Vault-13

BLUEPRINT MEDICINES CORP BPMC

COM · Common Stock · CUSIP 09627Y109 · ISIN US09627Y1091

356 institutional holders +3 vs Q1 2025
67,446,22867.4m shares reported held*
$8.6bnreported value*
100 new 94 added 118 reduced 105 sold out net sold ≈ $865.0m (-6.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($9.7m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $128.18. Options: 18 managers hold calls ($144.6m notional), 18 hold puts ($210.0m).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

0200400Q3 22: 240Q4 22: 223Q1 23: 215Q2 23: 222Q3 23: 220Q4 23: 260Q1 24: 283Q2 24: 306Q3 24: 320Q4 24: 346Q1 25: 353Q2 25: 356356Q3 22Q2 23Q1 24Q4 24Q2 25
Numbers
QuarterHolders
Q3 2022240
Q4 2022223
Q1 2023215
Q2 2023222
Q3 2023220
Q4 2023260
Q1 2024283
Q2 2024306
Q3 2024320
Q4 2024346
Q1 2025353
Q2 2025356

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
4000400Q3 23: 123 bought or addedQ3 23: 81 cut or sold outQ4 23: 120 bought or addedQ4 23: 114 cut or sold outQ4 23Q1 24: 152 bought or addedQ1 24: 116 cut or sold outQ2 24: 160 bought or addedQ2 24: 124 cut or sold outQ2 24Q3 24: 194 bought or addedQ3 24: 121 cut or sold outQ4 24: 190 bought or addedQ4 24: 127 cut or sold outQ4 24Q1 25: 193 bought or addedQ1 25: 166 cut or sold outQ2 25: 194 bought or addedQ2 25: 223 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q3 202312381
Q4 2023120114
Q1 2024152116
Q2 2024160124
Q3 2024194121
Q4 2024190127
Q1 2025193166
Q2 2025194223

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100m$200m$300mQ3 24 calls: $218.1mQ3 24 puts: $124.1mQ3 24P/C 0.57Q4 24 calls: $148.5mQ4 24 puts: $131.0mQ4 24P/C 0.88Q1 25 calls: $144.3mQ1 25 puts: $100.4mQ1 25P/C 0.70Q2 25 calls: $144.6mQ2 25 puts: $210.0mQ2 25P/C 1.45
Numbers
QuarterCallsPutsP/C
Q3 2024$218.1m$124.1m0.57
Q4 2024$148.5m$131.0m0.88
Q1 2025$144.3m$100.4m0.70
Q2 2025$144.6m$210.0m1.45

Biggest buyers

Pentwater Capital Management LP New +3,900,000+3.9m
UBS Group AG Added +1,953,223+2.0m
FIL Ltd New +1,759,500+1.8m
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) Added +1,698,722+1.7m
BARCLAYS PLC Added +1,427,323+1.4m
GLAZER CAPITAL, LLC New +1,331,300+1.3m
Beryl Capital Management LLC New +1,067,224+1.1m
ALPINE ASSOCIATES MANAGEMENT INC. New +1,060,307+1.1m
SYQUANT CAPITAL SAS New +805,603+805.6k
Magnetar Financial LLC Added +725,479+725.5k

Biggest sellers

PRICE T ROWE ASSOCIATES INC /MD/ Reduced -3,950,869-4.0m
Avoro Capital Advisors LLC Reduced -3,475,000-3.5m
WELLINGTON MANAGEMENT GROUP LLP Reduced -2,637,330-2.6m
JPMORGAN CHASE & CO Reduced -2,088,454-2.1m
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC Reduced -1,421,094-1.4m
T. Rowe Price Investment Management, Inc. Sold out -1,302,810-1.3m
ALKEON CAPITAL MANAGEMENT LLC Sold out -900,628-900.6k
Hood River Capital Management LLC Sold out -900,205-900.2k
FMR LLC Reduced -874,209-874.2k
AMERICAN CENTURY COMPANIES INC Reduced -843,993-844.0k

