Vault-13

BLUEPRINT MEDICINES CORP BPMC

COM · Common Stock · CUSIP 09627Y109 · ISIN US09627Y1091

223 institutional holders -17 vs Q3 2022
62,582,01562.6m shares reported held*
$2.7bnreported value*
28 new 89 added 66 reduced 46 sold out net sold ≈ $22.6m (-516.1k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.2m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $43.81. Options: 9 managers hold calls ($10.8m notional), 12 hold puts ($15.9m).

Trends to Q4 2022

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 240Q4 22: 223223Q3 22Q4 22
Numbers
QuarterHolders
Q3 2022240
Q4 2022223

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30mQ3 22 calls: $24.4mQ3 22 puts: $14.2mQ3 22P/C 0.58Q4 22 calls: $10.8mQ4 22 puts: $15.9mQ4 22P/C 1.47
Numbers
QuarterCallsPutsP/C
Q3 2022$24.4m$14.2m0.58
Q4 2022$10.8m$15.9m1.47

Biggest buyers

WELLINGTON MANAGEMENT GROUP LLP Added +1,179,449+1.2m
STATE STREET CORP Added +615,123+615.1k
MARSHALL WACE, LLP New +529,456+529.5k
BlackRock Inc. Added +518,184+518.2k
Rock Springs Capital Management LP Added +353,315+353.3k
PRICE T ROWE ASSOCIATES INC /MD/ Added +267,479+267.5k
T. Rowe Price Investment Management, Inc. Added +233,624+233.6k
MILLENNIUM MANAGEMENT LLC Added +221,486+221.5k
Hudson Bay Capital Management LP Added +178,168+178.2k
ExodusPoint Capital Management, LP New +157,367+157.4k

Biggest sellers

CADIAN CAPITAL MANAGEMENT, LP Sold out -1,459,431-1.5m
MORGAN STANLEY Reduced -1,074,179-1.1m
ALKEON CAPITAL MANAGEMENT LLC Reduced -693,144-693.1k
BROWN ADVISORY INC Reduced -370,712-370.7k
LOOMIS SAYLES & CO L P Sold out -325,815-325.8k
WESTFIELD CAPITAL MANAGEMENT CO LP Reduced -324,176-324.2k
Boxer Capital, LLC Sold out -275,000-275.0k
MOORE CAPITAL MANAGEMENT, LP Sold out -226,782-226.8k
Casdin Capital, LLC Reduced -222,200-222.2k
PICTET ASSET MANAGEMENT SA Reduced -193,788-193.8k

Biggest calls

JANE STREET GROUP, LLC Reduced $4.3m98.7k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $1.9m44.5k shares
WELLS FARGO & COMPANY/MN New $1.6m36.0k shares
CITIGROUP INC Reduced $1.1m25.0k shares
SIMPLEX TRADING, LLC Reduced $771.0k17.6k shares
CITADEL ADVISORS LLC Reduced $757.9k17.3k shares
Walleye Trading LLC New $170.9k3.9k shares
Walleye Capital LLC New $140.2k3.2k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $5.6m128.9k shares
JANE STREET GROUP, LLC Added $4.5m102.8k shares
CITADEL ADVISORS LLC Added $1.9m42.9k shares
GROUP ONE TRADING LLC Added $1.3m30.4k shares
CITIGROUP INC Reduced $1.1m25.0k shares
Jefferies Financial Group Inc. New $486.3k11.1k shares
WOLVERINE TRADING, LLC New $289.0k6.6k shares
Walleye Trading LLC New $219.1k5.0k shares
Walleye Capital LLC New $201.5k4.6k shares
SIMPLEX TRADING, LLC Added $201.0k4.6k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-04-23 8.0% 5.1m 2025-04-23
Pentwater Capital Management LP 13G · institution new · filed 2025-08-14 6.0% new 3.9m 2025-08-14

