BIOCRYST PHARMACEUTICALS INC BCRX
COM · Common Stock · CUSIP 09058V103
American pharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersDurham, NC
- Founded1986
- Websitebiocryst.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($594.4k this quarter). Holder counts are more reliable. Shares outstanding: 209.3m as of 2025-04-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $7.54. Options: 7 managers hold calls ($9.6m notional), 8 hold puts ($4.8m).
Trends to Q1 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 234 |
| Q4 2022 | 230 |
| Q1 2023 | 243 |
| Q2 2023 | 237 |
| Q3 2023 | 234 |
| Q4 2023 | 235 |
| Q1 2024 | 238 |
| Q2 2024 | 243 |
| Q3 2024 | 258 |
| Q4 2024 | 259 |
| Q1 2025 | 276 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2023 | 124 | 88 |
| Q3 2023 | 121 | 80 |
| Q4 2023 | 109 | 102 |
| Q1 2024 | 114 | 98 |
| Q2 2024 | 123 | 105 |
| Q3 2024 | 127 | 109 |
| Q4 2024 | 99 | 122 |
| Q1 2025 | 146 | 94 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2024 | $8.8m | $9.0m | 1.03 |
| Q3 2024 | $12.6m | $6.4m | 0.51 |
| Q4 2024 | $12.1m | $8.5m | 0.70 |
| Q1 2025 | $9.6m | $4.8m | 0.50 |
Biggest buyers
| MILLENNIUM MANAGEMENT LLC | Added | +3.0m |
| UBS Group AG | Added | +2.2m |
| D. E. Shaw & Co., Inc. | Added | +1.3m |
| JUPITER ASSET MANAGEMENT LTD | Added | +971.0k |
| Parkman Healthcare Partners LLC | Added | +783.7k |
| TWO SIGMA ADVISERS, LP | Added | +720.9k |
| Legal & General Group Plc | Added | +706.1k |
| BlackRock, Inc. | Added | +674.1k |
| Qube Research & Technologies Ltd | Added | +667.8k |
| GOLDMAN SACHS GROUP INC | Added | +640.7k |
Biggest sellers
| Avoro Capital Advisors LLC | Reduced | -3.2m |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Reduced | -3.0m |
| Rock Springs Capital Management LP | Reduced | -2.5m |
| ORACLE INVESTMENT MANAGEMENT INC | Sold out | -535.6k |
| Woodline Partners LP | Sold out | -450.2k |
| PRUDENTIAL FINANCIAL INC | Reduced | -393.7k |
| PANAGORA ASSET MANAGEMENT INC | Reduced | -306.4k |
| NORGES BANK | Reduced | -236.8k |
| VANGUARD GROUP INC | Reduced | -230.7k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | Reduced | -209.3k |
Biggest calls
| JANE STREET GROUP, LLC | Added | $4.0m531.5k shares |
| GROUP ONE TRADING LLC | Reduced | $3.7m494.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $714.0k95.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $452.0k60.3k shares |
| CITADEL ADVISORS LLC | Reduced | $382.5k51.0k shares |
| WOLVERINE TRADING, LLC | Reduced | $340.3k43.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| JANE STREET GROUP, LLC | Reduced | $2.1m280.3k shares |
| CITADEL ADVISORS LLC | Reduced | $709.5k94.6k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $633.0k84.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $622.0k83.0k shares |
| GROUP ONE TRADING LLC | Added | $510.8k68.1k shares |
| WOLVERINE TRADING, LLC | Added | $167.4k21.3k shares |
| UBS Group AG | Unchanged | $60.0k8.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 8.4% |
| Flynn James E 13G · passive investor +1.0 pts · filed 2026-02-12 | 6.8% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor -1.1 pts · filed 2026-08-14 | 6.2% |
| STATE STREET CORP 13G · institution +1.1 pts · filed 2026-08-07 | 6.0% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q1 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2023 | 0 | — | 3 | $193.4k | $58.0k |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 10 | $1.0m | 3 | $123.4k | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 1 | $52.8k | $52.8k |
| Q1 2025 | 0 | — | 0 | — | — |
None reported in Q1 2025.
