 56,16056.2k $85.4k $85.4k 0.00% New
51 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 51,03651.0k $77.6k $77.6k 0.00% Added +44.6k +44,621
52 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 50,62150.6k $76.9k $76.9k 0.00% Reduced -109.2k -109,245
53 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 49,06649.1k $74.6k $74.6k 0.00% Reduced -12.3k -12,339
54 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 47,81047.8k $72.7k $72.7k 0.00% Reduced -107.4k -107,364
55 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio HOUSTON, TX 45,67545.7k $69.4k $69.4k 0.00% Unchanged
56 MYDA Advisors LLC 0.02% of their portfolio WOODMERE, NY 40,00040.0k $60.8k $60.8k 0.02% New
57 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 39,77039.8k $60.5k $60.5k 0.00% Reduced -17.3k -17,266
58 Point72 Asia (Singapore) Pte. Ltd. 0.01% of their portfolio SINGAPORE, U0 34,76734.8k $52.8k $52.8k 0.01% New
59 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 32,12932.1k $48.8k $48.8k 0.00% Reduced -41.8k -41,827
60 Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio OAKLAND, CA 24,94824.9k $37.9k $37.9k 0.00% Added +5.6k +5,569
61 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 24,04824.0k $37.0k $37.0k 0.00% Reduced -12.2k -12,228
62 Catalyst Funds Management Pty Ltd 0.01% of their portfolio SYDNEY NSW, C3 21,00021.0k $31.9k $31.9k 0.01% New
63 TWO SIGMA SECURITIES, LLC 0.00% of their portfolio NEW YORK, NY 16,49116.5k $25.1k $25.1k 0.00% New
64 Rangeley Capital, LLC 0.03% of their portfolio NEW CANAAN, CT 16,00016.0k $24.3k $24.3k 0.03% New
65 FMR LLC 0.00% of their portfolio BOSTON, MA 15,45615.5k $23.5k $23.5k 0.00% Added +11.3k +11,295
66 ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio Boston, MA 15,14115.1k $23.0k $23.0k 0.00% Reduced -667.5k -667,529
67 Hudson Bay Capital Management LP 0.00% of their portfolio STAMFORD, CT 13,07013.1k $19.9k $19.9k 0.00% New
68 DRW Securities, LLC 0.00% of their portfolio CHICAGO, IL 12,84012.8k $19.5k $19.5k 0.00% New
69 CRA Financial Services, LLC 0.00% of their portfolio NORTHFIELD, NJ 11,00011.0k $16.7k $16.7k 0.00% Unchanged
70 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 9,7379.7k $14.8k $14.8k 0.00% Reduced -46.7k -46,701
71 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 6,6866.7k $10.2k $10.2k 0.00% Reduced -25.3k -25,293
72 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 6,5166.5k $9.9k $9.9k 0.00% Added +3.6k +3,600
73 SUMMIT SECURITIES GROUP LLC 0.00% of their portfolio NEW YORK, NY 4,8244.8k $7.3k $7.3k 0.00% New
74 Point72 (DIFC) Ltd 0.00% of their portfolio DUBAI, C0 2,4322.4k $3.7k $3.7k 0.00% New
75 Truvestments Capital LLC 0.00% of their portfolio SARASOTA, FL 1,9732.0k $3.0k $3.0k 0.00% Unchanged
76 CWM, LLC 0.00% of their portfolio OMAHA, NE 1,5971.6k $2.0k $2.0k 0.00% Reduced -4.6k -4,594
77 PNC Financial Services Group, Inc. 0.00% of their portfolio Pittsburgh, PA 1,3091.3k $2.0k $2.0k 0.00% Added +1.2k +1,155
78 Rise Advisors, LLC 0.00% of their portfolio ROCHESTER, NY 1,0831.1k $1.6k $1.6k 0.00% New
79 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 939939 $1.4k $1.4k 0.00% New
80 NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio ST. LOUIS, MO 912912 $1.4k $1.4k 0.00% Added +718 +718
81 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 340340 $517 $517 0.00% Unchanged
82 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 126126 $0 $0 0.00% Reduced -2.2k -2,237
83 Mid-American Wealth Advisory Group, Inc. 0.00% of their portfolio KANSAS CITY, MO 9191 $138 $138 0.00% New
84 EverSource Wealth Advisors, LLC 0.00% of their portfolio BIRMINGHAM, AL 4141 $62 $62 0.00% Reduced -49 -49
85 Covestor Ltd 0.00% of their portfolio LONDON, X0 3434 $0 $0 0.00% Reduced -3 -3
86 True Wealth Design, LLC 0.00% of their portfolio AKRON, OH 1717 $26 $26 0.00% Reduced -46 -46
87 CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio BIRMINGHAM, AL 00 $0 $0 — Unchanged