Vault-13

ASCENDIS PHARMA A/S

SPONSORED ADR · CUSIP 04351P101 · ISIN US04351P1012

221 institutional holders +17 vs Q2 2024
62,679,51062.7m shares reported held*
$9.3bnreported value*
39 new 78 added 69 reduced 25 sold out net bought ≈ $209.7m (+1.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $148.79. Options: 12 managers hold calls ($39.3m notional), 10 hold puts ($58.8m).

Trends to Q3 2024

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 183Q4 22: 187Q1 23: 165Q2 23: 159Q3 23: 161Q4 23: 186Q1 24: 190Q2 24: 204Q3 24: 221221Q3 22Q1 23Q3 23Q1 24Q3 24
Numbers
QuarterHolders
Q3 2022183
Q4 2022187
Q1 2023165
Q2 2023159
Q3 2023161
Q4 2023186
Q1 2024190
Q2 2024204
Q3 2024221

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 94 bought or addedQ4 22: 91 cut or sold outQ1 23: 75 bought or addedQ1 23: 100 cut or sold outQ1 23Q2 23: 87 bought or addedQ2 23: 88 cut or sold outQ3 23: 71 bought or addedQ3 23: 78 cut or sold outQ3 23Q4 23: 90 bought or addedQ4 23: 86 cut or sold outQ1 24: 111 bought or addedQ1 24: 83 cut or sold outQ1 24Q2 24: 111 bought or addedQ2 24: 89 cut or sold outQ3 24: 117 bought or addedQ3 24: 94 cut or sold outQ3 24
Numbers
QuarterBought or addedCut or sold out
Q4 20229491
Q1 202375100
Q2 20238788
Q3 20237178
Q4 20239086
Q1 202411183
Q2 202411189
Q3 202411794

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ4 23 calls: $26.8mQ4 23 puts: $20.7mQ4 23P/C 0.77Q1 24 calls: $48.3mQ1 24 puts: $51.8mQ1 24P/C 1.07Q2 24 calls: $21.1mQ2 24 puts: $43.9mQ2 24P/C 2.08Q3 24 calls: $39.3mQ3 24 puts: $58.8mQ3 24P/C 1.49
Numbers
QuarterCallsPutsP/C
Q4 2023$26.8m$20.7m0.77
Q1 2024$48.3m$51.8m1.07
Q2 2024$21.1m$43.9m2.08
Q3 2024$39.3m$58.8m1.49

Biggest buyers

T. Rowe Price Investment Management, Inc. Added +1,734,478+1.7m
Avoro Capital Advisors LLC Added +792,227+792.2k
Camber Capital Management LP New +700,000+700.0k
Point72 Asset Management, L.P. New +495,547+495.5k
GROUPAMA ASSET MANAGMENT New +404,000+404.0k
PRICE T ROWE ASSOCIATES INC /MD/ Added +336,980+337.0k
JANUS HENDERSON GROUP PLC Added +267,881+267.9k
Duquesne Family Office LLC New +265,040+265.0k
Polar Capital Holdings Plc New +225,000+225.0k
FIL Ltd Added +197,751+197.8k

