CABALETTA BIO INC CABA
COM · Common Stock · CUSIP 12674W109
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersPhiladelphia, PA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($4.1m this quarter). Holder counts are more reliable. Shares outstanding: 48.2m as of 2024-03-15, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $17.06. Options: 8 managers hold calls ($8.9m notional), 10 hold puts ($15.6m).
Trends to Q1 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 54 |
| Q4 2022 | 62 |
| Q1 2023 | 73 |
| Q2 2023 | 85 |
| Q3 2023 | 98 |
| Q4 2023 | 129 |
| Q1 2024 | 160 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 31 | 35 |
| Q1 2023 | 44 | 26 |
| Q2 2023 | 57 | 29 |
| Q3 2023 | 73 | 22 |
| Q4 2023 | 76 | 40 |
| Q1 2024 | 91 | 61 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2023 | $1.4m | $529.1k | 0.37 |
| Q3 2023 | $1.4m | $740.7k | 0.52 |
| Q4 2023 | $6.4m | $8.7m | 1.37 |
| Q1 2024 | $8.9m | $15.6m | 1.76 |
Biggest buyers
| MORGAN STANLEY | Added | +1.9m |
| JENNISON ASSOCIATES LLC | Added | +1.8m |
| STATE STREET CORP | Added | +1.1m |
| Cormorant Asset Management, LP | New | +1.1m |
| T. Rowe Price Investment Management, Inc. | Added | +637.6k |
| STEMPOINT CAPITAL LP | Added | +553.2k |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +468.4k |
| MILLENNIUM MANAGEMENT LLC | New | +459.4k |
| Duquesne Family Office LLC | New | +417.0k |
| Qube Research & Technologies Ltd | Added | +382.3k |
Biggest sellers
| Holocene Advisors, LP | Sold out | -1.9m |
| Venrock Adviser, LLC | Reduced | -1.0m |
| Redmile Group, LLC | Reduced | -931.4k |
| Commodore Capital LP | Reduced | -800.0k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Reduced | -749.1k |
| Invesco Ltd. | Reduced | -653.2k |
| TCG Crossover Management, LLC | Reduced | -400.0k |
| Bain Capital Life Sciences Investors, LLC | Reduced | -382.6k |
| BlackRock Inc. | Reduced | -351.9k |
| Blackstone Inc. | Reduced | -300.7k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $2.1m124.7k shares |
| MILLENNIUM MANAGEMENT LLC | New | $1.7m100.0k shares |
| Atika Capital Management LLC | New | $1.7m1.0k shares |
| CITADEL ADVISORS LLC | Added | $1.3m74.0k shares |
| SIMPLEX TRADING, LLC | Added | $1.1m67.1k shares |
| JANE STREET GROUP, LLC | Added | $621.0k36.4k shares |
| GROUP ONE TRADING LLC | Added | $305.4k17.9k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| Caption Management, LLC | Added | $7.3m425.0k shares |
| Ikarian Capital, LLC | Unchanged | $3.4m200.0k shares |
| GROUP ONE TRADING LLC | Added | $1.5m88.6k shares |
| STEMPOINT CAPITAL LP | New | $1.1m500.0k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | Added | $992.9k58.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $576.6k33.8k shares |
| HAP Trading, LLC | New | $363.8k75.0k shares |
| CITADEL ADVISORS LLC | Added | $290.0k17.0k shares |
| SIMPLEX TRADING, LLC | Added | $127.0k7.5k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| T. Rowe Price Investment Management, Inc. 13G · institution +1.4 pts · filed 2026-08-14 | 11.6% |
| PRUDENTIAL FINANCIAL INC 13G · institution +2.5 pts · filed 2026-06-05 | 11.4% |
| JENNISON ASSOCIATES LLC 13G · institution +2.5 pts · filed 2026-06-04 | 11.4% |
| Bain Capital Life Sciences Opportunities III, LP 13G · passive investor no change · filed 2026-08-14 | 10.0% |
| Adage Capital Management, L.P. 13G · institution -1.6 pts · filed 2026-08-12 | 8.4% |
| BlackRock, Inc. 13G · institution +1.8 pts · filed 2026-10-27 | 7.7% |
| Cormorant Asset Management, LP 13G · institution -3.1 pts · filed 2026-08-14 | 6.0% |
| NORGES BANK 13G · institution new · filed 2026-08-12 | 5.4% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.1% |
Fell to 5% or below in the last year: MILLENNIUM MANAGEMENT LLC (1.3%, 2026-07-23), Alyeska Investment Group, L.P. (4.7%, 2026-02-17), CITADEL ADVISORS LLC (3.4%, 2025-11-14)
Insider purchases and sales in Q1 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 5 | $343.4k | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 1 | $402.7k | $402.7k |
| Q3 2023 | 0 | — | 1 | $492.9k | $492.9k |
| Q4 2023 | 0 | — | 1 | $583.7k | — |
