LEONABIO INC LONA
COM · Common Stock · CUSIP 04746L203
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersBothell, WA
- FilingsSEC EDGAR
42
institutional holders
+8 vs Q3 2025
6.1m
shares reported held*
$45.6mreported value*
12 new
8 added
6 reduced
7 sold out
net bought ≈ $27.1m (+3.6m shares)
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.1m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $7.53.
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2025 | 34 |
| Q4 2025 | 42 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
CallsPuts
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $0 | $0 | — |
| Q2 2025 | $0 | $0 | — |
| Q3 2025 | $2.5k | $0 | 0.00 |
| Q4 2025 | $0 | $0 | — |
Biggest buyers
| PERCEPTIVE ADVISORS LLC | Added | +1.3m |
| ACORN CAPITAL ADVISORS, LLC | New | +501.7k |
| NEA Management Company, LLC | New | +464.4k |
| Commodore Capital LP | New | +464.4k |
| TCG Crossover Management, LLC | New | +464.4k |
| ADAR1 Capital Management, LLC | New | +393.7k |
| MILLENNIUM MANAGEMENT LLC | New | +324.4k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +23.2k |
| JANE STREET GROUP, LLC | New | +13.2k |
| Laird Norton Wetherby Trust Company, LLC | Added | +11.7k |
Biggest sellers
| BML Capital Management, LLC | Sold out | -323.1k |
| TANG CAPITAL MANAGEMENT LLC | Sold out | -60.0k |
| CITADEL ADVISORS LLC | Sold out | -34.0k |
| TWO SIGMA ADVISERS, LP | Sold out | -14.9k |
| Focus Partners Wealth | Sold out | -8.4k |
| ACADIAN ASSET MANAGEMENT LLC | Reduced | -2.7k |
| Tower Research Capital LLC (TRC) | Reduced | -259 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -50 |
| MORGAN STANLEY | Reduced | -40 |
| JPMORGAN CHASE & CO | Reduced | -12 |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Sermonix Pharmaceuticals, Inc.
13D · may seek influence
-11.8 pts · filed 2026-10-28
Stated purposeThe assignment of the remaining prefunded warrant rights to acquire 2,352,932 common shares of Issuer effects the previously disclosed distribution-in-kind to PXV II as part of the plan of distribution to the owners of Sermonix's common stock as described in the original Schedule 13D and Item 5. Full filing |
25.1% |
| PERCEPTIVE ADVISORS LLC 13D · may seek influence no change · filed 2026-10-26 | 20.0% |
| ACORN BIOVENTURES, L.P. 13G · passive investor filed 2026-08-20 | 12.1% |
| ADAR1 Capital Management, LLC 13G · institution new · filed 2026-05-15 | 7.7% |
Fell to 5% or below in the last year: Baselake Partners, LP (1.9%, 2026-02-06)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
BuyingSelling
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 5 | $24.6k | — |
| Q2 2024 | 1 | $100.2k | 0 | — | — |
| Q3 2024 | 0 | — | 5 | $5.0k | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 5 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 5 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
None reported in Q4 2025.
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| PERCEPTIVE ADVISORS LLC 0.26% of their portfolio | 1.9m $14.1m | Added +1.3m |
| ACORN CAPITAL ADVISORS, LLC 1.29% of their portfolio | 501.7k $3.8m | New |
| NEA Management Company, LLC 0.18% of their portfolio | 464.4k $3.5m | New |
| Commodore Capital LP 0.23% of their portfolio | 464.4k $3.5m | New |
| TCG Crossover Management, LLC 0.11% of their portfolio | 464.4k $3.3m | New |
| ADAR1 Capital Management, LLC 0.22% of their portfolio | 393.7k $2.9m | New |
| Spruce Street Capital LP 0.98% of their portfolio | 393.7k $3.0m | First filing |
| Kalehua Capital Management LLC 2.95% of their portfolio | 393.7k $3.0m | First filing |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 324.4k $2.5m | New |
| VANGUARD GROUP INC 0.00% of their portfolio | 153.8k $1.2m | Unchanged |
| Simplify Asset Management Inc. 0.02% of their portfolio | 149.3k $1.1m | Unchanged |
| Propel Bio Management, LLC 0.96% of their portfolio | 149.3k $1.1m | Unchanged |
| Seven Fleet Capital Management LP 0.66% of their portfolio | 128.0k $968.6k | First filing |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 75.1k $568.9k | Added +23.2k |
| Pathstone Holdings, LLC 0.00% of their portfolio | 38.6k $278.9k | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 37.6k $285.0k | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 37.5k $282.0k | Reduced -2.7k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 32.8k $248.6k | Added +226 |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 30.9k $234.3k | Added +351 |
| Laird Norton Wetherby Trust Company, LLC 0.00% of their portfolio | 21.8k $165.2k | Added +11.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 20.9k $158.5k | Reduced -50 |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 13.2k $99.8k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 10.7k $81.3k | New |
| STATE STREET CORP 0.00% of their portfolio | 10.7k $81.3k | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 10.5k $79.2k | New |
| Scientech Research LLC 0.05% of their portfolio | 10.1k $76.5k | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 9.2k $69.7k | Added +2.2k |
| UBS Group AG 0.00% of their portfolio | 3.4k $25.6k | Added +3.2k |
| MORGAN STANLEY 0.00% of their portfolio | 470 $3.6k | Reduced -40 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 379 $2.9k | Reduced -259 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 334 $3.0k | Added +267 |
| American Capital Advisory, LLC 0.00% of their portfolio | 200 $1.5k | Unchanged |
| ROTHSCHILD INVESTMENT LLC 0.00% of their portfolio | 150 $1.1k | Unchanged |
| McIlrath & Eck, LLC 0.00% of their portfolio | 82 $621 | Unchanged |
| US BANCORP \DE\ 0.00% of their portfolio | 81 $613 | Unchanged |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 69 $522 | New |
| Global Retirement Partners, LLC 0.00% of their portfolio | 52 $393 | Unchanged |
| NewEdge Advisors, LLC 0.00% of their portfolio | 50 $378 | New |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 33 $250 | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 23 $174 | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 12 $91 | Reduced -12 |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 12 $91 | Reduced -10 |