Biggest sellers

WELLINGTON MANAGEMENT GROUP LLP Reduced -1,351,376-1.4m
Sofinnova Investments, Inc. Sold out -734,284-734.3k
Paradigm Biocapital Advisors LP Sold out -664,307-664.3k
FRANKLIN RESOURCES INC Reduced -625,128-625.1k
Vestal Point Capital, LP Reduced -500,000-500.0k
RA CAPITAL MANAGEMENT, L.P. Reduced -397,972-398.0k
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -333,555-333.6k
Tri Locum Partners LP Sold out -227,762-227.8k
TWO SIGMA INVESTMENTS, LP Reduced -205,232-205.2k
D. E. Shaw & Co., Inc. Reduced -191,157-191.2k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $18.1m121.3k shares
GOLDMAN SACHS GROUP INC Added $6.7m45.0k shares
Caption Management, LLC New $4.9m32.5k shares
CITADEL ADVISORS LLC Reduced $3.0m19.8k shares
JANE STREET GROUP, LLC Added $1.9m12.8k shares
GROUP ONE TRADING LLC Added $1.7m11.4k shares
Point72 Asset Management, L.P. New $1.5m10.0k shares
D. E. Shaw & Co., Inc. New $746.5k5.0k shares
SIMPLEX TRADING, LLC Reduced $582.0k3.9k shares
Walleye Trading LLC New $134.4k900 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $22.7m152.2k shares
JANE STREET GROUP, LLC Added $11.6m77.7k shares
Walleye Trading LLC New $9.6m64.2k shares
MILLENNIUM MANAGEMENT LLC New $5.7m38.0k shares
CITADEL ADVISORS LLC Added $4.0m26.7k shares
SIMPLEX TRADING, LLC Added $2.0m13.3k shares
Caption Management, LLC Added $1.9m12.5k shares
GROUP ONE TRADING LLC Reduced $1.0m6.7k shares
CITIGROUP INC Reduced $373.3k2.5k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
T. Rowe Price Investment Management, Inc. 13G · institution +0.6 pts · filed 2026-05-07 10.5% +0.6 pts 6.5m 2026-05-07
WESTFIELD CAPITAL MANAGEMENT CO LP 13G · institution -0.7 pts · filed 2026-02-11 8.5% -0.7 pts 5.2m 2026-02-11
FMR LLC 13G · institution filed 2025-05-12 8.0% 4.6m 2025-05-12
JANUS HENDERSON GROUP PLC 13G · institution -1.8 pts · filed 2026-05-15 6.0% -1.8 pts 3.7m 2026-05-15
Artisan Partners Limited Partnership 13G · institution filed 2026-02-03 5.2% 3.2m 2026-02-03

Fell to 5% or below in the last year: Capital International Investors (3.2%, 2026-05-14)