| Q1 2024 | 0 | — | 1 | $215.5k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-01-19 | Binder Gwendolyn Officer | Sold | $215.5k11.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2024
| Manager | Shares | Change |
|---|---|---|
| BlackRock Inc. 0.00% of their portfolio | 4.1m $69.2m | Reduced -351.9k |
| STATE STREET CORP 0.00% of their portfolio | 3.7m $63.8m | Added +1.1m |
| JENNISON ASSOCIATES LLC 0.04% of their portfolio | 3.4m $58.4m | Added +1.8m |
| FRED ALGER MANAGEMENT, LLC 0.26% of their portfolio | 3.1m $53.1m | Reduced -216.8k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.10% of their portfolio | 3.0m $51.8m | Reduced -230.0k |
| MORGAN STANLEY 0.00% of their portfolio | 2.7m $45.3m | Added +1.9m |
| T. Rowe Price Investment Management, Inc. 0.03% of their portfolio | 2.5m $42.1m | Added +637.6k |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.3m $38.8m | Added +144.3k |
| Lynx1 Capital Management LP 9.15% of their portfolio | 2.1m $35.5m | Reduced -27.4k |
| PERCEPTIVE ADVISORS LLC 0.52% of their portfolio | 1.7m $29.3m | Reduced -286.4k |
| Bain Capital Life Sciences Investors, LLC 2.22% of their portfolio | 1.6m $27.6m | Reduced -382.6k |
| Venrock Adviser, LLC 1.27% of their portfolio | 1.6m $26.7m | Reduced -1.0m |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.37% of their portfolio | 1.3m $21.5m | Reduced -749.1k |
| Polar Capital Holdings Plc 0.11% of their portfolio | 1.2m $21.3m | Unchanged |
| Cormorant Asset Management, LP 0.83% of their portfolio | 1.1m $18.8m | New |
| Commodore Capital LP 1.25% of their portfolio | 1.1m $18.8m | Reduced -800.0k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 1.0m $17.2m | Added +468.4k |
| STEMPOINT CAPITAL LP 4.58% of their portfolio | 1.0m $17.1m | Added +553.2k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 773.1k $13.2m | Added +19.9k |
| Invesco Ltd. 0.00% of their portfolio | 744.8k $12.7m | Reduced -653.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 612.4k $10.4m | Added +84.6k |
| ALKEON CAPITAL MANAGEMENT LLC 0.05% of their portfolio | 500.0k $8.5m | Added +140.0k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 459.4k $7.8m | New |
| Redmile Group, LLC 0.28% of their portfolio | 442.8k $7.6m | Reduced -931.4k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 434.5k $7.4m | Added +382.3k |
| Sofinnova Investments, Inc. 0.43% of their portfolio | 429.7k $7.3m | Added +351 |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 425.2k $7.3m | Added +187.0k |
| Integral Health Asset Management, LLC 0.71% of their portfolio | 425.0k $7.3m | Reduced -95.0k |
| Duquesne Family Office LLC 0.19% of their portfolio | 417.0k $7.1m | New |
| Ghost Tree Capital, LLC 2.06% of their portfolio | 375.0k $6.4m | Added +225.0k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 371.6k $6.3m | Reduced -32.3k |
| Rafferty Asset Management, LLC 0.02% of their portfolio | 354.4k $6.0m | Added +145.2k |
| Artisan Partners Limited Partnership 0.01% of their portfolio | 334.8k $5.7m | New |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 330.9k $5.6m | Added +212.9k |
| Schonfeld Strategic Advisors LLC 0.04% of their portfolio | 317.5k $5.4m | Added +65.9k |
| Cutter Capital Management, LP 1.04% of their portfolio | 315.9k $5.4m | Added +85.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 304.2k $5.2m | Reduced -6.5k |
| CITIGROUP INC 0.01% of their portfolio | 301.9k $5.2m | Added +215.3k |
| SUPERSTRING CAPITAL MANAGEMENT LP 3.28% of their portfolio | 290.8k $5.0m | New |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 282.7k $4.8m | Reduced -2.0k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 278.1k $4.7m | Added +41.7k |
| Woodline Partners LP 0.04% of their portfolio | 242.7k $4.1m | Added +1.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 238.1k $4.1m | Added +77.6k |
| UBS Group AG 0.00% of their portfolio | 209.5k $3.6m | Added +70.8k |
| Candriam S.C.A. 0.02% of their portfolio | 200.0k $3.4m | New |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 198.0k $3.4m | Reduced -43.8k |
| AXA S.A. 0.01% of their portfolio | 178.2k $3.0m | New |
| Saturn V Capital Management LP 1.18% of their portfolio | 173.2k $3.0m | New |
