AXSOME THERAPEUTICS INC AXSM
COM · Common Stock · CUSIP 05464T104 · ISIN US05464T1043
American biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Founded2012
- Websiteaxsome.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($489.9k this quarter). Holder counts are more reliable. Shares outstanding: 47.4m as of 2024-02-13, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $79.59. Options: 18 managers hold calls ($79.2m notional), 15 hold puts ($41.4m).
Trends to Q4 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 189 |
| Q4 2022 | 219 |
| Q1 2023 | 198 |
| Q2 2023 | 233 |
| Q3 2023 | 229 |
| Q4 2023 | 247 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 110 | 101 |
| Q1 2023 | 90 | 106 |
| Q2 2023 | 135 | 72 |
| Q3 2023 | 111 | 98 |
| Q4 2023 | 106 | 112 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2023 | $79.2m | $56.9m | 0.72 |
| Q2 2023 | $105.6m | $60.5m | 0.57 |
| Q3 2023 | $56.4m | $36.8m | 0.65 |
| Q4 2023 | $79.2m | $41.4m | 0.52 |
Biggest buyers
| MORGAN STANLEY | Added | +940.3k |
| PERCEPTIVE ADVISORS LLC | Added | +556.4k |
| MILLENNIUM MANAGEMENT LLC | Added | +406.9k |
| Point72 Asset Management, L.P. | Added | +305.3k |
| BlackRock Inc. | Added | +305.3k |
| JPMORGAN CHASE & CO | Added | +207.4k |
| BARCLAYS PLC | Added | +175.1k |
| Avidity Partners Management LP | Added | +162.6k |
| BANK OF AMERICA CORP /DE/ | Added | +139.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +123.9k |
Biggest sellers
| FMR LLC | Reduced | -976.5k |
| Nicholas Investment Partners, LP | Reduced | -312.3k |
| Soleus Capital Management, L.P. | Sold out | -237.5k |
| CITADEL ADVISORS LLC | Reduced | -206.5k |
| BVF INC/IL | Reduced | -150.0k |
| Deep Track Capital, LP | Reduced | -140.7k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Reduced | -121.7k |
| Allspring Global Investments Holdings, LLC | Sold out | -103.7k |
| HHLR ADVISORS, LTD. | Sold out | -100.0k |
| Squarepoint Ops LLC | Reduced | -94.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $25.5m321.0k shares |
| GROUP ONE TRADING LLC | Added | $11.7m147.6k shares |
| JANE STREET GROUP, LLC | Added | $10.3m128.9k shares |
| CITADEL ADVISORS LLC | Added | $8.8m110.9k shares |
| GTS SECURITIES LLC | Added | $6.0m76.0k shares |
| BARCLAYS PLC | New | $4.1m52.0k shares |
| SIMPLEX TRADING, LLC | Added | $3.0m37.2k shares |
| D. E. Shaw & Co., Inc. | Unchanged | $2.8m34.6k shares |
| PEAK6 Investments LLC | Added | $2.2m27.7k shares |
| WOLVERINE TRADING, LLC | Added | $2.0m25.4k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $11.1m139.5k shares |
| CITADEL ADVISORS LLC | Reduced | $7.2m90.7k shares |
| GROUP ONE TRADING LLC | Reduced | $5.5m68.6k shares |
| JANE STREET GROUP, LLC | Reduced | $4.7m59.1k shares |
| BARCLAYS PLC | New | $4.1m52.0k shares |
| GOLDMAN SACHS GROUP INC | Unchanged | $2.8m35.4k shares |
| WOLVERINE TRADING, LLC | Added | $1.9m23.3k shares |
| MILLENNIUM MANAGEMENT LLC | Added | $1.7m21.2k shares |
| SIMPLEX TRADING, LLC | Added | $1.4m17.3k shares |
| GTS SECURITIES LLC | Reduced | $509.4k6.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2026-07-27 | 5.3% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q4 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 1 | $2.2m | $2.2m |
| Q4 2023 | 0 | — | 0 | — | — |
None reported in Q4 2023.
