AXSOME THERAPEUTICS INC AXSM
COM · Common Stock · CUSIP 05464T104 · ISIN US05464T1043
American biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Founded2012
- Websiteaxsome.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($15.5m this quarter). Holder counts are more reliable. Shares outstanding: 48.8m as of 2025-02-11, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $84.60. Options: 25 managers hold calls ($180.6m notional), 17 hold puts ($121.1m).
Trends to Q4 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 189 |
| Q4 2022 | 219 |
| Q1 2023 | 198 |
| Q2 2023 | 233 |
| Q3 2023 | 229 |
| Q4 2023 | 247 |
| Q1 2024 | 261 |
| Q2 2024 | 258 |
| Q3 2024 | 281 |
| Q4 2024 | 293 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 90 | 106 |
| Q2 2023 | 135 | 72 |
| Q3 2023 | 111 | 98 |
| Q4 2023 | 106 | 112 |
| Q1 2024 | 140 | 100 |
| Q2 2024 | 109 | 130 |
| Q3 2024 | 127 | 117 |
| Q4 2024 | 141 | 129 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2024 | $49.5m | $66.4m | 1.34 |
| Q2 2024 | $50.0m | $45.3m | 0.91 |
| Q3 2024 | $95.7m | $94.0m | 0.98 |
| Q4 2024 | $180.6m | $121.1m | 0.67 |
Biggest buyers
| LAZARD ASSET MANAGEMENT LLC | Added | +451.7k |
| BVF INC/IL | Added | +342.1k |
| PRINCIPAL FINANCIAL GROUP INC | Added | +203.7k |
| CITADEL ADVISORS LLC | Added | +190.7k |
| BNP PARIBAS FINANCIAL MARKETS | Added | +171.9k |
| MORGAN STANLEY | Added | +166.7k |
| Man Group plc | New | +163.4k |
| Tri Locum Partners LP | Added | +158.0k |
| BlackRock, Inc. | Added | +135.0k |
| MARSHALL WACE, LLP | New | +127.1k |
Biggest sellers
| Fairmount Funds Management LLC | Reduced | -891.1k |
| Deep Track Capital, LP | Sold out | -857.2k |
| BANK OF AMERICA CORP /DE/ | Reduced | -522.9k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -465.0k |
| Boxer Capital, LLC | Sold out | -400.0k |
| Point72 Asset Management, L.P. | Reduced | -357.5k |
| Iron Triangle Partners LP | Sold out | -252.3k |
| Bellevue Group AG | Reduced | -248.3k |
| JPMORGAN CHASE & CO | Reduced | -222.3k |
| AMERIPRISE FINANCIAL INC | Reduced | -179.7k |
Biggest calls
| JANE STREET GROUP, LLC | Added | $33.5m395.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $29.4m347.9k shares |
| CITADEL ADVISORS LLC | Added | $18.3m216.2k shares |
| SIMPLEX TRADING, LLC | Added | $14.0m165.6k shares |
| BANK OF AMERICA CORP /DE/ | Added | $12.4m146.0k shares |
| GROUP ONE TRADING LLC | Reduced | $11.6m137.1k shares |
| Caption Management, LLC | Added | $10.9m128.9k shares |
| Sofinnova Investments, Inc. | New | $8.5m100.0k shares |
| Ikarian Capital, LLC | New | $8.5m100.0k shares |
| LMR Partners LLP | New | $6.1m72.2k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $33.1m391.0k shares |
| Caption Management, LLC | New | $18.6m220.0k shares |
| JANE STREET GROUP, LLC | Added | $13.6m160.4k shares |
| GROUP ONE TRADING LLC | Added | $12.9m152.7k shares |
| SIMPLEX TRADING, LLC | Added | $11.0m130.5k shares |
| CITADEL ADVISORS LLC | Added | $10.4m123.5k shares |
| MILLENNIUM MANAGEMENT LLC | Added | $10.1m118.8k shares |
| WOLVERINE TRADING, LLC | Added | $3.0m35.3k shares |
| JPMORGAN CHASE & CO | New | $2.9m34.0k shares |
| D. E. Shaw & Co., Inc. | Unchanged | $2.7m31.5k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2026-07-27 | 5.3% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q4 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 1 | $2.2m | $2.2m |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 1 | $2.3m | $2.3m |
| Q2 2024 | 0 | — | 2 | $3.3m | $2.7m |
| Q3 2024 | 0 | — | 2 | $5.0m | $5.0m |
| Q4 2024 | 0 | — | 0 | — | — |
None reported in Q4 2024.