Biggest calls

JANE STREET GROUP, LLC Reduced $74.4m580.6k shares
JPMORGAN CHASE & CO Added $13.3m104.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $12.2m95.4k shares
BARCLAYS PLC New $12.2m95.3k shares
CITADEL ADVISORS LLC Reduced $9.1m71.0k shares
D. E. Shaw & Co., Inc. Unchanged $5.0m39.1k shares
Twin Tree Management, LP Unchanged $3.7m28.8k shares
Caption Management, LLC New $3.5m27.1k shares
CITIGROUP INC Unchanged $2.9m23.0k shares
IMC-Chicago, LLC New $2.8m22.0k shares

Biggest puts

JANE STREET GROUP, LLC Reduced $74.7m583.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $58.6m457.3k shares
EQUITEC PROPRIETARY MARKETS, LLC New $17.5m136.5k shares
CSS LLC/IL New $12.1m94.3k shares
Caption Management, LLC New $11.7m91.1k shares
GROUP ONE TRADING LLC Added $9.4m73.3k shares
CITADEL ADVISORS LLC Reduced $9.3m72.3k shares
MILLENNIUM MANAGEMENT LLC New $4.9m37.9k shares
SIMPLEX TRADING, LLC Added $4.4m34.7k shares
CITIGROUP INC Unchanged $2.9m23.0k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-04-23 8.0% 5.1m 2025-04-23
Pentwater Capital Management LP 13G · institution new · filed 2025-08-14 6.0% new 3.9m 2025-08-14

