BIOCRYST PHARMACEUTICALS INC BCRX
COM · Common Stock · CUSIP 09058V103
American pharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersDurham, NC
- Founded1986
- Websitebiocryst.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($907.1k this quarter). Holder counts are more reliable. Shares outstanding: 207.1m as of 2024-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $7.52. Options: 9 managers hold calls ($12.1m notional), 11 hold puts ($8.5m).
Trends to Q4 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 234 |
| Q4 2022 | 230 |
| Q1 2023 | 243 |
| Q2 2023 | 237 |
| Q3 2023 | 234 |
| Q4 2023 | 235 |
| Q1 2024 | 238 |
| Q2 2024 | 243 |
| Q3 2024 | 258 |
| Q4 2024 | 259 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 132 | 92 |
| Q2 2023 | 124 | 88 |
| Q3 2023 | 121 | 80 |
| Q4 2023 | 109 | 102 |
| Q1 2024 | 114 | 98 |
| Q2 2024 | 123 | 105 |
| Q3 2024 | 127 | 109 |
| Q4 2024 | 99 | 122 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2024 | $7.8m | $9.3m | 1.19 |
| Q2 2024 | $8.8m | $9.0m | 1.03 |
| Q3 2024 | $12.6m | $6.4m | 0.51 |
| Q4 2024 | $12.1m | $8.5m | 0.70 |
Biggest buyers
| VANGUARD GROUP INC | Added | +1.6m |
| Eversept Partners, LP | Added | +1.4m |
| BlackRock, Inc. | Added | +1.2m |
| Hillsdale Investment Management Inc. | Added | +541.3k |
| Balyasny Asset Management L.P. | New | +529.7k |
| Woodline Partners LP | New | +450.2k |
| SCHRODER INVESTMENT MANAGEMENT GROUP | Added | +438.9k |
| Caligan Partners LP | Added | +412.3k |
| Squarepoint Ops LLC | Added | +345.7k |
| TWO SIGMA ADVISERS, LP | Added | +318.8k |
Biggest sellers
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -2.1m |
| Nuveen Asset Management, LLC | Reduced | -1.4m |
| STATE STREET CORP | Reduced | -1.4m |
| FMR LLC | Reduced | -1.2m |
| GOLDMAN SACHS GROUP INC | Reduced | -1.0m |
| Rock Springs Capital Management LP | Reduced | -944.4k |
| Cutter Capital Management, LP | Sold out | -798.1k |
| JPMORGAN CHASE & CO | Reduced | -679.9k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -532.8k |
| PRINCIPAL FINANCIAL GROUP INC | Reduced | -393.6k |
Biggest calls
| GROUP ONE TRADING LLC | Reduced | $6.0m792.0k shares |
| Caption Management, LLC | New | $2.2m296.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $949.0k126.2k shares |
| CITADEL ADVISORS LLC | Reduced | $941.5k125.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $670.0k89.2k shares |
| JANE STREET GROUP, LLC | Reduced | $575.3k76.5k shares |
| WOLVERINE TRADING, LLC | Added | $408.9k54.3k shares |
| Squarepoint Ops LLC | New | $372.2k49.5k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| JANE STREET GROUP, LLC | Reduced | $3.1m406.3k shares |
| Caption Management, LLC | New | $2.2m296.5k shares |
| CITADEL ADVISORS LLC | Added | $1.2m155.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $691.1k91.9k shares |
| SIMPLEX TRADING, LLC | Added | $652.0k86.8k shares |
| GROUP ONE TRADING LLC | Added | $404.6k53.8k shares |
| WOLVERINE TRADING, LLC | Reduced | $140.8k18.7k shares |
| BARCLAYS PLC | Unchanged | $75.2k10.0k shares |
| UBS Group AG | Unchanged | $60.2k8.0k shares |
| Walleye Capital LLC | Reduced | $22.6k3.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 8.4% |
| Flynn James E 13G · passive investor +1.0 pts · filed 2026-02-12 | 6.8% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor -1.1 pts · filed 2026-08-14 | 6.2% |
| STATE STREET CORP 13G · institution +1.1 pts · filed 2026-08-07 | 6.0% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q4 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2023 | 0 | — | 1 | $1.0m | — |
| Q2 2023 | 0 | — | 3 | $193.4k | $58.0k |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 10 | $1.0m | 3 | $123.4k | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 1 | $52.8k | $52.8k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-12-13 | Hutson Nancy J Director | Sold plan | $52.8k7.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2024
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 22.1m $166.2m | Added +1.2m |
| VANGUARD GROUP INC 0.00% of their portfolio | 21.9m $164.6m | Added +1.6m |