Holders, Q4 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.04% of their portfolio BOSTON, MA 8,974,5459.0m $393.2m $393.2m 0.04% Added +16.6k +16,619
2 BlackRock Inc. 0.01% of their portfolio New York, NY 6,274,6856.3m $274.9m $274.9m 0.01% Added +518.2k +518,184
3 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 5,774,4565.8m $253.0m $253.0m 0.01% Added +113.4k +113,353
4 WELLINGTON MANAGEMENT GROUP LLP 0.04% of their portfolio Boston, MA 5,003,4285.0m $219.2m $219.2m 0.04% Added +1.2m +1,179,449
5 PRICE T ROWE ASSOCIATES INC /MD/ 0.03% of their portfolio BALTIMORE, MD 4,299,2904.3m $188.4m $188.4m 0.03% Added +267.5k +267,479
6 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,834,9212.8m $124.2m $124.2m 0.01% Added +615.1k +615,123
7 T. Rowe Price Investment Management, Inc. 0.08% of their portfolio BALTIMORE, MD 2,492,3812.5m $109.2m $109.2m 0.08% Added +233.6k +233,624
8 Rock Springs Capital Management LP 1.99% of their portfolio Baltimore, MD 1,891,5101.9m $82.9m $82.9m 1.99% Added +353.3k +353,315
9 ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio NASHVILLE, TN 1,536,1551.5m $67.3m $67.3m 0.03% Added +127.0k +127,048
10 Casdin Capital, LLC 5.06% of their portfolio New York, NY 1,477,8001.5m $64.7m $64.7m 5.06% Reduced -222.2k -222,200
11 JPMORGAN CHASE & CO 0.01% of their portfolio NEW YORK, NY 1,448,2151.4m $63.4m $63.4m 0.01% Reduced -42.4k -42,419
12 MACQUARIE GROUP LTD 0.07% of their portfolio Sydney, NSW 2000, C3 1,310,7501.3m $57.4m $57.4m 0.07% Added +24.2k +24,161
13 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 1,114,3371.1m $48.8m $48.8m 0.01% Added +39.0k +39,044
14 WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.17% of their portfolio CHICAGO, IL 1,024,6141.0m $44.9m $44.9m 0.17% Reduced -49.7k -49,670
15 Fisher Asset Management, LLC 0.02% of their portfolio PLANO, TX 843,090843.1k $36.9m $36.9m 0.02% Added +117.6k +117,553
16 NORGES BANK 0.01% of their portfolio OSLO, Q8 634,045634.0k $27.8m $27.8m 0.01% Reduced -156.9k -156,910
17 AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio KANSAS CITY, MO 616,292616.3k $27.0m $27.0m 0.02% Added +6.0k +6,036
18 BROWN ADVISORY INC 0.05% of their portfolio BALTIMORE, MD 601,282601.3k $26.3m $26.3m 0.05% Reduced -370.7k -370,712
19 Aquilo Capital Management, LLC 11.34% of their portfolio SAN FRANCISCO, CA 581,768581.8k $25.5m $25.5m 11.34% Added +57.5k +57,500
20 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 557,888557.9k $24.4m $24.4m 0.01% Added +3.1k +3,055
21 MARSHALL WACE, LLP 0.06% of their portfolio LONDON, X0 529,456529.5k $23.2m $23.2m 0.06% New
22 WESTFIELD CAPITAL MANAGEMENT CO LP 0.16% of their portfolio BOSTON, MA 479,467479.5k $21.0m $21.0m 0.16% Reduced -324.2k -324,176
23 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 468,459468.5k $20.5m $20.5m 0.01% Added +10.8k +10,750
24 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 465,529465.5k $20.4m $20.4m 0.00% Reduced -1.1m -1,074,179
25 EVENTIDE ASSET MANAGEMENT, LLC 0.38% of their portfolio Boston, MA 438,500438.5k $19.2m $19.2m 0.38% Unchanged
26 ALKEON CAPITAL MANAGEMENT LLC 0.14% of their portfolio New York, NY 426,268426.3k $18.7m $18.7m 0.14% Reduced -693.1k -693,144
27 EMERALD ADVISERS, LLC 0.83% of their portfolio LEOLA, PA 391,156391.2k $17.1m $17.1m 0.83% Added +72.6k +72,582
28 NOVO HOLDINGS A/S 1.01% of their portfolio HELLERUP, G7 370,000370.0k $16.2m $16.2m 1.01% Added +53.3k +53,326
29 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 357,731357.7k $15.7m $15.7m 0.01% Reduced -76.7k -76,725
30 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 336,081336.1k $14.7m $14.7m 0.00% Added +58.2k +58,227
31 MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio NEW YORK, NY 328,293328.3k $14.4m $14.4m 0.02% Added +221.5k +221,486
32 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 317,262317.3k $13.9m $13.9m 0.00% Reduced -5.3k -5,288