Holders, Q4 2023
| Manager | Shares | Change |
|---|---|---|
| RTW INVESTMENTS, LP 5.58% of their portfolio | 4.5m $357.3m | Unchanged |
| VANGUARD GROUP INC 0.01% of their portfolio | 3.7m $294.2m | Reduced -32.4k |
| BlackRock Inc. 0.01% of their portfolio | 3.2m $257.9m | Added +305.3k |
| Fairmount Funds Management LLC 19.85% of their portfolio | 2.4m $187.8m | Added +18.8k |
| BVF INC/IL 3.95% of their portfolio | 2.0m $157.7m | Reduced -150.0k |
| MORGAN STANLEY 0.00% of their portfolio | 1.2m $98.6m | Added +940.3k |
| CITADEL ADVISORS LLC 0.09% of their portfolio | 1.1m $86.7m | Reduced -206.5k |
| PERCEPTIVE ADVISORS LLC 1.85% of their portfolio | 1.0m $82.6m | Added +556.4k |
| RA CAPITAL MANAGEMENT, L.P. 1.24% of their portfolio | 1.0m $79.6m | Unchanged |
| Deep Track Capital, LP 2.79% of their portfolio | 1.0m $79.6m | Reduced -140.7k |
| STATE STREET CORP 0.00% of their portfolio | 924.2k $73.6m | Added +56.5k |
| MILLENNIUM MANAGEMENT LLC 0.07% of their portfolio | 910.0k $72.4m | Added +406.9k |
| FMR LLC 0.01% of their portfolio | 882.0k $70.2m | Reduced -976.5k |
| Point72 Asset Management, L.P. 0.20% of their portfolio | 837.2k $66.6m | Added +305.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 822.3k $65.5m | Added +43.8k |
| ALETHEA CAPITAL MANAGEMENT, LLC 69.06% of their portfolio | 752.0k $59.9m | Reduced -6.8k |
| Pictet Asset Management Holding SA 0.06% of their portfolio | 698.9k $55.6m | Added +52.5k |
| Bellevue Group AG 0.77% of their portfolio | 635.4k $50.6m | Added +3.9k |
| Jefferies Financial Group Inc. 0.70% of their portfolio | 563.3k $44.8m | Added +10.1k |
| Woodline Partners LP 0.49% of their portfolio | 562.2k $44.7m | Added +110.1k |
| PFM Health Sciences, LP 2.23% of their portfolio | 467.4k $37.2m | Reduced -55.8k |
| Avidity Partners Management LP 1.40% of their portfolio | 459.4k $36.6m | Added +162.6k |
| Boxer Capital, LLC 1.59% of their portfolio | 400.0k $31.8m | Unchanged |
| Hood River Capital Management LLC 0.86% of their portfolio | 392.8k $31.3m | Added +9.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 379.8k $30.2m | Added +207.4k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.06% of their portfolio | 365.0k $29.1m | Added +40.0k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.45% of their portfolio | 346.7k $27.6m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 343.3k $27.3m | Reduced -5.7k |
| TANG CAPITAL MANAGEMENT LLC 2.35% of their portfolio | 320.0k $25.5m | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 295.7k $23.5m | Added +5.8k |
| First Turn Management, LLC 3.38% of their portfolio | 295.4k $23.5m | First filing |
| Driehaus Capital Management LLC 0.25% of their portfolio | 265.8k $21.2m | Added +17.0k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 239.8k $19.1m | Added +2.3k |
| Nuveen Asset Management, LLC 0.01% of their portfolio | 234.6k $18.7m | Added +18.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 205.8k $16.4m | Added +46.6k |
| NORGES BANK 0.00% of their portfolio | 195.1k $15.5m | Reduced -15.1k |
| BARCLAYS PLC 0.01% of their portfolio | 191.9k $15.3m | Added +175.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 176.2k $14.0m | Added +139.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 166.3k $13.2m | Reduced -1.7k |
| Ghost Tree Capital, LLC 7.56% of their portfolio | 165.0k $13.1m | Added +55.0k |
| Checkpoint Capital L.P. 8.63% of their portfolio | 155.3k $12.4m | First filing |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 146.6k $11.7m | Added +123.9k |
| US BANCORP \DE\ 0.02% of their portfolio | 143.4k $11.4m | Added +4.7k |
| IRIDIAN ASSET MANAGEMENT LLC/CT 2.00% of their portfolio | 138.3k $11.0m | Reduced -6.7k |
| Altium Capital Management LLC 7.57% of their portfolio | 138.0k $11.0m | Added +46.0k |
| Tri Locum Partners LP 5.11% of their portfolio | 130.7k $10.4m | Reduced -11.8k |
| Schonfeld Strategic Advisors LLC 0.07% of their portfolio | 106.8k $8.5m | Added +39.1k |
| WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 104.8k $8.3m | Added +8.8k |
| CITIGROUP INC 0.01% of their portfolio | 101.7k $8.1m | Reduced -935 |
