| 1 |
RA CAPITAL MANAGEMENT, L.P.
24.92% of their portfolio |
BOSTON, MA |
10,281,49610.3m
$2.4bn |
$2.4bn |
24.92% |
Unchanged |
|
| 2 |
Avoro Capital Advisors LLC
11.41% of their portfolio |
NEW YORK, NY |
5,062,5005.1m
$1.2bn |
$1.2bn |
11.41% |
Reduced
-48.6k |
-48,611 |
| 3 |
WESTFIELD CAPITAL MANAGEMENT CO LP
4.62% of their portfolio |
BOSTON, MA |
4,813,4404.8m
$1.1bn |
$1.1bn |
4.62% |
Reduced
-372.3k |
-372,256 |
| 4 |
FMR LLC
0.05% of their portfolio |
BOSTON, MA |
3,876,6013.9m
$886.7m |
$886.7m |
0.05% |
Reduced
-276.7k |
-276,710 |
| 5 |
Artisan Partners Limited Partnership
1.21% of their portfolio |
Milwaukee, WI |
3,230,1883.2m
$738.8m |
$738.8m |
1.21% |
Added
+4.3k |
+4,303 |
| 6 |
FRANKLIN RESOURCES INC
0.11% of their portfolio |
San Mateo, CA |
2,051,9482.1m
$469.3m |
$469.3m |
0.11% |
Added
+141.9k |
+141,869 |
| 7 |
Capital International Investors
0.11% of their portfolio |
Los Angeles, CA |
1,958,8432.0m
$448.0m |
$448.0m |
0.11% |
Reduced
-1.1m |
-1,105,100 |
| 8 |
MASSACHUSETTS FINANCIAL SERVICES CO /MA/
0.14% of their portfolio |
Boston, MA |
1,860,6691.9m
$425.6m |
$425.6m |
0.14% |
Reduced
-25.7k |
-25,724 |
| 9 |
WELLINGTON MANAGEMENT GROUP LLP
0.08% of their portfolio |
Boston, MA |
1,757,6331.8m
$402.0m |
$402.0m |
0.08% |
Reduced
-5.1k |
-5,088 |
| 10 |
PERCEPTIVE ADVISORS LLC
6.92% of their portfolio |
NEW YORK, NY |
1,531,4211.5m
$350.3m |
$350.3m |
6.92% |
Added
+450.0k |
+450,000 |
| 11 |
AMERICAN CENTURY COMPANIES INC
0.16% of their portfolio |
KANSAS CITY, MO |
1,397,1191.4m
$319.6m |
$319.6m |
0.16% |
Reduced
-46.0k |
-46,022 |
| 12 |
Capital World Investors
0.03% of their portfolio |
LOS ANGELES, CA |
900,517900.5k
$206.0m |
$206.0m |
0.03% |
New |
|
| 13 |
PRINCIPAL FINANCIAL GROUP INC
0.11% of their portfolio |
DES MOINES, IA |
896,397896.4k
$205.0m |
$205.0m |
0.11% |
Reduced
-130.0k |
-130,010 |
| 14 |
BlackRock, Inc.
0.00% of their portfolio |
New York, NY |
661,054661.1k
$151.2m |
$151.2m |
0.00% |
Added
+32.9k |
+32,854 |
| 15 |
Polar Capital Holdings Plc
0.65% of their portfolio |
London, X0 |
651,712651.7k
$149.1m |
$149.1m |
0.65% |
Added
+281.2k |
+281,239 |
| 16 |
MORGAN STANLEY
0.01% of their portfolio |
NEW YORK, NY |
606,348606.3k
$138.7m |
$138.7m |
0.01% |
Reduced
-11.6k |
-11,620 |
| 17 |
GOLDMAN SACHS GROUP INC
0.02% of their portfolio |
NEW YORK, NY |
566,192566.2k
$129.5m |
$129.5m |
0.02% |
Reduced
-30.5k |
-30,511 |
| 18 |
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.