33 EMERALD MUTUAL FUND ADVISERS TRUST 0.83% of their portfolio LEOLA, PA 305,709305.7k $13.4m $13.4m 0.83% Added +52.1k +52,064
34 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 262,536262.5k $11.5m $11.5m 0.00% Added +2.8k +2,789
35 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio NEW YORK, NY 261,685261.7k $11.5m $11.5m 0.01% Reduced -6.8k -6,790
36 DAFNA Capital Management LLC 3.22% of their portfolio LOS ANGELES, CA 261,235261.2k $11.4m $11.4m 3.22% Unchanged
37 Candriam S.C.A. 0.08% of their portfolio STRASSEN, N4 258,311258.3k $11.3m $11.3m 0.08% Unchanged
38 Woodline Partners LP 0.15% of their portfolio San Francisco, CA 240,694240.7k $10.5m $10.5m 0.15% Added +147.3k +147,307
39 PANAGORA ASSET MANAGEMENT INC 0.07% of their portfolio BOSTON, MA 235,594235.6k $10.3m $10.3m 0.07% Added +28.7k +28,701
40 Granahan Investment Management, LLC 0.30% of their portfolio WALTHAM, MA 224,814224.8k $9.8m $9.8m 0.30% Added +80.6k +80,637
41 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 223,422223.4k $9.8m $9.8m 0.01% Reduced -81.4k -81,365
42 Hudson Bay Capital Management LP 0.11% of their portfolio STAMFORD, CT 213,168213.2k $9.3m $9.3m 0.11% Added +178.2k +178,168
43 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 194,597194.6k $8.5m $8.5m 0.00% Reduced -7.0k -6,994
44 Nextech Invest Ltd. 3.28% of their portfolio Zurich, V8 188,228188.2k $8.2m $8.2m 3.28% Unchanged
45 SEGALL BRYANT & HAMILL, LLC 0.09% of their portfolio CHICAGO, IL 182,660182.7k $8.0m $8.0m 0.09% Reduced -26.0k -25,971
46 EAGLE ASSET MANAGEMENT INC 0.05% of their portfolio ST PETERSBURG, FL 179,436179.4k $7.8m $7.8m 0.05% Added +4.2k +4,154
47 CAPITAL FUND MANAGEMENT S.A. 0.17% of their portfolio PARIS, I0 178,294178.3k $7.8m $7.8m 0.17% Added +75.5k +75,534
48 Rafferty Asset Management, LLC 0.06% of their portfolio New York, NY 170,682170.7k $7.5m $7.5m 0.06% Added +79.6k +79,592
49 PICTET ASSET MANAGEMENT SA 0.01% of their portfolio GENEVA 73, V8 162,029162.0k $7.1m $7.1m 0.01% Reduced -193.8k -193,788
50 ExodusPoint Capital Management, LP 0.11% of their portfolio NEW YORK, NY 157,367157.4k $6.9m $6.9m 0.11% New
51 Swiss National Bank 0.00% of their portfolio ZURICH, V8 144,200144.2k $6.3m $6.3m 0.00% Added +2.9k +2,900
52 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 143,124143.1k $6.3m $6.3m 0.01% Added +16.2k +16,200
53 UBS Group AG 0.00% of their portfolio ZURICH, V8 134,858134.9k $5.9m $5.9m 0.00% Added +125.5k +125,458
54 PFM Health Sciences, LP 0.24% of their portfolio SAN FRANCISCO, CA 130,366130.4k $5.7m $5.7m 0.24% Unchanged
55 NOMURA HOLDINGS INC 0.06% of their portfolio TOKYO, M0 129,451129.5k $5.7m $5.7m 0.06% Added +121.4k +121,440
56 PEREGRINE CAPITAL MANAGEMENT LLC 0.18% of their portfolio MINNEAPOLIS, MN 128,242128.2k $5.6m $5.6m 0.18% Added +16.0k +15,954
57 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 124,186124.2k $5.4m $5.4m 0.00% First filing
58 SECTORAL ASSET MANAGEMENT INC 0.98% of their portfolio MONTREAL, A8 115,900115.9k $5.1m $5.1m 0.98% Added +6.0k +6,000
59 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 112,274112.3k $4.9m $4.9m 0.01% Reduced -485 -485
60 EFG Asset Management (North America) Corp. 1.07% of their portfolio Portland, OR 110,853110.9k $4.8m $4.8m 1.07% Reduced -4.1k -4,141
61 California Public Employees Retirement System 0.00% of their portfolio Sacramento, CA 106,681106.7k $4.7m $4.7m 0.00% Reduced -5.3k -5,265
62 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.03% of their portfolio SAN FRANCISCO, CA 94,00094.0k $4.1m $4.1m 0.03% Not comparable
63 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 93,49893.5k $4.0m $4.0m 0.00% Added +12.4k +12,356
64 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 87,31987.3k $3.8m $3.8m 0.01% Reduced -13.3k -13,257
65 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 85,40085.4k $3.7m $3.7m 0.01% New
