BIOCRYST PHARMACEUTICALS INC BCRX
COM · Common Stock · CUSIP 09058V103
American pharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersDurham, NC
- Founded1986
- Websitebiocryst.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.8m this quarter). Holder counts are more reliable. Shares outstanding: 254.2m as of 2026-04-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $9.52. Options: 10 managers hold calls ($14.2m notional), 8 hold puts ($6.1m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 234 |
| Q4 2022 | 230 |
| Q1 2023 | 243 |
| Q2 2023 | 237 |
| Q3 2023 | 234 |
| Q4 2023 | 235 |
| Q1 2024 | 238 |
| Q2 2024 | 243 |
| Q3 2024 | 258 |
| Q4 2024 | 259 |
| Q1 2025 | 276 |
| Q2 2025 | 295 |
| Q3 2025 | 286 |
| Q4 2025 | 273 |
| Q1 2026 | 302 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 123 | 105 |
| Q3 2024 | 127 | 109 |
| Q4 2024 | 99 | 122 |
| Q1 2025 | 146 | 94 |
| Q2 2025 | 163 | 116 |
| Q3 2025 | 131 | 143 |
| Q4 2025 | 135 | 158 |
| Q1 2026 | 178 | 119 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $12.7m | $6.5m | 0.51 |
| Q3 2025 | $6.8m | $4.9m | 0.72 |
| Q4 2025 | $12.0m | $7.3m | 0.61 |
| Q1 2026 | $14.2m | $6.1m | 0.43 |
Biggest buyers
| TCG Crossover Management, LLC | New | +11.0m |
| Vestal Point Capital, LP | Added | +4.8m |
| PERCEPTIVE ADVISORS LLC | Added | +4.3m |
| Aberdeen Group plc | Added | +4.1m |
| Frazier Life Sciences Management, L.P. | New | +4.0m |
| BANK OF AMERICA CORP /DE/ | Added | +3.6m |
| RFG Advisory, LLC | New | +2.9m |
| Candriam S.C.A. | New | +2.3m |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +2.1m |
| TWO SIGMA INVESTMENTS, LP | Added | +1.9m |
Biggest sellers
| TWO SIGMA ADVISERS, LP | Sold out | -4.1m |
| Kynam Capital Management, LP | Reduced | -3.7m |
| BAKER BROS. ADVISORS LP | Sold out | -2.8m |
| Qube Research & Technologies Ltd | Sold out | -2.2m |
| Squarepoint Ops LLC | Reduced | -1.6m |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -1.4m |
| BNP PARIBAS FINANCIAL MARKETS | Reduced | -1.2m |
| Point72 Asset Management, L.P. | Sold out | -1.2m |
| Elmind Capital, LP | Reduced | -1.1m |
| D. E. Shaw & Co., Inc. | Reduced | -945.4k |
Biggest calls
| JANE STREET GROUP, LLC | Added | $5.2m545.0k shares |
| SIMPLEX TRADING, LLC | New | $2.3m240.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.7m179.5k shares |
| MILLENNIUM MANAGEMENT LLC | New | $1.2m130.0k shares |
| TUDOR INVESTMENT CORP ET AL | New | $911.1k95.7k shares |
| CITIGROUP INC | Added | $904.4k95.0k shares |
| NOMURA HOLDINGS INC | Added | $903.4k94.9k shares |
| CITADEL ADVISORS LLC | Reduced | $541.5k56.9k shares |
| GROUP ONE TRADING LLC | Reduced | $515.0k54.1k shares |
| Walleye Capital LLC | Reduced | $21.9k2.3k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.5m156.9k shares |
| CITADEL ADVISORS LLC | Added | $1.3m139.3k shares |
| CITIGROUP INC | Added | $904.4k95.0k shares |
| NOMURA HOLDINGS INC | Added | $903.4k94.9k shares |
| GROUP ONE TRADING LLC | Added | $597.9k62.8k shares |
| JANE STREET GROUP, LLC | Reduced | $529.3k55.6k shares |
| SIMPLEX TRADING, LLC | New | $330.3k34.7k shares |
| Walleye Capital LLC | Reduced | $5.7k600 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 8.4% |
| Flynn James E 13G · passive investor +1.0 pts · filed 2026-02-12 | 6.8% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor -1.1 pts · filed 2026-08-14 | 6.2% |
| STATE STREET CORP 13G · institution +1.1 pts · filed 2026-08-07 | 6.0% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 10 | $1.0m | 3 | $123.4k | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 1 | $52.8k | $52.8k |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 1 | $595.7k | — |
| Q4 2025 | 0 | — | 2 | $1.6m | $1.6m |
| Q1 2026 | 0 | — | 2 | $1.9m | $1.4m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-03-20 | HEGGIE THERESA Director | Sold | $504.8k49.9k shares |
| 2026-03-16 | Barnes Alane P Chief Legal Officer | Sold plan | $1.4m150.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 22.7m $215.6m | Added +1.5m |