0.22% of their portfolio |
PHILADELPHIA, PA |
556,427556.4k
$127.3m |
$127.3m |
0.22% |
Added
+59.6k |
+59,590 |
| 19 |
JPMORGAN CHASE & CO
0.01% of their portfolio |
NEW YORK, NY |
539,434539.4k
$117.8m |
$117.8m |
0.01% |
Added
+32.2k |
+32,194 |
| 20 |
AMERIPRISE FINANCIAL INC
0.03% of their portfolio |
MINNEAPOLIS, MN |
476,466476.5k
$109.0m |
$109.0m |
0.03% |
Reduced
-74.0k |
-74,011 |
| 21 |
FIL Ltd
0.08% of their portfolio |
HAMILTON, D0 |
447,421447.4k
$102.3m |
$102.3m |
0.08% |
Reduced
-31.2k |
-31,220 |
| 22 |
Vestal Point Capital, LP
2.40% of their portfolio |
NEW YORK, NY |
375,000375.0k
$85.8m |
$85.8m |
2.40% |
Added
+200.0k |
+200,000 |
| 23 |
Spyglass Capital Management LLC
5.96% of their portfolio |
Greenbrae, CA |
367,972368.0k
$84.2m |
$84.2m |
5.96% |
Reduced
-47.6k |
-47,577 |
| 24 |
Invesco Ltd.
0.01% of their portfolio |
ATLANTA, GA |
362,109362.1k
$82.8m |
$82.8m |
0.01% |
Reduced
-224.0k |
-223,985 |
| 25 |
SEI INVESTMENTS CO
0.07% of their portfolio |
OAKS, PA |
351,146351.1k
$80.3m |
$80.3m |
0.07% |
Added
+69.7k |
+69,673 |
| 26 |
BNP PARIBAS FINANCIAL MARKETS
0.05% of their portfolio |
PARIS, I0 |
309,173309.2k
$70.7m |
$70.7m |
0.05% |
Added
+2.1k |
+2,087 |
| 27 |
FRED ALGER MANAGEMENT, LLC
0.31% of their portfolio |
NEW YORK, NY |
304,896304.9k
$69.7m |
$69.7m |
0.31% |
Reduced
-47.2k |
-47,213 |
| 28 |
ALLIANCEBERNSTEIN L.P.
0.02% of their portfolio |
NASHVILLE, TN |
278,203278.2k
$59.3m |
$59.3m |
0.02% |
Reduced
-10.4k |
-10,389 |
| 29 |
Tri Locum Partners LP
8.20% of their portfolio |
NEW YORK, NY |
255,332255.3k
$58.4m |
$58.4m |
8.20% |
Reduced
-9.7k |
-9,683 |
| 30 |
Pictet Asset Management Holding SA
0.06% of their portfolio |
CAROUGE, V8 |
251,833251.8k
$56.9m |
$56.9m |
0.06% |
Added
+178.4k |
+178,415 |
| 31 |
Candriam S.C.A.
0.27% of their portfolio |
STRASSEN, N4 |
230,278230.3k
$52.7m |
$52.7m |
0.27% |
Added
+43.3k |
+43,338 |
| 32 |
Bank of New York Mellon Corp
0.01% of their portfolio |
NEW YORK, NY |
228,675228.7k
$52.3m |
$52.3m |
0.01% |
Added
+34.1k |
+34,070 |
| 33 |
TWO SIGMA INVESTMENTS, LP
0.04% of their portfolio |
NEW YORK, NY |
220,341220.3k
$50.4m |
$50.4m |
0.04% |
Reduced
-27.6k |
-27,551 |
| 34 |
TD Asset Management Inc
0.04% of their portfolio |
Toronto, A6 |
217,992218.0k
$49.9m |
$49.9m |
0.04% |
Reduced
-16.0k |
-16,020 |
| 35 |
Aberdeen Group plc
0.08% of their portfolio |
EDINBURGH, X0 |
210,154210.2k
$48.1m |
$48.1m |
0.08% |
Reduced
-11.5k |
-11,523 |
| 36 |
ARS Investment Partners, LLC
2.49% of their portfolio |
New York, NY |
209,456209.5k
$47.9m |
$47.9m |
2.49% |
Added
+34.8k |
+34,845 |
| 37 |
UBS Group AG
0.01% of their portfolio |
ZURICH, V8 |
207,339207.3k
$47.4m |
$47.4m |
0.01% |
Reduced
-100.9k |
-100,851 |
| 38 |
BANK OF AMERICA CORP /DE/
0.00% of their portfolio |
CHARLOTTE, NC |
198,505198.5k
$45.4m |
$45.4m |
0.00% |