| Ally Bridge Group (NY) LLC 4.78% of their portfolio | 100.9k $8.0m | Reduced -9.7k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.08% of their portfolio | 94.9k $7.6m | Reduced -65.8k |
| MPM BIOIMPACT LLC 1.74% of their portfolio | 93.4k $7.4m | Reduced -199 |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 92.8k $7.4m | Reduced -32.8k |
| Artia Global Partners LP 2.77% of their portfolio | 87.8k $7.0m | Unchanged |
| Candriam S.C.A. 0.05% of their portfolio | 85.1k $6.8m | Added +35.0k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.20% of their portfolio | 84.8k $6.8m | Reduced -6.3k |
| Lindbrook Capital, LLC 0.67% of their portfolio | 84.1k $6.7m | Reduced -233 |
| Cannell & Co. 0.21% of their portfolio | 82.8k $6.6m | Reduced -21.3k |
| Nicholas Investment Partners, LP 0.77% of their portfolio | 82.6k $6.6m | Reduced -312.3k |
| HSBC HOLDINGS PLC 0.01% of their portfolio | 80.4k $6.4m | Reduced -68.4k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 79.9k $6.4m | Added +19.8k |
| Rhenman & Partners Asset Management AB 0.63% of their portfolio | 79.1k $6.3m | Added +39.0k |
| Privium Fund Management B.V. 1.55% of their portfolio | 72.0k $5.6m | Unchanged |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 69.9k $5.6m | New |
| Moody Aldrich Partners LLC 0.96% of their portfolio | 66.9k $5.3m | Reduced -6.8k |
| Atika Capital Management LLC 0.75% of their portfolio | 66.7k $5.3m | Reduced -4.3k |
| HighVista Strategies LLC 1.80% of their portfolio | 62.3k $5.0m | Added +5.3k |
| Hennion & Walsh Asset Management, Inc. 0.28% of their portfolio | 60.6k $4.8m | Reduced -6.4k |
| Swiss National Bank 0.00% of their portfolio | 60.5k $4.8m | Reduced -11.2k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 58.3k $4.6m | New |
| Lighthouse Investment Partners, LLC 0.33% of their portfolio | 56.2k $4.5m | New |
| WMS Partners, LLC 0.30% of their portfolio | 50.7k $4.0m | Reduced -30.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 50.6k $4.0m | Reduced -208 |
| Affinity Asset Advisors, LLC 0.79% of their portfolio | 50.0k $4.0m | New |
| BALDWIN WEALTH PARTNERS LLC/MA 0.31% of their portfolio | 49.0k $3.9m | Added +1.0k |
| Invesco Ltd. 0.00% of their portfolio | 46.2k $3.7m | Reduced -16.3k |
| PUTNAM INVESTMENTS LLC 0.00% of their portfolio | 45.5k $3.6m | Reduced -74.8k |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 44.3k $3.5m | New |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 44.1k $3.5m | Reduced -13.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 41.3k $3.3m | Unchanged |
| UBS Group AG 0.00% of their portfolio | 40.1k $3.2m | Added +7.3k |
| CWM, LLC 0.02% of their portfolio | 38.4k $3.1m | Reduced -1.8k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 38.0k $3.0m | Added +5.6k |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.03% of their portfolio | 34.6k $2.8m | Reduced -1.6k |
| SVB FINANCIAL GROUP 2.39% of their portfolio | 33.8k $2.7m | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 33.2k $2.6m | Reduced -3.4k |
| Legal & General Group Plc 0.00% of their portfolio | 33.0k $2.6m | Reduced -883 |
| SEI INVESTMENTS CO 0.00% of their portfolio | 33.0k $2.6m | Reduced -28.2k |
| ALPS ADVISORS INC 0.02% of their portfolio | 32.5k $2.6m | Reduced -2.3k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 30.3k $2.4m | Added +9.9k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 30.0k $2.4m | Reduced -4.4k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 30.0k $2.4m | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 28.0k $2.2m | Added +3.1k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 27.5k $2.2m | Added +6.0k |
| Phocas Financial Corp. 0.28% of their portfolio | 26.9k $2.1m | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 26.2k $2.1m | Added +6.4k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 25.2k $2.0m | Reduced -3.9k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 21.6k $1.7m | Reduced -35.0k |
| TRUIST FINANCIAL CORP 0.00% of their portfolio | 21.1k $1.7m | New |
| SIMPLEX TRADING, LLC 0.05% of their portfolio | 20.8k $1.7m | Added +13.3k |