BIOCRYST PHARMACEUTICALS INC BCRX
COM · Common Stock · CUSIP 09058V103
American pharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersDurham, NC
- Founded1986
- Websitebiocryst.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($83.4k this quarter). Holder counts are more reliable. Shares outstanding: 207.1m as of 2024-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $7.60. Options: 11 managers hold calls ($12.6m notional), 10 hold puts ($6.4m).
Trends to Q3 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 234 |
| Q4 2022 | 230 |
| Q1 2023 | 243 |
| Q2 2023 | 237 |
| Q3 2023 | 234 |
| Q4 2023 | 235 |
| Q1 2024 | 238 |
| Q2 2024 | 243 |
| Q3 2024 | 258 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 124 | 97 |
| Q1 2023 | 132 | 92 |
| Q2 2023 | 124 | 88 |
| Q3 2023 | 121 | 80 |
| Q4 2023 | 109 | 102 |
| Q1 2024 | 114 | 98 |
| Q2 2024 | 123 | 105 |
| Q3 2024 | 127 | 109 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2023 | $22.1m | $9.1m | 0.41 |
| Q1 2024 | $7.8m | $9.3m | 1.19 |
| Q2 2024 | $8.8m | $9.0m | 1.03 |
| Q3 2024 | $12.6m | $6.4m | 0.51 |
Biggest buyers
| VANGUARD GROUP INC | Added | +1.5m |
| JUPITER ASSET MANAGEMENT LTD | New | +1.1m |
| Invesco Ltd. | Added | +903.2k |
| PRUDENTIAL FINANCIAL INC | Added | +876.2k |
| FIRST TRUST ADVISORS LP | New | +593.5k |
| Fisher Asset Management, LLC | Added | +481.4k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | New | +431.2k |
| BNP PARIBAS FINANCIAL MARKETS | Added | +409.9k |
| Exome Asset Management LLC | New | +393.0k |
| PRINCIPAL FINANCIAL GROUP INC | Added | +375.9k |
Biggest sellers
| Caligan Partners LP | Reduced | -2.0m |
| Cutter Capital Management, LP | Reduced | -1.2m |
| Cubist Systematic Strategies, LLC | Sold out | -1.1m |
| Sarissa Capital Management LP | Sold out | -1.1m |
| BOOTHBAY FUND MANAGEMENT, LLC | Reduced | -941.2k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Reduced | -798.0k |
| Avoro Capital Advisors LLC | Reduced | -705.0k |
| AlphaCentric Advisors LLC | Sold out | -675.0k |
| Eversept Partners, LP | Reduced | -617.2k |
| STATE STREET CORP | Reduced | -497.2k |
Biggest calls
| GROUP ONE TRADING LLC | Added | $6.8m895.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.3m165.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.1m140.8k shares |
| CITADEL ADVISORS LLC | Added | $1.1m139.8k shares |
| MILLENNIUM MANAGEMENT LLC | New | $769.9k101.3k shares |
| JANE STREET GROUP, LLC | Reduced | $674.1k88.7k shares |
| GTS SECURITIES LLC | Added | $562.4k74.0k shares |
| WOLVERINE TRADING, LLC | Reduced | $309.4k40.6k shares |
| Valence8 US LP | New | $99.6k13.1k shares |
| Walleye Capital LLC | New | $10.6k1.4k shares |
Biggest puts
| JANE STREET GROUP, LLC | Reduced | $3.5m462.2k shares |
| CITADEL ADVISORS LLC | Reduced | $1.1m141.6k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $637.6k83.9k shares |
| SIMPLEX TRADING, LLC | Added | $484.0k63.7k shares |
| GROUP ONE TRADING LLC | Reduced | $334.4k44.0k shares |
| WOLVERINE TRADING, LLC | Added | $229.4k30.1k shares |
| BARCLAYS PLC | New | $76.0k10.0k shares |
| UBS Group AG | Unchanged | $60.8k8.0k shares |
| Walleye Capital LLC | New | $23.6k3.1k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 8.4% |
| Flynn James E 13G · passive investor +1.0 pts · filed 2026-02-12 | 6.8% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor -1.1 pts · filed 2026-08-14 | 6.2% |
| STATE STREET CORP 13G · institution +1.1 pts · filed 2026-08-07 | 6.0% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q3 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2022 | 0 | — | 7 | $4.8m | — |
| Q1 2023 | 0 | — | 1 | $1.0m | — |
| Q2 2023 | 0 | — | 3 | $193.4k | $58.0k |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 10 | $1.0m | 3 | $123.4k | — |
| Q3 2024 | 0 | — | 0 | — | — |
None reported in Q3 2024.