Holders, Q3 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 16.72% of their portfolio BOSTON, MA 9,710,4289.7m $1.4bn $1.4bn 16.72% Reduced -398.0k -397,972
2 WESTFIELD CAPITAL MANAGEMENT CO LP 3.46% of their portfolio BOSTON, MA 5,133,7665.1m $766.5m $766.5m 3.46% Added +170.9k +170,942
3 Avoro Capital Advisors LLC 10.86% of their portfolio NEW YORK, NY 4,988,8885.0m $744.9m $744.9m 10.86% Added +792.2k +792,227
4 FMR LLC 0.04% of their portfolio BOSTON, MA 4,907,8464.9m $732.8m $732.8m 0.04% Reduced -14.7k -14,709
5 Artisan Partners Limited Partnership 0.99% of their portfolio Milwaukee, WI 4,411,1114.4m $658.6m $658.6m 0.99% Added +116.1k +116,082
6 JANUS HENDERSON GROUP PLC 0.32% of their portfolio LONDON, X0 4,186,6944.2m $625.1m $625.1m 0.32% Added +267.9k +267,881
7 PRICE T ROWE ASSOCIATES INC /MD/ 0.04% of their portfolio BALTIMORE, MD 2,121,1282.1m $316.7m $316.7m 0.04% Added +337.0k +336,980
8 Capital International Investors 0.06% of their portfolio Los Angeles, CA 2,109,3902.1m $315.0m $315.0m 0.06% Added +5.1k +5,092
9 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.08% of their portfolio Boston, MA 1,866,9861.9m $278.8m $278.8m 0.08% Added +156.0k +155,971
10 T. Rowe Price Investment Management, Inc. 0.16% of their portfolio BALTIMORE, MD 1,765,0421.8m $263.5m $263.5m 0.16% Added +1.7m +1,734,478
11 FRANKLIN RESOURCES INC 0.05% of their portfolio San Mateo, CA 1,459,7231.5m $187.5m $187.5m 0.05% Reduced -625.1k -625,128
12 WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio Boston, MA 1,261,4801.3m $188.4m $188.4m 0.03% Reduced -1.4m -1,351,376
13 Invesco Ltd. 0.03% of their portfolio ATLANTA, GA 1,162,2451.2m $173.5m $173.5m 0.03% Added +55.8k +55,796
14 Camber Capital Management LP 4.06% of their portfolio BOSTON, MA 700,000700.0k $104.5m $104.5m 4.06% New
15 AMERIPRISE FINANCIAL INC 0.03% of their portfolio MINNEAPOLIS, MN 669,717669.7k $100.0m $100.0m 0.03% Added +9.1k +9,055
16 CITADEL ADVISORS LLC 0.10% of their portfolio MIAMI, FL 663,924663.9k $99.1m $99.1m 0.10% Added +126.2k +126,162
17 Spyglass Capital Management LLC 6.40% of their portfolio Greenbrae, CA 652,841652.8k $97.5m $97.5m 6.40% Reduced -10.0k -10,047
18 FIL Ltd 0.09% of their portfolio HAMILTON, D0 640,259640.3k $95.6m $95.6m 0.09% Added +197.8k +197,751
19 BlackRock, Inc. 0.00% of their portfolio New York, NY 536,104536.1k $80.0m $80.0m 0.00% First filing
20 MILLENNIUM MANAGEMENT LLC 0.06% of their portfolio NEW YORK, NY 501,690501.7k $74.9m $74.9m 0.06% Added +28.2k +28,241
21 TimesSquare Capital Management, LLC 1.12% of their portfolio NEW YORK, NY 500,920500.9k $74.8m $74.8m 1.12% Reduced -95.4k -95,394
22 Point72 Asset Management, L.P. 0.26% of their portfolio STAMFORD, CT 495,547495.5k $74.0m $74.0m 0.26% New
23 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 490,351490.4k $73.2m $73.2m 0.01% Added +68.8k +68,800
24 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.13% of their portfolio Boston, MA 486,957487.0k $72.7m $72.7m 0.13% Reduced -333.6k -333,555
25 BROWN ADVISORY INC 0.09% of their portfolio BALTIMORE, MD 467,652467.7k $69.8m $69.8m 0.09% Reduced -11.0k -11,024
26 ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio NASHVILLE, TN 454,788454.8k $67.9m $67.9m 0.02% Reduced -20.2k -20,213
27 GROUPAMA ASSET MANAGMENT 0.01% of their portfolio PARIS, I0 404,000404.0k $373.3k $373.3k 0.01% New
28 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.22% of their portfolio JUPITER, FL 397,013397.0k $59.3m $59.3m 0.22% Added +50.8k +50,795
29 Siren, L.L.C. 2.60% of their portfolio New York, NY 347,921347.9k $51.9m $51.9m 2.60% First filing
30 AMERICAN CENTURY COMPANIES INC 0.03% of their portfolio KANSAS CITY, MO 346,746346.7k $51.8m $51.8m 0.03% Added +40.8k +40,772
31 Rock Springs Capital Management LP 1.58% of their portfolio Baltimore, MD 325,000325.0k $48.5m $48.5m 1.58% Added +35.0k +35,000
32 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 312,488312.5k $46.7m $46.7m 0.00% Added +145.5k +145,519