Holders, Q1 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 22.8m $170.8m | Added +674.1k |
| VANGUARD GROUP INC 0.00% of their portfolio | 21.7m $162.4m | Reduced -230.7k |
| Kynam Capital Management, LP 5.73% of their portfolio | 8.9m $67.0m | Reduced -156.8k |
| Avoro Capital Advisors LLC 1.02% of their portfolio | 8.7m $65.2m | Reduced -3.2m |
| STATE STREET CORP 0.00% of their portfolio | 7.8m $58.6m | Added +314.4k |
| ALKEON CAPITAL MANAGEMENT LLC 0.32% of their portfolio | 7.2m $54.1m | Added +120.2k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.77% of their portfolio | 5.2m $38.9m | Reduced -3.0m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 5.0m $37.2m | Added +136.9k |
| RP Management, LLC 20.78% of their portfolio | 3.8m $28.8m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio | 3.8m $28.6m | Added +3.0m |
| TWO SIGMA ADVISERS, LP 0.05% of their portfolio | 3.2m $24.2m | Added +720.9k |
| Caligan Partners LP 4.86% of their portfolio | 3.1m $23.3m | Added +111.7k |
| Fisher Asset Management, LLC 0.01% of their portfolio | 3.1m $22.9m | Reduced -130.5k |
| GW&K Investment Management, LLC 0.20% of their portfolio | 2.9m $21.6m | Reduced -56.7k |
| UBS Group AG 0.00% of their portfolio | 2.4m $18.0m | Added +2.2m |
| MORGAN STANLEY 0.00% of their portfolio | 2.3m $17.2m | Added +631.9k |
| Eversept Partners, LP 1.84% of their portfolio | 2.2m $16.3m | Added +192.1k |
| JUPITER ASSET MANAGEMENT LTD 0.15% of their portfolio | 2.1m $16.1m | Added +971.0k |
| TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio | 2.0m $15.3m | Added +271.3k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.06% of their portfolio | 2.0m $15.3m | Added +453.8k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.89% of their portfolio | 2.0m $15.2m | Reduced -53.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 2.0m $14.7m | Reduced -49.7k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.9m $14.5m | Added +640.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.9m $14.4m | Reduced -58.0k |
| STIFEL FINANCIAL CORP 0.01% of their portfolio | 1.8m $13.8m | Reduced -6.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 1.7m $13.1m | Added +26.7k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 1.6m $11.9m | Added +1.3m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.4m $10.8m | Added +535.8k |
| Nuveen, LLC 0.01% of their portfolio | 1.4m $17.2m | First filing |
| SEGALL BRYANT & HAMILL, LLC 0.15% of their portfolio | 1.3m $10.0m | Reduced -91.9k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.34% of their portfolio | 1.3m $9.9m | Reduced -60.4k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 1.2m $9.0m | Added +362.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.1m $8.0m | Added +591.2k |
| Connor, Clark & Lunn Investment Management Ltd. 0.03% of their portfolio | 1.0m $7.8m | Added +408.6k |
| Parkman Healthcare Partners LLC 0.89% of their portfolio | 1.0m $7.5m | Added +783.7k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 993.6k $7.5m | Added +367.7k |
| Legal & General Group Plc 0.00% of their portfolio | 981.2k $7.4m | Added +706.1k |
| Invesco Ltd. 0.00% of their portfolio | 968.2k $7.3m | Reduced -104.4k |
| ALGERT GLOBAL LLC 0.18% of their portfolio | 960.1k $7.2m | Added +234.8k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 940.7k $7.1m | Added +667.8k |
| TANG CAPITAL MANAGEMENT LLC 0.33% of their portfolio | 800.0k $6.0m | Unchanged |
| PDT Partners, LLC 0.41% of their portfolio | 778.7k $5.8m | Added +256.4k |
| Squarepoint Ops LLC 0.01% of their portfolio | 764.9k $5.7m | Added +405.0k |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 670.4k $5.0m | Added +475.6k |
| Pictet Asset Management Holding SA 0.01% of their portfolio | 612.3k $4.8m | Added +585.9k |
| Schonfeld Strategic Advisors LLC 0.03% of their portfolio | 612.2k $4.6m | Added +394.5k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 605.2k $4.5m | Added +60.2k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 589.9k $4.4m | Reduced -7.1k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 589.3k $4.4m | Reduced -393.7k |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 586.2k $4.4m | Added +56.6k |