Holders, Q3 2024
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 20.9m $159.0m | First filing |
| VANGUARD GROUP INC 0.00% of their portfolio | 20.3m $154.3m | Added +1.5m |
| Avoro Capital Advisors LLC 1.31% of their portfolio | 11.9m $90.2m | Reduced -705.0k |
| Kynam Capital Management, LP 5.35% of their portfolio | 9.1m $69.0m | Added +258.7k |
| STATE STREET CORP 0.00% of their portfolio | 8.8m $67.3m | Reduced -497.2k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.92% of their portfolio | 8.1m $61.8m | Unchanged |
| ALKEON CAPITAL MANAGEMENT LLC 0.30% of their portfolio | 7.1m $53.9m | Reduced -5.7k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 4.8m $36.8m | Added +127.7k |
| Nuveen Asset Management, LLC 0.01% of their portfolio | 4.8m $36.6m | Added +319.2k |
| RP Management, LLC 12.84% of their portfolio | 3.8m $29.2m | Unchanged |
| Rock Springs Capital Management LP 0.90% of their portfolio | 3.6m $27.5m | Added +3.1k |
| Fisher Asset Management, LLC 0.01% of their portfolio | 3.3m $25.4m | Added +481.4k |
| GW&K Investment Management, LLC 0.21% of their portfolio | 3.3m $24.9m | Reduced -127.1k |
| Caligan Partners LP 6.22% of their portfolio | 2.6m $19.6m | Reduced -2.0m |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 2.3m $17.6m | Reduced -209.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 2.3m $17.1m | Added +303.8k |
| TWO SIGMA ADVISERS, LP 0.04% of their portfolio | 2.2m $16.6m | Added +261.5k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.89% of their portfolio | 2.2m $16.4m | Added +84.1k |
| FMR LLC 0.00% of their portfolio | 2.0m $15.1m | Added +46.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.9m $14.3m | Added +102.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.9m $14.1m | Added +106.2k |
| STIFEL FINANCIAL CORP 0.01% of their portfolio | 1.8m $14.0m | Reduced -363 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.05% of their portfolio | 1.8m $13.6m | Reduced -798.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 1.8m $13.5m | Reduced -93.1k |
| TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio | 1.8m $13.4m | Added +86.4k |
| MORGAN STANLEY 0.00% of their portfolio | 1.7m $13.2m | Added +161.1k |
| SEGALL BRYANT & HAMILL, LLC 0.15% of their portfolio | 1.5m $11.3m | Reduced -36.1k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 1.3m $10.1m | Reduced -428.7k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.27% of their portfolio | 1.2m $9.1m | Reduced -941.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.2m $8.8m | Reduced -139.4k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.2m $8.8m | Reduced -340.8k |
| JUPITER ASSET MANAGEMENT LTD 0.07% of their portfolio | 1.1m $8.1m | New |
| Invesco Ltd. 0.00% of their portfolio | 1.0m $7.6m | Added +903.2k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 892.4k $6.8m | Added +876.2k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 883.8k $6.7m | Added +37.0k |
| Trexquant Investment LP 0.08% of their portfolio | 881.0k $6.7m | Reduced -156.2k |
| TANG CAPITAL MANAGEMENT LLC 0.43% of their portfolio | 800.0k $6.1m | Unchanged |
| Cutter Capital Management, LP 1.79% of their portfolio | 798.1k $6.1m | Reduced -1.2m |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 787.2k $6.0m | Added +244.0k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 711.4k $5.4m | Reduced -128.1k |
| Connor, Clark & Lunn Investment Management Ltd. 0.03% of their portfolio | 682.3k $5.2m | Reduced -100.3k |
| PANAGORA ASSET MANAGEMENT INC 0.02% of their portfolio | 676.3k $5.1m | Added +26.0k |
| DAFNA Capital Management LLC 1.20% of their portfolio | 667.0k $5.1m | Reduced -37.5k |
| NORGES BANK 0.00% of their portfolio | 611.9k $4.7m | Reduced -39.7k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 596.8k $4.5m | Reduced -179.1k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 593.5k $4.5m | New |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 589.1k $4.5m | Reduced -371.1k |
| ORACLE INVESTMENT MANAGEMENT INC 3.25% of their portfolio | 535.6k $4.1m | Unchanged |
| Eversept Partners, LP 0.31% of their portfolio | 535.4k $4.1m | Reduced -617.2k |
