BIOCRYST PHARMACEUTICALS INC BCRX
COM · Common Stock · CUSIP 09058V103
American pharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersDurham, NC
- Founded1986
- Websitebiocryst.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.5m this quarter). Holder counts are more reliable. Shares outstanding: 209.9m as of 2025-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $8.96. Options: 10 managers hold calls ($12.7m notional), 10 hold puts ($6.5m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 234 |
| Q4 2022 | 230 |
| Q1 2023 | 243 |
| Q2 2023 | 237 |
| Q3 2023 | 234 |
| Q4 2023 | 235 |
| Q1 2024 | 238 |
| Q2 2024 | 243 |
| Q3 2024 | 258 |
| Q4 2024 | 259 |
| Q1 2025 | 276 |
| Q2 2025 | 295 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 121 | 80 |
| Q4 2023 | 109 | 102 |
| Q1 2024 | 114 | 98 |
| Q2 2024 | 123 | 105 |
| Q3 2024 | 127 | 109 |
| Q4 2024 | 99 | 122 |
| Q1 2025 | 146 | 94 |
| Q2 2025 | 163 | 116 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $12.6m | $6.4m | 0.51 |
| Q4 2024 | $12.1m | $8.5m | 0.70 |
| Q1 2025 | $9.6m | $4.8m | 0.50 |
| Q2 2025 | $12.7m | $6.5m | 0.51 |
Biggest buyers
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | Added | +4.1m |
| Assenagon Asset Management S.A. | Added | +3.6m |
| UBS Group AG | Added | +3.2m |
| MORGAN STANLEY | Added | +3.0m |
| D. E. Shaw & Co., Inc. | Added | +2.8m |
| TWO SIGMA INVESTMENTS, LP | Added | +2.2m |
| Walleye Capital LLC | Added | +2.1m |
| Nuveen, LLC | Added | +2.1m |
| CITADEL ADVISORS LLC | Added | +2.0m |
| RENAISSANCE TECHNOLOGIES LLC | Added | +1.9m |
Biggest sellers
| Avoro Capital Advisors LLC | Reduced | -4.2m |
| RP Management, LLC | Sold out | -3.8m |
| Caligan Partners LP | Reduced | -2.5m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -1.9m |
| AMERIPRISE FINANCIAL INC | Reduced | -1.6m |
| ALKEON CAPITAL MANAGEMENT LLC | Reduced | -1.5m |
| BlackRock, Inc. | Reduced | -1.3m |
| VANGUARD GROUP INC | Reduced | -1.1m |
| BOOTHBAY FUND MANAGEMENT, LLC | Reduced | -1.1m |
| Eversept Partners, LP | Reduced | -964.8k |
Biggest calls
| JANE STREET GROUP, LLC | Added | $5.9m657.5k shares |
| GROUP ONE TRADING LLC | Reduced | $3.1m350.1k shares |
| SIMPLEX TRADING, LLC | Added | $1.2m136.2k shares |
| MILLENNIUM MANAGEMENT LLC | New | $896.0k100.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $480.3k53.6k shares |
| WOLVERINE TRADING, LLC | Added | $425.9k45.5k shares |
| CITADEL ADVISORS LLC | Reduced | $402.3k44.9k shares |
| Caption Management, LLC | New | $179.2k20.0k shares |
| Walleye Capital LLC | New | $74.4k8.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| JANE STREET GROUP, LLC | Reduced | $2.5m276.4k shares |
| CITADEL ADVISORS LLC | Added | $1.0m116.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.0m115.4k shares |
| SIMPLEX TRADING, LLC | Added | $956.0k106.8k shares |
| GROUP ONE TRADING LLC | Reduced | $602.1k67.2k shares |
| Caption Management, LLC | New | $179.2k20.0k shares |
| WOLVERINE TRADING, LLC | Reduced | $133.8k14.3k shares |
| UBS Group AG | Unchanged | $71.7k8.0k shares |
| Walleye Capital LLC | New | $26.9k3.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 8.4% |
| Flynn James E 13G · passive investor +1.0 pts · filed 2026-02-12 | 6.8% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor -1.1 pts · filed 2026-08-14 | 6.2% |
| STATE STREET CORP 13G · institution +1.1 pts · filed 2026-08-07 | 6.0% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 10 | $1.0m | 3 | $123.4k | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 1 | $52.8k | $52.8k |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 21.4m $192.0m | Reduced -1.3m |
| VANGUARD GROUP INC 0.00% of their portfolio | 20.5m $184.1m | Reduced -1.1m |
| STATE STREET CORP 0.00% of their portfolio | 8.5m $76.2m | Added +692.0k |
| Kynam Capital Management, LP 8.16% of their portfolio | 8.5m $75.8m | Reduced -464.8k |
| ALKEON CAPITAL MANAGEMENT LLC 0.25% of their portfolio | 5.7m $51.2m | Reduced -1.5m |
