CABALETTA BIO INC CABA
COM · Common Stock · CUSIP 12674W109
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersPhiladelphia, PA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.3m this quarter). Holder counts are more reliable. Shares outstanding: 42.8m as of 2023-11-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $22.70. Options: 7 managers hold calls ($6.4m notional), 9 hold puts ($8.7m).
Trends to Q4 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 54 |
| Q4 2022 | 62 |
| Q1 2023 | 73 |
| Q2 2023 | 85 |
| Q3 2023 | 98 |
| Q4 2023 | 129 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 31 | 35 |
| Q1 2023 | 44 | 26 |
| Q2 2023 | 57 | 29 |
| Q3 2023 | 73 | 22 |
| Q4 2023 | 76 | 40 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2023 | $800.3k | $120.2k | 0.15 |
| Q2 2023 | $1.4m | $529.1k | 0.37 |
| Q3 2023 | $1.4m | $740.7k | 0.52 |
| Q4 2023 | $6.4m | $8.7m | 1.37 |
Biggest buyers
| BlackRock Inc. | Added | +2.0m |
| T. Rowe Price Investment Management, Inc. | New | +1.8m |
| Polar Capital Holdings Plc | New | +1.2m |
| STATE STREET CORP | Added | +1.1m |
| PERCEPTIVE ADVISORS LLC | Added | +870.6k |
| Holocene Advisors, LP | Added | +737.3k |
| Venrock Adviser, LLC | Added | +590.7k |
| MORGAN STANLEY | Added | +552.7k |
| Invesco Ltd. | Added | +543.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +512.5k |
Biggest sellers
| Cormorant Asset Management, LP | Sold out | -2.9m |
| BAKER BROS. ADVISORS LP | Reduced | -1.6m |
| FRED ALGER MANAGEMENT, LLC | Reduced | -932.3k |
| Commodore Capital LP | Reduced | -625.8k |
| Redmile Group, LLC | Reduced | -400.1k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Reduced | -332.4k |
| Velan Capital Investment Management LP | Sold out | -150.0k |
| PRUDENTIAL FINANCIAL INC | Reduced | -118.0k |
| FIRST MANHATTAN CO. LLC. | Reduced | -115.0k |
| Rokos Capital Management LLP | Reduced | -93.5k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $3.8m166.6k shares |
| CITADEL ADVISORS LLC | Added | $1.2m54.8k shares |
| SIMPLEX TRADING, LLC | Added | $594.0k26.2k shares |
| JANE STREET GROUP, LLC | New | $494.9k21.8k shares |
| GROUP ONE TRADING LLC | Reduced | $249.7k11.0k shares |
| Cutler Group LLC / CA | New | $3.0k300 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| Ikarian Capital, LLC | New | $4.5m200.0k shares |
| Caption Management, LLC | New | $2.3m100.0k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $1.1m47.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $519.8k22.9k shares |
| CITADEL ADVISORS LLC | Reduced | $161.2k7.1k shares |
| SIMPLEX TRADING, LLC | Added | $111.0k4.9k shares |
| GROUP ONE TRADING LLC | Added | $45.4k2.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| Cutler Group LLC / CA | New | $0300 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| T. Rowe Price Investment Management, Inc. 13G · institution +1.4 pts · filed 2026-08-14 | 11.6% |
| PRUDENTIAL FINANCIAL INC 13G · institution +2.5 pts · filed 2026-06-05 | 11.4% |
| JENNISON ASSOCIATES LLC 13G · institution +2.5 pts · filed 2026-06-04 | 11.4% |
| Bain Capital Life Sciences Opportunities III, LP 13G · passive investor no change · filed 2026-08-14 | 10.0% |
| Adage Capital Management, L.P. 13G · institution -1.6 pts · filed 2026-08-12 | 8.4% |
| BlackRock, Inc. 13G · institution +1.8 pts · filed 2026-10-27 | 7.7% |
| Cormorant Asset Management, LP 13G · institution -3.1 pts · filed 2026-08-14 | 6.0% |
| NORGES BANK 13G · institution new · filed 2026-08-12 | 5.4% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.1% |
Fell to 5% or below in the last year: MILLENNIUM MANAGEMENT LLC (1.3%, 2026-07-23), Alyeska Investment Group, L.P. (4.7%, 2026-02-17), CITADEL ADVISORS LLC (3.4%, 2025-11-14)
Insider purchases and sales in Q4 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 5 | $343.4k | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 1 | $402.7k | $402.7k |
| Q3 2023 | 0 | — | 1 | $492.9k | $492.9k |
| Q4 2023 | 0 | — | 1 | $583.7k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-12-19 | Binder Gwendolyn Officer | Sold | $240.8k11.0k shares |
