AYTU BIOPHARMA INC AYTU
COM · Common Stock · CUSIP 054754858
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersDenver, CO
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $2.15.
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2023 | 20 |
| Q2 2023 | 22 |
| Q3 2023 | 23 |
| Q4 2023 | 23 |
| Q1 2024 | 28 |
| Q2 2024 | 28 |
| Q3 2024 | 25 |
| Q4 2024 | 30 |
| Q1 2025 | 32 |
| Q2 2025 | 33 |
| Q3 2025 | 33 |
| Q4 2025 | 39 |
| Q1 2026 | 37 |
| Q2 2026 | 38 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 4 | 11 |
| Q4 2024 | 11 | 7 |
| Q1 2025 | 13 | 7 |
| Q2 2025 | 12 | 11 |
| Q3 2025 | 15 | 7 |
| Q4 2025 | 17 | 9 |
| Q1 2026 | 12 | 10 |
| Q2 2026 | 15 | 7 |
Biggest buyers
| Nantahala Capital Management, LLC | Added | +1.1m |
| Stonepine Capital Management, LLC | Added | +120.6k |
| CROWN ADVISORS MANAGEMENT, INC. | Added | +55.0k |
| CITADEL ADVISORS LLC | Added | +12.6k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +11.1k |
| NORTHERN TRUST CORP | Added | +8.8k |
| DIMENSIONAL FUND ADVISORS LP | Added | +1.7k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +1.0k |
| UBS Group AG | Added | +714 |
| Tower Research Capital LLC (TRC) | Added | +668 |
Biggest sellers
| DIADEMA PARTNERS LP | Reduced | -204.5k |
| Persistent Asset Partners Ltd | Reduced | -54.9k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -16.6k |
| MAI Capital Management | Sold out | -3.6k |
| XTX Topco Ltd | Reduced | -166 |
| NewEdge Advisors, LLC | Sold out | -21 |
| SBI Securities Co., Ltd. | Reduced | -1 |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Nantahala Capital Management, LLC
13D · may seek influence
filed 2025-06-09
Stated purposeItem 4 is amended by the addition of the following: On June 6, 2025, the Reporting Persons caused the Nantahala Investors to purchase prefunded warrants (the "June 2025 Prefunded Warrants") in an underwritten offering (the "June 2025 Offering") by the Issuer. Using cash on hand, the Nantahala Investors purchased June 2025 Prefunded Warrants exercisable, subject to the terms and conditions thereof, for 4,000,000 shares of Common Stock. The Nantahala Investors purchased the June 2025 Prefunded Warrants for $1.4999 per share of Common Stock represented by the June 2025 Prefunded Warrants. The June 2025 Prefunded Warrant may be exercised at any time by payment of cash in the amount of $0.0001 per share of Common Stock, or by customary cashless exercise, provided that the June 2025 Prefunded W… Full filing |
14.4% |
| Stonepine Capital Management, LLC 13G · passive investor filed 2025-08-13 | 9.9% |
Fell to 5% or below in the last year: LYTTON LAURENCE W (5.0%, 2026-08-14), Philotimo Fund, LP (0.0%, 2025-11-12)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 1 | $19.5k | 0 | — | — |
| Q2 2025 | 2 | $125.0k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Nantahala Capital Management, LLC 0.14% of their portfolio | 2.2m $4.7m | Added +1.1m |
| Stonepine Capital Management, LLC 1.49% of their portfolio | 912.9k $2.0m | Added +120.6k |
| AWM Investment Company, Inc. 0.12% of their portfolio | 619.6k $1.3m | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 261.1k $561.5k | Unchanged |
| CROWN ADVISORS MANAGEMENT, INC. 0.24% of their portfolio | 200.0k $430.0k | Added +55.0k |
| DIADEMA PARTNERS LP 0.11% of their portfolio | 148.5k $319.4k | Reduced -204.5k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 105.3k $226.5k | Reduced -16.6k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 104.8k $225.4k | Added +11.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 93.6k $201.4k | Added +1.0k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 49.4k $106.2k | Added +12.6k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 47.0k $101.2k | Unchanged |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 45.3k $97.5k | Added +1.7k |
| Persistent Asset Partners Ltd 0.03% of their portfolio | 38.0k $81.7k | Reduced -54.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 27.9k $60.0k | Added +8.8k |
| BELLEVUE ASSET MANAGEMENT, LLC 0.02% of their portfolio | 25.0k $53.8k | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 22.8k $49.0k | Unchanged |
| XTX Topco Ltd 0.00% of their portfolio | 21.4k $46.0k | Reduced -166 |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 10.2k $22.0k | Unchanged |
| Daytona Street Capital LLC 0.02% of their portfolio | 10.0k $22.4k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 2.4k $5.1k | Added +714 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 2.2k $4.8k | Added +668 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 462 $991 | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 378 $1.0k | Added +342 |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 154 $337 | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 127 $273 | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 125 $269 | Unchanged |
| FNY Investment Advisers, LLC 0.00% of their portfolio | 110 $0 | Added +20 |
| BARCLAYS PLC 0.00% of their portfolio | 50 $108 | New |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 37 $80 | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 23 $49 | Unchanged |
| Rockefeller Capital Management L.P. 0.00% of their portfolio | 10 $22 | Unchanged |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 10 $22 | Reduced -1 |
| Farther Finance Advisors, LLC 0.00% of their portfolio | 4 $9 | New |
| VISION FINANCIAL MARKETS LLC 0.00% of their portfolio | 2 $5 | Unchanged |
| Arax Advisory Partners 0.00% of their portfolio | 2 $4 | New |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 2 $4 | Unchanged |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 1 $2 | Unchanged |
| TSFG, LLC 0.00% of their portfolio | 1 $0 | Unchanged |