| UBS Group AG 0.01% of their portfolio | 5.6m $50.3m | Added +3.2m |
| MORGAN STANLEY 0.00% of their portfolio | 5.3m $47.8m | Added +3.0m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 5.1m $45.3m | Added +94.0k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.76% of their portfolio | 4.7m $42.0m | Reduced -497.7k |
| Avoro Capital Advisors LLC 0.71% of their portfolio | 4.5m $40.3m | Reduced -4.2m |
| D. E. Shaw & Co., Inc. 0.04% of their portfolio | 4.4m $39.3m | Added +2.8m |
| TWO SIGMA INVESTMENTS, LP 0.07% of their portfolio | 4.3m $38.4m | Added +2.2m |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.03% of their portfolio | 4.3m $38.3m | Added +4.1m |
| TWO SIGMA ADVISERS, LP 0.08% of their portfolio | 4.2m $37.9m | Added +1.0m |
| Assenagon Asset Management S.A. 0.05% of their portfolio | 3.6m $32.4m | Added +3.6m |
| Nuveen, LLC 0.01% of their portfolio | 3.5m $31.7m | Added +2.1m |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 3.5m $31.6m | Added +1.6m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 2.8m $25.5m | Added +1.4m |
| Fisher Asset Management, LLC 0.01% of their portfolio | 2.8m $24.9m | Reduced -269.6k |
| GW&K Investment Management, LLC 0.21% of their portfolio | 2.6m $23.5m | Reduced -261.1k |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 2.6m $22.9m | Added +2.0m |
| RENAISSANCE TECHNOLOGIES LLC 0.03% of their portfolio | 2.5m $22.6m | Added +1.9m |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.08% of their portfolio | 2.5m $22.2m | Added +440.3k |
| Qube Research & Technologies Ltd 0.03% of their portfolio | 2.4m $21.3m | Added +1.4m |
| Walleye Capital LLC 0.19% of their portfolio | 2.3m $20.6m | Added +2.1m |
| JUPITER ASSET MANAGEMENT LTD 0.16% of their portfolio | 2.1m $18.6m | Reduced -71.0k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.99% of their portfolio | 2.1m $18.5m | Added +32.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 2.0m $17.7m | Added +47.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.9m $17.1m | Reduced -41.5k |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 1.9m $17.1m | Reduced -1.9m |
| STIFEL FINANCIAL CORP 0.02% of their portfolio | 1.8m $16.3m | Reduced -13.7k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.6m $14.2m | Added +518.6k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 1.5m $13.1m | Added +1.3m |
| Jump Financial, LLC 0.15% of their portfolio | 1.3m $12.1m | Added +1.2m |
| Connor, Clark & Lunn Investment Management Ltd. 0.04% of their portfolio | 1.3m $11.3m | Added +215.3k |
| Hood River Capital Management LLC 0.16% of their portfolio | 1.2m $11.1m | New |
| SEGALL BRYANT & HAMILL, LLC 0.15% of their portfolio | 1.2m $10.9m | Reduced -110.2k |
| Eversept Partners, LP 1.09% of their portfolio | 1.2m $10.8m | Reduced -964.8k |
| Legal & General Group Plc 0.00% of their portfolio | 1.2m $10.8m | Added +223.3k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 1.1m $10.3m | Reduced -52.7k |
| M&G PLC 0.05% of their portfolio | 1.0m $9.4m | New |
| Parkman Healthcare Partners LLC 1.04% of their portfolio | 1.0m $9.0m | Added +7.4k |
| ALGERT GLOBAL LLC 0.19% of their portfolio | 1.0m $9.0m | Added +42.8k |
| Invesco Ltd. 0.00% of their portfolio | 993.1k $8.9m | Added +25.0k |
| Pictet Asset Management Holding SA 0.01% of their portfolio | 969.0k $9.1m | Added +356.7k |
| BARCLAYS PLC 0.00% of their portfolio | 804.1k $7.2m | Added +401.5k |
| TANG CAPITAL MANAGEMENT LLC 0.36% of their portfolio | 800.0k $7.2m | Unchanged |
| Driehaus Capital Management LLC 0.05% of their portfolio | 766.9k $6.9m | New |
| Schonfeld Strategic Advisors LLC 0.05% of their portfolio | 753.0k $6.7m | Added +140.8k |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 727.5k $6.5m | Added +242.0k |
| Squarepoint Ops LLC 0.01% of their portfolio | 723.3k $6.5m | Reduced -41.6k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 692.0k $6.2m | Added +243.5k |
| PDT Partners, LLC 0.35% of their portfolio | 683.4k $6.1m | Reduced -95.3k |