| RA CAPITAL MANAGEMENT, L.P. 1.60% of their portfolio | 15.8m $150.7m | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. 1.69% of their portfolio | 15.0m $143.2m | Added +697.0k |
| STATE STREET CORP 0.00% of their portfolio | 12.2m $116.2m | Added +1.1m |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.01% of their portfolio | 11.2m $107.0m | First filing |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 11.1m $106.0m | First filing |
| TCG Crossover Management, LLC 3.00% of their portfolio | 11.0m $104.9m | New |
| JANUS HENDERSON GROUP PLC 0.04% of their portfolio | 8.9m $84.9m | Added +1.5m |
| PERCEPTIVE ADVISORS LLC 1.40% of their portfolio | 7.4m $70.8m | Added +4.3m |
| Vestal Point Capital, LP 1.87% of their portfolio | 7.0m $66.9m | Added +4.8m |
| TWO SIGMA INVESTMENTS, LP 0.05% of their portfolio | 6.4m $60.9m | Added +1.9m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 5.8m $55.1m | Added +729.0k |
| Kynam Capital Management, LP 3.43% of their portfolio | 5.7m $54.1m | Reduced -3.7m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 5.1m $48.5m | Added +3.6m |
| Aberdeen Group plc 0.08% of their portfolio | 5.0m $48.0m | Added +4.1m |
| UBS Group AG 0.01% of their portfolio | 4.9m $47.1m | Reduced -319.9k |
| Frazier Life Sciences Management, L.P. 0.98% of their portfolio | 4.0m $38.2m | New |
| Royalty Pharma Sub-Manager, LLC 21.19% of their portfolio | 3.8m $36.6m | Unchanged |
| Nuveen, LLC 0.01% of their portfolio | 3.8m $36.4m | Added +206.9k |
| GW&K Investment Management, LLC 0.27% of their portfolio | 3.2m $30.9m | Added +79.5k |
| Eversept Partners, LP 1.91% of their portfolio | 3.0m $28.9m | Added +46.9k |
| RFG Advisory, LLC 0.50% of their portfolio | 2.9m $27.3m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.03% of their portfolio | 2.8m $26.8m | Added +2.1m |
| Fisher Asset Management, LLC 0.01% of their portfolio | 2.7m $26.0m | Added +265.7k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 2.7m $25.6m | Added +1.5m |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 2.4m $22.4m | Added +345.5k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 2.3m $22.3m | Reduced -865.3k |
| Candriam S.C.A. 0.11% of their portfolio | 2.3m $21.8m | New |
| RICE HALL JAMES & ASSOCIATES, LLC 1.18% of their portfolio | 2.2m $21.2m | Added +326.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 2.1m $20.0m | Added +247.8k |
| MORGAN STANLEY 0.00% of their portfolio | 2.0m $19.3m | Added +277.4k |
| Nantahala Capital Management, LLC 1.18% of their portfolio | 2.0m $18.9m | Added +631.0k |
| STIFEL FINANCIAL CORP 0.02% of their portfolio | 1.8m $17.4m | Added +667 |
| Parkman Healthcare Partners LLC 1.69% of their portfolio | 1.7m $16.3m | Added +808.0k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 1.7m $15.8m | First filing |
| Pacer Advisors, Inc. 0.04% of their portfolio | 1.6m $14.9m | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.5m $14.6m | Added +698.6k |
| ORBIMED ADVISORS LLC 0.30% of their portfolio | 1.4m $13.6m | Reduced -316.6k |
| Legal & General Group Plc 0.00% of their portfolio | 1.4m $13.4m | Added +1.2m |
| Schonfeld Strategic Advisors LLC 0.10% of their portfolio | 1.3m $12.7m | Added +1.2m |
| Invesco Ltd. 0.00% of their portfolio | 1.3m $12.5m | Reduced -46.1k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 1.3m $12.4m | Reduced -1.2m |
| Man Group plc 0.03% of their portfolio | 1.3m $12.3m | Added +885.5k |
| OP Asset Management Ltd 0.12% of their portfolio | 1.3m $11.9m | Added +1.1m |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.02% of their portfolio | 1.2m $11.7m | New |
| JUPITER ASSET MANAGEMENT LTD 0.06% of their portfolio | 1.2m $11.4m | Reduced -1.2k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 1.0m $9.7m | Reduced -280.2k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.04% of their portfolio | 1.0m $9.6m | Reduced -27.1k |
| Elmind Capital, LP 2.70% of their portfolio | 1.0m $9.5m | Reduced -1.1m |
| Rosalind Advisors, Inc. 3.60% of their portfolio | 923.1k $8.8m | New |