| PDT Partners, LLC 0.35% of their portfolio | 522.3k $4.0m | Added +155.5k |
| ALGERT GLOBAL LLC 0.11% of their portfolio | 516.2k $3.9m | Added +163.1k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 496.8k $3.8m | Added +409.9k |
| BARCLAYS PLC 0.00% of their portfolio | 476.7k $3.6m | Added +250.1k |
| Parkman Healthcare Partners LLC 0.45% of their portfolio | 464.0k $3.5m | Added +63.6k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 460.5k $3.5m | Added +28.5k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio | 431.2k $3.3m | New |
| UBS Group AG 0.00% of their portfolio | 425.0k $3.2m | Added +33.5k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 411.4k $3.1m | Added +375.9k |
| Exome Asset Management LLC 1.02% of their portfolio | 393.0k $3.0m | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 389.5k $3.0m | Reduced -43.4k |
| Knott David M Jr 1.02% of their portfolio | 382.0k $2.9m | Added +67.7k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 371.0k $2.8m | Reduced -94.7k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 367.5k $2.8m | Reduced -372.1k |
| Swiss National Bank 0.00% of their portfolio | 364.0k $2.8m | Unchanged |
| CAPITAL FUND MANAGEMENT S.A. 0.03% of their portfolio | 357.6k $2.7m | Added +110.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 303.5k $2.3m | Reduced -15.1k |
| TD Asset Management Inc 0.00% of their portfolio | 302.7k $2.3m | Added +62.1k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 299.2k $2.3m | Added +86.6k |
| GSA CAPITAL PARTNERS LLP 0.16% of their portfolio | 285.6k $2.2m | Reduced -78.2k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 279.1k $2.1m | Reduced -38.8k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 275.8k $2.1m | Unchanged |
| Cinctive Capital Management LP 0.12% of their portfolio | 274.0k $2.1m | New |
| Jump Financial, LLC 0.04% of their portfolio | 271.7k $2.1m | Added +71.5k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 263.7k $2.0m | Added +168.8k |
| Walleye Capital LLC 0.02% of their portfolio | 259.4k $2.0m | Added +50.6k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 253.9k $1.9m | New |
| Legal & General Group Plc 0.00% of their portfolio | 249.7k $1.9m | Reduced -16.5k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 249.5k $1.9m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 234.9k $1.8m | Reduced -41.5k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 229.1k $1.7m | Reduced -121.7k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 183.9k $1.4m | Reduced -49.6k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 177.3k $1.3m | Reduced -5.6k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 171.1k $1.3m | Reduced -281.5k |
| SG Americas Securities, LLC 0.00% of their portfolio | 158.9k $1.2m | New |
| ALPS ADVISORS INC 0.01% of their portfolio | 158.1k $1.2m | Reduced -2.9k |
| Inspire Investing, LLC 0.12% of their portfolio | 158.0k $1.2m | Added +100.5k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 155.4k $1.2m | Added +6.9k |
| Bison Wealth, LLC 0.19% of their portfolio | 153.3k $1.2m | Added +1.3k |
| CITIGROUP INC 0.00% of their portfolio | 152.9k $1.2m | Added +36.0k |
| Crestline Management, L.P. 0.06% of their portfolio | 149.8k $1.1m | New |
| Semanteon Capital Management, LP 0.77% of their portfolio | 149.6k $1.1m | New |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 142.7k $1.1m | Reduced -1.2k |
| Aquatic Capital Management LLC 0.03% of their portfolio | 136.1k $1.0m | Added +122.4k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 127.7k $971.0k | Added +14.2k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 119.8k $910.1k | Unchanged |
| Skandinaviska Enskilda Banken AB (publ) 0.00% of their portfolio | 114.1k $866.9k | Unchanged |
| Capula Management Ltd 0.01% of their portfolio | 113.2k $860.2k | Reduced -48.1k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 111.0k $843.8k | New |
| Corebridge Financial, Inc. 0.00% of their portfolio | 110.5k $839.7k | Reduced -681 |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 107.8k $819.4k | New |