33 Candriam S.C.A. 0.24% of their portfolio STRASSEN, N4 282,331282.3k $42.2m $42.2m 0.24% Added +87.0k +86,984
34 SEI INVESTMENTS CO 0.05% of their portfolio OAKS, PA 273,747273.7k $40.9m $40.9m 0.05% Added +9.2k +9,176
35 Duquesne Family Office LLC 1.39% of their portfolio New York, NY 265,040265.0k $39.6m $39.6m 1.39% New
36 ARS Investment Partners, LLC 3.52% of their portfolio New York, NY 263,111263.1k $39.3m $39.3m 3.52% Added +10.0k +9,972
37 FRED ALGER MANAGEMENT, LLC 0.19% of their portfolio NEW YORK, NY 258,210258.2k $38.6m $38.6m 0.19% Reduced -48.9k -48,863
38 TD Asset Management Inc 0.03% of their portfolio Toronto, A6 253,124253.1k $36.6m $36.6m 0.03% Added +153.2k +153,178
39 Vestal Point Capital, LP 2.95% of their portfolio NEW YORK, NY 250,000250.0k $37.3m $37.3m 2.95% Reduced -500.0k -500,000
40 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.09% of their portfolio Paris, I0 243,856243.9k $36.4m $36.4m 0.09% Added +80.7k +80,746
41 Woodline Partners LP 0.30% of their portfolio San Francisco, CA 235,018235.0k $35.1m $35.1m 0.30% Added +36.3k +36,252
42 Schonfeld Strategic Advisors LLC 0.28% of their portfolio NEW YORK, NY 228,525228.5k $34.1m $34.1m 0.28% Added +130.4k +130,384
43 Polar Capital Holdings Plc 0.19% of their portfolio London, X0 225,000225.0k $33.6m $33.6m 0.19% New
44 MARSHALL WACE, LLP 0.04% of their portfolio LONDON, X0 221,075221.1k $33.0m $33.0m 0.04% Added +190.8k +190,786
45 Q Global Advisors, LLC 28.82% of their portfolio FORT WORTH, TX 219,459219.5k $32.8m $32.8m 28.82% Unchanged
46 Saturn V Capital Management LP 10.69% of their portfolio AUSTIN, TX 200,285200.3k $29.9m $29.9m 10.69% Added +87.1k +87,061
47 Finepoint Capital LP 3.45% of their portfolio BOSTON, MA 190,072190.1k $28.4m $28.4m 3.45% Added +800 +800
48 LOOMIS SAYLES & CO L P 0.04% of their portfolio BOSTON, MA 184,623184.6k $27.6m $27.6m 0.04% Added +63.0k +63,029
49 NEW YORK STATE COMMON RETIREMENT FUND 0.04% of their portfolio ALBANY, NY 179,318179.3k $26.8m $26.8m 0.04% Reduced -20.1k -20,083
50 BNP PARIBAS FINANCIAL MARKETS 0.03% of their portfolio PARIS, I0 178,705178.7k $26.7m $26.7m 0.03% Added +50.6k +50,631
51 Allspring Global Investments Holdings, LLC 0.04% of their portfolio CHARLOTTE, NC 161,410161.4k $24.1m $24.1m 0.04% Reduced -17.8k -17,842
52 ADAR1 Capital Management, LLC 4.04% of their portfolio AUSTIN, TX 161,402161.4k $24.1m $24.1m 4.04% Added +110.1k +110,139
53 RICE HALL JAMES & ASSOCIATES, LLC 1.30% of their portfolio San Diego, CA 160,614160.6k $24.0m $24.0m 1.30% Added +9.0k +8,958
54 Aberdeen Group plc 0.04% of their portfolio EDINBURGH, X0 158,213158.2k $23.6m $23.6m 0.04% Reduced -2.4k -2,389
55 Pictet Asset Management Holding SA 0.02% of their portfolio CAROUGE, V8 154,044154.0k $22.3m $22.3m 0.02% Added +7.7k +7,717
56 First Turn Management, LLC 3.56% of their portfolio DEL MAR, CA 150,593150.6k $22.5m $22.5m 3.56% Reduced -36.0k -35,988
57 VICTORY CAPITAL MANAGEMENT INC 0.02% of their portfolio San Antonio, TX 133,858133.9k $20.0m $20.0m 0.02% Reduced -551 -551
58 Frazier Life Sciences Management, L.P. 0.80% of their portfolio PALO ALTO, CA 133,333133.3k $19.9m $19.9m 0.80% New
59 ACADIAN ASSET MANAGEMENT LLC 0.06% of their portfolio Boston, MA 120,894120.9k $18.0m $18.0m 0.06% Reduced -21.3k -21,271
60 Avidity Partners Management LP 0.91% of their portfolio DALLAS, TX 119,000119.0k $17.8m $17.8m 0.91% New
61 Alyeska Investment Group, L.P. 0.09% of their portfolio CHICAGO, IL 115,000115.0k $17.2m $17.2m 0.09% Added +55.0k +55,000
62 Driehaus Capital Management LLC 0.15% of their portfolio Chicago, IL 114,314114.3k $17.1m $17.1m 0.15% Added +32.9k +32,918
63 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 112,572112.6k $16.8m $16.8m 0.00% Reduced -134.4k -134,389
64 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 105,218105.2k $15.7m $15.7m 0.00% Reduced -5.4k -5,423
65 Resolute Capital Asset Partners LLC 8.12% of their portfolio DENVER, CO 104,500104.5k $15.6m $15.6m 8.12% Added +57.5k +57,500