| SPHERA FUNDS MANAGEMENT LTD. 1.42% of their portfolio | 866.5k $8.2m | Added +28.6k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 821.4k $7.8m | Added +330.3k |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 800.9k $7.6m | Added +425.9k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 777.0k $7.4m | Reduced -1.4m |
| Hillsdale Investment Management Inc. 0.17% of their portfolio | 639.1k $6.1m | Added +80.0k |
| Bridgewater Associates, LP 0.03% of their portfolio | 638.1k $6.1m | Added +402.5k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 637.7k $6.1m | Added +29.7k |
| FMR LLC 0.00% of their portfolio | 633.1k $6.0m | Added +73.0k |
| IMC-Chicago, LLC 0.09% of their portfolio | 631.3k $6.0m | New |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 622.6k $5.9m | Reduced -26.8k |
| PDT Partners, LLC 0.32% of their portfolio | 563.4k $5.4m | Reduced -120.0k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 536.3k $5.1m | Reduced -89.2k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 523.3k $5.0m | Reduced -46.9k |
| Hudson Bay Capital Management LP 0.03% of their portfolio | 490.4k $4.7m | Reduced -527.0k |
| Pictet Asset Management Holding SA 0.00% of their portfolio | 471.6k $4.5m | Reduced -268.9k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 440.1k $4.2m | Reduced -264.1k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 430.6k $4.1m | Added +54.0k |
| DAFNA Capital Management LLC 0.93% of their portfolio | 430.2k $4.1m | Added +12.0k |
| Swiss National Bank 0.00% of their portfolio | 408.7k $3.9m | Added +14.3k |
| DOLIVER ADVISORS, LP 0.81% of their portfolio | 374.3k $3.6m | Added +100.0k |
| Susquehanna Portfolio Strategies, LLC 0.05% of their portfolio | 374.0k $3.6m | Reduced -404.5k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 369.0k $3.5m | Reduced -9.9k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 354.3k $3.4m | Reduced -28.3k |
| Gotham Asset Management, LLC 0.01% of their portfolio | 313.0k $3.0m | Added +96.0k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 306.5k $2.9m | Added +13.6k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 302.1k $2.9m | Reduced -945.4k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 279.1k $2.7m | Reduced -68.1k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 271.7k $2.6m | Added +42.4k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 266.1k $2.5m | Reduced -425 |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 263.7k $2.1m | Reduced -14.5k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 258.3k $2.5m | Added +66.5k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 246.5k $2.3m | New |
| MACKENZIE FINANCIAL CORP 0.00% of their portfolio | 243.4k $2.3m | Added +92.7k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 236.9k $2.3m | Added +3.3k |
| Assenagon Asset Management S.A. 0.00% of their portfolio | 232.9k $2.2m | Reduced -126.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 231.0k $2.2m | Added +53.6k |
| VIRGINIA RETIREMENT SYSTEMS ET Al 0.02% of their portfolio | 213.3k $2.0m | Reduced -20.1k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 208.9k $2.0m | Added +151.6k |
| Capricorn Fund Managers Ltd 0.30% of their portfolio | 202.9k $1.9m | New |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 196.3k $1.9m | First filing |
| Phocas Financial Corp. 0.29% of their portfolio | 195.5k $1.9m | Reduced -55.3k |
| Engineers Gate Manager LP 0.02% of their portfolio | 194.5k $1.9m | Reduced -30.1k |
| ExodusPoint Capital Management, LP 0.02% of their portfolio | 190.1k $1.8m | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 187.7k $1.8m | Added +50.1k |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 186.1k $1.8m | New |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 180.0k $1.7m | Added +94.7k |
| Janney Montgomery Scott LLC 0.00% of their portfolio | 163.3k $1.6m | Added +137.1k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 160.5k $1.5m | Added +29.4k |
| PROFUND ADVISORS LLC 0.06% of their portfolio | 158.5k $1.5m | Added +16.5k |
| QTR Family Wealth, LLC 0.63% of their portfolio | 157.1k $1.5m | Added +3.0k |