| 2023-11-20 | Binder Gwendolyn Officer | Sold | $196.0k11.0k shares |
| 2023-10-19 | Binder Gwendolyn Officer | Sold | $146.9k11.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2023
| Manager | Shares | Change |
|---|---|---|
| BlackRock Inc. 0.00% of their portfolio | 4.4m $100.1m | Added +2.0m |
| FRED ALGER MANAGEMENT, LLC 0.41% of their portfolio | 3.3m $75.5m | Reduced -932.3k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.15% of their portfolio | 3.3m $74.2m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 2.6m $58.9m | Added +1.1m |
| Venrock Adviser, LLC 3.99% of their portfolio | 2.6m $58.2m | Added +590.7k |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.1m $48.4m | Added +163.8k |
| Lynx1 Capital Management LP 18.84% of their portfolio | 2.1m $47.9m | Added +4.4k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.84% of their portfolio | 2.0m $45.6m | Reduced -332.4k |
| PERCEPTIVE ADVISORS LLC 1.02% of their portfolio | 2.0m $45.5m | Added +870.6k |
| Bain Capital Life Sciences Investors, LLC 4.35% of their portfolio | 2.0m $45.4m | Unchanged |
| Holocene Advisors, LP 0.17% of their portfolio | 1.9m $43.6m | Added +737.3k |
| Commodore Capital LP 3.77% of their portfolio | 1.9m $43.1m | Reduced -625.8k |
| T. Rowe Price Investment Management, Inc. 0.03% of their portfolio | 1.8m $41.6m | New |
| JENNISON ASSOCIATES LLC 0.03% of their portfolio | 1.6m $36.9m | Added +204.3k |
| Invesco Ltd. 0.01% of their portfolio | 1.4m $31.7m | Added +543.9k |
| Redmile Group, LLC 1.12% of their portfolio | 1.4m $31.2m | Reduced -400.1k |
| Polar Capital Holdings Plc 0.17% of their portfolio | 1.2m $28.4m | New |
| MORGAN STANLEY 0.00% of their portfolio | 774.8k $17.6m | Added +552.7k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 753.2k $17.1m | Added +61.3k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 539.9k $12.3m | Added +293.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 527.8k $12.0m | Added +512.5k |
| Integral Health Asset Management, LLC 1.70% of their portfolio | 520.0k $11.8m | Added +190.0k |
| TCG Crossover Management, LLC 1.23% of their portfolio | 486.8k $11.1m | Unchanged |
| STEMPOINT CAPITAL LP 2.94% of their portfolio | 450.7k $10.2m | First filing |
| Sofinnova Investments, Inc. 0.55% of their portfolio | 429.4k $9.7m | New |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 403.9k $9.2m | Added +337.3k |
| ALKEON CAPITAL MANAGEMENT LLC 0.05% of their portfolio | 360.0k $8.2m | New |
| Blackstone Inc. 0.04% of their portfolio | 347.5k $7.9m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 310.7k $7.1m | Added +10.9k |
| Point72 Asset Management, L.P. 0.02% of their portfolio | 284.7k $6.5m | New |
| Schonfeld Strategic Advisors LLC 0.05% of their portfolio | 251.6k $5.7m | New |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 241.8k $5.5m | Added +105.8k |
| Woodline Partners LP 0.06% of their portfolio | 241.5k $5.5m | Added +107.3k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 238.1k $5.4m | Reduced -61.9k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 236.4k $5.4m | Added +225.6k |
| Cutter Capital Management, LP 2.50% of their portfolio | 230.0k $5.2m | First filing |
| Ikarian Capital, LLC 1.35% of their portfolio | 216.6k $4.9m | New |
| Rafferty Asset Management, LLC 0.02% of their portfolio | 209.3k $4.8m | Added +91.1k |
| First Turn Management, LLC 0.57% of their portfolio | 175.4k $4.0m | First filing |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 160.5k $3.6m | Added +19.3k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 157.0k $3.6m | Added +11.5k |
| Ghost Tree Capital, LLC 1.96% of their portfolio | 150.0k $3.4m | New |
| UBS Group AG 0.00% of their portfolio | 138.6k $3.1m | Added +103.7k |
| BARCLAYS PLC 0.00% of their portfolio | 129.1k $2.9m | Added +64.5k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 118.0k $2.7m | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 97.0k $2.2m | Reduced -7.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 96.3k $2.2m | Added +305 |