| FMR LLC 0.00% of their portfolio | 583.6k $4.4m | Reduced -193.7k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 574.2k $4.3m | Added +315.6k |
| DAFNA Capital Management LLC 1.19% of their portfolio | 558.3k $4.2m | Reduced -108.7k |
| PANAGORA ASSET MANAGEMENT INC 0.02% of their portfolio | 529.6k $4.0m | Reduced -306.4k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 528.2k $4.0m | Added +101.0k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 522.7k $4.1m | Unchanged |
| Hillsdale Investment Management Inc. 0.20% of their portfolio | 522.3k $3.9m | Reduced -19.8k |
| Hudson Bay Capital Management LP 0.02% of their portfolio | 498.7k $3.7m | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 496.0k $3.7m | Reduced -23.2k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 485.8k $3.6m | Reduced -86.5k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 485.5k $3.6m | Reduced -79.7k |
| Kodai Capital Management LP 0.14% of their portfolio | 468.8k $3.5m | New |
| Knott David M Jr 1.63% of their portfolio | 460.0k $3.5m | Added +20.0k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 448.5k $3.4m | Added +47.4k |
| BARCLAYS PLC 0.00% of their portfolio | 402.6k $3.0m | Reduced -61.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 396.9k $3.0m | Added +171.2k |
| Trexquant Investment LP 0.03% of their portfolio | 389.4k $2.9m | Reduced -105.0k |
| Swiss National Bank 0.00% of their portfolio | 381.3k $2.9m | Reduced -5.3k |
| CITIGROUP INC 0.00% of their portfolio | 352.2k $2.6m | Added +75.5k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 324.4k $2.4m | Added +62.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 321.2k $2.4m | Added +12.0k |
| HUSSMAN STRATEGIC ADVISORS, INC. 0.57% of their portfolio | 315.0k $2.4m | New |
| NORGES BANK 0.00% of their portfolio | 288.0k $2.2m | Reduced -236.8k |
| GSA CAPITAL PARTNERS LLP 0.19% of their portfolio | 278.6k $2.1m | Added +114.1k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 276.9k $2.1m | Added +29.1k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 275.4k $2.1m | Unchanged |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 253.3k $1.9m | Added +18.5k |
| Man Group plc 0.01% of their portfolio | 232.4k $1.7m | Added +142.4k |
| Rock Springs Capital Management LP 0.10% of their portfolio | 222.0k $1.7m | Reduced -2.5m |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 218.1k $1.6m | Added +113.9k |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 194.6k $1.5m | Added +33.0k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio | 194.2k $1.5m | Reduced -209.3k |
| DANSKE BANK A/S 0.00% of their portfolio | 193.6k $1.5m | New |
| Semanteon Capital Management, LP 0.77% of their portfolio | 189.7k $1.4m | Reduced -8.1k |
| SummitTX Capital, L.P. 0.06% of their portfolio | 189.1k $1.4m | First filing |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 184.9k $1.4m | Added +16.9k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 179.1k $1.3m | Reduced -5.3k |
| Walleye Capital LLC 0.01% of their portfolio | 154.7k $1.2m | Reduced -204.8k |
| ALPS ADVISORS INC 0.01% of their portfolio | 153.0k $1.1m | Reduced -14.5k |
| QTR Family Wealth, LLC 0.86% of their portfolio | 151.6k $1.1m | First filing |
| Jump Financial, LLC 0.02% of their portfolio | 148.8k $1.1m | Reduced -114.5k |
| Y-Intercept (Hong Kong) Ltd 0.07% of their portfolio | 141.9k $1.1m | Added +73.2k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 141.1k $1.1m | Added +2.0k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 137.7k $1.0m | Reduced -17.3k |
| Graham Capital Management, L.P. 0.03% of their portfolio | 136.1k $1.0m | Added +38.8k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 135.3k $1.0m | Added +8.5k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 134.3k $1.0m | Added +7.5k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 125.6k $942.2k | First filing |
| INTECH INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 124.2k $931.3k | Added +26.4k |
| IEQ CAPITAL, LLC 0.01% of their portfolio | 122.7k $920.3k | Added +93.3k |