Holders, Q4 2024
| Manager | Shares | Change |
|---|---|---|
| RTW INVESTMENTS, LP 5.18% of their portfolio | 4.1m $342.8m | Reduced -138.2k |
| VANGUARD GROUP INC 0.01% of their portfolio | 3.9m $330.2m | Reduced -92.9k |
| BlackRock, Inc. 0.01% of their portfolio | 3.5m $299.0m | Added +135.0k |
| Fairmount Funds Management LLC 12.36% of their portfolio | 1.5m $124.3m | Reduced -891.1k |
| BVF INC/IL 3.98% of their portfolio | 1.4m $117.4m | Added +342.1k |
| FMR LLC 0.01% of their portfolio | 1.0m $84.6m | Reduced -87.6k |
| RA CAPITAL MANAGEMENT, L.P. 1.13% of their portfolio | 1.0m $84.6m | Unchanged |
| MACQUARIE GROUP LTD 0.10% of their portfolio | 964.0k $81.6m | Reduced -31.2k |
| STATE STREET CORP 0.00% of their portfolio | 947.3k $80.1m | Added +30.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 912.5k $77.2m | Added +4.1k |
| EVENTIDE ASSET MANAGEMENT, LLC 1.28% of their portfolio | 828.7k $70.1m | Added +824 |
| ALETHEA CAPITAL MANAGEMENT, LLC 53.19% of their portfolio | 734.3k $62.1m | Reduced -4.2k |
| Invesco Ltd. 0.01% of their portfolio | 692.5k $58.6m | Added +67.3k |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 673.2k $57.0m | Reduced -69.6k |
| PERCEPTIVE ADVISORS LLC 1.57% of their portfolio | 664.1k $56.2m | Reduced -118.8k |
| Hood River Capital Management LLC 0.81% of their portfolio | 644.8k $54.6m | Added +19.7k |
| MORGAN STANLEY 0.00% of their portfolio | 576.9k $48.8m | Added +166.7k |
| LAZARD ASSET MANAGEMENT LLC 0.07% of their portfolio | 537.7k $45.5m | Added +451.7k |
| CITADEL ADVISORS LLC 0.04% of their portfolio | 495.4k $41.9m | Added +190.7k |
| Sofinnova Investments, Inc. 3.05% of their portfolio | 491.7k $41.6m | Added +112.2k |
| Boxer Capital Management, LLC 3.39% of their portfolio | 470.0k $39.8m | First filing |
| PFM Health Sciences, LP 3.01% of their portfolio | 467.4k $39.5m | Unchanged |
| Woodline Partners LP 0.23% of their portfolio | 408.4k $34.6m | Added +109.9k |
| NORGES BANK 0.00% of their portfolio | 403.0k $34.1m | Added +11.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 402.5k $34.1m | Added +69.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 328.0k $27.8m | Added +5.4k |
| Cormorant Asset Management, LP 1.51% of their portfolio | 325.0k $27.5m | Reduced -75.0k |
| LOOMIS SAYLES & CO L P 0.03% of their portfolio | 290.1k $24.5m | Reduced -8.5k |
| Tri Locum Partners LP 4.38% of their portfolio | 249.8k $21.1m | Added +158.0k |
| Nuveen Asset Management, LLC 0.01% of their portfolio | 221.2k $18.7m | Added +119.8k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 217.6k $18.4m | Reduced -145.1k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 207.1k $17.5m | Added +203.7k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 204.6k $17.3m | Reduced -522.9k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 201.9k $17.1m | Reduced -222.3k |
| First Turn Management, LLC 2.91% of their portfolio | 192.1k $16.3m | Reduced -63.1k |
| Avidity Partners Management LP 1.59% of their portfolio | 188.0k $15.9m | Reduced -108.1k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 185.7k $15.7m | Added +171.9k |
| Point72 Asset Management, L.P. 0.04% of their portfolio | 185.1k $15.7m | Reduced -357.5k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 182.3k $15.4m | Added +21.8k |
| Balyasny Asset Management L.P. 0.04% of their portfolio | 181.2k $15.3m | Added +119.0k |
| Checkpoint Capital L.P. 7.53% of their portfolio | 174.8k $14.8m | Reduced -34.9k |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 174.6k $14.8m | First filing |
| Man Group plc 0.04% of their portfolio | 163.4k $13.8m | New |
| Qube Research & Technologies Ltd 0.02% of their portfolio | 155.9k $13.2m | Added +125.5k |
| UBS Group AG 0.00% of their portfolio | 147.3k $12.5m | Added +99.6k |
| HSBC HOLDINGS PLC 0.01% of their portfolio | 136.8k $11.6m | Reduced -279 |
| Bank of New York Mellon Corp 0.00% of their portfolio | 134.6k $11.4m | Reduced -1.9k |
| US BANCORP \DE\ 0.01% of their portfolio | 131.0k $11.1m | Reduced -2.1k |
| MARSHALL WACE, LLP 0.01% of their portfolio | 127.1k $10.8m | New |
| IRIDIAN ASSET MANAGEMENT LLC/CT 2.82% of their portfolio | 125.1k $10.6m | Reduced -1.7k |