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 6,416,6036.4m $822.5m $822.5m 0.01% Reduced -223.9k -223,920
2 BlackRock, Inc. 0.02% of their portfolio New York, NY 6,118,4286.1m $784.3m $784.3m 0.02% Reduced -592.3k -592,280
3 Pentwater Capital Management LP 6.38% of their portfolio Naples, FL 3,900,0003.9m $499.9m $499.9m 6.38% New
4 HBK INVESTMENTS L P 7.29% of their portfolio DALLAS, TX 3,200,9243.2m $410.3m $410.3m 7.29% Not comparable
5 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,230,9802.2m $286.0m $286.0m 0.01% Reduced -453.1k -453,137
6 UBS Group AG 0.06% of their portfolio ZURICH, V8 2,167,0282.2m $277.8m $277.8m 0.06% Added +2.0m +1,953,223
7 FIL Ltd 0.19% of their portfolio HAMILTON, D0 1,759,5001.8m $225.5m $225.5m 0.19% New
8 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 6.00% of their portfolio CHICAGO, IL 1,713,5871.7m $219.6m $219.6m 6.00% Added +1.7m +1,698,722
9 BARCLAYS PLC 0.08% of their portfolio LONDON, X0 1,556,9181.6m $199.6m $199.6m 0.08% Added +1.4m +1,427,323
10 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 1,541,0131.5m $197.6m $197.6m 0.01% Added +18.4k +18,366
11 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 1,464,9681.5m $187.8m $187.8m 0.02% Reduced -4.0m -3,950,869
12 GLAZER CAPITAL, LLC 6.10% of their portfolio New York, NY 1,331,3001.3m $170.6m $170.6m 6.10% New
13 NORGES BANK 0.02% of their portfolio OSLO, Q8 1,074,9361.1m $137.8m $137.8m 0.02% Added +472.0k +472,009
14 Beryl Capital Management LLC 20.60% of their portfolio REDONDO BEACH, CA 1,067,2241.1m $136.8m $136.8m 20.60% New
15 ALPINE ASSOCIATES MANAGEMENT INC. 7.27% of their portfolio PALM BEACH, FL 1,060,3071.1m $135.9m $135.9m 7.27% New
16 Davidson Kempner Capital Management LP 2.02% of their portfolio New York, NY 1,035,1001.0m $132.7m $132.7m 2.02% Not comparable
17 MORGAN STANLEY 0.01% of their portfolio NEW YORK, NY 1,031,1701.0m $132.2m $132.2m 0.01% Added +462.5k +462,471
18 MACQUARIE GROUP LTD 0.14% of their portfolio Sydney, NSW 2000, C3 922,167922.2k $118.2m $118.2m 0.14% Reduced -364.7k -364,730
19 GOLDMAN SACHS GROUP INC 0.02% of their portfolio NEW YORK, NY 891,287891.3k $114.2m $114.2m 0.02% Reduced -35.4k -35,381
20 SYQUANT CAPITAL SAS 34.24% of their portfolio PARIS, I0 805,603805.6k $103.3m $103.3m 34.24% New
21 ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio NASHVILLE, TN 765,387765.4k $98.1m $98.1m 0.03% Reduced -430.9k -430,853
22 Magnetar Financial LLC 0.45% of their portfolio EVANSTON, IL 730,047730.0k $93.6m $93.6m 0.45% Added +725.5k +725,479
23 EVENTIDE ASSET MANAGEMENT, LLC 1.64% of their portfolio Boston, MA 728,821728.8k $93.4m $93.4m 1.64% Reduced -133.7k -133,728
24 RENAISSANCE TECHNOLOGIES LLC 0.12% of their portfolio NEW YORK, NY 674,500674.5k $86.5m $86.5m 0.12% New
25 BANK OF AMERICA CORP /DE/ 0.01% of their portfolio CHARLOTTE, NC 647,487647.5k $83.0m $83.0m 0.01% Reduced -69.4k -69,419
26 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 568,924568.9k $72.9m $72.9m 0.01% Reduced -20.6k -20,635
27 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 561,159561.2k $71.9m $71.9m 0.01% Reduced -38.6k -38,562
28 FMR LLC 0.00% of their portfolio BOSTON, MA 558,960559.0k $71.6m $71.6m 0.00% Reduced -874.2k -874,209
29 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.26% of their portfolio JUPITER, FL 558,768558.8k $71.6m $71.6m 0.26% Added +548.6k +548,633
30 Woodline Partners LP 0.36% of their portfolio San Francisco, CA 531,880531.9k $68.2m $68.2m 0.36% Reduced -8.9k -8,858
31 Man Group plc 0.14% of their portfolio LONDON, X0 516,258516.3k $66.2m $66.2m 0.14% Reduced -3.5k -3,479
32 Invesco Ltd. 0.01% of their portfolio ATLANTA, GA 511,091511.1k $65.5m $65.5m 0.01% Reduced -473.6k -473,583
33 Balyasny Asset Management L.P. 0.15% of their portfolio Chicago, IL 505,957506.0k $64.9m $64.9m 0.15% Added +445.7k +445,675