66 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 85,21785.2k $3.7m $3.7m 0.00% Reduced -100.2k -100,195
67 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 81,00781.0k $3.5m $3.5m 0.00% Added +1.7k +1,653
68 COMERICA BANK 0.03% of their portfolio DALLAS, TX 79,00079.0k $3.7m $3.7m 0.03% Added +6.4k +6,386
69 TWO SIGMA ADVISERS, LP 0.01% of their portfolio NEW YORK, NY 75,90075.9k $3.3m $3.3m 0.01% Added +14.0k +14,000
70 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio WEST SACRAMENTO, CA 75,81875.8k $3.3m $3.3m 0.01% Added +963 +963
71 JANE STREET GROUP, LLC 0.01% of their portfolio NEW YORK, NY 72,85372.9k $3.2m $3.2m 0.01% Added +49.9k +49,852
72 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 69,46569.5k $3.0m $3.0m 0.00% Added +3.3k +3,326
73 Tekla Capital Management LLC 0.11% of their portfolio Boston, MA 67,71067.7k $3.0m $3.0m 0.11% New
74 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 66,89566.9k $2.9m $2.9m 0.01% Reduced -1.0k -1,034
75 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 63,58963.6k $2.8m $2.8m 0.00% Reduced -1.4k -1,383
76 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 62,18662.2k $2.7m $2.7m 0.01% Reduced -7.5k -7,540
77 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 61,37761.4k $2.7m $2.7m 0.01% Added +12.9k +12,909
78 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 59,84659.8k $2.6m $2.6m 0.01% Reduced -758 -758
79 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 59,55059.5k $2.6m $2.6m 0.00% Added +1.1k +1,110
80 Legal & General Group Plc 0.00% of their portfolio London, X0 53,43953.4k $2.3m $2.3m 0.00% Reduced -32 -32
81 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 52,57552.6k $2.3m $2.3m 0.00% Added +2.8k +2,796
82 State of New Jersey Common Pension Fund D 0.01% of their portfolio TRENTON, NJ 51,95952.0k $2.3m $2.3m 0.01% Added +13.1k +13,101
83 SYNOVUS FINANCIAL CORP 0.02% of their portfolio Columbus, GA 47,82347.8k $2.1m $2.1m 0.02% Added +13.5k +13,466
84 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 45,70945.7k $2.0m $2.0m 0.01% Reduced -63.5k -63,526
85 Ergoteles LLC 0.07% of their portfolio NEW YORK, NY 40,95541.0k $1.8m $1.8m 0.07% New
86 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 40,55740.6k $1.8m $1.8m 0.02% New
87 TANG CAPITAL MANAGEMENT LLC 0.25% of their portfolio SAN DIEGO, CA 40,00040.0k $1.8m $1.8m 0.25% Unchanged
88 PLATINUM INVESTMENT MANAGEMENT LTD 0.07% of their portfolio SYDNEY AUSTRALIA 2000, C3 39,84239.8k $1.7m $1.7m 0.07% Added +7.0k +6,980
89 Jump Financial, LLC 0.09% of their portfolio Chicago, IL 39,52539.5k $1.7m $1.7m 0.09% New
90 NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio NEW YORK, NY 39,44039.4k $1.7m $1.7m 0.00% Added +11.5k +11,477
91 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 39,35639.4k $1.7m $1.7m 0.00% Added +7.8k +7,807
92 GUGGENHEIM CAPITAL LLC 0.02% of their portfolio CHICAGO, IL 38,84538.8k $1.7m $1.7m 0.02% Added +6.0k +5,975
93 MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.02% of their portfolio New York, NY 37,46237.5k $1.6m $1.6m 0.02% Added +511 +511
94 Assenagon Asset Management S.A. 0.01% of their portfolio SENNINGERBERG, N4 36,21136.2k $1.6m $1.6m 0.01% Reduced -23.2k -23,219
95 Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio ST. PETERSBURG, FL 35,65335.7k $1.6m $1.6m 0.00% Reduced -8.5k -8,533
96 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 31,78231.8k $1.4m $1.4m 0.01% Unchanged
97 FIRST TRUST ADVISORS LP 0.00% of their portfolio Wheaton, IL 31,59731.6k $1.4m $1.4m 0.00% Added +24.3k +24,333
98 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 30,23830.2k $1.3m $1.3m 0.00% Added +63 +63
99 HealthCor Management, L.P. 1.20% of their portfolio NEW YORK, NY 30,00030.0k $1.3m $1.3m 1.20% Reduced -74.6k -74,600
100 PDT Partners, LLC 0.21% of their portfolio New York, NY 29,11829.1k $1.3m $1.3m 0.21% Added +11.2k +11,170