| Avoro Capital Advisors LLC 1.26% of their portfolio | 11.9m $89.2m | Unchanged |
| Kynam Capital Management, LP 4.51% of their portfolio | 9.1m $68.3m | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. 1.17% of their portfolio | 8.1m $61.2m | Added +8.6k |
| STATE STREET CORP 0.00% of their portfolio | 7.5m $56.4m | Reduced -1.4m |
| ALKEON CAPITAL MANAGEMENT LLC 0.31% of their portfolio | 7.1m $53.3m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 4.8m $36.3m | Reduced -14.2k |
| RP Management, LLC 12.84% of their portfolio | 3.8m $29.2m | Unchanged |
| Nuveen Asset Management, LLC 0.01% of their portfolio | 3.4m $25.7m | Reduced -1.4m |
| Fisher Asset Management, LLC 0.01% of their portfolio | 3.2m $23.9m | Reduced -155.4k |
| Caligan Partners LP 5.71% of their portfolio | 3.0m $22.5m | Added +412.3k |
| GW&K Investment Management, LLC 0.19% of their portfolio | 2.9m $22.1m | Reduced -336.2k |
| Rock Springs Capital Management LP 0.77% of their portfolio | 2.7m $20.1m | Reduced -944.4k |
| TWO SIGMA ADVISERS, LP 0.04% of their portfolio | 2.5m $18.8m | Added +318.8k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.86% of their portfolio | 2.1m $15.7m | Reduced -82.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 2.0m $15.1m | Added +144.0k |
| Eversept Partners, LP 1.54% of their portfolio | 2.0m $14.9m | Added +1.4m |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 2.0m $14.9m | Added +92.0k |
| STIFEL FINANCIAL CORP 0.01% of their portfolio | 1.8m $13.9m | Reduced -303 |
| TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio | 1.8m $13.3m | Added +13.4k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 1.7m $12.9m | Reduced -51.9k |
| MORGAN STANLEY 0.00% of their portfolio | 1.7m $12.5m | Reduced -73.3k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.04% of their portfolio | 1.6m $11.9m | Reduced -212.9k |
| SEGALL BRYANT & HAMILL, LLC 0.15% of their portfolio | 1.4m $10.7m | Reduced -68.2k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.31% of their portfolio | 1.4m $10.4m | Added +190.6k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.3m $9.7m | Reduced -1.0m |
| JUPITER ASSET MANAGEMENT LTD 0.09% of their portfolio | 1.2m $8.9m | Added +108.0k |
| Invesco Ltd. 0.00% of their portfolio | 1.1m $8.1m | Added +67.5k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 983.0k $7.4m | Added +90.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 899.8k $6.8m | Reduced -261.1k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 839.3k $6.3m | Added +52.0k |
| PANAGORA ASSET MANAGEMENT INC 0.03% of their portfolio | 836.0k $6.3m | Added +159.7k |
| TANG CAPITAL MANAGEMENT LLC 0.40% of their portfolio | 800.0k $6.0m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 790.1k $5.9m | Reduced -532.8k |
| FMR LLC 0.00% of their portfolio | 777.3k $5.8m | Reduced -1.2m |
| ALGERT GLOBAL LLC 0.13% of their portfolio | 725.3k $5.5m | Added +209.1k |
| DAFNA Capital Management LLC 1.27% of their portfolio | 667.0k $5.0m | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. 0.02% of their portfolio | 633.9k $4.8m | Reduced -48.5k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 625.9k $4.7m | Reduced -257.9k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 596.9k $4.5m | Added +100 |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 572.3k $4.3m | Reduced -139.1k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 565.2k $4.3m | Reduced -28.3k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 545.0k $4.1m | Reduced -44.1k |
| Hillsdale Investment Management Inc. 0.21% of their portfolio | 542.1k $4.1m | Added +541.3k |
| ORACLE INVESTMENT MANAGEMENT INC 2.70% of their portfolio | 535.6k $4.0m | Unchanged |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 529.7k $4.0m | New |
| NORGES BANK 0.00% of their portfolio | 524.8k $3.9m | Reduced -87.1k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 522.7k $3.9m | Added +438.9k |
| PDT Partners, LLC 0.35% of their portfolio | 522.3k $3.9m | Added +10 |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 519.2k $3.9m | Added +58.7k |