| MARSHALL WACE, LLP 0.00% of their portfolio | 171.2k $2.9m | New |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 164.6k $2.8m | New |
| Caption Management, LLC 0.30% of their portfolio | 160.0k $2.7m | Added +121.7k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 146.1k $2.5m | Reduced -10.9k |
| Cubist Systematic Strategies, LLC 0.03% of their portfolio | 137.5k $2.3m | Added +108.3k |
| TD Asset Management Inc 0.00% of their portfolio | 127.0k $2.2m | Added +33.4k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 93.5k $1.6m | Reduced -2.8k |
| TCG Crossover Management, LLC 0.12% of their portfolio | 86.8k $1.5m | Reduced -400.0k |
| Crestline Management, L.P. 0.14% of their portfolio | 85.0k $1.5m | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 82.4k $1.4m | Added +57.2k |
| WESTWOOD HOLDINGS GROUP INC 0.01% of their portfolio | 82.2k $1.4m | New |
| Atle Fund Management AB 0.80% of their portfolio | 77.5k $1.3m | Added +56.5k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 77.2k $1.3m | Reduced -19.7k |
| Trexquant Investment LP 0.02% of their portfolio | 69.4k $1.2m | New |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 69.2k $1.2m | Unchanged |
| AlphaCentric Advisors LLC 0.67% of their portfolio | 65.0k $1.1m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 64.1k $1.1m | Added +42.0k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 59.5k $1.0m | Added +45.6k |
| Swiss National Bank 0.00% of their portfolio | 59.2k $1.0m | Added +8.2k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 59.0k $1.0m | New |
| PROFUND ADVISORS LLC 0.04% of their portfolio | 54.4k $928.5k | Added +20.6k |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 53.3k $910.0k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 52.2k $891.1k | Reduced -444 |
| Octagon Capital Advisors LP 0.11% of their portfolio | 52.0k $887.1k | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 50.7k $865.3k | Reduced -37.7k |
| Skandinaviska Enskilda Banken AB (publ) 0.00% of their portfolio | 49.6k $845.5k | New |
| BARCLAYS PLC 0.00% of their portfolio | 49.0k $835.4k | Reduced -80.1k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 47.3k $807.1k | Reduced -42.4k |
| Nan Fung Group Holdings Ltd 0.75% of their portfolio | 47.1k $804.4k | Unchanged |
| Blackstone Inc. 0.00% of their portfolio | 46.8k $798.1k | Reduced -300.7k |
| CHURCHILL MANAGEMENT Corp 0.01% of their portfolio | 46.6k $795.1k | Reduced -2.8k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 45.6k $778.0k | Added +1.5k |
| Squarepoint Ops LLC 0.00% of their portfolio | 42.4k $723.9k | Added +18.8k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 36.7k $625.7k | Reduced -38.1k |
| LPL Financial LLC 0.00% of their portfolio | 34.9k $596.0k | Reduced -2.7k |
| Cinctive Capital Management LP 0.03% of their portfolio | 34.6k $590.1k | New |
| Point72 (DIFC) Ltd 0.04% of their portfolio | 34.0k $579.6k | First filing |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 33.4k $570.1k | Added +5.7k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 33.4k $569.6k | Unchanged |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 32.6k $555.5k | Reduced -517 |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 31.3k $534.1k | Reduced -62.0k |
| Graham Capital Management, L.P. 0.02% of their portfolio | 31.2k $531.8k | New |
| AlphaQuest LLC 0.09% of their portfolio | 30.9k $526.7k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 30.4k $519.1k | Added +1.7k |
| Polar Asset Management Partners Inc. 0.01% of their portfolio | 27.9k $476.0k | New |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 27.3k $465.7k | Added +8.8k |
| Engineers Gate Manager LP 0.01% of their portfolio | 26.3k $448.5k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 25.4k $432.9k | Unchanged |
| HAP Trading, LLC 0.13% of their portfolio | 24.1k $410.6k | New |
| Legal & General Group Plc 0.00% of their portfolio | 23.4k $399.5k | Reduced -2.2k |
| HighVista Strategies LLC 0.14% of their portfolio | 22.2k $378.9k | New |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 21.3k $363.6k | New |