Added
+36.0k |
+36,002 |
| 39 |
Rock Springs Capital Management LP
2.62% of their portfolio |
Baltimore, MD |
194,000194.0k
$44.4m |
$44.4m |
2.62% |
Reduced
-9.5k |
-9,500 |
| 40 |
MILLENNIUM MANAGEMENT LLC
0.03% of their portfolio |
NEW YORK, NY |
189,027189.0k
$43.2m |
$43.2m |
0.03% |
Reduced
-73.3k |
-73,302 |
| 41 |
Allspring Global Investments Holdings, LLC
0.07% of their portfolio |
CHARLOTTE, NC |
184,224184.2k
$42.0m |
$42.0m |
0.07% |
Reduced
-3.4k |
-3,418 |
| 42 |
ORBIMED ADVISORS LLC
0.91% of their portfolio |
New York, NY |
181,977182.0k
$41.6m |
$41.6m |
0.91% |
Added
+10.0k |
+10,000 |
| 43 |
NEW YORK STATE COMMON RETIREMENT FUND
0.05% of their portfolio |
ALBANY, NY |
171,112171.1k
$39.1m |
$39.1m |
0.05% |
Reduced
-11.1k |
-11,122 |
| 44 |
WELLS FARGO & COMPANY/MN
0.01% of their portfolio |
SAN FRANCISCO, CA |
154,199154.2k
$35.3m |
$35.3m |
0.01% |
Added
+120.4k |
+120,419 |
| 45 |
PFM Health Sciences, LP
3.66% of their portfolio |
SAN FRANCISCO, CA |
152,034152.0k
$34.8m |
$34.8m |
3.66% |
Reduced
-25.7k |
-25,651 |
| 46 |
RICE HALL JAMES & ASSOCIATES, LLC
1.89% of their portfolio |
San Diego, CA |
148,386148.4k
$33.9m |
$33.9m |
1.89% |
Added
+3.3k |
+3,340 |
| 47 |
LORD, ABBETT & CO. LLC
0.11% of their portfolio |
JERSEY CITY, NJ |
145,317145.3k
$33.2m |
$33.2m |
0.11% |
Added
+25.1k |
+25,120 |
| 48 |
DEUTSCHE BANK AG\
0.01% of their portfolio |
FRANKFURT AM MAIN, 2M |
135,187135.2k
$30.9m |
$30.9m |
0.01% |
Reduced
-161.6k |
-161,631 |
| 49 |
Frazier Life Sciences Management, L.P.
0.78% of their portfolio |
PALO ALTO, CA |
133,333133.3k
$30.5m |
$30.5m |
0.78% |
Unchanged |
|
| 50 |
BRAUN STACEY ASSOCIATES INC
1.00% of their portfolio |
NEW YORK, NY |
130,992131.0k
$30.0m |
$30.0m |
1.00% |
Added
+11.9k |
+11,897 |
| 51 |
Catalio Capital Management, LP
6.17% of their portfolio |
NEW YORK, NY |
129,111129.1k
$29.5m |
$29.5m |
6.17% |
Added
+9.8k |
+9,846 |
| 52 |
ODDO BHF ASSET MANAGEMENT SAS
1.16% of their portfolio |
PARIS, I0 |
128,657128.7k
$29.4m |
$29.4m |
1.16% |
Reduced
-1.3k |
-1,284 |
| 53 |
SILVERARC CAPITAL MANAGEMENT, LLC
3.36% of their portfolio |
BOSTON, MA |
124,658124.7k
$28.5m |
$28.5m |
3.36% |
Added
+75.4k |
+75,430 |
| 54 |
Chevy Chase Trust Holdings, LLC
0.08% of their portfolio |
BETHESDA, MD |
123,467123.5k
$28.2m |
$28.2m |
0.08% |
Added
+66.8k |
+66,772 |
| 55 |
SG Americas Securities, LLC
0.03% of their portfolio |
NEW YORK, NY |
120,790120.8k
$27.6m |
$27.6m |
0.03% |
Added
+109.6k |
+109,577 |
| 56 |
RENAISSANCE TECHNOLOGIES LLC
0.04% of their portfolio |
NEW YORK, NY |
117,332117.3k
$26.8m |
$26.8m |
0.04% |
New |
|
| 57 |
Integral Health Asset Management, LLC
1.39% of their portfolio |
New York, NY |
115,000115.0k
$26.3m |
$26.3m |
1.39% |
Added
+25.0k |
+25,000 |
| 58 |
VOLORIDGE INVESTMENT MANAGEMENT, LLC
0.10% of their portfolio |
JUPITER, FL |