| FMR LLC 0.00% of their portfolio | 655.9k $5.9m | Added +72.3k |
| Caligan Partners LP 1.11% of their portfolio | 638.9k $5.7m | Reduced -2.5m |
| Bank of New York Mellon Corp 0.00% of their portfolio | 612.7k $5.5m | Added +22.8k |
| Trexquant Investment LP 0.06% of their portfolio | 559.2k $5.0m | Added +169.8k |
| Hillsdale Investment Management Inc. 0.18% of their portfolio | 536.0k $4.8m | Added +13.7k |
| LORD, ABBETT & CO. LLC 0.02% of their portfolio | 532.4k $4.8m | New |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.01% of their portfolio | 512.2k $4.6m | New |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 510.3k $4.6m | Added +499.7k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 480.8k $4.3m | Reduced -512.8k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 465.8k $4.2m | Reduced -30.2k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 445.2k $4.0m | Added +381.7k |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 440.2k $3.9m | Added +336.9k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 429.3k $3.8m | Reduced -160.0k |
| Man Group plc 0.01% of their portfolio | 421.8k $3.8m | Added +189.4k |
| Campbell & CO Investment Adviser LLC 0.23% of their portfolio | 412.5k $3.7m | Added +390.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 404.5k $3.6m | Added +7.7k |
| PANAGORA ASSET MANAGEMENT INC 0.02% of their portfolio | 394.0k $3.5m | Reduced -135.5k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 393.9k $3.5m | Added +69.5k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 381.5k $3.4m | Added +104.6k |
| Swiss National Bank 0.00% of their portfolio | 379.3k $3.4m | Reduced -2.0k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 375.2k $3.4m | Reduced -153.0k |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 371.8k $3.3m | Reduced -298.6k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 336.9k $3.0m | Added +15.8k |
| Y-Intercept (Hong Kong) Ltd 0.07% of their portfolio | 336.1k $3.0m | Added +194.2k |
| Informed Momentum Co LLC 0.45% of their portfolio | 334.3k $3.0m | New |
| Knott David M Jr 1.35% of their portfolio | 332.6k $3.0m | Reduced -127.4k |
| Hudson Bay Capital Management LP 0.02% of their portfolio | 304.8k $2.7m | Reduced -193.9k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 301.0k $2.7m | Added +47.6k |
| FEDERATED HERMES, INC. 0.01% of their portfolio | 298.2k $2.7m | Added +113.3k |
| Nebula Research & Development LLC 0.22% of their portfolio | 286.5k $2.6m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 284.9k $2.6m | Added +66.8k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 278.5k $2.5m | Reduced -207.3k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 275.4k $2.5m | Unchanged |
| DOLIVER ADVISORS, LP 0.67% of their portfolio | 274.3k $2.5m | Added +200.0k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.08% of their portfolio | 274.1k $2.5m | Reduced -1.1m |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 252.4k $2.3m | Reduced -333.8k |
| Jain Global LLC 0.03% of their portfolio | 240.7k $2.2m | New |
| SG Americas Securities, LLC 0.01% of their portfolio | 235.5k $2.1m | Added +192.0k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 223.2k $2.0m | Added +113.8k |
| Graham Capital Management, L.P. 0.06% of their portfolio | 219.1k $2.0m | Added +83.0k |
| DAFNA Capital Management LLC 0.54% of their portfolio | 218.3k $2.0m | Reduced -340.0k |
| ExodusPoint Capital Management, LP 0.02% of their portfolio | 210.8k $1.9m | Added +149.9k |
| HUSSMAN STRATEGIC ADVISORS, INC. 0.43% of their portfolio | 210.0k $1.9m | Reduced -105.0k |
| Aquatic Capital Management LLC 0.04% of their portfolio | 207.8k $1.9m | New |
| Gotham Asset Management, LLC 0.01% of their portfolio | 201.8k $1.8m | Added +157.7k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 188.2k $1.7m | Added +171.7k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 182.5k $1.6m | Added +3.3k |