| TD Asset Management Inc 0.00% of their portfolio | 93.6k $2.1m | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 93.3k $2.1m | Reduced -72.1k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 89.7k $2.0m | Added +66.0k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 88.4k $2.0m | New |
| CITIGROUP INC 0.00% of their portfolio | 86.5k $2.0m | Added +36.9k |
| Rokos Capital Management LLP 0.06% of their portfolio | 80.3k $1.8m | Reduced -93.5k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 74.8k $1.7m | Added +28.1k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 69.2k $1.6m | Reduced -118.0k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.05% of their portfolio | 58.8k $1.3m | New |
| Nicholas Investment Partners, LP 0.14% of their portfolio | 54.6k $1.2m | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 52.7k $1.2m | Added +39.4k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 52.2k $1.2m | New |
| Swiss National Bank 0.00% of their portfolio | 51.0k $1.2m | Reduced -10.1k |
| CHURCHILL MANAGEMENT Corp 0.02% of their portfolio | 49.4k $1.1m | Reduced -7.7k |
| Nan Fung Group Holdings Ltd 0.67% of their portfolio | 47.1k $1.1m | Unchanged |
| Exome Asset Management LLC 1.05% of their portfolio | 46.7k $1.1m | First filing |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 46.0k $1.0m | Reduced -4.6k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 44.1k $1.0m | Added +1.5k |
| Caption Management, LLC 0.09% of their portfolio | 38.3k $869.4k | New |
| LPL Financial LLC 0.00% of their portfolio | 37.6k $854.4k | Reduced -223 |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 33.9k $769.1k | Added +31.4k |
| PROFUND ADVISORS LLC 0.03% of their portfolio | 33.9k $768.6k | Added +13.7k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 33.4k $757.9k | Added +12.5k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 33.1k $750.9k | Reduced -42.3k |
| Cubist Systematic Strategies, LLC 0.01% of their portfolio | 29.2k $663.8k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 28.7k $651.9k | Reduced -3.4k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 27.7k $628.2k | Reduced -19.7k |
| Legal & General Group Plc 0.00% of their portfolio | 25.6k $581.4k | Reduced -6.0k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 25.4k $576.0k | Reduced -53.3k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 25.2k $571.8k | Added +14.8k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 23.7k $537.7k | Added +6.9k |
| Squarepoint Ops LLC 0.00% of their portfolio | 23.6k $536.5k | Added +4.3k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 23.1k $523.3k | Reduced -5.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 22.1k $500.6k | New |
| Atle Fund Management AB 0.37% of their portfolio | 21.0k $476.7k | First filing |
| Birchview Capital, LP 0.18% of their portfolio | 20.0k $454.0k | New |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 19.6k $444.3k | Reduced -38 |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 18.5k $420.8k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 18.3k $415.8k | Unchanged |
| ADVISORY RESEARCH INC 0.06% of their portfolio | 17.7k $400.9k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 17.3k $393.4k | Reduced -3.8k |
| DENALI ADVISORS LLC 0.12% of their portfolio | 17.3k $392.7k | New |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 17.1k $388.6k | Reduced -68 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 14.1k $319.1k | Reduced -17.0k |
| HRT FINANCIAL LP 0.00% of their portfolio | 14.0k $316.0k | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 13.9k $316.2k | Unchanged |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 13.8k $312.4k | Reduced -785 |
| BAKER BROS. ADVISORS LP 0.00% of their portfolio | 13.3k $302.6k | Reduced -1.6m |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 12.1k $273.9k | Unchanged |
| E Fund Management Co., Ltd. 0.02% of their portfolio | 11.2k $255.1k | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 11.2k $254.3k | New |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 11.1k $252.0k | New |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 9.8k $223.1k | New |