114,275114.3k
$26.1m |
$26.1m |
0.10% |
Reduced
-101.9k |
-101,898 |
| 59 |
Woodline Partners LP
0.09% of their portfolio |
San Francisco, CA |
102,469102.5k
$23.4m |
$23.4m |
0.09% |
Added
+8 |
+8 |
| 60 |
Perpetual Ltd
0.35% of their portfolio |
SYDNEY, NEW SOUTH WALES, C3 |
100,638100.6k
$23.0m |
$23.0m |
0.35% |
New |
|
| 61 |
Troluce Capital Advisors LLC
2.41% of their portfolio |
DORADO, PR |
99,60099.6k
$22.8m |
$22.8m |
2.41% |
New |
|
| 62 |
Resolute Capital Asset Partners LLC
11.87% of their portfolio |
DENVER, CO |
98,62798.6k
$22.6m |
$22.6m |
11.87% |
Added
+10.0k |
+10,000 |
| 63 |
Cormorant Asset Management, LP
1.10% of their portfolio |
BOSTON, MA |
95,00095.0k
$21.7m |
$21.7m |
1.10% |
Reduced
-5.0k |
-5,000 |
| 64 |
Affinity Asset Advisors, LLC
1.27% of their portfolio |
NEW YORK, NY |
95,00095.0k
$21.7m |
$21.7m |
1.27% |
Added
+65.0k |
+65,000 |
| 65 |
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP
0.01% of their portfolio |
BOSTON, MA |
91,47091.5k
$20.9m |
$20.9m |
0.01% |
New |
|
| 66 |
STATE STREET CORP
0.00% of their portfolio |
BOSTON, MA |
87,33487.3k
$20.0m |
$20.0m |
0.00% |
Added
+19.4k |
+19,385 |
| 67 |
Eagle Health Investments LP
4.16% of their portfolio |
Greenwich, CT |
86,65086.7k
$19.8m |
$19.8m |
4.16% |
New |
|
| 68 |
LOOMIS SAYLES & CO L P
0.02% of their portfolio |
BOSTON, MA |
80,40580.4k
$18.4m |
$18.4m |
0.02% |
Reduced
-31.8k |
-31,835 |
| 69 |
NATIONAL BANK OF CANADA /FI/
0.02% of their portfolio |
MONTREAL, A8 |
80,01780.0k
$18.3m |
$18.3m |
0.02% |
New |
|
| 70 |
First Turn Management, LLC
1.95% of their portfolio |
DEL MAR, CA |
76,30076.3k
$17.5m |
$17.5m |
1.95% |
Reduced
-55.5k |
-55,508 |
| 71 |
GEODE CAPITAL MANAGEMENT, LLC
0.00% of their portfolio |
BOSTON, MA |
72,94172.9k
$16.7m |
$16.7m |
0.00% |
Added
+4.1k |
+4,086 |
| 72 |
Synergy Asset Management, LLC
1.71% of their portfolio |
VANCOUVER, WA |
70,45670.5k
$16.1m |
$16.1m |
1.71% |
New |
|
| 73 |
SCHRODER INVESTMENT MANAGEMENT GROUP
0.01% of their portfolio |
London, X0 |
67,90267.9k
$14.8m |
$14.8m |
0.01% |
Reduced
-5.4k |
-5,408 |
| 74 |
Voleon Capital Management LP
0.33% of their portfolio |
BERKELEY, CA |
67,83967.8k
$15.5m |
$15.5m |
0.33% |
Reduced
-1.6k |
-1,550 |
| 75 |
CASTLEARK MANAGEMENT LLC
0.51% of their portfolio |
CHICAGO, IL |
67,61667.6k
$15.5m |
$15.5m |
0.51% |
Added
+1.3k |
+1,280 |
| 76 |
Trexquant Investment LP
0.11% of their portfolio |
STAMFORD, CT |
65,51765.5k
$15.0m |
$15.0m |
0.11% |
Added
+6.5k |
+6,492 |
| 77 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE
0.01% of their portfolio |
Toronto, A6 |
58,85958.9k
$13.5m |
$13.5m |
0.01% |
Reduced
-2.0k |
-2,036 |
| 78 |
Qube Research & Technologies Ltd
0.02% of their portfolio |
LONDON, X0 |
52,75352.8k
$12.1m |
$12.1m |
0.02% |
Reduced
-140.7k |
-140,711 |
| 79 |
Defilade Capital Management, L.P.