| Rhenman & Partners Asset Management AB 1.07% of their portfolio | 122.6k $10.4m | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 120.5k $10.2m | Added +32.8k |
| Bellevue Group AG 0.19% of their portfolio | 118.9k $10.1m | Reduced -248.3k |
| Cubist Systematic Strategies, LLC 0.16% of their portfolio | 116.9k $9.9m | New |
| Caption Management, LLC 0.40% of their portfolio | 115.7k $9.8m | Added +105.7k |
| Clearbridge Investments, LLC 0.01% of their portfolio | 113.1k $9.6m | Reduced -1.2k |
| WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 112.0k $9.5m | Reduced -1.7k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 102.7k $8.7m | Added +8.3k |
| BARCLAYS PLC 0.00% of their portfolio | 98.0k $8.3m | Added +36.2k |
| Granite Investment Partners, LLC 0.34% of their portfolio | 91.6k $7.8m | New |
| Squarepoint Ops LLC 0.02% of their portfolio | 89.4k $7.6m | New |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.22% of their portfolio | 87.2k $7.4m | Added +15.3k |
| Cannell & Spears LLC 0.14% of their portfolio | 82.1k $6.9m | Unchanged |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 78.4k $6.6m | Reduced -51.6k |
| Affinity Asset Advisors, LLC 0.99% of their portfolio | 75.0k $6.3m | Reduced -5.0k |
| DNB Asset Management AS 0.03% of their portfolio | 73.8k $6.2m | Added +67.6k |
| Connor, Clark & Lunn Investment Management Ltd. 0.03% of their portfolio | 73.5k $6.2m | New |
| Aberdeen Group plc 0.01% of their portfolio | 72.2k $6.1m | Added +61.1k |
| IFP Advisors, Inc 0.19% of their portfolio | 67.8k $5.7m | Added +18.0k |
| Ally Bridge Group (NY) LLC 4.84% of their portfolio | 66.7k $5.6m | New |
| Privium Fund Management B.V. 1.19% of their portfolio | 62.2k $5.3m | Reduced -18.0k |
| Lindbrook Capital, LLC 0.47% of their portfolio | 62.1k $5.3m | Reduced -2.6k |
| Swiss National Bank 0.00% of their portfolio | 61.4k $5.2m | Added +900 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.01% of their portfolio | 60.0k $5.1m | Reduced -465.0k |
| Hennion & Walsh Asset Management, Inc. 0.22% of their portfolio | 57.8k $4.9m | Reduced -312 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 57.6k $4.9m | Added +9.9k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 54.6k $4.6m | Added +11.5k |
| BLAIR WILLIAM & CO/IL 0.01% of their portfolio | 54.4k $4.6m | Reduced -788 |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.04% of their portfolio | 52.8k $4.5m | Reduced -67.8k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 51.2k $4.3m | Reduced -148 |
| MPM BIOIMPACT LLC 0.60% of their portfolio | 50.0k $4.2m | New |
| BALDWIN WEALTH PARTNERS LLC/MA 0.29% of their portfolio | 49.6k $4.2m | Reduced -125 |
| SEI INVESTMENTS CO 0.01% of their portfolio | 48.2k $4.1m | Reduced -131 |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 46.6k $3.9m | Reduced -78.4k |
| Moody Aldrich Partners LLC 0.71% of their portfolio | 45.1k $3.8m | Reduced -15.5k |
| GROUP ONE TRADING LLC 0.13% of their portfolio | 43.8k $3.7m | Reduced -6.3k |
| CITIGROUP INC 0.00% of their portfolio | 43.0k $3.6m | Added +7.3k |
| Point72 Europe (London) LLP 0.20% of their portfolio | 41.7k $3.5m | Added +7.2k |
| Tetragon Partners GP Ltd 1.13% of their portfolio | 41.2k $3.5m | New |
| Jefferies Financial Group Inc. 0.04% of their portfolio | 40.7k $3.4m | New |
| J. Goldman & Co LP 0.12% of their portfolio | 40.3k $3.4m | Added +32.0k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 39.7k $3.4m | Reduced -221 |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.04% of their portfolio | 39.5k $3.3m | Reduced -35 |
| ALPS ADVISORS INC 0.02% of their portfolio | 39.2k $3.3m | New |
| Brevan Howard Capital Management LP 0.08% of their portfolio | 38.7k $3.3m | Added +24.4k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 38.2k $3.2m | Added +11.0k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.07% of their portfolio | 37.9k $3.2m | Added +18.5k |
| ROYCE & ASSOCIATES LP 0.03% of their portfolio | 37.0k $3.1m | Added +14.5k |
| Legal & General Group Plc 0.00% of their portfolio | 36.4k $3.1m | Added +2.1k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 35.1k $3.0m | Added +15.0k |