34 Nuveen, LLC 0.02% of their portfolio CHARLOTTE, NC 488,612488.6k $62.6m $62.6m 0.02% Added +221.0k +220,952
35 NEXPOINT ASSET MANAGEMENT, L.P. 5.82% of their portfolio Dallas, TX 476,742476.7k $61.1m $61.1m 5.82% New
36 TUDOR INVESTMENT CORP ET AL 0.45% of their portfolio STAMFORD, CT 468,623468.6k $60.1m $60.1m 0.45% Added +446.6k +446,612
37 BROWN ADVISORY INC 0.08% of their portfolio BALTIMORE, MD 458,559458.6k $58.8m $58.8m 0.08% Reduced -123.3k -123,305
38 First Trust Capital Management L.P. 3.95% of their portfolio CHICAGO, IL 456,068456.1k $58.5m $58.5m 3.95% New
39 WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio Boston, MA 435,976436.0k $55.9m $55.9m 0.01% Reduced -2.6m -2,637,330
40 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 418,060418.1k $53.6m $53.6m 0.00% Reduced -2.1m -2,088,454
41 Clearbridge Investments, LLC 0.04% of their portfolio NEW YORK, NY 405,708405.7k $52.0m $52.0m 0.04% Reduced -265.9k -265,909
42 LMR Partners LLP 0.79% of their portfolio LONDON, X0 395,857395.9k $50.7m $50.7m 0.79% Added +385.2k +385,168
43 Quadrature Capital Ltd 0.85% of their portfolio LONDON, X0 382,677382.7k $49.1m $49.1m 0.85% New
44 Avoro Capital Advisors LLC 0.84% of their portfolio NEW YORK, NY 375,000375.0k $48.1m $48.1m 0.84% Reduced -3.5m -3,475,000
45 READYSTATE ASSET MANAGEMENT LP 1.76% of their portfolio CHICAGO, IL 329,831329.8k $42.3m $42.3m 1.76% New
46 WHITEBOX ADVISORS LLC 1.08% of their portfolio MINNEAPOLIS, MN 310,001310.0k $39.7m $39.7m 1.08% New
47 TIG Advisors, LLC 2.13% of their portfolio New York, NY 305,097305.1k $39.1m $39.1m 2.13% New
48 MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio NEW YORK, NY 295,879295.9k $37.9m $37.9m 0.03% Reduced -395.5k -395,516
49 Slotnik Capital, LLC 15.11% of their portfolio DALLAS, TX 292,694292.7k $37.5m $37.5m 15.11% New
50 Bellevue Group AG 0.80% of their portfolio ZURICH, V8 284,900284.9k $36.5m $36.5m 0.80% New
51 JANUS HENDERSON GROUP PLC 0.02% of their portfolio LONDON, X0 268,928268.9k $34.5m $34.5m 0.02% Added +240.2k +240,179
52 Cinctive Capital Management LP 1.90% of their portfolio New York, NY 265,000265.0k $34.0m $34.0m 1.90% Added +233.8k +233,806
53 NOVO HOLDINGS A/S 2.40% of their portfolio HELLERUP, G7 264,956265.0k $34.0m $34.0m 2.40% Added +36.2k +36,152
54 Polar Asset Management Partners Inc. 0.84% of their portfolio TORONTO, A6 262,964263.0k $33.7m $33.7m 0.84% New
55 SOROS FUND MANAGEMENT LLC 0.55% of their portfolio NEW YORK, NY 250,000250.0k $32.0m $32.0m 0.55% New
56 Affinity Asset Advisors, LLC 4.74% of their portfolio NEW YORK, NY 250,000250.0k $32.0m $32.0m 4.74% New
57 KRYGER CAPITAL Ltd 5.89% of their portfolio LONDON, X0 248,219248.2k $31.8m $31.8m 5.89% New
58 Trium Capital LLP 7.66% of their portfolio LONDON, X0 240,099240.1k $30.8m $30.8m 7.66% Not comparable
59 Bank of New York Mellon Corp 0.01% of their portfolio NEW YORK, NY 227,843227.8k $29.2m $29.2m 0.01% Reduced -79.2k -79,175
60 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio NEW YORK, NY 215,946215.9k $27.7m $27.7m 0.01% Reduced -28.5k -28,465
61 JANE STREET GROUP, LLC 0.04% of their portfolio NEW YORK, NY 214,394214.4k $27.5m $27.5m 0.04% Reduced -161.4k -161,424
62 GABELLI FUNDS LLC 0.19% of their portfolio Rye, NY 211,169211.2k $27.1m $27.1m 0.19% New
63 Sand Grove Capital Management LLP 13.62% of their portfolio LONDON, X0 211,124211.1k $27.1m $27.1m 13.62% New
64 HIGHBRIDGE CAPITAL MANAGEMENT LLC 1.26% of their portfolio NEW YORK, NY 189,822189.8k $24.3m $24.3m 1.26% New
65 DEUTSCHE BANK AG\ 0.01% of their portfolio FRANKFURT AM MAIN, 2M 189,250189.2k $24.3m $24.3m 0.01% Reduced -10.7k -10,687
66 Rock Springs Capital Management LP 1.48% of their portfolio Baltimore, MD 185,500185.5k $23.8m $23.8m 1.48% Reduced -822.1k -822,069
67 ODDO BHF ASSET MANAGEMENT SAS 0.90% of their portfolio PARIS, I0 185,000185.0k $23.7m $23.7m 0.90% Not comparable