1.67% of their portfolio |
EMERYVILLE, CA |
51,89551.9k
$11.9m |
$11.9m |
1.67% |
Reduced
-33.8k |
-33,799 |
| 80 |
Empowered Funds, LLC
0.07% of their portfolio |
NEWTOWN SQUARE, PA |
51,13551.1k
$11.7m |
$11.7m |
0.07% |
Added
+14.4k |
+14,438 |
| 81 |
VOYA INVESTMENT MANAGEMENT LLC
0.01% of their portfolio |
ATLANTA, GA |
45,59045.6k
$10.4m |
$10.4m |
0.01% |
Reduced
-11.5k |
-11,485 |
| 82 |
NORTHERN TRUST CORP
0.00% of their portfolio |
CHICAGO, IL |
44,97145.0k
$10.3m |
$10.3m |
0.00% |
Added
+12.1k |
+12,117 |
| 83 |
NOMURA ASSET MANAGEMENT CO LTD
0.03% of their portfolio |
TOKYO, M0 |
43,48443.5k
$9.9m |
$9.9m |
0.03% |
Reduced
-217 |
-217 |
| 84 |
Russell Investments Group, Ltd.
0.01% of their portfolio |
Seattle, WA |
40,26640.3k
$9.2m |
$9.2m |
0.01% |
Added
+5.4k |
+5,356 |
| 85 |
SEB Asset Management AB
0.04% of their portfolio |
STOCKHOLM, V7 |
38,66538.7k
$8.8m |
$8.8m |
0.04% |
First filing |
|
| 86 |
DIVERSIFIED TRUST CO
0.16% of their portfolio |
MEMPHIS, TN |
37,16137.2k
$8.5m |
$8.5m |
0.16% |
Reduced
-5.1k |
-5,090 |
| 87 |
BARCLAYS PLC
0.00% of their portfolio |
LONDON, X0 |
35,45335.5k
$8.1m |
$8.1m |
0.00% |
Added
+24.2k |
+24,209 |
| 88 |
FIRST TRUST ADVISORS LP
0.01% of their portfolio |
Wheaton, IL |
31,13531.1k
$7.1m |
$7.1m |
0.01% |
Added
+18.9k |
+18,905 |
| 89 |
VICTORY CAPITAL MANAGEMENT INC
0.00% of their portfolio |
San Antonio, TX |
30,77030.8k
$7.0m |
$7.0m |
0.00% |
Reduced
-12.4k |
-12,420 |
| 90 |
CANADA PENSION PLAN INVESTMENT BOARD
0.00% of their portfolio |
TORONTO ONTARIO, A6 |
30,66330.7k
$7.0m |
$7.0m |
0.00% |
Reduced
-40.9k |
-40,853 |
| 91 |
CITIGROUP INC
0.00% of their portfolio |
NEW YORK, NY |
29,70129.7k
$6.8m |
$6.8m |
0.00% |
Reduced
-1.1k |
-1,142 |
| 92 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP
0.01% of their portfolio |
BALA CYNWYD, PA |
28,06228.1k
$6.4m |
$6.4m |
0.01% |
Reduced
-442.9k |
-442,889 |
| 93 |
Nicholas Investment Partners, LP
0.44% of their portfolio |
RANCHO SANTA FE, CA |
26,86726.9k
$6.1m |
$6.1m |
0.44% |
Added
+20.6k |
+20,602 |
| 94 |
Brevan Howard Capital Management LP
0.06% of their portfolio |
ST. HELIER, Y9 |
26,20026.2k
$6.0m |
$6.0m |
0.06% |
Reduced
-22.1k |
-22,060 |
| 95 |
Matisse Capital
2.55% of their portfolio |
PORTLAND, OR |
26,07726.1k
$6.0m |
$6.0m |
2.55% |
Reduced
-1.2k |
-1,228 |
| 96 |
ADAR1 Capital Management, LLC
0.34% of their portfolio |
AUSTIN, TX |
25,01425.0k
$5.7m |
$5.7m |
0.34% |
Reduced
-300 |
-300 |
| 97 |
CAPITAL INTERNATIONAL SARL
0.09% of their portfolio |
Los Angeles, CA |
24,74924.7k
$5.7m |
$5.7m |
0.09% |
Reduced
-194 |
-194 |
| 98 |
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main
0.01% of their portfolio |
FRANKFURT AM MAIN, 2M |
23,99724.0k
$5.5m |
$5.5m |
0.01% |
Reduced
-24.1k |
-24,100 |
| 99 |
KENNEDY CAPITAL MANAGEMENT LLC
0.12% of their portfolio |
ST LOUIS, MO |
23,83823.8k
$5.5m |
$5.5m |
0.12% |
Added
+4.0k |
+3,976 |
| 100 |
DAFNA Capital Management LLC
1.21% of their portfolio |
LOS ANGELES, CA |
23,17723.2k
$5.3m |
$5.3m |
1.21% |
Reduced
-5.0k |
-5,000 |