| Trexquant Investment LP 0.04% of their portfolio | 494.4k $3.7m | Reduced -386.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 474.4k $3.6m | Reduced -679.9k |
| BARCLAYS PLC 0.00% of their portfolio | 464.2k $3.5m | Reduced -12.4k |
| Woodline Partners LP 0.02% of their portfolio | 450.2k $3.4m | New |
| Knott David M Jr 1.20% of their portfolio | 440.0k $3.3m | Added +58.0k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 427.3k $3.2m | Added +243.4k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio | 403.4k $3.0m | Reduced -27.8k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 401.1k $3.0m | Added +11.6k |
| Swiss National Bank 0.00% of their portfolio | 386.6k $2.9m | Added +22.6k |
| Squarepoint Ops LLC 0.01% of their portfolio | 359.9k $2.7m | Added +345.7k |
| Walleye Capital LLC 0.03% of their portfolio | 359.5k $2.7m | Added +100.1k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 315.3k $2.4m | Added +86.2k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 309.1k $2.3m | Added +5.6k |
| CITIGROUP INC 0.00% of their portfolio | 276.7k $2.1m | Added +123.8k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 275.4k $2.1m | Reduced -400 |
| Legal & General Group Plc 0.00% of their portfolio | 275.1k $2.1m | Added +25.3k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 272.8k $2.1m | Added +18.9k |
| Jump Financial, LLC 0.04% of their portfolio | 263.3k $2.0m | Reduced -8.4k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 262.4k $2.0m | Reduced -1.4k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 258.5k $1.9m | Reduced -20.6k |
| MACKENZIE FINANCIAL CORP 0.00% of their portfolio | 254.0k $1.8m | Added +224.9k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 247.8k $1.9m | Reduced -119.7k |
| UBS Group AG 0.00% of their portfolio | 240.4k $1.8m | Reduced -184.7k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 234.8k $1.8m | Reduced -136.2k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 225.7k $1.7m | Reduced -9.2k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 217.7k $1.6m | Added +46.6k |
| Parkman Healthcare Partners LLC 0.22% of their portfolio | 216.9k $1.6m | Reduced -247.2k |
| Semanteon Capital Management, LP 0.80% of their portfolio | 197.8k $1.5m | Added +48.2k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 196.2k $1.5m | Reduced -300.6k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 194.8k $1.5m | Added +183.5k |
| Cinctive Capital Management LP 0.08% of their portfolio | 194.4k $1.5m | Reduced -79.6k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 184.5k $1.4m | Added +7.2k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 168.0k $1.3m | Added +56.9k |
| ALPS ADVISORS INC 0.01% of their portfolio | 167.5k $1.3m | Added +9.4k |
| GSA CAPITAL PARTNERS LLP 0.09% of their portfolio | 164.5k $1.2m | Reduced -121.1k |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 161.5k $1.2m | Added +65.4k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 155.0k $1.2m | Reduced -330 |
| Bison Wealth, LLC 0.25% of their portfolio | 153.3k $1.2m | Unchanged |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 139.1k $1.0m | Reduced -3.6k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 126.9k $954.7k | Added +7.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 126.8k $954.0k | Reduced -2.1m |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 126.8k $953.6k | Reduced -929 |
| Skandinaviska Enskilda Banken AB (publ) 0.00% of their portfolio | 114.1k $858.9k | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 104.2k $783.3k | Added +36.2k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 103.5k $778.6k | Reduced -195.6k |
| Corebridge Financial, Inc. 0.00% of their portfolio | 102.7k $772.5k | Reduced -7.8k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 101.2k $760.9k | Added +14.7k |
| TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio | 99.5k $747.9k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 97.8k $735.4k | Added +43.6k |