68 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.04% of their portfolio BALA CYNWYD, PA 184,115184.1k $23.6m $23.6m 0.04% Reduced -228.4k -228,425
69 GABELLI & Co INVESTMENT ADVISERS, INC. 3.61% of their portfolio Rye, NY 183,374183.4k $23.5m $23.5m 3.61% New
70 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 173,510173.5k $22.2m $22.2m 0.01% Added +37.4k +37,399
71 PICTON MAHONEY ASSET MANAGEMENT 0.31% of their portfolio Toronto, A6 170,000170.0k $21.8m $21.8m 0.31% Added +169.8k +169,783
72 DAFNA Capital Management LLC 5.97% of their portfolio LOS ANGELES, CA 168,763168.8k $21.6m $21.6m 5.97% Added +16.5k +16,500
73 Nearwater Capital Markets, Ltd 0.33% of their portfolio NEW YORK, NY 160,000160.0k $20.5m $20.5m 0.33% New
74 Capula Management Ltd 0.25% of their portfolio Grand Cayman, E9 156,114156.1k $20.0m $20.0m 0.25% Not comparable
75 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 154,048154.0k $19.7m $19.7m 0.01% Reduced -150.8k -150,790
76 PANAGORA ASSET MANAGEMENT INC 0.09% of their portfolio BOSTON, MA 149,440149.4k $19.2m $19.2m 0.09% Reduced -56.1k -56,142
77 Jump Financial, LLC 0.23% of their portfolio Chicago, IL 147,325147.3k $18.9m $18.9m 0.23% New
78 Susquehanna Portfolio Strategies, LLC 0.38% of their portfolio Bala Cynwyd, PA 135,057135.1k $17.3m $17.3m 0.38% New
79 Squarepoint Ops LLC 0.04% of their portfolio NEW YORK, NY 130,066130.1k $16.7m $16.7m 0.04% Added +105.0k +104,960
80 Hudson Bay Capital Management LP 0.11% of their portfolio STAMFORD, CT 129,398129.4k $16.6m $16.6m 0.11% New
81 BAKER BROS. ADVISORS LP 0.16% of their portfolio NEW YORK, NY 125,538125.5k $16.1m $16.1m 0.16% New
82 Swiss National Bank 0.01% of their portfolio ZURICH, V8 122,000122.0k $15.6m $15.6m 0.01% Reduced -1.1k -1,100
83 CREDIT INDUSTRIEL ET COMMERCIAL 2.46% of their portfolio PARIS FRANCE, I0 120,850120.8k $15.5m $15.5m 2.46% New
84 Twin Securities, Inc. 13.63% of their portfolio New York, NY 120,126120.1k $15.4m $15.4m 13.63% New
85 Pictet Asset Management Holding SA 0.02% of their portfolio CAROUGE, V8 119,817119.8k $15.4m $15.4m 0.02% Reduced -834.8k -834,779
86 Verition Fund Management LLC 0.09% of their portfolio GREENWICH, CT 118,988119.0k $15.3m $15.3m 0.09% Added +101.8k +101,775
87 WATER ISLAND CAPITAL LLC 2.62% of their portfolio NEW YORK, NY 116,631116.6k $14.9m $14.9m 2.62% New
88 Melqart Asset Management (UK) Ltd 2.00% of their portfolio London, X0 109,437109.4k $14.0m $14.0m 2.00% New
89 Orion Investment Co 4.82% of their portfolio ST. LOUIS, MO 106,134106.1k $13.6m $13.6m 4.82% Reduced -2.9k -2,899
90 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 102,552102.6k $13.1m $13.1m 0.01% Reduced -380.8k -380,792
91 RHUMBLINE ADVISERS 0.01% of their portfolio BOSTON, MA 99,64999.6k $12.8m $12.8m 0.01% Added +7.7k +7,716
92 Legal & General Group Plc 0.00% of their portfolio London, X0 99,22499.2k $12.7m $12.7m 0.00% Added +3.6k +3,558
93 HARVEST MANAGEMENT LLC 5.91% of their portfolio New York, NY 95,00095.0k $12.2m $12.2m 5.91% New
94 Groupe la Francaise 0.20% of their portfolio PARIS, I0 94,15094.2k $12.1m $12.1m 0.20% New
95 EQUITEC PROPRIETARY MARKETS, LLC 47.25% of their portfolio CHICAGO, IL 92,50092.5k $11.9m $11.9m 47.25% New
96 AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio Greenwich, CT 92,46992.5k $11.9m $11.9m 0.01% Reduced -55.8k -55,802
97 STATE OF WISCONSIN INVESTMENT BOARD 0.03% of their portfolio MADISON, WI 89,37389.4k $11.5m $11.5m 0.03% Added +25.3k +25,307
98 Versor Investments LP 1.99% of their portfolio New York, NY 88,04288.0k $11.3m $11.3m 1.99% New
99 California Public Employees Retirement System 0.01% of their portfolio Sacramento, CA 86,70986.7k $11.1m $11.1m 0.01% Added +9.2k +9,153
100 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 83,97384.0k $10.8m $10.8m 0.01% Reduced -9.5k -9,495