66 PFM Health Sciences, LP 0.78% of their portfolio SAN FRANCISCO, CA 90,76690.8k $13.6m $13.6m 0.78% New
67 D. E. Shaw & Co., Inc. 0.02% of their portfolio New York, NY 90,38090.4k $13.5m $13.5m 0.02% Reduced -191.2k -191,157
68 DAFNA Capital Management LLC 3.16% of their portfolio LOS ANGELES, CA 89,57289.6k $13.4m $13.4m 3.16% Added +8.6k +8,600
69 Exome Asset Management LLC 4.46% of their portfolio NEW YORK, NY 87,69887.7k $13.1m $13.1m 4.46% Added +67.7k +67,698
70 HARBOR CAPITAL ADVISORS, INC. 0.57% of their portfolio CHICAGO, IL 87,30287.3k $13.0m $13.0m 0.57% Added +35.1k +35,102
71 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 80,98981.0k $11.7m $11.7m 0.01% Added +36.1k +36,071
72 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 79,66879.7k $11.9m $11.9m 0.00% Reduced -50.9k -50,856
73 Thrivent Financial for Lutherans 0.02% of their portfolio Minneapolis, MN 78,47378.5k $11.7m $11.7m 0.02% Added +228 +228
74 Zimmer Partners, LP 0.22% of their portfolio NEW YORK, NY 78,00078.0k $11.6m $11.6m 0.22% New
75 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 71,45971.5k $10.7m $10.7m 0.00% Added +36.4k +36,402
76 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio Toronto, A6 71,30771.3k $10.6m $10.6m 0.01% Added +23.6k +23,595
77 BIT Capital GmbH 0.98% of their portfolio BERLIN, 2M 68,42168.4k $10.2m $10.2m 0.98% Reduced -36.2k -36,217
78 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 56,44856.4k $8.4m $8.4m 0.00% Reduced -1.3k -1,338
79 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 0.37% of their portfolio Boston, MA 55,10155.1k $8.2m $8.2m 0.37% Reduced -178.6k -178,572
80 Ghost Tree Capital, LLC 2.84% of their portfolio NEW YORK, NY 52,50052.5k $7.8m $7.8m 2.84% Reduced -34.2k -34,221
81 First Light Asset Management, LLC 0.64% of their portfolio Edina, MN 51,72351.7k $7.7m $7.7m 0.64% Added +15.6k +15,566
82 Gray Foundation 2.29% of their portfolio Cohoes, NY 51,70051.7k $7.7m $7.7m 2.29% Unchanged
83 TWO SIGMA INVESTMENTS, LP 0.02% of their portfolio NEW YORK, NY 50,08850.1k $7.5m $7.5m 0.02% Reduced -205.2k -205,232
84 Maven Securities LTD 0.84% of their portfolio ST HELIER, Y9 50,00050.0k $7.5m $7.5m 0.84% New
85 Sterling Capital Management LLC 0.09% of their portfolio CHARLOTTE, NC 47,78547.8k $7.1m $7.1m 0.09% First filing
86 TWO SIGMA ADVISERS, LP 0.02% of their portfolio NEW YORK, NY 47,25847.3k $7.1m $7.1m 0.02% Reduced -154.7k -154,742
87 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 45,50645.5k $6.8m $6.8m 0.00% Reduced -135.5k -135,523
88 Atika Capital Management LLC 0.69% of their portfolio NEW YORK, NY 43,00043.0k $6.4m $6.4m 0.69% New
89 DIVERSIFIED TRUST CO 0.16% of their portfolio MEMPHIS, TN 41,92441.9k $6.3m $6.3m 0.16% New
90 MOORE CAPITAL MANAGEMENT, LP 0.17% of their portfolio NEW YORK, NY 40,00040.0k $6.0m $6.0m 0.17% New
91 NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio NEW YORK, NY 39,76239.8k $5.9m $5.9m 0.00% Added +9.5k +9,466
92 JANE STREET GROUP, LLC 0.01% of their portfolio NEW YORK, NY 35,45435.5k $5.3m $5.3m 0.01% Added +19.2k +19,193
93 Matisse Capital 2.45% of their portfolio PORTLAND, OR 33,68433.7k $5.0m $5.0m 2.45% Reduced -1.0k -1,045
94 Evolutionary Tree Capital Management, LLC 4.90% of their portfolio ALEXANDRIA, VA 32,75332.8k $4.9m $4.9m 4.90% Added +7.9k +7,891
95 DekaBank Deutsche Girozentrale 0.01% of their portfolio FRANKFURT, 2M 30,00030.0k $4.3m $4.3m 0.01% Unchanged
96 TUDOR INVESTMENT CORP ET AL 0.04% of their portfolio STAMFORD, CT 25,89125.9k $3.9m $3.9m 0.04% Reduced -7.5k -7,484
97 BAILLIE GIFFORD & CO 0.00% of their portfolio EDINBURGH, X0 21,40321.4k $3.2m $3.2m 0.00% Reduced -49.7k -49,668
98 Henry James International Management Inc. 1.11% of their portfolio NEW YORK, NY 21,35121.4k $3.2m $3.2m 1.11% Reduced -3.1k -3,146
99 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 21,26821.3k $3.2m $3.2m 0.00% Reduced -4.0k -4,013
100 ACUTA CAPITAL PARTNERS, LLC 2.54% of their portfolio REDWOOD CITY, CA 21,00021.0k $3.1m $3.1m 2.54% New